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Intermediate Atypical Prostate Carcinoma

MedGen UID:
1614896
•Concept ID:
C4527149
•
Neoplastic Process
Synonyms: Intermediate Atypical Carcinoma; Intermediate Atypical mCRPC; Intermediate Atypical Metastatic Castration-Resistant Prostate Cancer; Intermediate Atypical Metastatic Castration-Resistant Prostate Carcinoma

Definition

An aggressive, castration-resistant, histologically distinct, metastatic carcinoma arising from the prostate gland. It is characterized by the presence of a pure population of cytologically bland malignant epithelial cells with moderate to abundant cytoplasm and rare mitotic figures. The prognosis is poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntermediate Atypical Prostate Carcinoma

Professional guidelines

PubMed

Implications of a diagnosis of atypical small acinar proliferation (ASAP) and high-grade prostatic intraepithelial neoplasia (HGPIN) on prostate biopsy: a 5-year follow-up study.
O'Connor E, Dowling C, Casey M, O'Connor D, McHale T
Ir J Med Sci 2022 Oct;191(5):2035-2040. Epub 2021 Nov 19 doi: 10.1007/s11845-021-02854-2. PMID: 34799794

Recent clinical studies

Etiology

Non-prostate cancer tumours: incidence on (18)F-DCFPyL PSMA PET/CT and uptake characteristics in 1445 patients.
Perry E, Talwar A, Sharma S, O'Connor D, Wong LM, Taubman K, Sutherland TR
Eur J Nucl Med Mol Imaging 2022 Jul;49(9):3277-3288. Epub 2022 Mar 7 doi: 10.1007/s00259-022-05721-z. PMID: 35254481Free PMC Article
Implications of a diagnosis of atypical small acinar proliferation (ASAP) and high-grade prostatic intraepithelial neoplasia (HGPIN) on prostate biopsy: a 5-year follow-up study.
O'Connor E, Dowling C, Casey M, O'Connor D, McHale T
Ir J Med Sci 2022 Oct;191(5):2035-2040. Epub 2021 Nov 19 doi: 10.1007/s11845-021-02854-2. PMID: 34799794
Prostatic intraepithelial neoplasia: recent advances.
Ayala AG, Ro JY
Arch Pathol Lab Med 2007 Aug;131(8):1257-66. doi: 10.5858/2007-131-1257-PINRA. PMID: 17683188
Histological markers of risk and the role of high-grade prostatic intraepithelial neoplasia.
Sakr WA, Partin AW
Urology 2001 Apr;57(4 Suppl 1):115-20. doi: 10.1016/s0090-4295(00)00953-5. PMID: 11295607
Prospective origins of prostate carcinoma. Prostatic intraepithelial neoplasia and atypical adenomatous hyperplasia.
Bostwick DG
Cancer 1996 Jul 15;78(2):330-6. doi: 10.1002/(SICI)1097-0142(19960715)78:2<330::AID-CNCR22>3.0.CO;2-W. PMID: 8674012

Diagnosis

Implications of a diagnosis of atypical small acinar proliferation (ASAP) and high-grade prostatic intraepithelial neoplasia (HGPIN) on prostate biopsy: a 5-year follow-up study.
O'Connor E, Dowling C, Casey M, O'Connor D, McHale T
Ir J Med Sci 2022 Oct;191(5):2035-2040. Epub 2021 Nov 19 doi: 10.1007/s11845-021-02854-2. PMID: 34799794
Pitfalls in the interpretation of specimens from patients with testicular tumours, with an emphasis on variant morphologies.
Ulbright TM
Pathology 2018 Jan;50(1):88-99. Epub 2017 Nov 10 doi: 10.1016/j.pathol.2017.07.013. PMID: 29129333
Precursors of prostate cancer.
Bostwick DG, Cheng L
Histopathology 2012 Jan;60(1):4-27. doi: 10.1111/j.1365-2559.2011.04007.x. PMID: 22212075
Prostatic intraepithelial neoplasia: recent advances.
Ayala AG, Ro JY
Arch Pathol Lab Med 2007 Aug;131(8):1257-66. doi: 10.5858/2007-131-1257-PINRA. PMID: 17683188
Prospective origins of prostate carcinoma. Prostatic intraepithelial neoplasia and atypical adenomatous hyperplasia.
Bostwick DG
Cancer 1996 Jul 15;78(2):330-6. doi: 10.1002/(SICI)1097-0142(19960715)78:2<330::AID-CNCR22>3.0.CO;2-W. PMID: 8674012

