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Pituitary adenoma 5, multiple types(PITA5)

MedGen UID:
1615593
Concept ID:
C4539685
Neoplastic Process
Synonyms: PITA5; PITUITARY ADENOMA 5, MULTIPLE TYPES
 
Gene (location): CDH23 (10q22.1)
 
Monarch Initiative: MONDO:0054601
OMIM®: 617540

Definition

Both familial and sporadic pituitary adenomas have been found to be caused by germline mutation in the CDH23 gene. Familial pituitary adenoma types include growth hormone (GH)-secreting and nonfunctional tumors. Sporadic pituitary adenoma types include GH-secreting, nonfunctional, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid-stimulating hormone (TSH)-secreting, and plurihormonal (GH and TSH) tumors. For a general description and a discussion of genetic heterogeneity of pituitary adenomas, see PITA1 (102200). [from OMIM]

Clinical features

From HPO
Pituitary adenoma
MedGen UID:
45933
Concept ID:
C0032000
Neoplastic Process
A benign epithelial tumor derived from intrinsic cells of the adenohypophysis (anterior pituitary).

Professional guidelines

PubMed

Zhao Y, Lian W, Xing B, Wang R
Clin Neurol Neurosurg 2019 Sep;184:105423. Epub 2019 Jul 12 doi: 10.1016/j.clineuro.2019.105423. PMID: 31376772
Murayi R, Chittiboina P
Childs Nerv Syst 2016 Dec;32(12):2293-2302. Epub 2016 Sep 9 doi: 10.1007/s00381-016-3240-x. PMID: 27613642Free PMC Article
Martens D, Oster I, Gottschlling S, Papanagiotou P, Ziegler K, Eymann R, Ong MF, Gortner L, Meyer S
Swiss Med Wkly 2012;142:w13625. Epub 2012 Jul 10 doi: 10.4414/smw.2012.13625. PMID: 22782255

Recent clinical studies

Etiology

Araujo-Castro M, Berrocal VR, Pascual-Corrales E
Hormones (Athens) 2020 Jun;19(2):145-155. Epub 2020 Jan 14 doi: 10.1007/s42000-019-00168-8. PMID: 31933100
Yano S, Hide T, Shinojima N
World Neurosurg 2017 Mar;99:533-542. Epub 2016 Dec 23 doi: 10.1016/j.wneu.2016.12.068. PMID: 28024972
Nozières C, Berlier P, Dupuis C, Raynaud-Ravni C, Morel Y, Chazot FB, Nicolino M
Orphanet J Rare Dis 2011 Oct 24;6:67. doi: 10.1186/1750-1172-6-67. PMID: 22024364Free PMC Article
Hafez B
Arch Androl 1998 May-Jun;40(3):187-210. doi: 10.3109/01485019808987943. PMID: 9583357
Oberg K, Skogseid B, Eriksson B
Acta Oncol 1989;28(3):383-7. doi: 10.3109/02841868909111211. PMID: 2568120

Diagnosis

Araujo-Castro M, Berrocal VR, Pascual-Corrales E
Hormones (Athens) 2020 Jun;19(2):145-155. Epub 2020 Jan 14 doi: 10.1007/s42000-019-00168-8. PMID: 31933100
Sofela AA, Hettige S, Curran O, Bassi S
Neurosurgery 2014 Sep;75(3):306-14; discussion 314. doi: 10.1227/NEU.0000000000000380. PMID: 24978859
Scheithauer BW, Kovacs K, Horvath E, Kim DS, Osamura RY, Ketterling RP, Lloyd RV, Kim OL
Acta Neuropathol 2008 Dec;116(6):657-66. Epub 2008 Jun 13 doi: 10.1007/s00401-008-0388-9. PMID: 18551299
Berezin M, Karasik A
Clin Endocrinol (Oxf) 1995 May;42(5):483-6. doi: 10.1111/j.1365-2265.1995.tb02666.x. PMID: 7621566
Oberg K, Skogseid B, Eriksson B
Acta Oncol 1989;28(3):383-7. doi: 10.3109/02841868909111211. PMID: 2568120

