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Motor aphasia

MedGen UID:
1622
•Concept ID:
C0003550
•
Mental or Behavioral Dysfunction
Synonyms: Agrammatic Broca Aphasia; Agrammatic Broca Aphasias; Agrammatic Broca's Aphasia; Agrammatic Broca's Aphasias; Agrammatic Brocas Aphasia; Agrammatism; Aphasia Syndrome, Verbal; Aphasia Syndromes, Verbal; Aphasia, Agrammatic Broca; Aphasia, Agrammatic Broca's; Aphasia, Broca; Aphasia, Frontocortical; Aphasia, Motor; Aphasia, Nonfluent; Aphasias, Agrammatic Broca; Aphasias, Agrammatic Broca's; Aphasias, Broca; Aphasias, Frontocortical; Broca Aphasia; Broca Aphasia, Agrammatic; Broca Aphasias; Broca Aphasias, Agrammatic; Broca Dysphasia; Broca's Aphasia, Agrammatic; Broca's Aphasias, Agrammatic; Broca's Dysphasia; Dysphasia, Broca; Dysphasia, Broca's; Dysphasia, Brocas; Frontocortical Aphasia; Frontocortical Aphasias; Motor Aphasia; Nonfluent Aphasia; Syndrome, Verbal Aphasia; Syndromes, Verbal Aphasia; Verbal Aphasia Syndrome; Verbal Aphasia Syndromes
SNOMED CT: Broca dysphasia (229654003); Broca's dysphasia (229654003); Broca's aphasia (229654003); Frontocortical aphasia (328681008); Motor aphasia (328681008)

Definition

Aphasia characterized by impairment of expressive language due to injury to the motor association cortex in the frontal lobe. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMotor aphasia

Professional guidelines

PubMed

Current situation and trend of translational research of acupuncture-moxibustion in treatment of aphasia based on knowledge graph analysis.
Zhou BY, Zhu CF, Wei P, Zhao HY, Wang C, Cheng L, Liu L, Wu AQ
Zhen Ci Yan Jiu 2023 Nov 25;48(11):1175-1182. doi: 10.13702/j.1000-0607.20221182. PMID: 37984916
Aphasia predicts unfavorable outcome in mild ischemic stroke patients and prompts thrombolytic treatment.
Nesi M, Lucente G, Nencini P, Fancellu L, Inzitari D
J Stroke Cerebrovasc Dis 2014 Feb;23(2):204-8. Epub 2013 Jan 24 doi: 10.1016/j.jstrokecerebrovasdis.2012.11.018. PMID: 23352114
Treatment of adynamia in aphasia.
Raymer AM
Front Biosci 2003 Sep 1;8:s845-51. doi: 10.2741/1142. PMID: 12957880

Recent clinical studies

Etiology

Effect of Acupuncture vs Sham Acupuncture on Patients With Poststroke Motor Aphasia: A Randomized Clinical Trial.
Li B, Deng S, Zhuo B, Sang B, Chen J, Zhang M, Tian G, Zhang L, Du Y, Zheng P, Yue G, Meng Z
JAMA Netw Open 2024 Jan 2;7(1):e2352580. doi: 10.1001/jamanetworkopen.2023.52580. PMID: 38252438Free PMC Article
The efficacy and safety of acupuncture combined with language training for motor aphasia after stroke: study protocol for a multicenter randomized sham-controlled trial.
Deng S, Sang B, Li B, Lu H, Zhang L, Tian G, Hao T, Zhang Y, Shi L, Sun K, Ba T, Li F, Kong Y, Qin M, Zhang J, Zhao X, Meng Z
Trials 2022 Jun 30;23(1):540. doi: 10.1186/s13063-022-06280-2. PMID: 35773693Free PMC Article
Effects of mirror therapy on motor aphasia after acute cerebral infarction: A randomized controlled trial.
Chen Q, Shen W, Sun H, Shen D, Cai X, Ke J, Zhang L, Fang Q
NeuroRehabilitation 2021;49(1):103-117. doi: 10.3233/NRE-210125. PMID: 34180428
Early discrimination of cognitive motor dissociation from disorders of consciousness: pitfalls and clues.
Pincherle A, Rossi F, Jöhr J, Dunet V, Ryvlin P, Oddo M, Schiff N, Diserens K
J Neurol 2021 Jan;268(1):178-188. Epub 2020 Aug 4 doi: 10.1007/s00415-020-10125-w. PMID: 32754829Free PMC Article
Intermittent Transient Motor Aphasia Associated with Acute Lithium Toxicity: A Case Report and Brief Review.
Madhusoodanan S, Reddy V, Mohan S
Curr Drug Saf 2017;12(3):201-204. doi: 10.2174/1574886312666170601092949. PMID: 28571548

