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Cortical Cataract Grade 4

MedGen UID:
1616128
•Concept ID:
C4525730
•
Disease or Syndrome

Definition

A stage of cortical cataract characterized by greater than 90% of the intrapupillary space obscured by opacity. (Modified LOCS II) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCortical Cataract Grade 4

Recent clinical studies

Etiology

Comparative study between conventional and 4 mm manual small-incision cataract surgery.
Chauhan RA, Agrawal SO, Sawarkar RR, Agrawal S
Indian J Ophthalmol 2022 Nov;70(11):3879-3882. doi: 10.4103/ijo.IJO_1607_22. PMID: 36308119Free PMC Article
Nanosecond Laser Cataract Surgery in LOCS III Grade 4 and 5: A Case Series.
Sauder G, Ruf E, Moedl S, Thyzel R
Asia Pac J Ophthalmol (Phila) 2017 Sep-Oct;6(5):425-428. Epub 2017 Sep 14 doi: 10.22608/APO.2017123. PMID: 28905540
Cataract and quality of life in patients with glaucoma.
Skalicky SE, Martin KR, Fenwick E, Crowston JG, Goldberg I, McCluskey P
Clin Exp Ophthalmol 2015 May-Jun;43(4):335-41. Epub 2014 Oct 30 doi: 10.1111/ceo.12454. PMID: 25294739
Myopia and incident cataract and cataract surgery: the blue mountains eye study.
Younan C, Mitchell P, Cumming RG, Rochtchina E, Wang JJ
Invest Ophthalmol Vis Sci 2002 Dec;43(12):3625-32. PMID: 12454028
Iris color and incident cataract and cataract surgery: the Blue Mountains Eye Study.
Younan C, Mitchell P, Cumming RG, Rochtchina E, Wang JJ
Am J Ophthalmol 2002 Aug;134(2):273-4. doi: 10.1016/s0002-9394(02)01496-4. PMID: 12140040

Diagnosis

Age-related cataract - Prevalence, epidemiological pattern and emerging risk factors in a cross-sectional study from Central India.
Sarkar D, Sharma R, Singh P, Verma V, Karkhur S, Verma S, Soni D, Sharma B
Indian J Ophthalmol 2023 May;71(5):1905-1912. doi: 10.4103/ijo.IJO_2020_22. PMID: 37203054Free PMC Article
Lens Opacities Classification System III-based artificial intelligence program for automatic cataract grading.
Lu Q, Wei L, He W, Zhang K, Wang J, Zhang Y, Rong X, Zhao Z, Cai L, He X, Wu J, Ding D, Lu Y, Zhu X
J Cataract Refract Surg 2022 May 1;48(5):528-534. doi: 10.1097/j.jcrs.0000000000000790. PMID: 34433780
Pseudoexfoliation syndrome and the long-term incidence of cataract and cataract surgery: the blue mountains eye study.
Kanthan GL, Mitchell P, Burlutsky G, Rochtchina E, Wang JJ
Am J Ophthalmol 2013 Jan;155(1):83-88.e1. Epub 2012 Oct 2 doi: 10.1016/j.ajo.2012.07.002. PMID: 23036566
Influence of cataract morphology on straylight and contrast sensitivity and its relevance to fitness to drive.
Bal T, Coeckelbergh T, Van Looveren J, Rozema JJ, Tassignon MJ
Ophthalmologica 2011;225(2):105-11. Epub 2010 Sep 24 doi: 10.1159/000317076. PMID: 20881445
Use of inhaled and oral corticosteroids and the long-term risk of cataract.
Wang JJ, Rochtchina E, Tan AG, Cumming RG, Leeder SR, Mitchell P
Ophthalmology 2009 Apr;116(4):652-7. Epub 2009 Feb 25 doi: 10.1016/j.ophtha.2008.12.001. PMID: 19243828

