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Reduced contraction of the left ventricular apex

MedGen UID:
1621478
•Concept ID:
C4531092
•
Finding
Synonym: Left ventricular apical hypokinesis
 
HPO: HP:0031483

Definition

Reduced wall motion (contraction) of the apex of the left ventricle. This manifestation can be observed on echocardiography. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced contraction of the left ventricular apex

Professional guidelines

PubMed

Pacing induced cardiomyopathy: recognition and management.
Ponnusamy SS, Syed T, Vijayaraman P
Heart 2023 Aug 24;109(18):1407-1415. doi: 10.1136/heartjnl-2022-321723. PMID: 36990681

Recent clinical studies

Etiology

Pacing induced cardiomyopathy: recognition and management.
Ponnusamy SS, Syed T, Vijayaraman P
Heart 2023 Aug 24;109(18):1407-1415. doi: 10.1136/heartjnl-2022-321723. PMID: 36990681
Ineffective and prolonged apical contraction is associated with chest pain and ischaemia in apical hypertrophic cardiomyopathy.
Stephenson E, Monney P, Pugliese F, Malcolmson J, Petersen SE, Knight C, Mills P, Wragg A, O'Mahony C, Sekhri N, Mohiddin SA
Int J Cardiol 2018 Jan 15;251:65-70. doi: 10.1016/j.ijcard.2017.09.206. PMID: 29197461
Characterizing the spectrum of right ventricular remodelling in response to chronic training.
Sitges M, Merino B, Butakoff C, de la Garza MS, Paré C, Montserrat S, Vidal B, Azqueta M, Sarquella G, Gutierrez JA, Canal R, Brugada J, Bijnens BH
Int J Cardiovasc Imaging 2017 Mar;33(3):331-339. Epub 2016 Nov 15 doi: 10.1007/s10554-016-1014-x. PMID: 27848162
Differential right ventricular regional function and the effect of pulmonary hypertension: three-dimensional echo study.
Calcutteea A, Chung R, Lindqvist P, Hodson M, Henein MY
Heart 2011 Jun;97(12):1004-11. Epub 2011 Apr 12 doi: 10.1136/hrt.2010.208900. PMID: 21487122
Retiming the failing heart: principles and current clinical status of cardiac resynchronization.
Leclercq C, Kass DA
J Am Coll Cardiol 2002 Jan 16;39(2):194-201. doi: 10.1016/s0735-1097(01)01747-8. PMID: 11788207

Diagnosis

Pacing induced cardiomyopathy: recognition and management.
Ponnusamy SS, Syed T, Vijayaraman P
Heart 2023 Aug 24;109(18):1407-1415. doi: 10.1136/heartjnl-2022-321723. PMID: 36990681
Phase-contrast magnet resonance imaging reveals regional, transmural, and base-to-apex dispersion of mechanical dysfunction in patients with long QT syndrome.
Brado J, Dechant MJ, Menza M, Komancsek A, Lang CN, Bugger H, Foell D, Jung BA, Stiller B, Bode C, Odening KE
Heart Rhythm 2017 Sep;14(9):1388-1397. Epub 2017 May 4 doi: 10.1016/j.hrthm.2017.04.045. PMID: 28479515
Altered Regional Myocardial Mechanics in Transplanted Hearts: Influence of Time and Transplantation.
Wengenmayer T, Stephan A, Grundmann S, Föll D, Beyersdorf F, Bode C, Geibel A
Thorac Cardiovasc Surg 2017 Aug;65(5):415-422. Epub 2016 Dec 28 doi: 10.1055/s-0036-1597591. PMID: 28030875
Characterizing the spectrum of right ventricular remodelling in response to chronic training.
Sitges M, Merino B, Butakoff C, de la Garza MS, Paré C, Montserrat S, Vidal B, Azqueta M, Sarquella G, Gutierrez JA, Canal R, Brugada J, Bijnens BH
Int J Cardiovasc Imaging 2017 Mar;33(3):331-339. Epub 2016 Nov 15 doi: 10.1007/s10554-016-1014-x. PMID: 27848162
The use of unipolar intracardiac impedance for discrimination of haemodynamically stable and unstable arrhythmias in man.
Kaye G, Arthur W, Edgar D, Lippert M, Czygan G
Europace 2006 Nov;8(11):988-93. Epub 2006 Sep 28 doi: 10.1093/europace/eul103. PMID: 17008329

