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Primary EBV-Positive Nodal T-Cell or NK-Cell Lymphoma

MedGen UID:
1619391
Concept ID:
C4528405
Neoplastic Process
Synonyms: Node-Based EBV-Positive Peripheral T-Cell Lymphoma; Node-Based Epstein-Barr Virus -Positive Peripheral T-Cell Lymphoma

Definition

An EBV-positive peripheral T-cell lymphoma that arises from the lymph nodes. It is characterized by a monomorphic pattern of infiltration and abscence of the angiodestruction and necrosis seen in extranodal NK/T-cell lymphomas. These lymphomas are more common in elderly patient, or in the setting of immune deficiency. For the time being, they are considered a variant of peripheral T-cell lymphoma, not otherwise specified. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary EBV-Positive Nodal T-Cell or NK-Cell Lymphoma

Professional guidelines

PubMed

Montes-Mojarro IA, Kim WY, Fend F, Quintanilla-Martinez L
Semin Diagn Pathol 2020 Jan;37(1):32-46. Epub 2019 Dec 17 doi: 10.1053/j.semdp.2019.12.004. PMID: 31889602

Recent clinical studies

Etiology

de Leval L, Feldman AL, Pileri S, Nakamura S, Gaulard P
Virchows Arch 2023 Jan;482(1):245-264. Epub 2022 Nov 7 doi: 10.1007/s00428-022-03434-0. PMID: 36336765Free PMC Article
Quintanilla-Martinez L, Swerdlow SH, Tousseyn T, Barrionuevo C, Nakamura S, Jaffe ES
Virchows Arch 2023 Jan;482(1):227-244. Epub 2022 Oct 11 doi: 10.1007/s00428-022-03414-4. PMID: 36216980Free PMC Article
Feldman AL, Laurent C, Narbaitz M, Nakamura S, Chan WC, de Leval L, Gaulard P
Virchows Arch 2023 Jan;482(1):265-279. Epub 2022 Oct 10 doi: 10.1007/s00428-022-03412-6. PMID: 36210383
Hue SS, Oon ML, Wang S, Tan SY, Ng SB
Pathology 2020 Jan;52(1):111-127. Epub 2019 Nov 22 doi: 10.1016/j.pathol.2019.09.011. PMID: 31767131
Cohen JI
Curr Top Microbiol Immunol 2015;390(Pt 1):241-65. doi: 10.1007/978-3-319-22822-8_10. PMID: 26424649Free PMC Article

Diagnosis

de Leval L, Feldman AL, Pileri S, Nakamura S, Gaulard P
Virchows Arch 2023 Jan;482(1):245-264. Epub 2022 Nov 7 doi: 10.1007/s00428-022-03434-0. PMID: 36336765Free PMC Article
Quintanilla-Martinez L, Swerdlow SH, Tousseyn T, Barrionuevo C, Nakamura S, Jaffe ES
Virchows Arch 2023 Jan;482(1):227-244. Epub 2022 Oct 11 doi: 10.1007/s00428-022-03414-4. PMID: 36216980Free PMC Article
Feldman AL, Laurent C, Narbaitz M, Nakamura S, Chan WC, de Leval L, Gaulard P
Virchows Arch 2023 Jan;482(1):265-279. Epub 2022 Oct 10 doi: 10.1007/s00428-022-03412-6. PMID: 36210383
He X, Gao Y, Li Z, Huang H
Hematol Oncol 2023 Apr;41(2):221-229. Epub 2021 Dec 9 doi: 10.1002/hon.2944. PMID: 34731509
Hue SS, Oon ML, Wang S, Tan SY, Ng SB
Pathology 2020 Jan;52(1):111-127. Epub 2019 Nov 22 doi: 10.1016/j.pathol.2019.09.011. PMID: 31767131

Therapy

Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Liu E, Marin D, Banerjee P, Macapinlac HA, Thompson P, Basar R, Nassif Kerbauy L, Overman B, Thall P, Kaplan M, Nandivada V, Kaur I, Nunez Cortes A, Cao K, Daher M, Hosing C, Cohen EN, Kebriaei P, Mehta R, Neelapu S, Nieto Y, Wang M, Wierda W, Keating M, Champlin R, Shpall EJ, Rezvani K
N Engl J Med 2020 Feb 6;382(6):545-553. doi: 10.1056/NEJMoa1910607. PMID: 32023374Free PMC Article
Su S, Zhao J, Xing Y, Zhang X, Liu J, Ouyang Q, Chen J, Su F, Liu Q, Song E
Cell 2018 Oct 4;175(2):442-457.e23. doi: 10.1016/j.cell.2018.09.007. PMID: 30290143
Weiner GJ
Semin Hematol 2010 Apr;47(2):115-23. doi: 10.1053/j.seminhematol.2010.01.011. PMID: 20350658Free PMC Article