Therapy

Precancerous lesions and conditions of the prostate: from morphological and biological characterization to chemoprevention.
Montironi R, Mazzucchelli R, Scarpelli M
Ann N Y Acad Sci 2002 Jun;963:169-84. doi: 10.1111/j.1749-6632.2002.tb04108.x. PMID: 12095942
Prostatic intraepithelial neoplasia and prostate cancer.
Montironi R, Santinelli A, Mazzucchelli R
Panminerva Med 2002 Sep;44(3):213-20. PMID: 12094135
High-grade prostatic intraepithelial neoplasia as an exposure biomarker for prostate cancer chemoprevention research.
Marshall JR
IARC Sci Publ 2001;154:191-8. PMID: 11220658

Prognosis

Non-prostate cancer tumours: incidence on (18)F-DCFPyL PSMA PET/CT and uptake characteristics in 1445 patients.
Perry E, Talwar A, Sharma S, O'Connor D, Wong LM, Taubman K, Sutherland TR
Eur J Nucl Med Mol Imaging 2022 Jul;49(9):3277-3288. Epub 2022 Mar 7 doi: 10.1007/s00259-022-05721-z. PMID: 35254481Free PMC Article
Implications of a diagnosis of atypical small acinar proliferation (ASAP) and high-grade prostatic intraepithelial neoplasia (HGPIN) on prostate biopsy: a 5-year follow-up study.
O'Connor E, Dowling C, Casey M, O'Connor D, McHale T
Ir J Med Sci 2022 Oct;191(5):2035-2040. Epub 2021 Nov 19 doi: 10.1007/s11845-021-02854-2. PMID: 34799794
Precursors of prostate cancer.
Bostwick DG, Cheng L
Histopathology 2012 Jan;60(1):4-27. doi: 10.1111/j.1365-2559.2011.04007.x. PMID: 22212075
Prospective origins of prostate carcinoma. Prostatic intraepithelial neoplasia and atypical adenomatous hyperplasia.
Bostwick DG
Cancer 1996 Jul 15;78(2):330-6. doi: 10.1002/(SICI)1097-0142(19960715)78:2<330::AID-CNCR22>3.0.CO;2-W. PMID: 8674012
Nucleolar and AgNOR-analysis of prostatic intraepithelial neoplasia (PIN), atypical adenomatous hyperplasia (AAH) and prostatic carcinoma.
Helpap B, Riede C
Pathol Res Pract 1995 Jun;191(5):381-90. doi: 10.1016/S0344-0338(11)80723-5. PMID: 7479355

Clinical prediction guides

Non-prostate cancer tumours: incidence on (18)F-DCFPyL PSMA PET/CT and uptake characteristics in 1445 patients.
Perry E, Talwar A, Sharma S, O'Connor D, Wong LM, Taubman K, Sutherland TR
Eur J Nucl Med Mol Imaging 2022 Jul;49(9):3277-3288. Epub 2022 Mar 7 doi: 10.1007/s00259-022-05721-z. PMID: 35254481Free PMC Article
Atypical intraductal proliferation and intraductal carcinoma of the prostate on core needle biopsy: a comparative clinicopathological and molecular study with a proposal to expand the morphological spectrum of intraductal carcinoma.
Shah RB, Yoon J, Liu G, Tian W
Histopathology 2017 Nov;71(5):693-702. Epub 2017 Aug 8 doi: 10.1111/his.13273. PMID: 28570007
Precursors of prostate cancer.
Bostwick DG, Cheng L
Histopathology 2012 Jan;60(1):4-27. doi: 10.1111/j.1365-2559.2011.04007.x. PMID: 22212075
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells.
Leroux ME, Auzenne E, Evans R, Hail N Jr, Spohn W, Ghosh SC, Farquhar D, McDonnell T, Klostergaard J
Prostate 2007 Nov 1;67(15):1699-717. doi: 10.1002/pros.20645. PMID: 17879964
Prospective origins of prostate carcinoma. Prostatic intraepithelial neoplasia and atypical adenomatous hyperplasia.
Bostwick DG
Cancer 1996 Jul 15;78(2):330-6. doi: 10.1002/(SICI)1097-0142(19960715)78:2<330::AID-CNCR22>3.0.CO;2-W. PMID: 8674012

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