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Locally Advanced Malignant Solid Neoplasm

MedGen UID:
1616641
Concept ID:
C4524377
Neoplastic Process
Synonyms: Locally Advanced Malignant Solid Tumor; Locally Advanced Solid Neoplasm; Locally Advanced Solid Tumor

Definition

A malignant solid neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Malignant Solid Neoplasm

Professional guidelines

PubMed

Gauci ML, Aristei C, Becker JC, Blom A, Bataille V, Dreno B, Del Marmol V, Forsea AM, Fargnoli MC, Grob JJ, Gomes F, Hauschild A, Hoeller C, Harwood C, Kelleners-Smeets N, Kaufmann R, Lallas A, Malvehy J, Moreno-Ramirez D, Peris K, Pellacani G, Saiag P, Stratigos AJ, Vieira R, Zalaudek I, van Akkooi ACJ, Lorigan P, Garbe C, Lebbé C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Aug;171:203-231. Epub 2022 Jun 19 doi: 10.1016/j.ejca.2022.03.043. PMID: 35732101
Gondi V, Bauman G, Bradfield L, Burri SH, Cabrera AR, Cunningham DA, Eaton BR, Hattangadi-Gluth JA, Kim MM, Kotecha R, Kraemer L, Li J, Nagpal S, Rusthoven CG, Suh JH, Tomé WA, Wang TJC, Zimmer AS, Ziu M, Brown PD
Pract Radiat Oncol 2022 Jul-Aug;12(4):265-282. Epub 2022 May 6 doi: 10.1016/j.prro.2022.02.003. PMID: 35534352
Al-Adra DP, Hammel L, Roberts J, Woodle ES, Levine D, Mandelbrot D, Verna E, Locke J, D'Cunha J, Farr M, Sawinski D, Agarwal PK, Plichta J, Pruthi S, Farr D, Carvajal R, Walker J, Zwald F, Habermann T, Gertz M, Bierman P, Dizon DS, Langstraat C, Al-Qaoud T, Eggener S, Richgels JP, Chang GJ, Geltzeiler C, Sapisochin G, Ricciardi R, Krupnick AS, Kennedy C, Mohindra N, Foley DP, Watt KD
Am J Transplant 2021 Feb;21(2):460-474. Epub 2020 Oct 23 doi: 10.1111/ajt.16318. PMID: 32969590Free PMC Article

Recent clinical studies

Etiology

Flugel CL, Majzner RG, Krenciute G, Dotti G, Riddell SR, Wagner DL, Abou-El-Enein M
Nat Rev Clin Oncol 2023 Jan;20(1):49-62. Epub 2022 Nov 23 doi: 10.1038/s41571-022-00704-3. PMID: 36418477Free PMC Article
Monk BJ, Enomoto T, Kast WM, McCormack M, Tan DSP, Wu X, González-Martín A
Cancer Treat Rev 2022 May;106:102385. Epub 2022 Mar 31 doi: 10.1016/j.ctrv.2022.102385. PMID: 35413489Free PMC Article
Sivori S, Pende D, Quatrini L, Pietra G, Della Chiesa M, Vacca P, Tumino N, Moretta F, Mingari MC, Locatelli F, Moretta L
Mol Aspects Med 2021 Aug;80:100870. Epub 2020 Aug 13 doi: 10.1016/j.mam.2020.100870. PMID: 32800530
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Cohen PA, Jhingran A, Oaknin A, Denny L
Lancet 2019 Jan 12;393(10167):169-182. doi: 10.1016/S0140-6736(18)32470-X. PMID: 30638582

Diagnosis

DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, McNamara J, Lowe ES, Ah-See ML, Moore KN; SOLO1 Investigators
J Clin Oncol 2023 Jan 20;41(3):609-617. Epub 2022 Sep 9 doi: 10.1200/JCO.22.01549. PMID: 36082969Free PMC Article
Fernandes CJ, Leung G, Eads JR, Katona BW
Gastroenterol Clin North Am 2022 Sep;51(3):625-647. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.002. PMID: 36153114
Cercek A, Lumish M, Sinopoli J, Weiss J, Shia J, Lamendola-Essel M, El Dika IH, Segal N, Shcherba M, Sugarman R, Stadler Z, Yaeger R, Smith JJ, Rousseau B, Argiles G, Patel M, Desai A, Saltz LB, Widmar M, Iyer K, Zhang J, Gianino N, Crane C, Romesser PB, Pappou EP, Paty P, Garcia-Aguilar J, Gonen M, Gollub M, Weiser MR, Schalper KA, Diaz LA Jr
N Engl J Med 2022 Jun 23;386(25):2363-2376. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2201445. PMID: 35660797Free PMC Article
Zhang J, Huang D, Saw PE, Song E
Trends Immunol 2022 Jul;43(7):523-545. Epub 2022 May 25 doi: 10.1016/j.it.2022.04.010. PMID: 35624021
Cohen PA, Jhingran A, Oaknin A, Denny L
Lancet 2019 Jan 12;393(10167):169-182. doi: 10.1016/S0140-6736(18)32470-X. PMID: 30638582