Diagnosis

Effect of Acupuncture vs Sham Acupuncture on Patients With Poststroke Motor Aphasia: A Randomized Clinical Trial.
Li B, Deng S, Zhuo B, Sang B, Chen J, Zhang M, Tian G, Zhang L, Du Y, Zheng P, Yue G, Meng Z
JAMA Netw Open 2024 Jan 2;7(1):e2352580. doi: 10.1001/jamanetworkopen.2023.52580. PMID: 38252438Free PMC Article
How Do Clinicians Judge Fluency in Aphasia?
Gordon JK, Clough S
J Speech Lang Hear Res 2022 Apr 4;65(4):1521-1542. Epub 2022 Mar 10 doi: 10.1044/2021_JSLHR-21-00484. PMID: 35271379
Alexia and agraphia in Spanish.
Gonzalez R, Rojas M, Ardila A
Int J Lang Commun Disord 2020 Nov;55(6):875-883. Epub 2020 Jul 31 doi: 10.1111/1460-6984.12566. PMID: 32735061
Frontal-opercular aphasia.
Taubner RW, Raymer AM, Heilman KM
Brain Lang 1999 Nov;70(2):240-61. doi: 10.1006/brln.1999.2157. PMID: 10550229
Clinical forms of aphasia.
Kertesz A
Acta Neurochir Suppl (Wien) 1993;56:52-8. doi: 10.1007/978-3-7091-9239-9_9. PMID: 8498201

Therapy

Effect of Acupuncture vs Sham Acupuncture on Patients With Poststroke Motor Aphasia: A Randomized Clinical Trial.
Li B, Deng S, Zhuo B, Sang B, Chen J, Zhang M, Tian G, Zhang L, Du Y, Zheng P, Yue G, Meng Z
JAMA Netw Open 2024 Jan 2;7(1):e2352580. doi: 10.1001/jamanetworkopen.2023.52580. PMID: 38252438Free PMC Article
The efficacy and safety of acupuncture combined with language training for motor aphasia after stroke: study protocol for a multicenter randomized sham-controlled trial.
Deng S, Sang B, Li B, Lu H, Zhang L, Tian G, Hao T, Zhang Y, Shi L, Sun K, Ba T, Li F, Kong Y, Qin M, Zhang J, Zhao X, Meng Z
Trials 2022 Jun 30;23(1):540. doi: 10.1186/s13063-022-06280-2. PMID: 35773693Free PMC Article
Effects of mirror therapy on motor aphasia after acute cerebral infarction: A randomized controlled trial.
Chen Q, Shen W, Sun H, Shen D, Cai X, Ke J, Zhang L, Fang Q
NeuroRehabilitation 2021;49(1):103-117. doi: 10.3233/NRE-210125. PMID: 34180428
Effect of electroacupuncture in patients with post-stroke motor aphasia : Neurolinguistic and neuroimaging characteristics.
Chang J, Zhang H, Tan Z, Xiao J, Li S, Gao Y
Wien Klin Wochenschr 2017 Feb;129(3-4):102-109. Epub 2016 Sep 2 doi: 10.1007/s00508-016-1070-1. PMID: 27590260
Effortful echolalia.
Hadano K, Nakamura H, Hamanaka T
Cortex 1998 Feb;34(1):67-82. doi: 10.1016/s0010-9452(08)70737-8. PMID: 9533994

