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IRF4 Gene Rearrangement

MedGen UID:
1620046
•Concept ID:
C4524677
•
Cell or Molecular Dysfunction
Synonyms: Interferon Regulatory Factor 4 Gene Rearrangement; LSIRF Gene Rearrangement; Multiple Myeloma Oncogene 1 Gene Rearrangement; MUM1 Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the IRF4 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIRF4 Gene Rearrangement

Professional guidelines

PubMed

Impact of tofacitinib treatment on human B-cells in vitro and in vivo.
Rizzi M, Lorenzetti R, Fischer K, Staniek J, Janowska I, Troilo A, Strohmeier V, Erlacher M, Kunze M, Bannert B, Kyburz D, Voll RE, Venhoff N, Thiel J
J Autoimmun 2017 Feb;77:55-66. Epub 2016 Oct 26 doi: 10.1016/j.jaut.2016.10.005. PMID: 27793425

Recent clinical studies

Etiology

An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement.
Verma A, Epari S, Gujral S, Shet T
Indian J Pathol Microbiol 2018 Apr-Jun;61(2):271-274. doi: 10.4103/IJPM.IJPM_194_17. PMID: 29676376

Diagnosis

Primary Low-Grade B-Cell Lymphoma of Skull With Translocation Between Immunoglobulin and Interferon Regulatory Factor 4 Genes.
Nasim MM, Chalif DJ, Demopoulos AM, Brody J, Lee-Huang R, Spitzer SG, Kolitz JE, Zhang X
Int J Surg Pathol 2020 May;28(3):330-335. Epub 2019 Oct 20 doi: 10.1177/1066896919883013. PMID: 31631721

Therapy

An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement.
Verma A, Epari S, Gujral S, Shet T
Indian J Pathol Microbiol 2018 Apr-Jun;61(2):271-274. doi: 10.4103/IJPM.IJPM_194_17. PMID: 29676376

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