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Elevated left atrial pressure

MedGen UID:
1614970
•Concept ID:
C4531219
•
Finding
HPO: HP:0031299

Definition

An abnormal increase in magnitude of the pressure in the left atrium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated left atrial pressure

Professional guidelines

PubMed

Pulmonary hypertension associated with left heart disease: characteristics, emerging concepts, and treatment strategies.
Haddad F, Kudelko K, Mercier O, Vrtovec B, Zamanian RT, de Jesus Perez V
Prog Cardiovasc Dis 2011 Sep-Oct;54(2):154-67. doi: 10.1016/j.pcad.2011.06.003. PMID: 21875514
Mechanical ventilation in the management of acute respiratory distress syndrome.
Delong P, Murray JA, Cook CK
Semin Dial 2006 Nov-Dec;19(6):517-24. doi: 10.1111/j.1525-139X.2006.00215.x. PMID: 17150053
Canadian consensus recommendations for the measurement and reporting of diastolic dysfunction by echocardiography: from the Investigators of Consensus on Diastolic Dysfunction by Echocardiography.
Rakowski H, Appleton C, Chan KL, Dumesnil JG, Honos G, Jue J, Koilpillai C, Lepage S, Martin RP, Mercier LA, O'Kelly B, Prieur T, Sanfilippo A, Sasson Z, Alvarez N, Pruitt R, Thompson C, Tomlinson C
J Am Soc Echocardiogr 1996 Sep-Oct;9(5):736-60. doi: 10.1016/s0894-7317(96)90076-0. PMID: 8887883

Recent clinical studies

Etiology

Exercise-Induced Left Atrial Hypertension in Heart Failure With Preserved Ejection Fraction.
Litwin SE, Komtebedde J, Hu M, Burkhoff D, Hasenfuß G, Borlaug BA, Solomon SD, Zile MR, Mohan RC, Khawash R, Sverdlov AL, Fail P, Chung ES, Kaye DM, Blair J, Eicher JC, Hummel SL, Zirlik A, Westenfeld R, Hayward C, Gorter TM, Demers C, Shetty R, Lewis G, Starling RC, Patel S, Gupta DK, Morsli H, Penicka M, Cikes M, Gustafsson F, Silvestry FE, Rowin EJ, Cutlip DE, Leon MB, Kitzman DW, Kleber FX, Shah SJ; REDUCE LAP-HF Investigators and Research Staff
JACC Heart Fail 2023 Aug;11(8 Pt 2):1103-1117. Epub 2023 Mar 20 doi: 10.1016/j.jchf.2023.01.030. PMID: 36939661
Venting during venoarterial extracorporeal membrane oxygenation.
Lüsebrink E, Binzenhöfer L, Kellnar A, Müller C, Scherer C, Schrage B, Joskowiak D, Petzold T, Braun D, Brunner S, Peterss S, Hausleiter J, Zimmer S, Born F, Westermann D, Thiele H, Schäfer A, Hagl C, Massberg S, Orban M
Clin Res Cardiol 2023 Apr;112(4):464-505. Epub 2022 Aug 20 doi: 10.1007/s00392-022-02069-0. PMID: 35986750Free PMC Article
Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure.
Borlaug BA, Blair J, Bergmann MW, Bugger H, Burkhoff D, Bruch L, Celermajer DS, Claggett B, Cleland JGF, Cutlip DE, Dauber I, Eicher JC, Gao Q, Gorter TM, Gustafsson F, Hayward C, van der Heyden J, Hasenfuß G, Hummel SL, Kaye DM, Komtebedde J, Massaro JM, Mazurek JA, McKenzie S, Mehta SR, Petrie MC, Post MC, Nair A, Rieth A, Silvestry FE, Solomon SD, Trochu JN, Van Veldhuisen DJ, Westenfeld R, Leon MB, Shah SJ; REDUCE LAP-HF-II Investigators
Circulation 2022 May 24;145(21):1592-1604. Epub 2022 Mar 31 doi: 10.1161/CIRCULATIONAHA.122.059486. PMID: 35354306Free PMC Article
Pulmonary Hypertension Due to Left Heart Disease: Diagnosis, Pathophysiology, and Therapy.
Al-Omary MS, Sugito S, Boyle AJ, Sverdlov AL, Collins NJ
Hypertension 2020 Jun;75(6):1397-1408. Epub 2020 Apr 27 doi: 10.1161/HYPERTENSIONAHA.119.14330. PMID: 32336230
One-Year Safety and Clinical Outcomes of a Transcatheter Interatrial Shunt Device for the Treatment of Heart Failure With Preserved Ejection Fraction in the Reduce Elevated Left Atrial Pressure in Patients With Heart Failure (REDUCE LAP-HF I) Trial: A Randomized Clinical Trial.
Shah SJ, Feldman T, Ricciardi MJ, Kahwash R, Lilly S, Litwin S, Nielsen CD, van der Harst P, Hoendermis E, Penicka M, Bartunek J, Fail PS, Kaye DM, Walton A, Petrie MC, Walker N, Basuray A, Yakubov S, Hummel SL, Chetcuti S, Forde-McLean R, Herrmann HC, Burkhoff D, Massaro JM, Cleland JGF, Mauri L
JAMA Cardiol 2018 Oct 1;3(10):968-977. doi: 10.1001/jamacardio.2018.2936. PMID: 30167646Free PMC Article

