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Pancytopenia caused by medication

MedGen UID:
1613695
•Concept ID:
C3251580
•
Disease or Syndrome
Synonyms: Drug induced pancytopenia; Drug Induced Pancytopenia; Drug-Induced Pancytopenia; Pancytopenia due to medication
SNOMED CT: Pancytopenia caused by medication (736024007); Drug induced pancytopenia (736024007); Pancytopenia due to medication (736024007)

Definition

Pancytopenia caused by exposure to certain drugs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancytopenia caused by medication

Professional guidelines

PubMed

Deficiency of Adenosine Deaminase 2: Clinical Manifestations, Diagnosis, and Treatment.
Grim A, Veiga KR, Saad N
Rheum Dis Clin North Am 2023 Nov;49(4):773-787. Epub 2023 Aug 1 doi: 10.1016/j.rdc.2023.06.004. PMID: 37821195
Herbal approach in the treatment of pancytopenia.
Bagwe SM, Kale PP, Bhatt LK, Prabhavalkar KS
J Complement Integr Med 2017 Mar 1;14(1) doi: 10.1515/jcim-2016-0053. PMID: 28195548
Management of immune cytopenias in patients with systemic lupus erythematosus - Old and new.
Newman K, Owlia MB, El-Hemaidi I, Akhtari M
Autoimmun Rev 2013 May;12(7):784-91. Epub 2013 Feb 24 doi: 10.1016/j.autrev.2013.02.001. PMID: 23462431

Recent clinical studies

Etiology

Low-dose methotrexate toxicity.
Pivovarov K, Zipursky JS
CMAJ 2019 Apr 15;191(15):E423. doi: 10.1503/cmaj.181054. PMID: 30988043Free PMC Article
Oral cancer in Fanconi anemia: Review of 121 cases.
Furquim CP, Pivovar A, Amenábar JM, Bonfim C, Torres-Pereira CC
Crit Rev Oncol Hematol 2018 May;125:35-40. Epub 2018 Mar 6 doi: 10.1016/j.critrevonc.2018.02.013. PMID: 29650274
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article
Disseminated intravascular coagulation.
Naz H, Fawad A, Islam A, Shahid H, Abbasi AU
J Ayub Med Coll Abbottabad 2011 Oct-Dec;23(4):111-3. PMID: 23472430
Adalimumab: a review of side effects.
Scheinfeld N
Expert Opin Drug Saf 2005 Jul;4(4):637-41. doi: 10.1517/14740338.4.4.637. PMID: 16011443

Diagnosis

Hemophagocytic Lymphohistiocytosis: Clinical Presentations and Diagnosis.
Risma KA, Marsh RA
J Allergy Clin Immunol Pract 2019 Mar;7(3):824-832. Epub 2018 Dec 14 doi: 10.1016/j.jaip.2018.11.050. PMID: 30557712
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article
Idiopathic aplastic anemia: diagnosis and classification.
Dolberg OJ, Levy Y
Autoimmun Rev 2014 Apr-May;13(4-5):569-73. Epub 2014 Jan 12 doi: 10.1016/j.autrev.2014.01.014. PMID: 24424170
Transfusion-associated graft-versus-host disease.
Dwyre DM, Holland PV
Vox Sang 2008 Aug;95(2):85-93. Epub 2008 Jun 9 doi: 10.1111/j.1423-0410.2008.01073.x. PMID: 18544121
Bone marrow necrosis.
Janssens AM, Offner FC, Van Hove WZ
Cancer 2000 Apr 15;88(8):1769-80. PMID: 10760751

Therapy

Low-dose methotrexate toxicity.
Pivovarov K, Zipursky JS
CMAJ 2019 Apr 15;191(15):E423. doi: 10.1503/cmaj.181054. PMID: 30988043Free PMC Article
Herbal approach in the treatment of pancytopenia.
Bagwe SM, Kale PP, Bhatt LK, Prabhavalkar KS
J Complement Integr Med 2017 Mar 1;14(1) doi: 10.1515/jcim-2016-0053. PMID: 28195548
Splenic irradiation for splenomegaly: A systematic review.
Zaorsky NG, Williams GR, Barta SK, Esnaola NF, Kropf PL, Hayes SB, Meyer JE
Cancer Treat Rev 2017 Feb;53:47-52. Epub 2016 Dec 22 doi: 10.1016/j.ctrv.2016.11.016. PMID: 28063304Free PMC Article
Transfusion-associated graft-versus-host disease.
Dwyre DM, Holland PV
Vox Sang 2008 Aug;95(2):85-93. Epub 2008 Jun 9 doi: 10.1111/j.1423-0410.2008.01073.x. PMID: 18544121
Adalimumab: a review of side effects.
Scheinfeld N
Expert Opin Drug Saf 2005 Jul;4(4):637-41. doi: 10.1517/14740338.4.4.637. PMID: 16011443

Prognosis

Splenic irradiation for splenomegaly: A systematic review.
Zaorsky NG, Williams GR, Barta SK, Esnaola NF, Kropf PL, Hayes SB, Meyer JE
Cancer Treat Rev 2017 Feb;53:47-52. Epub 2016 Dec 22 doi: 10.1016/j.ctrv.2016.11.016. PMID: 28063304Free PMC Article
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article
Adult acute leukemia.
Cornell RF, Palmer J
Dis Mon 2012 Apr;58(4):219-38. doi: 10.1016/j.disamonth.2012.01.011. PMID: 22449370
Disseminated intravascular coagulation.
Naz H, Fawad A, Islam A, Shahid H, Abbasi AU
J Ayub Med Coll Abbottabad 2011 Oct-Dec;23(4):111-3. PMID: 23472430
Orthopaedic management of the patient with osteopetrosis.
Landa J, Margolis N, Di Cesare P
J Am Acad Orthop Surg 2007 Nov;15(11):654-62. doi: 10.5435/00124635-200711000-00004. PMID: 17989416

Clinical prediction guides

Clinical features of idiopathic portal hypertension in China: A retrospective study of 338 patients and literature review.
Sun Y, Lan X, Shao C, Wang T, Yang Z
J Gastroenterol Hepatol 2019 Aug;34(8):1417-1423. Epub 2018 Dec 16 doi: 10.1111/jgh.14552. PMID: 30462857
Herbal approach in the treatment of pancytopenia.
Bagwe SM, Kale PP, Bhatt LK, Prabhavalkar KS
J Complement Integr Med 2017 Mar 1;14(1) doi: 10.1515/jcim-2016-0053. PMID: 28195548
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article
Influenza pandemics: past, present and future.
Hsieh YC, Wu TZ, Liu DP, Shao PL, Chang LY, Lu CY, Lee CY, Huang FY, Huang LM
J Formos Med Assoc 2006 Jan;105(1):1-6. doi: 10.1016/S0929-6646(09)60102-9. PMID: 16440064
Bone marrow necrosis.
Janssens AM, Offner FC, Van Hove WZ
Cancer 2000 Apr 15;88(8):1769-80. PMID: 10760751

Recent systematic reviews

Splenic irradiation for splenomegaly: A systematic review.
Zaorsky NG, Williams GR, Barta SK, Esnaola NF, Kropf PL, Hayes SB, Meyer JE
Cancer Treat Rev 2017 Feb;53:47-52. Epub 2016 Dec 22 doi: 10.1016/j.ctrv.2016.11.016. PMID: 28063304Free PMC Article

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