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Increased circulating thyroxine-binding globulin level

MedGen UID:
1613486
•Concept ID:
C4531267
•
Finding
Synonym: Thyroxine-binding globulin high in blood
 
HPO: HP:0031222

Definition

An elevated concentration of thyroxine-binding globulin (TBG) in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating thyroxine-binding globulin level

Professional guidelines

PubMed

Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment.
Bourebaba N, Ngo T, Śmieszek A, Bourebaba L, Marycz K
Biomed Pharmacother 2022 Sep;153:113261. Epub 2022 Jun 20 doi: 10.1016/j.biopha.2022.113261. PMID: 35738176
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574
Growth hormone treatment in hypopituitary GH deficient adults reduces circulating cortisol levels during hydrocortisone replacement therapy.
Rodríguez-Arnao J, Perry L, Besser GM, Ross RJ
Clin Endocrinol (Oxf) 1996 Jul;45(1):33-7. doi: 10.1111/j.1365-2265.1996.tb02057.x. PMID: 8796136

Recent clinical studies

Etiology

Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment.
Bourebaba N, Ngo T, Śmieszek A, Bourebaba L, Marycz K
Biomed Pharmacother 2022 Sep;153:113261. Epub 2022 Jun 20 doi: 10.1016/j.biopha.2022.113261. PMID: 35738176
A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort.
Aker AM, Ferguson KK, Rosario ZY, Mukherjee B, Alshawabkeh AN, Calafat AM, Cordero JF, Meeker JD
Environ Health 2019 Apr 2;18(1):28. doi: 10.1186/s12940-019-0459-5. PMID: 30940137Free PMC Article
Cross-sectional and longitudinal determinants of serum sex hormone binding globulin (SHBG) in a cohort of community-dwelling men.
Gyawali P, Martin SA, Heilbronn LK, Vincent AD, Jenkins AJ, Januszewski AS, Taylor AW, Adams RJT, O'Loughlin PD, Wittert GA
PLoS One 2018;13(7):e0200078. Epub 2018 Jul 11 doi: 10.1371/journal.pone.0200078. PMID: 29995902Free PMC Article
The role of thyroid autoimmunity in fertility and pregnancy.
Poppe K, Velkeniers B, Glinoer D
Nat Clin Pract Endocrinol Metab 2008 Jul;4(7):394-405. Epub 2008 May 27 doi: 10.1038/ncpendmet0846. PMID: 18506157
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Diagnosis

Evolution of circulating thyroid hormone levels in preterm infants during the first week of life: perinatal influences and impact on neurodevelopment.
Eerdekens A, Naulaers G, Ortibus E, Verhaeghe J, Langouche L, Vanhole C
J Pediatr Endocrinol Metab 2019 Jun 26;32(6):597-606. doi: 10.1515/jpem-2018-0537. PMID: 31112508
Characterization of sex hormone-binding globulin isoforms in hypothyroid women.
Brenta G, Bedecarras P, Schnitman M, Gurfinkiel M, Damilano S, Campo S, Pisarev MA
Thyroid 2002 Feb;12(2):101-5. doi: 10.1089/105072502753522329. PMID: 11916278
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574
Raised total thyroxine and free thyroxine index but normal free thyroxine. A serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein.
Hennemann G, Docter R, Krenning EP, Bos G, Otten M, Visser TJ
Lancet 1979 Mar 24;1(8117):639-42. doi: 10.1016/s0140-6736(79)91080-8. PMID: 85873
Measurement of 3,3',5'-Triiodothyroinine (reverse T3), 3,3'-L-diiodothyronine, T3 and T4 in human amniotic fluid and in cord and maternal serum.
Burman KD, Read J, Dimond RC, Strum D, Wright FD, Patow W, Earll JM, Wartofsky L
J Clin Endocrinol Metab 1976 Dec;43(6):1351-9. doi: 10.1210/jcem-43-6-1351. PMID: 826545

