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Reduced sex -hormone binding protein level

MedGen UID:
1619390
•Concept ID:
C4531135
•
Finding
Synonym: Reduced androgen-binding protein level
 
HPO: HP:0031419

Definition

A decreased concentration of sex-hormone binding protein in the circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced sex -hormone binding protein level

Professional guidelines

PubMed

Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.
Zhong X, Narasimhan A, Silverman LM, Young AR, Shahda S, Liu S, Wan J, Liu Y, Koniaris LG, Zimmers TA
J Cachexia Sarcopenia Muscle 2022 Aug;13(4):2146-2161. Epub 2022 May 5 doi: 10.1002/jcsm.12998. PMID: 35510530Free PMC Article
Estrogen treatment reduced oxalate transporting activity and enhanced migration through the involvement of SLC26A6 in lung cancer cells.
Lee D, Lee PC, Hong JH, Shin DM
Toxicol In Vitro 2022 Aug;82:105373. Epub 2022 Apr 29 doi: 10.1016/j.tiv.2022.105373. PMID: 35500753
Cross-Sectional, Primary Care-Based Study of the Prevalence of Hypoandrogenemia in Nondiabetic Young Men with Obesity.
Molina-Vega M, Asenjo-Plaza M, García-Ruiz MC, Varea-Marineto E, Casal-Nievas N, Álvarez-Millán JJ, Cabezas-Sanchez P, Cardona-Díaz F, Queipo-Ortuño MI, Castellano-Castillo D, Tinahones FJ, Fernández-García JC
Obesity (Silver Spring) 2019 Oct;27(10):1584-1590. Epub 2019 Aug 14 doi: 10.1002/oby.22579. PMID: 31411814

Recent clinical studies

Etiology

Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation.
Yuan S, Wang L, Sun J, Yu L, Zhou X, Yang J, Zhu Y, Gill D, Burgess S, Denny JC, Larsson SC, Theodoratou E, Li X
Int J Epidemiol 2022 Dec 13;51(6):1931-1942. doi: 10.1093/ije/dyac036. PMID: 35218343Free PMC Article
Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies.
Whittaker J, Wu K
J Steroid Biochem Mol Biol 2021 Jun;210:105878. Epub 2021 Mar 16 doi: 10.1016/j.jsbmb.2021.105878. PMID: 33741447
Effect of atorvastatin on testosterone levels.
Shawish MI, Bagheri B, Musini VM, Adams SP, Wright JM
Cochrane Database Syst Rev 2021 Jan 22;1(1):CD013211. doi: 10.1002/14651858.CD013211.pub2. PMID: 33482034Free PMC Article
Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis.
Jaruvongvanich V, Sanguankeo A, Riangwiwat T, Upala S
Ann Hepatol 2017 May-Jun;16(3):382-394. doi: 10.5604/16652681.1235481. PMID: 28425408
The endocrine system and ageing.
Chahal HS, Drake WM
J Pathol 2007 Jan;211(2):173-80. doi: 10.1002/path.2110. PMID: 17200939

Diagnosis

Serum clinical laboratory tests and risk of incident dementia: a prospective cohort study of 407,190 individuals.
He XY, Kuo K, Yang L, Zhang YR, Wu BS, Chen SD, Cheng W, Feng JF, Yu JT
Transl Psychiatry 2022 Aug 4;12(1):312. doi: 10.1038/s41398-022-02082-x. PMID: 35927253Free PMC Article
Reproductive health in patients with epilepsy.
Markoula S, Siarava E, Keramida A, Chatzistefanidis D, Zikopoulos A, Kyritsis AP, Georgiou I
Epilepsy Behav 2020 Dec;113:107563. Epub 2020 Nov 24 doi: 10.1016/j.yebeh.2020.107563. PMID: 33242778
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers.
Gaccioli F, Aye ILMH, Sovio U, Charnock-Jones DS, Smith GCS
Am J Obstet Gynecol 2018 Feb;218(2S):S725-S737. Epub 2017 Dec 22 doi: 10.1016/j.ajog.2017.12.002. PMID: 29275822
Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis.
Jaruvongvanich V, Sanguankeo A, Riangwiwat T, Upala S
Ann Hepatol 2017 May-Jun;16(3):382-394. doi: 10.5604/16652681.1235481. PMID: 28425408
Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome.
Pugeat M, Nader N, Hogeveen K, Raverot G, Déchaud H, Grenot C
Mol Cell Endocrinol 2010 Mar 5;316(1):53-9. Epub 2009 Sep 26 doi: 10.1016/j.mce.2009.09.020. PMID: 19786070

