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Motor aphasia

MedGen UID:
1622
•Concept ID:
C0003550
•
Mental or Behavioral Dysfunction
Synonyms: Agrammatic Broca Aphasia; Agrammatic Broca Aphasias; Agrammatic Broca's Aphasia; Agrammatic Broca's Aphasias; Agrammatic Brocas Aphasia; Agrammatism; Aphasia Syndrome, Verbal; Aphasia Syndromes, Verbal; Aphasia, Agrammatic Broca; Aphasia, Agrammatic Broca's; Aphasia, Broca; Aphasia, Frontocortical; Aphasia, Motor; Aphasia, Nonfluent; Aphasias, Agrammatic Broca; Aphasias, Agrammatic Broca's; Aphasias, Broca; Aphasias, Frontocortical; Broca Aphasia; Broca Aphasia, Agrammatic; Broca Aphasias; Broca Aphasias, Agrammatic; Broca Dysphasia; Broca's Aphasia, Agrammatic; Broca's Aphasias, Agrammatic; Broca's Dysphasia; Dysphasia, Broca; Dysphasia, Broca's; Dysphasia, Brocas; Frontocortical Aphasia; Frontocortical Aphasias; Motor Aphasia; Nonfluent Aphasia; Syndrome, Verbal Aphasia; Syndromes, Verbal Aphasia; Verbal Aphasia Syndrome; Verbal Aphasia Syndromes
SNOMED CT: Broca dysphasia (229654003); Broca's dysphasia (229654003); Broca's aphasia (229654003); Frontocortical aphasia (328681008); Motor aphasia (328681008)

Definition

Aphasia characterized by impairment of expressive language due to injury to the motor association cortex in the frontal lobe. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMotor aphasia

Professional guidelines

PubMed

Repetitive transcranial magnetic stimulation for management of post-stroke impairments: An overview of systematic reviews.
Kim WJ, Rosselin C, Amatya B, Hafezi P, Khan F
J Rehabil Med 2020 Feb 7;52(2) doi: 10.2340/16501977-2637. PMID: 31922207
Aphasia predicts unfavorable outcome in mild ischemic stroke patients and prompts thrombolytic treatment.
Nesi M, Lucente G, Nencini P, Fancellu L, Inzitari D
J Stroke Cerebrovasc Dis 2014 Feb;23(2):204-8. Epub 2013 Jan 24 doi: 10.1016/j.jstrokecerebrovasdis.2012.11.018. PMID: 23352114
Treatment of adynamia in aphasia.
Raymer AM
Front Biosci 2003 Sep 1;8:s845-51. doi: 10.2741/1142. PMID: 12957880

Recent clinical studies

Etiology

The efficacy and safety of acupuncture combined with language training for motor aphasia after stroke: study protocol for a multicenter randomized sham-controlled trial.
Deng S, Sang B, Li B, Lu H, Zhang L, Tian G, Hao T, Zhang Y, Shi L, Sun K, Ba T, Li F, Kong Y, Qin M, Zhang J, Zhao X, Meng Z
Trials 2022 Jun 30;23(1):540. doi: 10.1186/s13063-022-06280-2. PMID: 35773693Free PMC Article
Effects of mirror therapy on motor aphasia after acute cerebral infarction: A randomized controlled trial.
Chen Q, Shen W, Sun H, Shen D, Cai X, Ke J, Zhang L, Fang Q
NeuroRehabilitation 2021;49(1):103-117. doi: 10.3233/NRE-210125. PMID: 34180428
Early discrimination of cognitive motor dissociation from disorders of consciousness: pitfalls and clues.
Pincherle A, Rossi F, Jöhr J, Dunet V, Ryvlin P, Oddo M, Schiff N, Diserens K
J Neurol 2021 Jan;268(1):178-188. Epub 2020 Aug 4 doi: 10.1007/s00415-020-10125-w. PMID: 32754829Free PMC Article
Intermittent Transient Motor Aphasia Associated with Acute Lithium Toxicity: A Case Report and Brief Review.
Madhusoodanan S, Reddy V, Mohan S
Curr Drug Saf 2017;12(3):201-204. doi: 10.2174/1574886312666170601092949. PMID: 28571548
Clinical study of acupuncture treatment on motor aphasia after stroke.
Wu Q, Hu X, Wen X, Li F, Fu W
Technol Health Care 2016 Apr 29;24 Suppl 2:S691-6. doi: 10.3233/THC-161197. PMID: 27177100

Diagnosis

How Do Clinicians Judge Fluency in Aphasia?
Gordon JK, Clough S
J Speech Lang Hear Res 2022 Apr 4;65(4):1521-1542. Epub 2022 Mar 10 doi: 10.1044/2021_JSLHR-21-00484. PMID: 35271379
Alexia and agraphia in Spanish.
Gonzalez R, Rojas M, Ardila A
Int J Lang Commun Disord 2020 Nov;55(6):875-883. Epub 2020 Jul 31 doi: 10.1111/1460-6984.12566. PMID: 32735061
Intermittent Transient Motor Aphasia Associated with Acute Lithium Toxicity: A Case Report and Brief Review.
Madhusoodanan S, Reddy V, Mohan S
Curr Drug Saf 2017;12(3):201-204. doi: 10.2174/1574886312666170601092949. PMID: 28571548
Frontal-opercular aphasia.
Taubner RW, Raymer AM, Heilman KM
Brain Lang 1999 Nov;70(2):240-61. doi: 10.1006/brln.1999.2157. PMID: 10550229
Clinical forms of aphasia.
Kertesz A
Acta Neurochir Suppl (Wien) 1993;56:52-8. doi: 10.1007/978-3-7091-9239-9_9. PMID: 8498201