Prognosis

Quintanilla-Martinez L, Swerdlow SH, Tousseyn T, Barrionuevo C, Nakamura S, Jaffe ES
Virchows Arch 2023 Jan;482(1):227-244. Epub 2022 Oct 11 doi: 10.1007/s00428-022-03414-4. PMID: 36216980Free PMC Article
He X, Gao Y, Li Z, Huang H
Hematol Oncol 2023 Apr;41(2):221-229. Epub 2021 Dec 9 doi: 10.1002/hon.2944. PMID: 34731509
Chiba M, Shimono J, Ishio T, Takei N, Kasahara K, Ogasawara R, Ara T, Goto H, Izumiyama K, Otsuguro S, Perera LP, Hasegawa H, Maeda M, Hashino S, Maenaka K, Teshima T, Waldmann TA, Yang Y, Nakagawa M
Blood 2022 Nov 3;140(18):1951-1963. doi: 10.1182/blood.2022015646. PMID: 35921533Free PMC Article
Vose J, Armitage J, Weisenburger D; International T-Cell Lymphoma Project
J Clin Oncol 2008 Sep 1;26(25):4124-30. Epub 2008 Jul 14 doi: 10.1200/JCO.2008.16.4558. PMID: 18626005
Miller JS, Soignier Y, Panoskaltsis-Mortari A, McNearney SA, Yun GH, Fautsch SK, McKenna D, Le C, Defor TE, Burns LJ, Orchard PJ, Blazar BR, Wagner JE, Slungaard A, Weisdorf DJ, Okazaki IJ, McGlave PB
Blood 2005 Apr 15;105(8):3051-7. Epub 2005 Jan 4 doi: 10.1182/blood-2004-07-2974. PMID: 15632206

Clinical prediction guides

Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Salik B, Smyth MJ, Nakamura K
J Hematol Oncol 2020 Aug 12;13(1):111. doi: 10.1186/s13045-020-00947-6. PMID: 32787882Free PMC Article
Pahl JHW, Koch J, Götz JJ, Arnold A, Reusch U, Gantke T, Rajkovic E, Treder M, Cerwenka A
Cancer Immunol Res 2018 May;6(5):517-527. Epub 2018 Mar 7 doi: 10.1158/2326-6066.CIR-17-0550. PMID: 29514797
Swerdlow SH, Jaffe ES, Brousset P, Chan JK, de Leval L, Gaulard P, Harris NL, Pileri S, Weiss LM; International Lymphoma Study Group
Am J Surg Pathol 2014 Oct;38(10):e60-71. doi: 10.1097/PAS.0000000000000295. PMID: 25025449Free PMC Article

Recent systematic reviews

Yasuda H, Yasuda M, Komatsu N
Cancer Sci 2021 Jul;112(7):2607-2624. Epub 2021 Jun 11 doi: 10.1111/cas.14933. PMID: 33938097Free PMC Article
Kim SJ, Yoon SE, Kim WS
J Hematol Oncol 2018 Dec 20;11(1):140. doi: 10.1186/s13045-018-0687-0. PMID: 30567593Free PMC Article
Laribi K, Alani M, Truong C, de Materre AB
Recent Pat Anticancer Drug Discov 2018;13(3):308-340. doi: 10.2174/1574892813666180517102801. PMID: 29769011
Pokrovsky VS, Vinnikov D
Expert Rev Anticancer Ther 2017 Aug;17(8):759-768. Epub 2017 Jun 21 doi: 10.1080/14737140.2017.1344100. PMID: 28621166
Tarabay A, Cossu G, Berhouma M, Levivier M, Daniel RT, Messerer M
J Neurooncol 2016 Dec;130(3):383-395. Epub 2016 Aug 31 doi: 10.1007/s11060-016-2249-z. PMID: 27581598

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