Therapy

Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3.
Park WY, Song G, Park JY, Ahn KS, Kwak HJ, Park J, Lee JH, Um JY
Cell Death Dis 2022 Jun 17;13(6):554. doi: 10.1038/s41419-022-04995-3. PMID: 35715415Free PMC Article
Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation.
Yuan S, Wang L, Sun J, Yu L, Zhou X, Yang J, Zhu Y, Gill D, Burgess S, Denny JC, Larsson SC, Theodoratou E, Li X
Int J Epidemiol 2022 Dec 13;51(6):1931-1942. doi: 10.1093/ije/dyac036. PMID: 35218343Free PMC Article
Sex hormone-binding globulin: biomarker and hepatokine?
Simons PIHG, Valkenburg O, Stehouwer CDA, Brouwers MCGJ
Trends Endocrinol Metab 2021 Aug;32(8):544-553. Epub 2021 May 26 doi: 10.1016/j.tem.2021.05.002. PMID: 34052096
Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies.
Whittaker J, Wu K
J Steroid Biochem Mol Biol 2021 Jun;210:105878. Epub 2021 Mar 16 doi: 10.1016/j.jsbmb.2021.105878. PMID: 33741447
Interactions between antiepileptic drugs and hormones.
Svalheim S, Sveberg L, Mochol M, Taubøll E
Seizure 2015 May;28:12-7. Epub 2015 Feb 23 doi: 10.1016/j.seizure.2015.02.022. PMID: 25797888

Prognosis

Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation.
Yuan S, Wang L, Sun J, Yu L, Zhou X, Yang J, Zhu Y, Gill D, Burgess S, Denny JC, Larsson SC, Theodoratou E, Li X
Int J Epidemiol 2022 Dec 13;51(6):1931-1942. doi: 10.1093/ije/dyac036. PMID: 35218343Free PMC Article
Sex Hormone-Binding Globulin Expression Correlates With Acetyl-Coenzyme A Carboxylase and Triglyceride Content in Human Liver.
Sáez-López C, Salcedo-Allende MT, Hernandez C, Simó-Servat O, Simó R, Selva DM
J Clin Endocrinol Metab 2019 May 1;104(5):1500-1507. doi: 10.1210/jc.2018-00740. PMID: 30496542
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers.
Gaccioli F, Aye ILMH, Sovio U, Charnock-Jones DS, Smith GCS
Am J Obstet Gynecol 2018 Feb;218(2S):S725-S737. Epub 2017 Dec 22 doi: 10.1016/j.ajog.2017.12.002. PMID: 29275822
Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis.
Deswal R, Yadav A, Dang AS
Syst Biol Reprod Med 2018 Feb;64(1):12-24. Epub 2017 Dec 11 doi: 10.1080/19396368.2017.1410591. PMID: 29227165
Testosterone and type 2 diabetes.
Grossmann M, Gianatti EJ, Zajac JD
Curr Opin Endocrinol Diabetes Obes 2010 Jun;17(3):247-56. doi: 10.1097/MED.0b013e32833919cf. PMID: 20418720

Clinical prediction guides

Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.
Zhong X, Narasimhan A, Silverman LM, Young AR, Shahda S, Liu S, Wan J, Liu Y, Koniaris LG, Zimmers TA
J Cachexia Sarcopenia Muscle 2022 Aug;13(4):2146-2161. Epub 2022 May 5 doi: 10.1002/jcsm.12998. PMID: 35510530Free PMC Article
Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation.
Yuan S, Wang L, Sun J, Yu L, Zhou X, Yang J, Zhu Y, Gill D, Burgess S, Denny JC, Larsson SC, Theodoratou E, Li X
Int J Epidemiol 2022 Dec 13;51(6):1931-1942. doi: 10.1093/ije/dyac036. PMID: 35218343Free PMC Article
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers.
Gaccioli F, Aye ILMH, Sovio U, Charnock-Jones DS, Smith GCS
Am J Obstet Gynecol 2018 Feb;218(2S):S725-S737. Epub 2017 Dec 22 doi: 10.1016/j.ajog.2017.12.002. PMID: 29275822
Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis.
Deswal R, Yadav A, Dang AS
Syst Biol Reprod Med 2018 Feb;64(1):12-24. Epub 2017 Dec 11 doi: 10.1080/19396368.2017.1410591. PMID: 29227165
Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis.
Jaruvongvanich V, Sanguankeo A, Riangwiwat T, Upala S
Ann Hepatol 2017 May-Jun;16(3):382-394. doi: 10.5604/16652681.1235481. PMID: 28425408

Recent systematic reviews

Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies.
Whittaker J, Wu K
J Steroid Biochem Mol Biol 2021 Jun;210:105878. Epub 2021 Mar 16 doi: 10.1016/j.jsbmb.2021.105878. PMID: 33741447
Effect of atorvastatin on testosterone levels.
Shawish MI, Bagheri B, Musini VM, Adams SP, Wright JM
Cochrane Database Syst Rev 2021 Jan 22;1(1):CD013211. doi: 10.1002/14651858.CD013211.pub2. PMID: 33482034Free PMC Article
Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis.
Deswal R, Yadav A, Dang AS
Syst Biol Reprod Med 2018 Feb;64(1):12-24. Epub 2017 Dec 11 doi: 10.1080/19396368.2017.1410591. PMID: 29227165
Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis.
Jaruvongvanich V, Sanguankeo A, Riangwiwat T, Upala S
Ann Hepatol 2017 May-Jun;16(3):382-394. doi: 10.5604/16652681.1235481. PMID: 28425408
Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies.
Brand JS, van der Tweel I, Grobbee DE, Emmelot-Vonk MH, van der Schouw YT
Int J Epidemiol 2011 Feb;40(1):189-207. Epub 2010 Sep 24 doi: 10.1093/ije/dyq158. PMID: 20870782

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