Therapy

Dhillon S
Drugs 2023 Feb;83(3):275-285. doi: 10.1007/s40265-023-01839-y. PMID: 36763320
DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, McNamara J, Lowe ES, Ah-See ML, Moore KN; SOLO1 Investigators
J Clin Oncol 2023 Jan 20;41(3):609-617. Epub 2022 Sep 9 doi: 10.1200/JCO.22.01549. PMID: 36082969Free PMC Article
Shalhout SZ, Emerick KS, Kaufman HL, Miller DM
Curr Oncol Rep 2021 Aug 27;23(11):125. doi: 10.1007/s11912-021-01120-z. PMID: 34448958Free PMC Article
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, Blakely CM, Seto T, Cho BC, Tosi D, Besse B, Chawla SP, Bazhenova L, Krauss JC, Chae YK, Barve M, Garrido-Laguna I, Liu SV, Conkling P, John T, Fakih M, Sigal D, Loong HH, Buchschacher GL Jr, Garrido P, Nieva J, Steuer C, Overbeck TR, Bowles DW, Fox E, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Demetri GD; trial investigators
Lancet Oncol 2020 Feb;21(2):271-282. Epub 2019 Dec 11 doi: 10.1016/S1470-2045(19)30691-6. PMID: 31838007Free PMC Article

Prognosis

DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, McNamara J, Lowe ES, Ah-See ML, Moore KN; SOLO1 Investigators
J Clin Oncol 2023 Jan 20;41(3):609-617. Epub 2022 Sep 9 doi: 10.1200/JCO.22.01549. PMID: 36082969Free PMC Article
Zhao W, Jin L, Chen P, Li D, Gao W, Dong G
Cancer Lett 2022 Oct 1;545:215816. Epub 2022 Jul 8 doi: 10.1016/j.canlet.2022.215816. PMID: 35810989
Medikonda R, Dunn G, Rahman M, Fecci P, Lim M
J Neurooncol 2021 Jan;151(1):41-53. Epub 2020 Apr 6 doi: 10.1007/s11060-020-03448-1. PMID: 32253714
Cohen PA, Jhingran A, Oaknin A, Denny L
Lancet 2019 Jan 12;393(10167):169-182. doi: 10.1016/S0140-6736(18)32470-X. PMID: 30638582
Rini BI, Campbell SC, Escudier B
Lancet 2009 Mar 28;373(9669):1119-32. Epub 2009 Mar 5 doi: 10.1016/S0140-6736(09)60229-4. PMID: 19269025

Clinical prediction guides

Flugel CL, Majzner RG, Krenciute G, Dotti G, Riddell SR, Wagner DL, Abou-El-Enein M
Nat Rev Clin Oncol 2023 Jan;20(1):49-62. Epub 2022 Nov 23 doi: 10.1038/s41571-022-00704-3. PMID: 36418477Free PMC Article
Zhao W, Jin L, Chen P, Li D, Gao W, Dong G
Cancer Lett 2022 Oct 1;545:215816. Epub 2022 Jul 8 doi: 10.1016/j.canlet.2022.215816. PMID: 35810989
Hart NH, Crawford-Williams F, Crichton M, Yee J, Smith TJ, Koczwara B, Fitch MI, Crawford GB, Mukhopadhyay S, Mahony J, Cheah C, Townsend J, Cook O, Agar MR, Chan RJ
Crit Rev Oncol Hematol 2022 Aug;176:103728. Epub 2022 Jun 1 doi: 10.1016/j.critrevonc.2022.103728. PMID: 35662585
Grünewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, Di Pompo G, Distel M, Dorado-Garcia H, Garcia-Castro J, González-González L, Grigoriadis AE, Kasan M, Koelsche C, Krumbholz M, Lecanda F, Lemma S, Longo DL, Madrigal-Esquivel C, Morales-Molina Á, Musa J, Ohmura S, Ory B, Pereira-Silva M, Perut F, Rodriguez R, Seeling C, Al Shaaili N, Shaabani S, Shiavone K, Sinha S, Tomazou EM, Trautmann M, Vela M, Versleijen-Jonkers YM, Visgauss J, Zalacain M, Schober SJ, Lissat A, English WR, Baldini N, Heymann D
EMBO Mol Med 2020 Nov 6;12(11):e11131. Epub 2020 Oct 13 doi: 10.15252/emmm.201911131. PMID: 33047515Free PMC Article
Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485

Recent systematic reviews

Hart NH, Crawford-Williams F, Crichton M, Yee J, Smith TJ, Koczwara B, Fitch MI, Crawford GB, Mukhopadhyay S, Mahony J, Cheah C, Townsend J, Cook O, Agar MR, Chan RJ
Crit Rev Oncol Hematol 2022 Aug;176:103728. Epub 2022 Jun 1 doi: 10.1016/j.critrevonc.2022.103728. PMID: 35662585
Gondi V, Bauman G, Bradfield L, Burri SH, Cabrera AR, Cunningham DA, Eaton BR, Hattangadi-Gluth JA, Kim MM, Kotecha R, Kraemer L, Li J, Nagpal S, Rusthoven CG, Suh JH, Tomé WA, Wang TJC, Zimmer AS, Ziu M, Brown PD
Pract Radiat Oncol 2022 Jul-Aug;12(4):265-282. Epub 2022 May 6 doi: 10.1016/j.prro.2022.02.003. PMID: 35534352
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Tan AC, Bagley SJ, Wen PY, Lim M, Platten M, Colman H, Ashley DM, Wick W, Chang SM, Galanis E, Mansouri A, Khagi S, Mehta MP, Heimberger AB, Puduvalli VK, Reardon DA, Sahebjam S, Simes J, Antonia SJ, Berry D, Khasraw M
J Immunother Cancer 2021 Jul;9(7) doi: 10.1136/jitc-2021-002459. PMID: 34215688Free PMC Article
Agarwal G, Valderrama O, Luchey AM, Pow-Sang JM
Cancer Control 2015 Jul;22(3):283-90. doi: 10.1177/107327481502200305. PMID: 26351883

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