Therapy

Comparative study between conventional and 4 mm manual small-incision cataract surgery.
Chauhan RA, Agrawal SO, Sawarkar RR, Agrawal S
Indian J Ophthalmol 2022 Nov;70(11):3879-3882. doi: 10.4103/ijo.IJO_1607_22. PMID: 36308119Free PMC Article
Alcohol consumption and the long-term incidence of cataract and cataract surgery: the Blue Mountains Eye Study.
Kanthan GL, Mitchell P, Burlutsky G, Wang JJ
Am J Ophthalmol 2010 Sep;150(3):434-440.e1. Epub 2010 Jul 8 doi: 10.1016/j.ajo.2010.04.020. PMID: 20619390
Use of inhaled and oral corticosteroids and the long-term risk of cataract.
Wang JJ, Rochtchina E, Tan AG, Cumming RG, Leeder SR, Mitchell P
Ophthalmology 2009 Apr;116(4):652-7. Epub 2009 Feb 25 doi: 10.1016/j.ophtha.2008.12.001. PMID: 19243828
Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment project.
Vu HT, Robman L, Hodge A, McCarty CA, Taylor HR
Invest Ophthalmol Vis Sci 2006 Sep;47(9):3783-6. doi: 10.1167/iovs.05-0587. PMID: 16936087
Plasma antioxidant vitamins and carotenoids and age-related cataract.
Gale CR, Hall NF, Phillips DI, Martyn CN
Ophthalmology 2001 Nov;108(11):1992-8. doi: 10.1016/s0161-6420(01)00833-8. PMID: 11713067

Prognosis

Lens Opacities Classification System III-based artificial intelligence program for automatic cataract grading.
Lu Q, Wei L, He W, Zhang K, Wang J, Zhang Y, Rong X, Zhao Z, Cai L, He X, Wu J, Ding D, Lu Y, Zhu X
J Cataract Refract Surg 2022 May 1;48(5):528-534. doi: 10.1097/j.jcrs.0000000000000790. PMID: 34433780
Pseudoexfoliation syndrome and the long-term incidence of cataract and cataract surgery: the blue mountains eye study.
Kanthan GL, Mitchell P, Burlutsky G, Rochtchina E, Wang JJ
Am J Ophthalmol 2013 Jan;155(1):83-88.e1. Epub 2012 Oct 2 doi: 10.1016/j.ajo.2012.07.002. PMID: 23036566
Lens retrodots and vacuoles and their associations with the prevalence and incidence of age-related cataract.
Tan AG, Mitchell P, Rochtchina E, Hong T, Cumming RG, Wang JJ
Eye (Lond) 2012 Apr;26(4):568-75. Epub 2011 Dec 23 doi: 10.1038/eye.2011.349. PMID: 22193877Free PMC Article
Use of inhaled and oral corticosteroids and the long-term risk of cataract.
Wang JJ, Rochtchina E, Tan AG, Cumming RG, Leeder SR, Mitchell P
Ophthalmology 2009 Apr;116(4):652-7. Epub 2009 Feb 25 doi: 10.1016/j.ophtha.2008.12.001. PMID: 19243828
Myopia and incident cataract and cataract surgery: the blue mountains eye study.
Younan C, Mitchell P, Cumming RG, Rochtchina E, Wang JJ
Invest Ophthalmol Vis Sci 2002 Dec;43(12):3625-32. PMID: 12454028

Clinical prediction guides

Comparative study between conventional and 4 mm manual small-incision cataract surgery.
Chauhan RA, Agrawal SO, Sawarkar RR, Agrawal S
Indian J Ophthalmol 2022 Nov;70(11):3879-3882. doi: 10.4103/ijo.IJO_1607_22. PMID: 36308119Free PMC Article
Lens Opacities Classification System III-based artificial intelligence program for automatic cataract grading.
Lu Q, Wei L, He W, Zhang K, Wang J, Zhang Y, Rong X, Zhao Z, Cai L, He X, Wu J, Ding D, Lu Y, Zhu X
J Cataract Refract Surg 2022 May 1;48(5):528-534. doi: 10.1097/j.jcrs.0000000000000790. PMID: 34433780
Cataract and quality of life in patients with glaucoma.
Skalicky SE, Martin KR, Fenwick E, Crowston JG, Goldberg I, McCluskey P
Clin Exp Ophthalmol 2015 May-Jun;43(4):335-41. Epub 2014 Oct 30 doi: 10.1111/ceo.12454. PMID: 25294739
The impact of cataract, cataract types, and cataract grades on vision-specific functioning using Rasch analysis.
Chew M, Chiang PP, Zheng Y, Lavanya R, Wu R, Saw SM, Wong TY, Lamoureux EL
Am J Ophthalmol 2012 Jul;154(1):29-38.e2. Epub 2012 Apr 26 doi: 10.1016/j.ajo.2012.01.033. PMID: 22541931
Frailty and age-related cataract.
Klein BE, Klein R, Knudtson MD
Ophthalmology 2006 Dec;113(12):2209-12. Epub 2006 Sep 25 doi: 10.1016/j.ophtha.2006.04.035. PMID: 16996595

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