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Abnormal perifollicular morphology

MedGen UID:
1615717
Concept ID:
C4531226
Anatomical Abnormality
HPO: HP:0031285

Definition

Any structural anomaly in the areas surrounding the hair follicles. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal perifollicular morphology

Conditions with this feature

Keratosis pilaris atrophicans
MedGen UID:
75520
Concept ID:
C0263428
Disease or Syndrome
Keratosis pilaris atrophicans (KPA) represents a group of rare genodermatoses characterized by perifollicular keratosis and inflammation that progresses to atrophy and scarring of the facial skin. Keratosis pilaris of extensor surfaces of limbs is a common associated finding. Affected individuals may present with features that overlap between 3 subtypes, keratosis pilaris atrophicans faciei (KPAF), keratosis follicularis spinulosa decalvans (KFSD), and atrophoderma vermiculata (AVA; see 209700) (summary by Klar et al., 2015).

Professional guidelines

PubMed

Kodali N, Patel VM, Schwartz RA
Ital J Dermatol Venerol 2023 Jun;158(3):217-223. Epub 2023 May 11 doi: 10.23736/S2784-8671.23.07594-1. PMID: 37166753
Kwiek B, Rożalski M, Sieczych J, Paluch Ł, Kowalewski C, Ambroziak M
Lasers Surg Med 2019 Sep;51(7):569-583. Epub 2019 Mar 12 doi: 10.1002/lsm.23083. PMID: 30860283
Sperling LC, Homoky C, Pratt L, Sau P
Arch Dermatol 2000 Apr;136(4):479-84. doi: 10.1001/archderm.136.4.479. PMID: 10768646

Recent clinical studies

Etiology

Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M
Exp Dermatol 2023 Jul;32(7):945-954. Epub 2023 May 4 doi: 10.1111/exd.14830. PMID: 37140216
Miracco C, DE Piano E, Marruganti C, Baldino G, Sorrentino E, Batsikosta A, Rubegni P, Angotti R, Messina M, Cinotti E
Ital J Dermatol Venerol 2022 Aug;157(4):342-347. Epub 2022 Jun 6 doi: 10.23736/S2784-8671.22.07301-7. PMID: 35666664
George SM, Taylor MR, Farrant PB
Clin Exp Dermatol 2015 Oct;40(7):717-21. Epub 2015 Jul 23 doi: 10.1111/ced.12715. PMID: 26202646
Franks S, Roberts R, Hardy K
Reprod Biomed Online 2003 Mar;6(2):181-4. doi: 10.1016/s1472-6483(10)61708-7. PMID: 12675997
Sladkevicius P, Campbell S
Br Med Bull 2000;56(3):691-703. doi: 10.1258/0007142001903472. PMID: 11255554

Diagnosis

Kodali N, Patel VM, Schwartz RA
Ital J Dermatol Venerol 2023 Jun;158(3):217-223. Epub 2023 May 11 doi: 10.23736/S2784-8671.23.07594-1. PMID: 37166753
Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M
Exp Dermatol 2023 Jul;32(7):945-954. Epub 2023 May 4 doi: 10.1111/exd.14830. PMID: 37140216
Cardona R, Cancel-Artau KJ, Carrasquillo OY, Martin-Garcia RF
Am J Dermatopathol 2021 Jan 1;43(1):67-70. doi: 10.1097/DAD.0000000000001720. PMID: 32618706
Andrés-Ramos I, Alegría-Landa V, Gimeno I, Pérez-Plaza A, Rütten A, Kutzner H, Requena L
Am J Dermatopathol 2019 Feb;41(2):85-117. doi: 10.1097/DAD.0000000000001275. PMID: 30688725
Sladkevicius P, Campbell S
Br Med Bull 2000;56(3):691-703. doi: 10.1258/0007142001903472. PMID: 11255554

Therapy

Pimenta R, Borges-Costa J
Acta Dermatovenerol Croat 2019 Mar;27(1):49-50. PMID: 31032795
Kwiek B, Rożalski M, Sieczych J, Paluch Ł, Kowalewski C, Ambroziak M
Lasers Surg Med 2019 Sep;51(7):569-583. Epub 2019 Mar 12 doi: 10.1002/lsm.23083. PMID: 30860283
George SM, Taylor MR, Farrant PB
Clin Exp Dermatol 2015 Oct;40(7):717-21. Epub 2015 Jul 23 doi: 10.1111/ced.12715. PMID: 26202646
Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336
Franks S, Roberts R, Hardy K
Reprod Biomed Online 2003 Mar;6(2):181-4. doi: 10.1016/s1472-6483(10)61708-7. PMID: 12675997

Prognosis

Kwiek B, Rożalski M, Sieczych J, Paluch Ł, Kowalewski C, Ambroziak M
Lasers Surg Med 2019 Sep;51(7):569-583. Epub 2019 Mar 12 doi: 10.1002/lsm.23083. PMID: 30860283
Lis-Święty A, Miziołek B, Ranosz-Janicka I, Bierzyńska-Macyszyn G, Brzezińska-Wcisło L
J Cosmet Dermatol 2018 Apr;17(2):268-273. Epub 2017 Jul 20 doi: 10.1111/jocd.12379. PMID: 28727235
Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336
Carbillon L, Perrot N, Uzan M, Uzan S
Fetal Diagn Ther 2001 Nov-Dec;16(6):327-32. doi: 10.1159/000053936. PMID: 11694734
Sladkevicius P, Campbell S
Br Med Bull 2000;56(3):691-703. doi: 10.1258/0007142001903472. PMID: 11255554

Clinical prediction guides

Miracco C, DE Piano E, Marruganti C, Baldino G, Sorrentino E, Batsikosta A, Rubegni P, Angotti R, Messina M, Cinotti E
Ital J Dermatol Venerol 2022 Aug;157(4):342-347. Epub 2022 Jun 6 doi: 10.23736/S2784-8671.22.07301-7. PMID: 35666664
Secchin P, Quintella DC, Paula NÁO, Andrade LCDS, Sodré CT
An Bras Dermatol 2019;94(4):416-421. Epub 2019 Oct 17 doi: 10.1590/abd1806-4841.20197797. PMID: 31644613Free PMC Article
Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336
Carbillon L, Perrot N, Uzan M, Uzan S
Fetal Diagn Ther 2001 Nov-Dec;16(6):327-32. doi: 10.1159/000053936. PMID: 11694734
Sladkevicius P, Campbell S
Br Med Bull 2000;56(3):691-703. doi: 10.1258/0007142001903472. PMID: 11255554

Recent systematic reviews

Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M
Exp Dermatol 2023 Jul;32(7):945-954. Epub 2023 May 4 doi: 10.1111/exd.14830. PMID: 37140216

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