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Abnormal perifollicular morphology

MedGen UID:: 1615717
•Concept ID:: C4531226
•: Anatomical Abnormality

HPO:	HP:0031285

Definition

Any structural anomaly in the areas surrounding the hair follicles. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal perifollicular morphology

Phenotypic abnormality
- Abnormality of the integument
  - Abnormality of the skin
    - Abnormal perifollicular morphology

Conditions with this feature

Keratosis pilaris atrophicans

MedGen UID:: 75520
•Concept ID:: C0263428
•: Disease or Syndrome

Keratosis pilaris atrophicans (KPA) represents a group of rare genodermatoses characterized by perifollicular keratosis and inflammation that progresses to atrophy and scarring of the facial skin. Keratosis pilaris of extensor surfaces of limbs is a common associated finding. Affected individuals may present with features that overlap between 3 subtypes, keratosis pilaris atrophicans faciei (KPAF), keratosis follicularis spinulosa decalvans (KFSD), and atrophoderma vermiculata (AVA; see 209700) (summary by Klar et al., 2015).

See: Condition Record

Keratosis pilaris atrophicans

Professional guidelines

PubMed

Keratosis pilaris: an update and approach to management.

Kodali N, Patel VM, Schwartz RA
Ital J Dermatol Venerol 2023 Jun;158(3):217-223. Epub 2023 May 11 doi: 10.23736/S2784-8671.23.07594-1. PMID: 37166753

Predictive value of dermoscopy for the treatment of port-wine stains with large spot 532 nm laser.

Kwiek B, Rożalski M, Sieczych J, Paluch Ł, Kowalewski C, Ambroziak M
Lasers Surg Med 2019 Sep;51(7):569-583. Epub 2019 Mar 12 doi: 10.1002/lsm.23083. PMID: 30860283

Acne keloidalis is a form of primary scarring alopecia.

Sperling LC, Homoky C, Pratt L, Sau P
Arch Dermatol 2000 Apr;136(4):479-84. doi: 10.1001/archderm.136.4.479. PMID: 10768646

See all (4)

Recent clinical studies

Etiology

Confocal microscopy and optical coherence tomography of inflammatory skin diseases in hairs and pilosebaceous units: A systematic review.

Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M
Exp Dermatol 2023 Jul;32(7):945-954. Epub 2023 May 4 doi: 10.1111/exd.14830. PMID: 37140216

Psoriatic alopecia.

George SM, Taylor MR, Farrant PB
Clin Exp Dermatol 2015 Oct;40(7):717-21. Epub 2015 Jul 23 doi: 10.1111/ced.12715. PMID: 26202646

Gonadotrophin regimens and oocyte quality in women with polycystic ovaries.

Franks S, Roberts R, Hardy K
Reprod Biomed Online 2003 Mar;6(2):181-4. doi: 10.1016/s1472-6483(10)61708-7. PMID: 12675997

Advances in ultrasound assessment in the establishment and development of pregnancy.

Sladkevicius P, Campbell S
Br Med Bull 2000;56(3):691-703. doi: 10.1258/0007142001903472. PMID: 11255554

Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35.

Nezelof C, Barbey S, Gogusev J, Terrier-Lacombe MJ
Semin Diagn Pathol 1992 Feb;9(1):75-89. PMID: 1313990

See all (22)

Diagnosis

Keratosis pilaris: an update and approach to management.

Kodali N, Patel VM, Schwartz RA
Ital J Dermatol Venerol 2023 Jun;158(3):217-223. Epub 2023 May 11 doi: 10.23736/S2784-8671.23.07594-1. PMID: 37166753

Confocal microscopy and optical coherence tomography of inflammatory skin diseases in hairs and pilosebaceous units: A systematic review.

Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M
Exp Dermatol 2023 Jul;32(7):945-954. Epub 2023 May 4 doi: 10.1111/exd.14830. PMID: 37140216

Cutaneous Elastic Tissue Anomalies.

Andrés-Ramos I, Alegría-Landa V, Gimeno I, Pérez-Plaza A, Rütten A, Kutzner H, Requena L
Am J Dermatopathol 2019 Feb;41(2):85-117. doi: 10.1097/DAD.0000000000001275. PMID: 30688725

Trichoscopy: a new method for diagnosing hair loss.