Therapy

Cross-sectional and longitudinal determinants of serum sex hormone binding globulin (SHBG) in a cohort of community-dwelling men.
Gyawali P, Martin SA, Heilbronn LK, Vincent AD, Jenkins AJ, Januszewski AS, Taylor AW, Adams RJT, O'Loughlin PD, Wittert GA
PLoS One 2018;13(7):e0200078. Epub 2018 Jul 11 doi: 10.1371/journal.pone.0200078. PMID: 29995902Free PMC Article
Interaction of estrogen therapy and thyroid hormone replacement in postmenopausal women.
Mazer NA
Thyroid 2004;14 Suppl 1:S27-34. doi: 10.1089/105072504323024561. PMID: 15142374
Thyroid function in patients with chronic renal failure.
Lim VS
Am J Kidney Dis 2001 Oct;38(4 Suppl 1):S80-4. doi: 10.1053/ajkd.2001.27410. PMID: 11576928
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574
Thyroxine treatment increases circulating levels of insulin-like growth factor binding protein-1: a placebo-controlled study.
Angervo M, Tiihonen M, Leinonen P, Välimäki M, Seppälä M
Clin Endocrinol (Oxf) 1993 May;38(5):547-51. doi: 10.1111/j.1365-2265.1993.tb00352.x. PMID: 7687206

Prognosis

Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment.
Bourebaba N, Ngo T, Śmieszek A, Bourebaba L, Marycz K
Biomed Pharmacother 2022 Sep;153:113261. Epub 2022 Jun 20 doi: 10.1016/j.biopha.2022.113261. PMID: 35738176
Evolution of circulating thyroid hormone levels in preterm infants during the first week of life: perinatal influences and impact on neurodevelopment.
Eerdekens A, Naulaers G, Ortibus E, Verhaeghe J, Langouche L, Vanhole C
J Pediatr Endocrinol Metab 2019 Jun 26;32(6):597-606. doi: 10.1515/jpem-2018-0537. PMID: 31112508
Persistent organic pollutants and transthyretin-bound thyroxin in plasma of Inuit women of childbearing age.
Audet-Delage Y, Ouellet N, Dallaire R, Dewailly E, Ayotte P
Environ Sci Technol 2013 Nov 19;47(22):13086-92. Epub 2013 Nov 11 doi: 10.1021/es4027634. PMID: 24160776
Lower serum free thyroxine (T4) levels in painless thyroiditis compared with Graves' disease despite similar serum total T4 levels.
Shigemasa C, Abe K, Taniguchi S, Mitani Y, Ueda Y, Adachi T, Urabe K, Tanaka T, Yoshida A, Mashiba H
J Clin Endocrinol Metab 1987 Aug;65(2):359-63. doi: 10.1210/jcem-65-2-359. PMID: 3110204
Changes in serum thyrotropin (TSH) in man during halofenate administration.
Davis PJ, Davis FB, Utiger RD, Kulaga SF Jr
J Clin Endocrinol Metab 1976 Oct;43(4):873-81. doi: 10.1210/jcem-43-4-873. PMID: 824301

Clinical prediction guides

Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment.
Bourebaba N, Ngo T, Śmieszek A, Bourebaba L, Marycz K
Biomed Pharmacother 2022 Sep;153:113261. Epub 2022 Jun 20 doi: 10.1016/j.biopha.2022.113261. PMID: 35738176
Hypoandrogenaemia is associated with subclinical hypothyroidism in men.
Kumar A, Chaturvedi PK, Mohanty BP
Int J Androl 2007 Feb;30(1):14-20. Epub 2006 Jul 24 doi: 10.1111/j.1365-2605.2006.00705.x. PMID: 16879621
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574
Thyroid hormone-binding inhibitor in normal, pregnant, and lactating rat and postmenopausal human breast tissue.
Oberkotter LV, Farmer LC, Farber M
Endocrinology 1985 Aug;117(2):511-4. doi: 10.1210/endo-117-2-511. PMID: 3926454
Alterations in circulating thyroid hormones and thyroxine binding globulin in chronic alcoholism.
Geurts J, Demeester-Mirkine N, Glinoer D, Prigogine T, Fernandez-Deville M, Corvilain J
Clin Endocrinol (Oxf) 1981 Feb;14(2):113-8. doi: 10.1111/j.1365-2265.1981.tb00605.x. PMID: 6790200

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