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TP63 Gene Rearrangement

MedGen UID:
1622763
•Concept ID:
C4528407
•
Cell or Molecular Dysfunction
Synonyms: AIS Gene Rearrangement; B(p51A) Gene Rearrangement; B(p51B) Gene Rearrangement; EEC3 Gene Rearrangement; KET Gene Rearrangement; LMS Gene Rearrangement; NBP Gene Rearrangement; OFC8 Gene Rearrangement; p40 Gene Rearrangement; p51 Gene Rearrangement; p53CP Gene Rearrangement; P63 Gene Rearrangement; p63 Gene Rearrangement; P73H Gene Rearrangement; p73H Gene Rearrangement; P73L Gene Rearrangement; p73L Gene Rearrangement; RHS Gene Rearrangement; SHFM4 Gene Rearrangement; TP53CP Gene Rearrangement; TP53L Gene Rearrangement; TP73L Gene Rearrangement; Tumor Protein p53-Competing Protein Gene Rearrangement; Tumor Protein p53-Like Gene Rearrangement; Tumor Protein p63 Gene Rearrangement; Tumor Protein p73-Like Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the TP63 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTP63 Gene Rearrangement

Professional guidelines

PubMed

Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma.
Zhang X, Zegar T, Lucas A, Morrison-Smith C, Knox T, French CA, Knapp S, Müller S, Siveke JT
Oncogene 2020 Jun;39(24):4770-4779. Epub 2020 May 4 doi: 10.1038/s41388-020-1301-9. PMID: 32366905Free PMC Article

Recent clinical studies

Therapy

Genetics of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL).
Oishi N, Miranda RN, Feldman AL
Aesthet Surg J 2019 Jan 31;39(Suppl_1):S14-S20. doi: 10.1093/asj/sjy311. PMID: 30715169

Prognosis

Prognostic factors for primary cutaneous anaplastic large-cell lymphoma: a multicentre retrospective study from Japan.
Miyagaki T, Inoue N, Kamijo H, Boki H, Takahashi-Shishido N, Suga H, Shimauchi T, Kiyohara E, Hirai Y, Yonekura K, Takeuchi K, Sugaya M
Br J Dermatol 2023 Oct 25;189(5):612-620. doi: 10.1093/bjd/ljad266. PMID: 37539944
Immunohistochemical Approach to Genetic Subtyping of Anaplastic Large Cell Lymphoma.
Feldman AL, Oishi N, Ketterling RP, Ansell SM, Shi M, Dasari S
Am J Surg Pathol 2022 Nov 1;46(11):1490-1499. Epub 2022 Aug 8 doi: 10.1097/PAS.0000000000001941. PMID: 35941721Free PMC Article
ALCL by any other name: the many facets of anaplastic large cell lymphoma.
Irshaid L, Xu ML
Pathology 2020 Jan;52(1):100-110. Epub 2019 Nov 6 doi: 10.1016/j.pathol.2019.09.007. PMID: 31706671
Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping.
Wang X, Boddicker RL, Dasari S, Sidhu JS, Kadin ME, Macon WR, Ansell SM, Ketterling RP, Rech KL, Feldman AL
Hum Pathol 2017 Jun;64:19-27. Epub 2017 Jan 30 doi: 10.1016/j.humpath.2017.01.003. PMID: 28153507Free PMC Article
Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma.
Roden AC, García JJ, Wehrs RN, Colby TV, Khoor A, Leslie KO, Chen L
Mod Pathol 2014 Nov;27(11):1479-88. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.72. PMID: 24743219

Clinical prediction guides

Immunohistochemical Approach to Genetic Subtyping of Anaplastic Large Cell Lymphoma.
Feldman AL, Oishi N, Ketterling RP, Ansell SM, Shi M, Dasari S
Am J Surg Pathol 2022 Nov 1;46(11):1490-1499. Epub 2022 Aug 8 doi: 10.1097/PAS.0000000000001941. PMID: 35941721Free PMC Article
Primary cutaneous anaplastic large-cell lymphoma with DUSP22-IRF4 rearrangement following insect bites.
Zhang Y, Chen M, Yu Y, Liu X, Liu W, Jiang L, Zhang W
J Cutan Pathol 2022 Feb;49(2):187-190. Epub 2021 Oct 20 doi: 10.1111/cup.14147. PMID: 34622970Free PMC Article
Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping.
Wang X, Boddicker RL, Dasari S, Sidhu JS, Kadin ME, Macon WR, Ansell SM, Ketterling RP, Rech KL, Feldman AL
Hum Pathol 2017 Jun;64:19-27. Epub 2017 Jan 30 doi: 10.1016/j.humpath.2017.01.003. PMID: 28153507Free PMC Article
Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma.
Roden AC, García JJ, Wehrs RN, Colby TV, Khoor A, Leslie KO, Chen L
Mod Pathol 2014 Nov;27(11):1479-88. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.72. PMID: 24743219
ALK/EML4 fusion gene may be found in pure squamous carcinoma of the lung.
Caliò A, Nottegar A, Gilioli E, Bria E, Pilotto S, Peretti U, Kinspergher S, Simionato F, Pedron S, Knuutila S, Tortora G, Eccher A, Santo A, Tondulli L, Inghirami G, Tabbò F, Martignoni G, Chilosi M, Scarpa A, Brunelli M
J Thorac Oncol 2014 May;9(5):729-32. doi: 10.1097/JTO.0000000000000109. PMID: 24722159

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