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Nuclear Cataract Grade 3

MedGen UID:
1620804
Concept ID:
C4525725
Disease or Syndrome

Definition

A stage of nuclear sclerotic cataract marked by pronounced yellowing and sclerosis of the lens nucleus. (Modified LOCS II) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNuclear Cataract Grade 3

Professional guidelines

PubMed

Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Chee SP, Wong MH, Jap A
Am J Ophthalmol 2017 Jan;173:7-15. Epub 2016 Sep 23 doi: 10.1016/j.ajo.2016.09.021. PMID: 27670621

Recent clinical studies

Etiology

Niazi S, Gatzioufas Z, Dhubhghaill SN, Moshirfar M, Faramarzi A, Mohammadi F, Kheiri B, Peyman A, Heidari M, Doroodgar F
Adv Ther 2024 Jan;41(1):231-245. Epub 2023 Oct 27 doi: 10.1007/s12325-023-02698-5. PMID: 37884810
Patel C, Tan Y, Nygaard S, Guo B, Carrillo C, Burgess J, Souksamone K, Nouansavanh KO, Casson R
Ophthalmic Epidemiol 2023 Feb;30(1):57-65. Epub 2022 Feb 3 doi: 10.1080/09286586.2022.2028294. PMID: 35112939
Michael R, Pareja-Aricò L, Rauscher FG, Barraquer RI
Ophthalmic Res 2019;62(3):157-165. Epub 2019 Mar 28 doi: 10.1159/000496865. PMID: 30921809
Loomis SJ, Klein AP, Lee KE, Chen F, Bomotti S, Truitt B, Iyengar SK, Klein R, Klein BEK, Duggal P
Ophthalmic Epidemiol 2018 Jun;25(3):215-219. Epub 2017 Nov 28 doi: 10.1080/09286586.2017.1406122. PMID: 29182452Free PMC Article
Lee JH, Choo HG, Kim SW
Graefes Arch Clin Exp Ophthalmol 2016 Jun;254(6):1127-33. Epub 2016 Mar 17 doi: 10.1007/s00417-016-3316-z. PMID: 26984747

Diagnosis

Niazi S, Gatzioufas Z, Dhubhghaill SN, Moshirfar M, Faramarzi A, Mohammadi F, Kheiri B, Peyman A, Heidari M, Doroodgar F
Adv Ther 2024 Jan;41(1):231-245. Epub 2023 Oct 27 doi: 10.1007/s12325-023-02698-5. PMID: 37884810
Shimizu E, Tanji M, Nakayama S, Ishikawa T, Agata N, Yokoiwa R, Nishimura H, Khemlani RJ, Sato S, Hanyuda A, Sato Y
Sci Rep 2023 Dec 12;13(1):22046. doi: 10.1038/s41598-023-49563-7. PMID: 38086904Free PMC Article
Eom Y, Suh YW, Kim SW, Lee YJ, Jeon HS, Lee SY, Lee IH, Song JS, Kim HM
Graefes Arch Clin Exp Ophthalmol 2023 Jul;261(7):1923-1932. Epub 2023 Feb 24 doi: 10.1007/s00417-023-05999-1. PMID: 36826601
Loomis SJ, Klein AP, Lee KE, Chen F, Bomotti S, Truitt B, Iyengar SK, Klein R, Klein BEK, Duggal P
Ophthalmic Epidemiol 2018 Jun;25(3):215-219. Epub 2017 Nov 28 doi: 10.1080/09286586.2017.1406122. PMID: 29182452Free PMC Article
Kanthan GL, Mitchell P, Rochtchina E, Cumming RG, Wang JJ
Clin Exp Ophthalmol 2014 May-Jun;42(4):347-53. Epub 2013 Oct 11 doi: 10.1111/ceo.12206. PMID: 24024555

Therapy

Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Cai L, Ma D, Xu X, Han X, Qiu X, Lu Y, Yang J
J Cataract Refract Surg 2022 Dec 1;48(12):1381-1387. doi: 10.1097/j.jcrs.0000000000000998. PMID: 36449671
Menapace R, Schartmüller D, Röggla V, Reiter GS, Leydolt C, Schwarzenbacher L
Acta Ophthalmol 2022 Mar;100(2):e414-e422. Epub 2021 Sep 20 doi: 10.1111/aos.14983. PMID: 34543523Free PMC Article
Lyu D, Shen Z, Zhang L, Qin Z, Ni S, Wang W, Zhu Y, Yao K
Am J Ophthalmol 2020 May;213:283-292. Epub 2019 Dec 27 doi: 10.1016/j.ajo.2019.12.017. PMID: 31887280
Klein BE, Klein R, Lee KE, Grady LM
JAMA 2006 Jun 21;295(23):2752-8. doi: 10.1001/jama.295.23.2752. PMID: 16788130

Prognosis

Loomis SJ, Klein AP, Lee KE, Chen F, Bomotti S, Truitt B, Iyengar SK, Klein R, Klein BEK, Duggal P
Ophthalmic Epidemiol 2018 Jun;25(3):215-219. Epub 2017 Nov 28 doi: 10.1080/09286586.2017.1406122. PMID: 29182452Free PMC Article
Shao L, Xu L, Zhang JS, You QS, Chen CX, Wang YX, Jonas JB, Wei WB
Invest Ophthalmol Vis Sci 2015 Jan 20;56(2):810-5. doi: 10.1167/iovs.14-15736. PMID: 25604689
Kanthan GL, Mitchell P, Rochtchina E, Cumming RG, Wang JJ
Clin Exp Ophthalmol 2014 May-Jun;42(4):347-53. Epub 2013 Oct 11 doi: 10.1111/ceo.12206. PMID: 24024555
Tan AG, Mitchell P, Rochtchina E, Hong T, Cumming RG, Wang JJ
Eye (Lond) 2012 Apr;26(4):568-75. Epub 2011 Dec 23 doi: 10.1038/eye.2011.349. PMID: 22193877Free PMC Article
Younan C, Mitchell P, Cumming RG, Rochtchina E, Wang JJ
Invest Ophthalmol Vis Sci 2002 Dec;43(12):3625-32. PMID: 12454028

Clinical prediction guides

Niazi S, Gatzioufas Z, Dhubhghaill SN, Moshirfar M, Faramarzi A, Mohammadi F, Kheiri B, Peyman A, Heidari M, Doroodgar F
Adv Ther 2024 Jan;41(1):231-245. Epub 2023 Oct 27 doi: 10.1007/s12325-023-02698-5. PMID: 37884810
Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Hu J, Zhao C, Luo Y, Kong J, Shi W, Wang T
Graefes Arch Clin Exp Ophthalmol 2023 Jun;261(6):1609-1618. Epub 2023 Jan 20 doi: 10.1007/s00417-022-05971-5. PMID: 36662235
Sánchez RF, García-Guerra CE, Martínez-Roda JA, de Paul AG, Issolio LA, Pujol J
Curr Eye Res 2022 Mar;47(3):391-398. Epub 2021 Nov 18 doi: 10.1080/02713683.2021.2002908. PMID: 34738850
Skalicky SE, Martin KR, Fenwick E, Crowston JG, Goldberg I, McCluskey P
Clin Exp Ophthalmol 2015 May-Jun;43(4):335-41. Epub 2014 Oct 30 doi: 10.1111/ceo.12454. PMID: 25294739

Supplemental Content

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