Diagnosis

Exercise-Induced Left Atrial Hypertension in Heart Failure With Preserved Ejection Fraction.
Litwin SE, Komtebedde J, Hu M, Burkhoff D, Hasenfuß G, Borlaug BA, Solomon SD, Zile MR, Mohan RC, Khawash R, Sverdlov AL, Fail P, Chung ES, Kaye DM, Blair J, Eicher JC, Hummel SL, Zirlik A, Westenfeld R, Hayward C, Gorter TM, Demers C, Shetty R, Lewis G, Starling RC, Patel S, Gupta DK, Morsli H, Penicka M, Cikes M, Gustafsson F, Silvestry FE, Rowin EJ, Cutlip DE, Leon MB, Kitzman DW, Kleber FX, Shah SJ; REDUCE LAP-HF Investigators and Research Staff
JACC Heart Fail 2023 Aug;11(8 Pt 2):1103-1117. Epub 2023 Mar 20 doi: 10.1016/j.jchf.2023.01.030. PMID: 36939661
How to diagnose and treat acute pulmonary hypertension when you have no cardiology support.
Boyd SM, Chatmethakul T, McNamara PJ
Early Hum Dev 2022 Nov;174:105668. Epub 2022 Sep 15 doi: 10.1016/j.earlhumdev.2022.105668. PMID: 36155931
Left atrial hypertension and the risk of early incident heart failure after atrial fibrillation ablation.
Gilge JL, Ahmed A, Clark BA, Slaten A, Devathu R, Olson JA, Padanilam BJ, Nair GV, Joshi SA, Ravichandran AK, Patel PJ
J Cardiovasc Electrophysiol 2021 Feb;32(2):325-332. Epub 2020 Dec 14 doi: 10.1111/jce.14829. PMID: 33270311
Pulmonary Hypertension Due to Left Heart Disease: Diagnosis, Pathophysiology, and Therapy.
Al-Omary MS, Sugito S, Boyle AJ, Sverdlov AL, Collins NJ
Hypertension 2020 Jun;75(6):1397-1408. Epub 2020 Apr 27 doi: 10.1161/HYPERTENSIONAHA.119.14330. PMID: 32336230
Rationale and Design of the Reduce Elevated Left Atrial Pressure in Patients With Heart Failure (Reduce LAP-HF) Trial.
Hasenfuss G, Gustafsson F, Kaye D, Shah SJ, Burkhoff D, Reymond MC, Komtebedde J, Hünlich M; Reduce LAP-HF Trial Investigators
J Card Fail 2015 Jul;21(7):594-600. Epub 2015 Jun 6 doi: 10.1016/j.cardfail.2015.05.008. PMID: 26055211

