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Abnormal proportion of CD4-positive T cells

MedGen UID:
1619121
Concept ID:
C4531156
Finding
Synonym: Abnormal proportion of CD4 T cells
 
HPO: HP:0031392

Definition

Any abnormality in the proportion of CD4-positive T cells relative to the total number of T cells. [from HPO]

Conditions with this feature

Predisposition to invasive fungal disease due to CARD9 deficiency
MedGen UID:
347128
Concept ID:
C1859353
Disease or Syndrome
A rare genetic primary immunodeficiency with characteristics of increased susceptibility to fungal infections that typically manifest as recurrent, chronic mucocutaneous candidiasis, systemic candidiasis with meningoencephalitis and deep dermatophytosis. Dermatophytes invade skin, hair, nails, lymph nodes and brain, resulting in erythematosquamous lesions, nodular subcutaneous or ulcerative infiltrations, severe onychomycosis and lymphadenopathy.

Professional guidelines

PubMed

Sun S, Kong W, Cui X, Lin Y, Lu B, Pan Y, Huang J, Hu X
Int Immunopharmacol 2021 Jul;96:107784. Epub 2021 May 24 doi: 10.1016/j.intimp.2021.107784. PMID: 34162148
Raspadori D, Rondelli D, Birtolo S, Lenoci M, Nardi G, Scalia G, Sestigiani C, Tozzi M, Marotta G, Lauria F
Leukemia 1999 Aug;13(8):1254-7. doi: 10.1038/sj.leu.2401476. PMID: 10450754

Recent clinical studies

Etiology

Lin X, Chen M, Li X, Wang H, Bao Y
Mol Immunol 2022 Oct;150:114-125. Epub 2022 Aug 26 doi: 10.1016/j.molimm.2022.08.007. PMID: 36030709
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Smetanova J, Milota T, Rataj M, Bloomfield M, Sediva A, Klocperk A
J Clin Immunol 2022 Feb;42(2):274-285. Epub 2021 Oct 29 doi: 10.1007/s10875-021-01154-9. PMID: 34716533
Fox DA, Lundy SK, Whitfield ML, Berrocal V, Campbell P, Rasmussen S, Ohara R, Stinson A, Gurrea-Rubio M, Wiewiora E, Spino C, Bush E, Furst D, Pillai S, Khanna D
Arthritis Res Ther 2021 Jan 6;23(1):10. doi: 10.1186/s13075-020-02383-w. PMID: 33407866Free PMC Article
Wong GK, Huissoon AP
J Clin Pathol 2016 Aug;69(8):672-6. Epub 2016 May 6 doi: 10.1136/jclinpath-2015-203351. PMID: 27153873Free PMC Article

Diagnosis

Seledtsov VI, von Delwig AA
Expert Rev Vaccines 2020 Mar;19(3):209-215. Epub 2020 Apr 6 doi: 10.1080/14760584.2020.1745638. PMID: 32191535
Wang Y, Zhang S, Zhang N, Feng M, Liang Z, Zhao X, Gao C, Qin Y, Wu Y, Liu G, Zhao J, Guo H, Luo J
Mol Immunol 2020 Feb;118:19-29. Epub 2019 Dec 26 doi: 10.1016/j.molimm.2019.11.010. PMID: 31837507
Heikkilä N, Laakso SM, Mannerström H, Kekäläinen E, Saavalainen P, Jarva H, Arstila TP
J Clin Immunol 2016 Aug;36(6):555-63. Epub 2016 Jun 4 doi: 10.1007/s10875-016-0302-5. PMID: 27262317
Holm AM, Aukrust P, Aandahl EM, Müller F, Taskén K, Frøland SS
J Immunol 2003 Jun 1;170(11):5772-7. doi: 10.4049/jimmunol.170.11.5772. PMID: 12759461
Raspadori D, Rondelli D, Birtolo S, Lenoci M, Nardi G, Scalia G, Sestigiani C, Tozzi M, Marotta G, Lauria F
Leukemia 1999 Aug;13(8):1254-7. doi: 10.1038/sj.leu.2401476. PMID: 10450754

