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Refractory Soft Tissue Sarcoma

MedGen UID:
1621898
Concept ID:
C4528201
Neoplastic Process

Definition

A soft tissue sarcoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Hong JY, Cho HJ, Yun KH, Lee YH, Kim SH, Baek W, Kim SK, Lee Y, Choi YL, Kwon M, Kim HS, Lee J
Cancer Res Treat 2023 Apr;55(2):671-683. Epub 2022 Sep 27 doi: 10.4143/crt.2022.251. PMID: 36164943Free PMC Article
Ni JY, Sun HL, Chen YT, Luo JH, Wang WD, Jiang XY, Chen D, Xu LF
J Cancer Res Clin Oncol 2018 Jan;144(1):157-163. Epub 2017 Oct 9 doi: 10.1007/s00432-017-2530-3. PMID: 28993945
Wagner MJ, Amodu LI, Duh MS, Korves C, Solleza F, Manson SC, Diaz J, Neary MP, Demetri GD
BMC Cancer 2015 Mar 25;15:175. doi: 10.1186/s12885-015-1182-4. PMID: 25885530Free PMC Article

Recent clinical studies

Etiology

Schulte B, Mohindra N, Milhem M, Attia S, Robinson S, Monga V, Hirbe AC, Oppelt P, Charlson J, Helenowski I, Abbinanti S, Cehic R, Okuno S, Van Tine BA, Agulnik M
Br J Cancer 2021 Aug;125(4):528-533. Epub 2021 May 28 doi: 10.1038/s41416-021-01448-0. PMID: 34050255Free PMC Article
Kim SK, Kim JH, Kim SH, Lee YH, Han JW, Baek W, Woo HY, Jeon MK, Kim HS
BMC Cancer 2021 Mar 31;21(1):336. doi: 10.1186/s12885-021-08069-z. PMID: 33789622Free PMC Article
Schmoll HJ, Lindner LH, Reichardt P, Heißner K, Kopp HG, Kessler T, Mayer-Steinacker R, Rüssel J, Egerer G, Crysandt M, Kasper B, Niederwieser D, Kunitz A, Eigendorff E, Petersen I, Steighardt J, Cygon F, Meinert F, Stein A
JAMA Oncol 2021 Feb 1;7(2):255-262. doi: 10.1001/jamaoncol.2020.6564. PMID: 33355646Free PMC Article
Le Cesne A, Blay JY, Domont J, Tresch-Bruneel E, Chevreau C, Bertucci F, Delcambre C, Saada-Bouzid E, Piperno-Neumann S, Bay JO, Mir O, Ray-Coquard I, Ryckewaert T, Valentin T, Isambert N, Italiano A, Clisant S, Penel N
Lancet Oncol 2015 Mar;16(3):312-9. Epub 2015 Feb 11 doi: 10.1016/S1470-2045(15)70031-8. PMID: 25680558
Hartmann JT, Mayer F, Schleicher J, Horger M, Huober J, Meisinger I, Pintoffl J, Käfer G, Kanz L, Grünwald V; German sarcoma group
Cancer 2007 Aug 15;110(4):861-6. doi: 10.1002/cncr.22846. PMID: 17599772

Diagnosis

Veneroni L, Ferrari A, Proserpio T, Pagani Bagliacca E, Podda M, Massimino M, Alfredo Clerici C
Tumori 2018 Dec;104(6):413-414. Epub 2018 May 8 doi: 10.5301/tj.5000691. PMID: 29192737
Berry V, Basson L, Bogart E, Mir O, Blay JY, Italiano A, Bertucci F, Chevreau C, Clisant-Delaine S, Liegl-Antzager B, Tresch-Bruneel E, Wallet J, Taieb S, Decoupigny E, Le Cesne A, Brodowicz T, Penel N
Cancer 2017 Jun 15;123(12):2294-2302. Epub 2017 Mar 10 doi: 10.1002/cncr.30661. PMID: 28295221Free PMC Article
D'Incalci M, Simone M, Tavecchio M, Damia G, Garbi A, Erba E
J Chemother 2004 Nov;16 Suppl 4:86-9. doi: 10.1179/joc.2004.16.Supplement-1.86. PMID: 15688619
Bramwell VH, Morris D, Ernst DS, Hings I, Blackstein M, Venner PM, Ette EI, Harding MW, Waxman A, Demetri GD
Clin Cancer Res 2002 Feb;8(2):383-93. PMID: 11839653