Therapy

Exercise-Induced Left Atrial Hypertension in Heart Failure With Preserved Ejection Fraction.
Litwin SE, Komtebedde J, Hu M, Burkhoff D, Hasenfuß G, Borlaug BA, Solomon SD, Zile MR, Mohan RC, Khawash R, Sverdlov AL, Fail P, Chung ES, Kaye DM, Blair J, Eicher JC, Hummel SL, Zirlik A, Westenfeld R, Hayward C, Gorter TM, Demers C, Shetty R, Lewis G, Starling RC, Patel S, Gupta DK, Morsli H, Penicka M, Cikes M, Gustafsson F, Silvestry FE, Rowin EJ, Cutlip DE, Leon MB, Kitzman DW, Kleber FX, Shah SJ; REDUCE LAP-HF Investigators and Research Staff
JACC Heart Fail 2023 Aug;11(8 Pt 2):1103-1117. Epub 2023 Mar 20 doi: 10.1016/j.jchf.2023.01.030. PMID: 36939661
Venting during venoarterial extracorporeal membrane oxygenation.
Lüsebrink E, Binzenhöfer L, Kellnar A, Müller C, Scherer C, Schrage B, Joskowiak D, Petzold T, Braun D, Brunner S, Peterss S, Hausleiter J, Zimmer S, Born F, Westermann D, Thiele H, Schäfer A, Hagl C, Massberg S, Orban M
Clin Res Cardiol 2023 Apr;112(4):464-505. Epub 2022 Aug 20 doi: 10.1007/s00392-022-02069-0. PMID: 35986750Free PMC Article
Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure.
Borlaug BA, Blair J, Bergmann MW, Bugger H, Burkhoff D, Bruch L, Celermajer DS, Claggett B, Cleland JGF, Cutlip DE, Dauber I, Eicher JC, Gao Q, Gorter TM, Gustafsson F, Hayward C, van der Heyden J, Hasenfuß G, Hummel SL, Kaye DM, Komtebedde J, Massaro JM, Mazurek JA, McKenzie S, Mehta SR, Petrie MC, Post MC, Nair A, Rieth A, Silvestry FE, Solomon SD, Trochu JN, Van Veldhuisen DJ, Westenfeld R, Leon MB, Shah SJ; REDUCE LAP-HF-II Investigators
Circulation 2022 May 24;145(21):1592-1604. Epub 2022 Mar 31 doi: 10.1161/CIRCULATIONAHA.122.059486. PMID: 35354306Free PMC Article
Left atrial hypertension and the risk of early incident heart failure after atrial fibrillation ablation.
Gilge JL, Ahmed A, Clark BA, Slaten A, Devathu R, Olson JA, Padanilam BJ, Nair GV, Joshi SA, Ravichandran AK, Patel PJ
J Cardiovasc Electrophysiol 2021 Feb;32(2):325-332. Epub 2020 Dec 14 doi: 10.1111/jce.14829. PMID: 33270311
One-Year Safety and Clinical Outcomes of a Transcatheter Interatrial Shunt Device for the Treatment of Heart Failure With Preserved Ejection Fraction in the Reduce Elevated Left Atrial Pressure in Patients With Heart Failure (REDUCE LAP-HF I) Trial: A Randomized Clinical Trial.
Shah SJ, Feldman T, Ricciardi MJ, Kahwash R, Lilly S, Litwin S, Nielsen CD, van der Harst P, Hoendermis E, Penicka M, Bartunek J, Fail PS, Kaye DM, Walton A, Petrie MC, Walker N, Basuray A, Yakubov S, Hummel SL, Chetcuti S, Forde-McLean R, Herrmann HC, Burkhoff D, Massaro JM, Cleland JGF, Mauri L
JAMA Cardiol 2018 Oct 1;3(10):968-977. doi: 10.1001/jamacardio.2018.2936. PMID: 30167646Free PMC Article