Therapy

Effects of mirror therapy on motor aphasia after acute cerebral infarction: A randomized controlled trial.
Chen Q, Shen W, Sun H, Shen D, Cai X, Ke J, Zhang L, Fang Q
NeuroRehabilitation 2021;49(1):103-117. doi: 10.3233/NRE-210125. PMID: 34180428
Intermittent Transient Motor Aphasia Associated with Acute Lithium Toxicity: A Case Report and Brief Review.
Madhusoodanan S, Reddy V, Mohan S
Curr Drug Saf 2017;12(3):201-204. doi: 10.2174/1574886312666170601092949. PMID: 28571548
Clinical study of acupuncture treatment on motor aphasia after stroke.
Wu Q, Hu X, Wen X, Li F, Fu W
Technol Health Care 2016 Apr 29;24 Suppl 2:S691-6. doi: 10.3233/THC-161197. PMID: 27177100
Effortful echolalia.
Hadano K, Nakamura H, Hamanaka T
Cortex 1998 Feb;34(1):67-82. doi: 10.1016/s0010-9452(08)70737-8. PMID: 9533994
Pharmacotherapy for aphasia.
Albert ML, Bachman DL, Morgan A, Helm-Estabrooks N
Neurology 1988 Jun;38(6):877-9. doi: 10.1212/wnl.38.6.877. PMID: 3368068

Prognosis

Linguistic Characteristics of Mandarin-Speaking Huntington's Disease Patients.
Dong LL, Liu CY, Mao CH, Chu SS, Li J, Huang XY, Gao J
Chin Med Sci J 2020 Sep 30;35(3):207-214. doi: 10.24920/003669. PMID: 32972498
Incidence and Symptomatology of Vascular Crossed Aphasia in Bengali.
Lahiri D, Dubey S, Sawale VM, Das G, Ray BK, Chatterjee S, Ardila A
Cogn Behav Neurol 2019 Dec;32(4):256-267. doi: 10.1097/WNN.0000000000000210. PMID: 31800486
Malignant atrophic papulosis with motor aphasia and intestinal perforation: A case report and review of published works.
Hu P, Mao Z, Liu C, Hu X, Kang H, Zhou F
J Dermatol 2018 Jun;45(6):723-726. Epub 2018 Mar 8 doi: 10.1111/1346-8138.14280. PMID: 29516548Free PMC Article
Effectiveness and Limitations of Intraoperative Monitoring with Combined Motor and Somatosensory Evoked Potentials During Surgical Clipping of Unruptured Intracranial Aneurysms.
Choi HH, Ha EJ, Cho WS, Kang HS, Kim JE
World Neurosurg 2017 Dec;108:738-747. Epub 2017 Sep 23 doi: 10.1016/j.wneu.2017.09.096. PMID: 28951267
Strokes in the subinsular territory: clinical, topographical, and etiological patterns.
Kumral E, Ozdemirkiran T, Alper Y
Neurology 2004 Dec 28;63(12):2429-32. doi: 10.1212/01.wnl.0000147261.22630.f8. PMID: 15623721

Clinical prediction guides

Effects of mirror therapy on motor aphasia after acute cerebral infarction: A randomized controlled trial.
Chen Q, Shen W, Sun H, Shen D, Cai X, Ke J, Zhang L, Fang Q
NeuroRehabilitation 2021;49(1):103-117. doi: 10.3233/NRE-210125. PMID: 34180428
Alexia and agraphia in Spanish.
Gonzalez R, Rojas M, Ardila A
Int J Lang Commun Disord 2020 Nov;55(6):875-883. Epub 2020 Jul 31 doi: 10.1111/1460-6984.12566. PMID: 32735061
Intermittent Transient Motor Aphasia Associated with Acute Lithium Toxicity: A Case Report and Brief Review.
Madhusoodanan S, Reddy V, Mohan S
Curr Drug Saf 2017;12(3):201-204. doi: 10.2174/1574886312666170601092949. PMID: 28571548
Clinical study of acupuncture treatment on motor aphasia after stroke.
Wu Q, Hu X, Wen X, Li F, Fu W
Technol Health Care 2016 Apr 29;24 Suppl 2:S691-6. doi: 10.3233/THC-161197. PMID: 27177100
Neuropsychological syndromes in multiple sclerosis.
Gil Moreno MJ, Cerezo García M, Marasescu R, Pinel González A, López Álvarez L, Aladro Benito Y
Psicothema 2013;25(4):452-60. doi: 10.7334/psicothema2012.308. PMID: 24124777

Recent systematic reviews

Head Acupuncture Plus Schuell's Language Rehabilitation for Post-Stroke Aphasia: A Systematic Review and Meta-Analysis of 32 Randomized Controlled Trials.
Fu QW, Liu M, Zhang LZ, Yang H, Zhang LQ, Yang SS, Xie Y, Wan XX, Tang Y, Zhang QX
Chin J Integr Med 2022 Aug;28(8):743-752. Epub 2022 Jul 30 doi: 10.1007/s11655-022-3722-5. PMID: 35907173
Repetitive transcranial magnetic stimulation for management of post-stroke impairments: An overview of systematic reviews.
Kim WJ, Rosselin C, Amatya B, Hafezi P, Khan F
J Rehabil Med 2020 Feb 7;52(2) doi: 10.2340/16501977-2637. PMID: 31922207

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