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Abnormal neural tube morphology

MedGen UID:
1620065
Concept ID:
C4531030
Anatomical Abnormality
HPO: HP:0410043

Definition

Any structural anomaly of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord). [from HPO]

Professional guidelines

PubMed

Obstet Gynecol 2017 Dec;130(6):e279-e290. doi: 10.1097/AOG.0000000000002412. PMID: 29189693
Chitty LS
Best Pract Res Clin Obstet Gynaecol 2014 Apr;28(3):453-66. Epub 2014 Jan 18 doi: 10.1016/j.bpobgyn.2014.01.002. PMID: 24594366
De Catte L, De Keersmaeker B, Claus F
Paediatr Drugs 2012 Jun 1;14(3):143-55. doi: 10.2165/11597030-000000000-00000. PMID: 22242843

Recent clinical studies

Etiology

Holmes LB, Toufaily MH, Westgate MN
Birth Defects Res 2018 Jan;110(2):128-133. doi: 10.1002/bdr2.1082. PMID: 29377645
Ebara S
Congenit Anom (Kyoto) 2017 Sep;57(5):138-141. Epub 2017 Jul 25 doi: 10.1111/cga.12233. PMID: 28603928
Nikolopoulou E, Galea GL, Rolo A, Greene ND, Copp AJ
Development 2017 Feb 15;144(4):552-566. doi: 10.1242/dev.145904. PMID: 28196803Free PMC Article
Greene ND, Leung KY, Copp AJ
Birth Defects Res 2017 Jan 30;109(2):68-80. doi: 10.1002/bdra.23533. PMID: 27324558Free PMC Article
Lew SM, Kothbauer KF
Pediatr Neurosurg 2007;43(3):236-48. doi: 10.1159/000098836. PMID: 17409793

Diagnosis

Markovic I, Bosnjakovic P, Milenkovic Z
Curr Pediatr Rev 2020;16(3):200-205. doi: 10.2174/1573396315666191018161535. PMID: 31656152Free PMC Article
Ebara S
Congenit Anom (Kyoto) 2017 Sep;57(5):138-141. Epub 2017 Jul 25 doi: 10.1111/cga.12233. PMID: 28603928
Shimada IS, Mukhopadhyay S
Birth Defects Res 2017 Jan 30;109(2):129-139. doi: 10.1002/bdra.23567. PMID: 27731925Free PMC Article
Kaufman BA
Pediatr Clin North Am 2004 Apr;51(2):389-419. doi: 10.1016/S0031-3955(03)00207-4. PMID: 15062676
Kjaer I
Crit Rev Oral Biol Med 1998;9(2):224-44. doi: 10.1177/10454411980090020501. PMID: 9603237

Therapy

Ebara S
Congenit Anom (Kyoto) 2017 Sep;57(5):138-141. Epub 2017 Jul 25 doi: 10.1111/cga.12233. PMID: 28603928
Yamaguchi Y, Miyazawa H, Miura M
Congenit Anom (Kyoto) 2017 Sep;57(5):134-137. Epub 2017 May 31 doi: 10.1111/cga.12219. PMID: 28295633
Greene ND, Leung KY, Copp AJ
Birth Defects Res 2017 Jan 30;109(2):68-80. doi: 10.1002/bdra.23533. PMID: 27324558Free PMC Article
Momb J, Appling DR
Birth Defects Res A Clin Mol Teratol 2014 Aug;100(8):576-83. Epub 2014 Jul 1 doi: 10.1002/bdra.23268. PMID: 24985542
Copp AJ, Greene ND
Wiley Interdiscip Rev Dev Biol 2013 Mar-Apr;2(2):213-27. Epub 2012 May 29 doi: 10.1002/wdev.71. PMID: 24009034Free PMC Article

Prognosis

Zohn IE
Adv Exp Med Biol 2020;1236:39-64. doi: 10.1007/978-981-15-2389-2_2. PMID: 32304068
Markovic I, Bosnjakovic P, Milenkovic Z
Curr Pediatr Rev 2020;16(3):200-205. doi: 10.2174/1573396315666191018161535. PMID: 31656152Free PMC Article
Gaitanis J, Tarui T
Continuum (Minneap Minn) 2018 Feb;24(1, Child Neurology):72-95. doi: 10.1212/CON.0000000000000561. PMID: 29432238Free PMC Article
Evans MI, Krivchenia EL, Yaron Y
Best Pract Res Clin Obstet Gynaecol 2002 Oct;16(5):645-57. doi: 10.1053/beog.2002.0330. PMID: 12475545
Kjaer I
Crit Rev Oral Biol Med 1998;9(2):224-44. doi: 10.1177/10454411980090020501. PMID: 9603237

Clinical prediction guides

Radford K, Taylor RC, Hall JG, Gick B
Birth Defects Res 2019 Jan 15;111(2):41-52. Epub 2018 Dec 10 doi: 10.1002/bdr2.1424. PMID: 30537250
de Bakker BS, Driessen S, Boukens BJD, van den Hoff MJB, Oostra RJ
Clin Anat 2017 Oct;30(7):988-999. Epub 2017 Aug 29 doi: 10.1002/ca.22977. PMID: 28795440
Greene ND, Leung KY, Copp AJ
Birth Defects Res 2017 Jan 30;109(2):68-80. doi: 10.1002/bdra.23533. PMID: 27324558Free PMC Article
Marcorelles P, Laquerriere A
Am J Med Genet C Semin Med Genet 2010 Feb 15;154C(1):109-19. doi: 10.1002/ajmg.c.30249. PMID: 20104606
Evans MI, Krivchenia EL, Yaron Y
Best Pract Res Clin Obstet Gynaecol 2002 Oct;16(5):645-57. doi: 10.1053/beog.2002.0330. PMID: 12475545

Recent systematic reviews

Hazneci J, Bastacı F, Börekci A, Öztürk ÖÇ, İş M, Somay A, Ekşi MŞ, Çelikoğlu E
Childs Nerv Syst 2022 Oct;38(10):1977-1986. Epub 2022 Jun 10 doi: 10.1007/s00381-022-05578-5. PMID: 35687168
Nassr AA, Hessami K, Shazly SA, Meshinchi N, Corroenne R, Espinoza J, Donepudi R, Sanz Cortes M, Belfort MA, Shamshirsaz AA
Ultrasound Obstet Gynecol 2021 Sep;58(3):347-353. doi: 10.1002/uog.23588. PMID: 33428299
Wang X, Yu Y, Yang N, Xia L
J Orthop Surg Res 2020 Oct 21;15(1):485. doi: 10.1186/s13018-020-02015-8. PMID: 33087139Free PMC Article
Bidondo MP, Groisman B, Tardivo A, Tomasoni F, Tejeiro V, Camacho I, Vilas M, Liascovich R, Barbero P
Birth Defects Res A Clin Mol Teratol 2016 Dec;106(12):993-1007. Epub 2016 Oct 5 doi: 10.1002/bdra.23549. PMID: 27704687

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