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Lung adenocarcinoma in situ

MedGen UID:
1620128
•Concept ID:
C4521520
•
Neoplastic Process
Synonyms: adenosquamous cell carcinoma in situ of lung; adenosquamous cell carcinoma in situ of the lung; bronchioalveolar carcinoma; in situ pulmonary adenocarcinoma; Lung Adenocarcinoma In Situ; lung adenocarcinoma in situ; lung adenocarcinoma In situ; lung adenosquamous cell carcinoma in situ; stage 0 adenosquamous cell carcinoma of lung; stage 0 adenosquamous cell carcinoma of the lung; stage 0 adenosquamous cell lung carcinoma; stage 0 adenosquamous lung cancer; stage 0 adenosquamous lung carcinoma aJCC v6; stage 0 adenosquamous lung carcinoma aJCC v6 and v7; stage 0 adenosquamous lung carcinoma aJCC v7
 
Monarch Initiative: MONDO:0000503

Definition

A localized non-invasive adenocarcinoma of the lung measuring 3 cm or less. It is characterized by a pure lepidic growth pattern and the lack of stromal, vascular, or pleural invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung adenocarcinoma in situ

Professional guidelines

PubMed

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology.
Lindeman NI, Cagle PT, Aisner DL, Arcila ME, Beasley MB, Bernicker EH, Colasacco C, Dacic S, Hirsch FR, Kerr K, Kwiatkowski DJ, Ladanyi M, Nowak JA, Sholl L, Temple-Smolkin R, Solomon B, Souter LH, Thunnissen E, Tsao MS, Ventura CB, Wynes MW, Yatabe Y
Arch Pathol Lab Med 2018 Mar;142(3):321-346. Epub 2018 Jan 22 doi: 10.5858/arpa.2017-0388-CP. PMID: 29355391
Targeting HER2 in the treatment of non-small cell lung cancer.
Mar N, Vredenburgh JJ, Wasser JS
Lung Cancer 2015 Mar;87(3):220-5. Epub 2015 Jan 8 doi: 10.1016/j.lungcan.2014.12.018. PMID: 25601485
Minimizing over-diagnosis in lung cancer screening.
Grannis FW Jr
J Surg Oncol 2013 Oct;108(5):289-93. Epub 2013 Aug 26 doi: 10.1002/jso.23400. PMID: 24037999

Recent clinical studies

Etiology

Clinical significance of tumor abnormal protein in patients with type 2 diabetes complicated with lung adenocarcinoma in situ.
Chen K, Zheng X, Hu J, Wu M, Zhou Y
Ann Med 2023;55(2):2293243. Epub 2023 Dec 14 doi: 10.1080/07853890.2023.2293243. PMID: 38375812Free PMC Article
Clinical Significance of Thrombelastography Results in Patients with Lung Adenocarcinoma in Situ Complicated with Type 2 Diabetes.
Chen K, Wang Q, Du X, Hu J, Niu L, Zhou Y
Clin Appl Thromb Hemost 2022 Jan-Dec;28:10760296221112658. doi: 10.1177/10760296221112658. PMID: 35791519Free PMC Article
Clinical study of serum IGFBP7 in predicting lymphatic metastasis in patients with lung adenocarcinoma.
Chen C, Tian X, Zhao X, Ren L
Curr Probl Cancer 2020 Dec;44(6):100584. Epub 2020 May 21 doi: 10.1016/j.currproblcancer.2020.100584. PMID: 32475626
Secondhand Tobacco Smoke Exposure and Lung Adenocarcinoma In Situ/Minimally Invasive Adenocarcinoma (AIS/MIA).
Kim CH, Lee YC, Hung RJ, Boffetta P, Xie D, Wampfler JA, Cote ML, Chang SC, Ugolini D, Neri M, Le Marchand L, Schwartz AG, Morgenstern H, Christiani DC, Yang P, Zhang ZF
Cancer Epidemiol Biomarkers Prev 2015 Dec;24(12):1902-6. Epub 2015 Oct 26 doi: 10.1158/1055-9965.EPI-15-0436. PMID: 26503035Free PMC Article
Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS).
Bracci PM, Sison J, Hansen H, Walsh KM, Quesenberry CP, Raz DJ, Wrensch M, Wiencke JK
J Thorac Oncol 2012 Sep;7(9):1352-60. doi: 10.1097/JTO.0b013e31825aba47. PMID: 22814813Free PMC Article