Therapy

Hong JY, Cho HJ, Yun KH, Lee YH, Kim SH, Baek W, Kim SK, Lee Y, Choi YL, Kwon M, Kim HS, Lee J
Cancer Res Treat 2023 Apr;55(2):671-683. Epub 2022 Sep 27 doi: 10.4143/crt.2022.251. PMID: 36164943Free PMC Article
Kim SK, Kim JH, Kim SH, Lee YH, Han JW, Baek W, Woo HY, Jeon MK, Kim HS
BMC Cancer 2021 Mar 31;21(1):336. doi: 10.1186/s12885-021-08069-z. PMID: 33789622Free PMC Article
Schmoll HJ, Lindner LH, Reichardt P, Heißner K, Kopp HG, Kessler T, Mayer-Steinacker R, Rüssel J, Egerer G, Crysandt M, Kasper B, Niederwieser D, Kunitz A, Eigendorff E, Petersen I, Steighardt J, Cygon F, Meinert F, Stein A
JAMA Oncol 2021 Feb 1;7(2):255-262. doi: 10.1001/jamaoncol.2020.6564. PMID: 33355646Free PMC Article
Chi Y, Fang Z, Hong X, Yao Y, Sun P, Wang G, Du F, Sun Y, Wu Q, Qu G, Wang S, Song J, Yu J, Lu Y, Zhu X, Niu X, He Z, Wang J, Yu H, Cai J
Clin Cancer Res 2018 Nov 1;24(21):5233-5238. Epub 2018 Jun 12 doi: 10.1158/1078-0432.CCR-17-3766. PMID: 29895706
Berry V, Basson L, Bogart E, Mir O, Blay JY, Italiano A, Bertucci F, Chevreau C, Clisant-Delaine S, Liegl-Antzager B, Tresch-Bruneel E, Wallet J, Taieb S, Decoupigny E, Le Cesne A, Brodowicz T, Penel N
Cancer 2017 Jun 15;123(12):2294-2302. Epub 2017 Mar 10 doi: 10.1002/cncr.30661. PMID: 28295221Free PMC Article

Prognosis

Hong JY, Cho HJ, Yun KH, Lee YH, Kim SH, Baek W, Kim SK, Lee Y, Choi YL, Kwon M, Kim HS, Lee J
Cancer Res Treat 2023 Apr;55(2):671-683. Epub 2022 Sep 27 doi: 10.4143/crt.2022.251. PMID: 36164943Free PMC Article
Kim SK, Kim JH, Kim SH, Lee YH, Han JW, Baek W, Woo HY, Jeon MK, Kim HS
BMC Cancer 2021 Mar 31;21(1):336. doi: 10.1186/s12885-021-08069-z. PMID: 33789622Free PMC Article
Chi Y, Fang Z, Hong X, Yao Y, Sun P, Wang G, Du F, Sun Y, Wu Q, Qu G, Wang S, Song J, Yu J, Lu Y, Zhu X, Niu X, He Z, Wang J, Yu H, Cai J
Clin Cancer Res 2018 Nov 1;24(21):5233-5238. Epub 2018 Jun 12 doi: 10.1158/1078-0432.CCR-17-3766. PMID: 29895706
Reichardt P
Expert Rev Anticancer Ther 2013 Jun;13(6 Suppl 1):25-30. doi: 10.1586/era.13.50. PMID: 23638728
Foster BJ, LoRusso PM, Poplin E, Zalupski M, Valdivieso M, Wozniak A, Flaherty L, Kasunic DA, Earhart RH, Baker LH
Invest New Drugs 1996;13(4):321-6. doi: 10.1007/BF00873138. PMID: 8824350

Clinical prediction guides

Hong JY, Cho HJ, Yun KH, Lee YH, Kim SH, Baek W, Kim SK, Lee Y, Choi YL, Kwon M, Kim HS, Lee J
Cancer Res Treat 2023 Apr;55(2):671-683. Epub 2022 Sep 27 doi: 10.4143/crt.2022.251. PMID: 36164943Free PMC Article
Kim SK, Kim JH, Kim SH, Lee YH, Han JW, Baek W, Woo HY, Jeon MK, Kim HS
BMC Cancer 2021 Mar 31;21(1):336. doi: 10.1186/s12885-021-08069-z. PMID: 33789622Free PMC Article
Schmoll HJ, Lindner LH, Reichardt P, Heißner K, Kopp HG, Kessler T, Mayer-Steinacker R, Rüssel J, Egerer G, Crysandt M, Kasper B, Niederwieser D, Kunitz A, Eigendorff E, Petersen I, Steighardt J, Cygon F, Meinert F, Stein A
JAMA Oncol 2021 Feb 1;7(2):255-262. doi: 10.1001/jamaoncol.2020.6564. PMID: 33355646Free PMC Article
Hartmann JT, Bauer S, Egerer G, Horger MS, Kopp HG, Grünwald V, Mayer F
Invest New Drugs 2013 Feb;31(1):167-74. Epub 2012 Jul 5 doi: 10.1007/s10637-012-9840-8. PMID: 22763609
Hartmann JT, Mayer F, Schleicher J, Horger M, Huober J, Meisinger I, Pintoffl J, Käfer G, Kanz L, Grünwald V; German sarcoma group
Cancer 2007 Aug 15;110(4):861-6. doi: 10.1002/cncr.22846. PMID: 17599772

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