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Increased proportion of naive T cells

MedGen UID:
1618068
•Concept ID:
C4531151
•
Finding
Synonyms: Elevated proportion of naive T cells; Increased proportion of naive thymus-derived, alpha-beta T cells
 
HPO: HP:0031398

Definition

An abnormally increased proportion of naive T cells relative to the total number of T cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased proportion of naive T cells

Professional guidelines

PubMed

High-dimensional analysis of T-cell profiling variations following belimumab treatment in systemic lupus erythematosus.
Maeda S, Hashimoto H, Maeda T, Tamechika SY, Isogai S, Naniwa T, Niimi A
Lupus Sci Med 2023 Oct;10(2) doi: 10.1136/lupus-2023-000976. PMID: 37802602Free PMC Article
Vitiligo after alemtuzumab treatment: Secondary autoimmunity is not all about B cells.
Ruck T, Pfeuffer S, Schulte-Mecklenbeck A, Gross CC, Lindner M, Metze D, Ehrchen J, Sondermann W, Pul R, Kleinschnitz C, Wiendl H, Meuth SG, Klotz L
Neurology 2018 Dec 11;91(24):e2233-e2237. Epub 2018 Nov 7 doi: 10.1212/WNL.0000000000006648. PMID: 30404783Free PMC Article
Alemtuzumab for the treatment of relapsing-remitting multiple sclerosis.
Hersh CM, Cohen JA
Immunotherapy 2014;6(3):249-59. doi: 10.2217/imt.14.7. PMID: 24762071

Recent clinical studies

Etiology

CAR T cells vs bispecific antibody as third- or later-line large B-cell lymphoma therapy: a meta-analysis.
Kim J, Cho J, Lee MH, Yoon SE, Kim WS, Kim SJ
Blood 2024 Aug 8;144(6):629-638. doi: 10.1182/blood.2023023419. PMID: 38696731
Characteristics of premanufacture CD8(+)T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma.
Wang Y, Tong C, Lu Y, Wu Z, Guo Y, Liu Y, Wei J, Wang C, Yang Q, Han W
Signal Transduct Target Ther 2023 Oct 25;8(1):409. doi: 10.1038/s41392-023-01659-2. PMID: 37875502Free PMC Article
Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial.
Ma X, Yang F, Wu J, Xu B, Jiang M, Sun Y, Sun C, Yu Y, Xu D, Xiao L, Ren C, Chen C, Ye Z, Liang J, Lin J, Chen W
PLoS Med 2023 Jun;20(6):e1004249. Epub 2023 Jun 29 doi: 10.1371/journal.pmed.1004249. PMID: 37384596Free PMC Article
Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma.
Verkleij CPM, Broekmans MEC, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, Kaiser M, Morgan G, Axel A, Boominathan R, Sendecki J, Wong A, Verona RI, Sonneveld P, Zweegman S, Adams HC, Mutis T, van de Donk NWCJ
Blood Adv 2021 Apr 27;5(8):2196-2215. doi: 10.1182/bloodadvances.2020003805. PMID: 33890981Free PMC Article
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt(+) Regulatory T Cells and Exacerbate Colitis in Mice.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article

Diagnosis

T-Cell Characteristics Impact Response and Resistance to T-Cell-Redirecting Bispecific Antibodies in Multiple Myeloma.
Verkleij CPM, O'Neill CA, Broekmans MEC, Frerichs KA, Bruins WSC, Duetz C, Kruyswijk S, Baglio SR, Skerget S, Montes de Oca R, Zweegman S, Verona RI, Mutis T, van de Donk NWCJ
Clin Cancer Res 2024 Jul 15;30(14):3006-3022. doi: 10.1158/1078-0432.CCR-23-3333. PMID: 38687588
Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial.
Ma X, Yang F, Wu J, Xu B, Jiang M, Sun Y, Sun C, Yu Y, Xu D, Xiao L, Ren C, Chen C, Ye Z, Liang J, Lin J, Chen W
PLoS Med 2023 Jun;20(6):e1004249. Epub 2023 Jun 29 doi: 10.1371/journal.pmed.1004249. PMID: 37384596Free PMC Article
Role of thymus in health and disease.
Gulla S, Reddy MC, Reddy VC, Chitta S, Bhanoori M, Lomada D
Int Rev Immunol 2023;42(5):347-363. Epub 2022 May 20 doi: 10.1080/08830185.2022.2064461. PMID: 35593192
Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma.
Verkleij CPM, Broekmans MEC, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, Kaiser M, Morgan G, Axel A, Boominathan R, Sendecki J, Wong A, Verona RI, Sonneveld P, Zweegman S, Adams HC, Mutis T, van de Donk NWCJ
Blood Adv 2021 Apr 27;5(8):2196-2215. doi: 10.1182/bloodadvances.2020003805. PMID: 33890981Free PMC Article

