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Abnormal angiostatin level

MedGen UID:
1615279
•Concept ID:
C4531119
•
Finding
HPO: HP:0031439

Definition

A deviation from the normal concentration in the circulation of angiostatin, an endogenous angiogenesis inhibitor, which blocks the growth of new blood vessels. [from HPO]

Recent clinical studies

Etiology

Novel Biomarkers for Lupus Nephritis in the "OMICS" Era.
Dias R, Hasparyk UG, Lopes MP, de Barros JLVM, Simões E Silva AC
Curr Med Chem 2021;28(29):6011-6044. doi: 10.2174/0929867328666210212102438. PMID: 33583367
Systemic Sclerosis Sera Impair Angiogenic Performance of Dermal Microvascular Endothelial Cells: Therapeutic Implications of Cyclophosphamide.
Borghini A, Manetti M, Nacci F, Bellando-Randone S, Guiducci S, Matucci-Cerinic M, Ibba-Manneschi L, Weber E
PLoS One 2015;10(6):e0130166. Epub 2015 Jun 15 doi: 10.1371/journal.pone.0130166. PMID: 26076019Free PMC Article
Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma.
Yao DF, Wu XH, Zhu Y, Shi GS, Dong ZZ, Yao DB, Wu W, Qiu LW, Meng XY
Hepatobiliary Pancreat Dis Int 2005 May;4(2):220-6. PMID: 15908319

Diagnosis

Serum differentially expressed angiogenic cytokines in head and neck vascular malformations.
Zhang L, Shen Y, Wang Z, Li X, Xia W, Su L, Fan X, Wang D
J Oral Pathol Med 2022 Nov;51(10):911-919. Epub 2022 Aug 1 doi: 10.1111/jop.13335. PMID: 35854627
Novel Biomarkers for Lupus Nephritis in the "OMICS" Era.
Dias R, Hasparyk UG, Lopes MP, de Barros JLVM, Simões E Silva AC
Curr Med Chem 2021;28(29):6011-6044. doi: 10.2174/0929867328666210212102438. PMID: 33583367
Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma.
Yao DF, Wu XH, Zhu Y, Shi GS, Dong ZZ, Yao DB, Wu W, Qiu LW, Meng XY
Hepatobiliary Pancreat Dis Int 2005 May;4(2):220-6. PMID: 15908319

Therapy

Inhibition of angiogenic pathways in rheumatoid arthritis: potential for therapeutic targeting.
Veale DJ, Fearon U
Best Pract Res Clin Rheumatol 2006 Oct;20(5):941-7. doi: 10.1016/j.berh.2006.05.004. PMID: 16980216
AE-941, a multifunctional antiangiogenic compound: trials in renal cell carcinoma.
Bukowski RM
Expert Opin Investig Drugs 2003 Aug;12(8):1403-11. doi: 10.1517/13543784.12.8.1403. PMID: 12882625

Prognosis

Serum differentially expressed angiogenic cytokines in head and neck vascular malformations.
Zhang L, Shen Y, Wang Z, Li X, Xia W, Su L, Fan X, Wang D
J Oral Pathol Med 2022 Nov;51(10):911-919. Epub 2022 Aug 1 doi: 10.1111/jop.13335. PMID: 35854627
Novel Biomarkers for Lupus Nephritis in the "OMICS" Era.
Dias R, Hasparyk UG, Lopes MP, de Barros JLVM, Simões E Silva AC
Curr Med Chem 2021;28(29):6011-6044. doi: 10.2174/0929867328666210212102438. PMID: 33583367
Systemic Sclerosis Sera Impair Angiogenic Performance of Dermal Microvascular Endothelial Cells: Therapeutic Implications of Cyclophosphamide.
Borghini A, Manetti M, Nacci F, Bellando-Randone S, Guiducci S, Matucci-Cerinic M, Ibba-Manneschi L, Weber E
PLoS One 2015;10(6):e0130166. Epub 2015 Jun 15 doi: 10.1371/journal.pone.0130166. PMID: 26076019Free PMC Article
Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma.
Yao DF, Wu XH, Zhu Y, Shi GS, Dong ZZ, Yao DB, Wu W, Qiu LW, Meng XY
Hepatobiliary Pancreat Dis Int 2005 May;4(2):220-6. PMID: 15908319

Clinical prediction guides

Novel Biomarkers for Lupus Nephritis in the "OMICS" Era.
Dias R, Hasparyk UG, Lopes MP, de Barros JLVM, Simões E Silva AC
Curr Med Chem 2021;28(29):6011-6044. doi: 10.2174/0929867328666210212102438. PMID: 33583367
Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma.
Yao DF, Wu XH, Zhu Y, Shi GS, Dong ZZ, Yao DB, Wu W, Qiu LW, Meng XY
Hepatobiliary Pancreat Dis Int 2005 May;4(2):220-6. PMID: 15908319
AE-941, a multifunctional antiangiogenic compound: trials in renal cell carcinoma.
Bukowski RM
Expert Opin Investig Drugs 2003 Aug;12(8):1403-11. doi: 10.1517/13543784.12.8.1403. PMID: 12882625

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