Rudnicka L, Olszewska M, Rakowska A, Kowalska-Oledzka E, Slowinska M
J Drugs Dermatol 2008 Jul;7(7):651-4. PMID: 18664157

Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35.

Nezelof C, Barbey S, Gogusev J, Terrier-Lacombe MJ
Semin Diagn Pathol 1992 Feb;9(1):75-89. PMID: 1313990

See all (31)

Therapy

Successful Treatment with Fusidic Acid in a Patient with Folliculitis Decalvans.

Pimenta R, Borges-Costa J
Acta Dermatovenerol Croat 2019 Mar;27(1):49-50. PMID: 31032795

Predictive value of dermoscopy for the treatment of port-wine stains with large spot 532 nm laser.

Kwiek B, Rożalski M, Sieczych J, Paluch Ł, Kowalewski C, Ambroziak M
Lasers Surg Med 2019 Sep;51(7):569-583. Epub 2019 Mar 12 doi: 10.1002/lsm.23083. PMID: 30860283

Psoriatic alopecia.

George SM, Taylor MR, Farrant PB
Clin Exp Dermatol 2015 Oct;40(7):717-21. Epub 2015 Jul 23 doi: 10.1111/ced.12715. PMID: 26202646

Morphological selection of gametes.

Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336

Gonadotrophin regimens and oocyte quality in women with polycystic ovaries.

Franks S, Roberts R, Hardy K
Reprod Biomed Online 2003 Mar;6(2):181-4. doi: 10.1016/s1472-6483(10)61708-7. PMID: 12675997

See all (12)

Prognosis

Predictive value of dermoscopy for the treatment of port-wine stains with large spot 532 nm laser.

Kwiek B, Rożalski M, Sieczych J, Paluch Ł, Kowalewski C, Ambroziak M
Lasers Surg Med 2019 Sep;51(7):569-583. Epub 2019 Mar 12 doi: 10.1002/lsm.23083. PMID: 30860283

MRI of ovarian torsion: Correlation of imaging features with the presence of perifollicular hemorrhage and ovarian viability.

Petkovska I, Duke E, Martin DR, Irani Z, Geffre CP, Cragun JM, Costello JR, Arif-Tiwari H, Czeyda-Pommersheim F, Udayasankar U, Kalb B
Eur J Radiol 2016 Nov;85(11):2064-2071. Epub 2016 Sep 23 doi: 10.1016/j.ejrad.2016.09.020. PMID: 27776660

Morphological selection of gametes.

Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336

Doppler ultrasonography and implantation: a critical review.

Carbillon L, Perrot N, Uzan M, Uzan S
Fetal Diagn Ther 2001 Nov-Dec;16(6):327-32. doi: 10.1159/000053936. PMID: 11694734

Advances in ultrasound assessment in the establishment and development of pregnancy.

Sladkevicius P, Campbell S
Br Med Bull 2000;56(3):691-703. doi: 10.1258/0007142001903472. PMID: 11255554

See all (9)

Clinical prediction guides

Folliculosebaceous units are a frequent finding in early lichen sclerosus of the foreskin.

Miracco C, DE Piano E, Marruganti C, Baldino G, Sorrentino E, Batsikosta A, Rubegni P, Angotti R, Messina M, Cinotti E
Ital J Dermatol Venerol 2022 Aug;157(4):342-347. Epub 2022 Jun 6 doi: 10.23736/S2784-8671.22.07301-7. PMID: 35666664

Clinical-histopathological profile of the frontal fibrosing alopecia: a retrospective study of 16 cases of a university hospital.

Secchin P, Quintella DC, Paula NÁO, Andrade LCDS, Sodré CT
An Bras Dermatol 2019;94(4):416-421. Epub 2019 Oct 17 doi: 10.1590/abd1806-4841.20197797. PMID: 31644613 Free PMC Article

Morphological selection of gametes.

Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336

Doppler ultrasonography and implantation: a critical review.

Carbillon L, Perrot N, Uzan M, Uzan S
Fetal Diagn Ther 2001 Nov-Dec;16(6):327-32. doi: 10.1159/000053936. PMID: 11694734

Advances in ultrasound assessment in the establishment and development of pregnancy.

Sladkevicius P, Campbell S
Br Med Bull 2000;56(3):691-703. doi: 10.1258/0007142001903472. PMID: 11255554

See all (21)