Therapy

CAR T cells vs bispecific antibody as third- or later-line large B-cell lymphoma therapy: a meta-analysis.
Kim J, Cho J, Lee MH, Yoon SE, Kim WS, Kim SJ
Blood 2024 Aug 8;144(6):629-638. doi: 10.1182/blood.2023023419. PMID: 38696731
T-Cell Characteristics Impact Response and Resistance to T-Cell-Redirecting Bispecific Antibodies in Multiple Myeloma.
Verkleij CPM, O'Neill CA, Broekmans MEC, Frerichs KA, Bruins WSC, Duetz C, Kruyswijk S, Baglio SR, Skerget S, Montes de Oca R, Zweegman S, Verona RI, Mutis T, van de Donk NWCJ
Clin Cancer Res 2024 Jul 15;30(14):3006-3022. doi: 10.1158/1078-0432.CCR-23-3333. PMID: 38687588
LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001): results from arm 1 of a non-randomised, single-centre, phase 1/2 study.
Musher BL, Rowinsky EK, Smaglo BG, Abidi W, Othman M, Patel K, Jawaid S, Jing J, Brisco A, Leen AM, Wu M, Sandin LC, Wenthe J, Eriksson E, Ullenhag GJ, Grilley B, Leja-Jarblad J, Hilsenbeck SG, Brenner MK, Loskog ASI
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Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial.
Ma X, Yang F, Wu J, Xu B, Jiang M, Sun Y, Sun C, Yu Y, Xu D, Xiao L, Ren C, Chen C, Ye Z, Liang J, Lin J, Chen W
PLoS Med 2023 Jun;20(6):e1004249. Epub 2023 Jun 29 doi: 10.1371/journal.pmed.1004249. PMID: 37384596Free PMC Article
Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma.
Verkleij CPM, Broekmans MEC, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, Kaiser M, Morgan G, Axel A, Boominathan R, Sendecki J, Wong A, Verona RI, Sonneveld P, Zweegman S, Adams HC, Mutis T, van de Donk NWCJ
Blood Adv 2021 Apr 27;5(8):2196-2215. doi: 10.1182/bloodadvances.2020003805. PMID: 33890981Free PMC Article

Prognosis

Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Human immune phenotyping reveals accelerated aging in type 1 diabetes.
Shapiro MR, Dong X, Perry DJ, McNichols JM, Thirawatananond P, Posgai AL, Peters LD, Motwani K, Musca RS, Muir A, Concannon P, Jacobsen LM, Mathews CE, Wasserfall CH, Haller MJ, Schatz DA, Atkinson MA, Brusko MA, Bacher R, Brusko TM
JCI Insight 2023 Sep 8;8(17) doi: 10.1172/jci.insight.170767. PMID: 37498686Free PMC Article
Identification of evolutionary mechanisms of myelomatous effusion by single-cell RNA sequencing.
Sun Z, Ji J, Li Y, Cui Y, Fan L, Li J, Qu X
Blood Adv 2023 Aug 8;7(15):4148-4159. doi: 10.1182/bloodadvances.2022009477. PMID: 37276129Free PMC Article
T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer.
Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, Li C, Xu JX, Nie CP, Li K, Zhang X, Xia X, Li J
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005151. PMID: 36126994Free PMC Article
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt(+) Regulatory T Cells and Exacerbate Colitis in Mice.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article

Clinical prediction guides

CAR T cells vs bispecific antibody as third- or later-line large B-cell lymphoma therapy: a meta-analysis.
Kim J, Cho J, Lee MH, Yoon SE, Kim WS, Kim SJ
Blood 2024 Aug 8;144(6):629-638. doi: 10.1182/blood.2023023419. PMID: 38696731
Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related disease.
Lu C, Li S, Qing P, Zhang Q, Ji X, Tang Z, Chen C, Wu T, Hu Y, Zhao Y, Zhang X, He Q, Fox DA, Tan C, Luo Y, Liu Y
JCI Insight 2023 Sep 8;8(17) doi: 10.1172/jci.insight.167602. PMID: 37561593Free PMC Article
Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial.
Ma X, Yang F, Wu J, Xu B, Jiang M, Sun Y, Sun C, Yu Y, Xu D, Xiao L, Ren C, Chen C, Ye Z, Liang J, Lin J, Chen W
PLoS Med 2023 Jun;20(6):e1004249. Epub 2023 Jun 29 doi: 10.1371/journal.pmed.1004249. PMID: 37384596Free PMC Article
T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer.
Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, Li C, Xu JX, Nie CP, Li K, Zhang X, Xia X, Li J
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005151. PMID: 36126994Free PMC Article
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt(+) Regulatory T Cells and Exacerbate Colitis in Mice.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article

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