Therapy

Pacing induced cardiomyopathy: recognition and management.
Ponnusamy SS, Syed T, Vijayaraman P
Heart 2023 Aug 24;109(18):1407-1415. doi: 10.1136/heartjnl-2022-321723. PMID: 36990681
Acute effects of right ventricular pacing on cardiac haemodynamics and transvalvular impedance.
Taborsky M, Fedorco M, Skala T, Kocianova E, Pastucha D, Richter D, Petrkova J, Di Gregorio F, Barbetta A, Vaclavik J
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2014 Dec;158(4):569-76. Epub 2013 Feb 18 doi: 10.5507/bp.2013.009. PMID: 23446212
Right ventricular apex pacing: is it obsolete?
Sanaa I, Franceschi F, Prevot S, Bastard E, Deharo JC
Arch Cardiovasc Dis 2009 Feb;102(2):135-41. Epub 2009 Jan 8 doi: 10.1016/j.acvd.2008.10.010. PMID: 19303581
Physiologic pacing: new modalities and pacing sites.
Padeletti L, Lieberman R, Valsecchi S, Hettrick DA
Pacing Clin Electrophysiol 2006 Dec;29 Suppl 2:S73-7. doi: 10.1111/j.1540-8159.2006.00493.x. PMID: 17169136
Retiming the failing heart: principles and current clinical status of cardiac resynchronization.
Leclercq C, Kass DA
J Am Coll Cardiol 2002 Jan 16;39(2):194-201. doi: 10.1016/s0735-1097(01)01747-8. PMID: 11788207

Prognosis

Geometrical and functional cardiac changes after cardiac surgery: a phisiopatological explanation based on speckle tracking.
Moya Mur JL, García Martín A, García Lledó A, Lázaro Rivera C, Rincón Díaz LM, Miguelena Hycka J, Boretti I, Gimaraes C, Casas Rojo E, Jiménez Nacher JJ, Fernández-Golfín C, Rodríguez-Roda Stuart J, Zamorano JL
Int J Cardiovasc Imaging 2018 Dec;34(12):1905-1915. Epub 2018 Aug 2 doi: 10.1007/s10554-018-1424-z. PMID: 30073630
Altered Regional Myocardial Mechanics in Transplanted Hearts: Influence of Time and Transplantation.
Wengenmayer T, Stephan A, Grundmann S, Föll D, Beyersdorf F, Bode C, Geibel A
Thorac Cardiovasc Surg 2017 Aug;65(5):415-422. Epub 2016 Dec 28 doi: 10.1055/s-0036-1597591. PMID: 28030875
Characterizing the spectrum of right ventricular remodelling in response to chronic training.
Sitges M, Merino B, Butakoff C, de la Garza MS, Paré C, Montserrat S, Vidal B, Azqueta M, Sarquella G, Gutierrez JA, Canal R, Brugada J, Bijnens BH
Int J Cardiovasc Imaging 2017 Mar;33(3):331-339. Epub 2016 Nov 15 doi: 10.1007/s10554-016-1014-x. PMID: 27848162
Speckle tracking echocardiography derived 2-dimensional myocardial strain predicts left ventricular function and mass regression in aortic stenosis patients undergoing aortic valve replacement.
Staron A, Bansal M, Kalakoti P, Nakabo A, Gasior Z, Pysz P, Wita K, Jasinski M, Sengupta PP
Int J Cardiovasc Imaging 2013 Apr;29(4):797-808. Epub 2012 Nov 30 doi: 10.1007/s10554-012-0160-z. PMID: 23197274
Additive value of torsion to global longitudinal left ventricular strain in patients with reduced ejection fraction.
Mornos C, Ruşinaru D, Ionac A, Petrescu L, Cozma D, Pescariu S, Drăgulescu SI
Acta Cardiol 2011 Oct;66(5):565-72. doi: 10.1080/ac.66.5.2131080. PMID: 22032049

Clinical prediction guides

Characterizing the spectrum of right ventricular remodelling in response to chronic training.
Sitges M, Merino B, Butakoff C, de la Garza MS, Paré C, Montserrat S, Vidal B, Azqueta M, Sarquella G, Gutierrez JA, Canal R, Brugada J, Bijnens BH
Int J Cardiovasc Imaging 2017 Mar;33(3):331-339. Epub 2016 Nov 15 doi: 10.1007/s10554-016-1014-x. PMID: 27848162
Abnormal left ventricular contraction sequence in hypertrophic cardiomyopathy patients: first description of hypersynchrony and invert synchrony.
Duchateau J, Cornolle C, Peyrou J, Ritter P, Pillois X, Réant P, Reynaud A, Landelle M, Lafitte S
Ultrasound Med Biol 2015 Jun;41(6):1632-9. Epub 2015 Mar 5 doi: 10.1016/j.ultrasmedbio.2015.01.027. PMID: 25747939
Differential right ventricular regional function and the effect of pulmonary hypertension: three-dimensional echo study.
Calcutteea A, Chung R, Lindqvist P, Hodson M, Henein MY
Heart 2011 Jun;97(12):1004-11. Epub 2011 Apr 12 doi: 10.1136/hrt.2010.208900. PMID: 21487122
Physiologic pacing: new modalities and pacing sites.
Padeletti L, Lieberman R, Valsecchi S, Hettrick DA
Pacing Clin Electrophysiol 2006 Dec;29 Suppl 2:S73-7. doi: 10.1111/j.1540-8159.2006.00493.x. PMID: 17169136
Variability in the measurement of regional left ventricular wall motion from contrast angiograms.
Sheehan FH, Stewart DK, Dodge HT, Mitten S, Bolson EL, Brown BG
Circulation 1983 Sep;68(3):550-9. doi: 10.1161/01.cir.68.3.550. PMID: 6872167

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