Therapy

Merchant TE, Hoehn ME, Khan RB, Sabin ND, Klimo P, Boop FA, Wu S, Li Y, Burghen EA, Jurbergs N, Sandler ES, Aldana PR, Indelicato DJ, Conklin HM
Lancet Oncol 2023 May;24(5):523-534. Epub 2023 Apr 18 doi: 10.1016/S1470-2045(23)00146-8. PMID: 37084748Free PMC Article
Xue J, Jia X, Li J, Gao R, Zhang F, Yang A
Hell J Nucl Med 2015 Sep-Dec;18(3):247-51. PMID: 26637504
Nozières C, Berlier P, Dupuis C, Raynaud-Ravni C, Morel Y, Chazot FB, Nicolino M
Orphanet J Rare Dis 2011 Oct 24;6:67. doi: 10.1186/1750-1172-6-67. PMID: 22024364Free PMC Article
Szücs N, Varga I, Jakab C, Patócs A, Gláz E, Tóth M, Kiss R, Rácz K
Pituitary 2001 Jan-Apr;4(1-2):71-7. doi: 10.1023/a:1012990928218. PMID: 11824511
Collet-Solberg PF, Sernyak H, Satin-Smith M, Katz LL, Sutton L, Molloy P, Moshang T Jr
Clin Endocrinol (Oxf) 1997 Jul;47(1):79-85. doi: 10.1046/j.1365-2265.1997.2211032.x. PMID: 9302376

Prognosis

Hasegawa H, Jentoft ME, Young WF Jr, Lakomkin N, Van Gompel JJ, Link MJ, Atkinson JL, Meyer FB
World Neurosurg 2021 May;149:e51-e62. Epub 2021 Feb 26 doi: 10.1016/j.wneu.2021.02.091. PMID: 33647491
Zhao Y, Lian W, Xing B, Wang R
Clin Neurol Neurosurg 2019 Sep;184:105423. Epub 2019 Jul 12 doi: 10.1016/j.clineuro.2019.105423. PMID: 31376772
Xie Z, Wang Q, Lu X
Pituitary 2019 Aug;22(4):381-386. doi: 10.1007/s11102-019-00967-7. PMID: 31093846
Sofela AA, Hettige S, Curran O, Bassi S
Neurosurgery 2014 Sep;75(3):306-14; discussion 314. doi: 10.1227/NEU.0000000000000380. PMID: 24978859
Dworakowska D, Grossman AB
Eur J Clin Invest 2012 Jun;42(6):665-76. Epub 2011 Nov 19 doi: 10.1111/j.1365-2362.2011.02621.x. PMID: 22098190

Clinical prediction guides

Hagel C, Schüller U, Flitsch J, Knappe UJ, Kellner U, Bergmann M, Buslei R, Buchfelder M, Rüdiger T, Herms J, Saeger W
Pituitary 2021 Dec;24(6):904-913. Epub 2021 Sep 3 doi: 10.1007/s11102-021-01164-1. PMID: 34478014Free PMC Article
Hasegawa H, Jentoft ME, Young WF Jr, Lakomkin N, Van Gompel JJ, Link MJ, Atkinson JL, Meyer FB
World Neurosurg 2021 May;149:e51-e62. Epub 2021 Feb 26 doi: 10.1016/j.wneu.2021.02.091. PMID: 33647491
Zhao Y, Lian W, Xing B, Wang R
Clin Neurol Neurosurg 2019 Sep;184:105423. Epub 2019 Jul 12 doi: 10.1016/j.clineuro.2019.105423. PMID: 31376772
Xie Z, Wang Q, Lu X
Pituitary 2019 Aug;22(4):381-386. doi: 10.1007/s11102-019-00967-7. PMID: 31093846
Dworakowska D, Grossman AB
Eur J Clin Invest 2012 Jun;42(6):665-76. Epub 2011 Nov 19 doi: 10.1111/j.1365-2362.2011.02621.x. PMID: 22098190

Recent systematic reviews

Hasegawa H, Jentoft ME, Young WF Jr, Lakomkin N, Van Gompel JJ, Link MJ, Atkinson JL, Meyer FB
World Neurosurg 2021 May;149:e51-e62. Epub 2021 Feb 26 doi: 10.1016/j.wneu.2021.02.091. PMID: 33647491

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