Diagnosis

Clinical significance of tumor abnormal protein in patients with type 2 diabetes complicated with lung adenocarcinoma in situ.
Chen K, Zheng X, Hu J, Wu M, Zhou Y
Ann Med 2023;55(2):2293243. Epub 2023 Dec 14 doi: 10.1080/07853890.2023.2293243. PMID: 38375812Free PMC Article
Senescent alveolar macrophages promote early-stage lung tumorigenesis.
Prieto LI, Sturmlechner I, Graves SI, Zhang C, Goplen NP, Yi ES, Sun J, Li H, Baker DJ
Cancer Cell 2023 Jul 10;41(7):1261-1275.e6. Epub 2023 Jun 1 doi: 10.1016/j.ccell.2023.05.006. PMID: 37267954Free PMC Article
Clinical study of serum IGFBP7 in predicting lymphatic metastasis in patients with lung adenocarcinoma.
Chen C, Tian X, Zhao X, Ren L
Curr Probl Cancer 2020 Dec;44(6):100584. Epub 2020 May 21 doi: 10.1016/j.currproblcancer.2020.100584. PMID: 32475626
Diagnosis of lung adenocarcinoma in situ and minimally invasive adenocarcinoma from intraoperative frozen sections: an analysis of 136 cases.
He P, Yao G, Guan Y, Lin Y, He J
J Clin Pathol 2016 Dec;69(12):1076-1080. Epub 2016 May 12 doi: 10.1136/jclinpath-2016-203619. PMID: 27174927
Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS).
Bracci PM, Sison J, Hansen H, Walsh KM, Quesenberry CP, Raz DJ, Wrensch M, Wiencke JK
J Thorac Oncol 2012 Sep;7(9):1352-60. doi: 10.1097/JTO.0b013e31825aba47. PMID: 22814813Free PMC Article

Therapy

Secondhand Tobacco Smoke Exposure and Lung Adenocarcinoma In Situ/Minimally Invasive Adenocarcinoma (AIS/MIA).
Kim CH, Lee YC, Hung RJ, Boffetta P, Xie D, Wampfler JA, Cote ML, Chang SC, Ugolini D, Neri M, Le Marchand L, Schwartz AG, Morgenstern H, Christiani DC, Yang P, Zhang ZF
Cancer Epidemiol Biomarkers Prev 2015 Dec;24(12):1902-6. Epub 2015 Oct 26 doi: 10.1158/1055-9965.EPI-15-0436. PMID: 26503035Free PMC Article
Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS).
Bracci PM, Sison J, Hansen H, Walsh KM, Quesenberry CP, Raz DJ, Wrensch M, Wiencke JK
J Thorac Oncol 2012 Sep;7(9):1352-60. doi: 10.1097/JTO.0b013e31825aba47. PMID: 22814813Free PMC Article

Prognosis

Combined detection of serum IL-6 and CEA contributes to the diagnosis of lung adenocarcinoma in situ.
Pan J, Zhuang W, Xia Y, Huang Z, Zheng Y, Wang X, Huang Y
PeerJ 2024;12:e17141. Epub 2024 Mar 22 doi: 10.7717/peerj.17141. PMID: 38529301Free PMC Article
Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma.
Hong J, Shiba-Ishii A, Kim Y, Noguchi M, Sakamoto N
Cancer Sci 2021 Dec;112(12):5114-5126. Epub 2021 Oct 18 doi: 10.1111/cas.15160. PMID: 34628698Free PMC Article
Clinical study of serum IGFBP7 in predicting lymphatic metastasis in patients with lung adenocarcinoma.
Chen C, Tian X, Zhao X, Ren L
Curr Probl Cancer 2020 Dec;44(6):100584. Epub 2020 May 21 doi: 10.1016/j.currproblcancer.2020.100584. PMID: 32475626
Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma.
Zhang Z, Wang A, Sun B, Zhan Z, Chen K, Wang C
J Cardiothorac Surg 2013 Apr 16;8:95. doi: 10.1186/1749-8090-8-95. PMID: 23591077Free PMC Article
Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS).
Bracci PM, Sison J, Hansen H, Walsh KM, Quesenberry CP, Raz DJ, Wrensch M, Wiencke JK
J Thorac Oncol 2012 Sep;7(9):1352-60. doi: 10.1097/JTO.0b013e31825aba47. PMID: 22814813Free PMC Article

Clinical prediction guides

Combined detection of serum IL-6 and CEA contributes to the diagnosis of lung adenocarcinoma in situ.
Pan J, Zhuang W, Xia Y, Huang Z, Zheng Y, Wang X, Huang Y
PeerJ 2024;12:e17141. Epub 2024 Mar 22 doi: 10.7717/peerj.17141. PMID: 38529301Free PMC Article
Clinical study of serum IGFBP7 in predicting lymphatic metastasis in patients with lung adenocarcinoma.
Chen C, Tian X, Zhao X, Ren L
Curr Probl Cancer 2020 Dec;44(6):100584. Epub 2020 May 21 doi: 10.1016/j.currproblcancer.2020.100584. PMID: 32475626
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
Sakuma Y, Matsukuma S, Yoshihara M, Nakamura Y, Noda K, Nakayama H, Kameda Y, Tsuchiya E, Miyagi Y
Am J Clin Pathol 2007 Jul;128(1):100-8. doi: 10.1309/WVXFGAFLAUX48DU6. PMID: 17580276

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