Prognosis

Pulmonary Hypertension Due to Left Heart Disease: Diagnosis, Pathophysiology, and Therapy.
Al-Omary MS, Sugito S, Boyle AJ, Sverdlov AL, Collins NJ
Hypertension 2020 Jun;75(6):1397-1408. Epub 2020 Apr 27 doi: 10.1161/HYPERTENSIONAHA.119.14330. PMID: 32336230
Pulmonary hypertension and valvular heart disease.
Tichelbäcker T, Dumitrescu D, Gerhardt F, Stern D, Wissmüller M, Adam M, Schmidt T, Frerker C, Pfister R, Halbach M, Baldus S, Rosenkranz S
Herz 2019 Sep;44(6):491-501. doi: 10.1007/s00059-019-4823-6. PMID: 31312873
Interatrial septal motion as a novel index to predict left atrial pressure.
Masai K, Kishima H, Takahashi S, Ashida K, Goda A, Mine T, Asakura M, Ishihara M, Masuyama T
Heart Vessels 2018 Jul;33(7):762-769. Epub 2018 Jan 22 doi: 10.1007/s00380-017-1112-2. PMID: 29357094
Pulmonary hypertension associated with left heart disease.
Adir Y, Amir O
Semin Respir Crit Care Med 2013 Oct;34(5):665-80. Epub 2013 Sep 13 doi: 10.1055/s-0033-1356490. PMID: 24037633
Diastolic dysfunction and atrial fibrillation.
Nagarakanti R, Ezekowitz M
J Interv Card Electrophysiol 2008 Aug;22(2):111-8. Epub 2008 Feb 9 doi: 10.1007/s10840-008-9203-8. PMID: 18264747

Clinical prediction guides

Left atrial appendage (LAA) flow profile of its different waves and its correlation with direct left atrial pressure measurement: Can LAA flow profile be a surrogate to estimate left atrial pressure.
Tewari P, Mammen A, Pandey S, Ahmad SS, Hajela K
Ann Card Anaesth 2022 Jan-Mar;25(1):48-53. doi: 10.4103/aca.aca_134_21. PMID: 35075020Free PMC Article
Pulmonary hypertension and valvular heart disease.
Tichelbäcker T, Dumitrescu D, Gerhardt F, Stern D, Wissmüller M, Adam M, Schmidt T, Frerker C, Pfister R, Halbach M, Baldus S, Rosenkranz S
Herz 2019 Sep;44(6):491-501. doi: 10.1007/s00059-019-4823-6. PMID: 31312873
Interatrial septal motion as a novel index to predict left atrial pressure.
Masai K, Kishima H, Takahashi S, Ashida K, Goda A, Mine T, Asakura M, Ishihara M, Masuyama T
Heart Vessels 2018 Jul;33(7):762-769. Epub 2018 Jan 22 doi: 10.1007/s00380-017-1112-2. PMID: 29357094
The pulmonary capillary wedge pressure accurately reflects both normal and elevated left atrial pressure.
Nagy AI, Venkateshvaran A, Dash PK, Barooah B, Merkely B, Winter R, Manouras A
Am Heart J 2014 Jun;167(6):876-83. Epub 2014 Feb 26 doi: 10.1016/j.ahj.2014.01.012. PMID: 24890538
Diastolic dysfunction and atrial fibrillation.
Nagarakanti R, Ezekowitz M
J Interv Card Electrophysiol 2008 Aug;22(2):111-8. Epub 2008 Feb 9 doi: 10.1007/s10840-008-9203-8. PMID: 18264747

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