Prognosis

Linguistic Characteristics of Mandarin-Speaking Huntington's Disease Patients.
Dong LL, Liu CY, Mao CH, Chu SS, Li J, Huang XY, Gao J
Chin Med Sci J 2020 Sep 30;35(3):207-214. doi: 10.24920/003669. PMID: 32972498
Malignant atrophic papulosis with motor aphasia and intestinal perforation: A case report and review of published works.
Hu P, Mao Z, Liu C, Hu X, Kang H, Zhou F
J Dermatol 2018 Jun;45(6):723-726. Epub 2018 Mar 8 doi: 10.1111/1346-8138.14280. PMID: 29516548Free PMC Article
Effectiveness and Limitations of Intraoperative Monitoring with Combined Motor and Somatosensory Evoked Potentials During Surgical Clipping of Unruptured Intracranial Aneurysms.
Choi HH, Ha EJ, Cho WS, Kang HS, Kim JE
World Neurosurg 2017 Dec;108:738-747. Epub 2017 Sep 23 doi: 10.1016/j.wneu.2017.09.096. PMID: 28951267
Fatal ruxolitinib-related JC virus meningitis.
Ballesta B, González H, Martín V, Ballesta JJ
J Neurovirol 2017 Oct;23(5):783-785. Epub 2017 Aug 8 doi: 10.1007/s13365-017-0558-4. PMID: 28791626
Aphasia in border-zone infarcts has a specific initial pattern and good long-term prognosis.
Flamand-Roze C, Cauquil-Michon C, Roze E, Souillard-Scemama R, Maintigneux L, Ducreux D, Adams D, Denier C
Eur J Neurol 2011 Dec;18(12):1397-401. Epub 2011 May 7 doi: 10.1111/j.1468-1331.2011.03422.x. PMID: 21554494

Clinical prediction guides

Effect of Acupuncture vs Sham Acupuncture on Patients With Poststroke Motor Aphasia: A Randomized Clinical Trial.
Li B, Deng S, Zhuo B, Sang B, Chen J, Zhang M, Tian G, Zhang L, Du Y, Zheng P, Yue G, Meng Z
JAMA Netw Open 2024 Jan 2;7(1):e2352580. doi: 10.1001/jamanetworkopen.2023.52580. PMID: 38252438Free PMC Article
Early discrimination of cognitive motor dissociation from disorders of consciousness: pitfalls and clues.
Pincherle A, Rossi F, Jöhr J, Dunet V, Ryvlin P, Oddo M, Schiff N, Diserens K
J Neurol 2021 Jan;268(1):178-188. Epub 2020 Aug 4 doi: 10.1007/s00415-020-10125-w. PMID: 32754829Free PMC Article
Alexia and agraphia in Spanish.
Gonzalez R, Rojas M, Ardila A
Int J Lang Commun Disord 2020 Nov;55(6):875-883. Epub 2020 Jul 31 doi: 10.1111/1460-6984.12566. PMID: 32735061
Intermittent Transient Motor Aphasia Associated with Acute Lithium Toxicity: A Case Report and Brief Review.
Madhusoodanan S, Reddy V, Mohan S
Curr Drug Saf 2017;12(3):201-204. doi: 10.2174/1574886312666170601092949. PMID: 28571548
Clinical study of acupuncture treatment on motor aphasia after stroke.
Wu Q, Hu X, Wen X, Li F, Fu W
Technol Health Care 2016 Apr 29;24 Suppl 2:S691-6. doi: 10.3233/THC-161197. PMID: 27177100

Recent systematic reviews

Head Acupuncture Plus Schuell's Language Rehabilitation for Post-Stroke Aphasia: A Systematic Review and Meta-Analysis of 32 Randomized Controlled Trials.
Fu QW, Liu M, Zhang LZ, Yang H, Zhang LQ, Yang SS, Xie Y, Wan XX, Tang Y, Zhang QX
Chin J Integr Med 2022 Aug;28(8):743-752. Epub 2022 Jul 30 doi: 10.1007/s11655-022-3722-5. PMID: 35907173
Repetitive transcranial magnetic stimulation for management of post-stroke impairments: An overview of systematic reviews.
Kim WJ, Rosselin C, Amatya B, Hafezi P, Khan F
J Rehabil Med 2020 Feb 7;52(2) doi: 10.2340/16501977-2637. PMID: 31922207

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