Therapy

Fox DA, Lundy SK, Whitfield ML, Berrocal V, Campbell P, Rasmussen S, Ohara R, Stinson A, Gurrea-Rubio M, Wiewiora E, Spino C, Bush E, Furst D, Pillai S, Khanna D
Arthritis Res Ther 2021 Jan 6;23(1):10. doi: 10.1186/s13075-020-02383-w. PMID: 33407866Free PMC Article
Nakid-Cordero C, Arzouk N, Gauthier N, Tarantino N, Larsen M, Choquet S, Burrel S, Autran B, Vieillard V, Guihot A
PLoS One 2019;14(10):e0224211. Epub 2019 Oct 22 doi: 10.1371/journal.pone.0224211. PMID: 31639143Free PMC Article
Lu X, Song B, Weng W, Xia H, Su B, Wu H, Zhang T, Li W, Gao Y
Viral Immunol 2017 Nov;30(9):642-648. Epub 2017 Oct 16 doi: 10.1089/vim.2017.0017. PMID: 29035156
Tassiopoulos K, Landay A, Collier AC, Connick E, Deeks SG, Hunt P, Lewis DE, Wilson C, Bosch R
J Infect Dis 2012 Jun;205(11):1730-8. Epub 2012 Mar 23 doi: 10.1093/infdis/jis260. PMID: 22448010Free PMC Article
Raspadori D, Rondelli D, Birtolo S, Lenoci M, Nardi G, Scalia G, Sestigiani C, Tozzi M, Marotta G, Lauria F
Leukemia 1999 Aug;13(8):1254-7. doi: 10.1038/sj.leu.2401476. PMID: 10450754

Prognosis

Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Pranzatelli MR, Tate ED, Allison TJ
Clin Exp Immunol 2017 Nov;190(2):217-225. Epub 2017 Aug 7 doi: 10.1111/cei.13015. PMID: 28710878Free PMC Article
Sereti I, Estes JD, Thompson WL, Morcock DR, Fischl MA, Croughs T, Beq S, Lafaye de Micheaux S, Yao MD, Ober A, Wilson EM, Natarajan V, Imamichi H, Boulassel MR, Lederman MM, Routy JP
PLoS Pathog 2014 Jan;10(1):e1003890. Epub 2014 Jan 30 doi: 10.1371/journal.ppat.1003890. PMID: 24497828Free PMC Article
Tassiopoulos K, Landay A, Collier AC, Connick E, Deeks SG, Hunt P, Lewis DE, Wilson C, Bosch R
J Infect Dis 2012 Jun;205(11):1730-8. Epub 2012 Mar 23 doi: 10.1093/infdis/jis260. PMID: 22448010Free PMC Article
Dahle C, Vrethem M, Ernerudh J
J Neuroimmunol 1994 Sep;53(2):219-25. doi: 10.1016/0165-5728(94)90032-9. PMID: 7520920

Clinical prediction guides

Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Loretelli C, Abdelsalam A, D'Addio F, Ben Nasr M, Assi E, Usuelli V, Maestroni A, Seelam AJ, Ippolito E, Di Maggio S, Loreggian L, Radovanovic D, Vanetti C, Yang J, El Essawy B, Rossi A, Pastore I, Montefusco L, Lunati ME, Bolla AM, Biasin M, Antinori S, Santus P, Riva A, Zuccotti GV, Galli M, Rusconi S, Fiorina P
JCI Insight 2021 Dec 22;6(24) doi: 10.1172/jci.insight.146701. PMID: 34784300Free PMC Article
Fox DA, Lundy SK, Whitfield ML, Berrocal V, Campbell P, Rasmussen S, Ohara R, Stinson A, Gurrea-Rubio M, Wiewiora E, Spino C, Bush E, Furst D, Pillai S, Khanna D
Arthritis Res Ther 2021 Jan 6;23(1):10. doi: 10.1186/s13075-020-02383-w. PMID: 33407866Free PMC Article
Daltro PB, Ribeiro TO, Daltro GC, Meyer RJ, Fortuna V
Mediators Inflamm 2020;2020:1747894. Epub 2020 Oct 9 doi: 10.1155/2020/1747894. PMID: 33132753Free PMC Article
Ho LP, Urban BC, Thickett DR, Davies RJ, McMichael AJ
Lancet 2005 Mar 19-25;365(9464):1062-72. doi: 10.1016/S0140-6736(05)71143-0. PMID: 15781102

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