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TP63 Gene Rearrangement

MedGen UID:
1622763
•Concept ID:
C4528407
•
Cell or Molecular Dysfunction
Synonyms: AIS Gene Rearrangement; B(p51A) Gene Rearrangement; B(p51B) Gene Rearrangement; EEC3 Gene Rearrangement; KET Gene Rearrangement; LMS Gene Rearrangement; NBP Gene Rearrangement; OFC8 Gene Rearrangement; p40 Gene Rearrangement; p51 Gene Rearrangement; p53CP Gene Rearrangement; P63 Gene Rearrangement; p63 Gene Rearrangement; P73H Gene Rearrangement; p73H Gene Rearrangement; P73L Gene Rearrangement; p73L Gene Rearrangement; RHS Gene Rearrangement; SHFM4 Gene Rearrangement; TP53CP Gene Rearrangement; TP53L Gene Rearrangement; TP73L Gene Rearrangement; Tumor Protein p53-Competing Protein Gene Rearrangement; Tumor Protein p53-Like Gene Rearrangement; Tumor Protein p63 Gene Rearrangement; Tumor Protein p73-Like Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the TP63 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTP63 Gene Rearrangement

Professional guidelines

PubMed

Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma.
Zhang X, Zegar T, Lucas A, Morrison-Smith C, Knox T, French CA, Knapp S, Müller S, Siveke JT
Oncogene 2020 Jun;39(24):4770-4779. Epub 2020 May 4 doi: 10.1038/s41388-020-1301-9. PMID: 32366905Free PMC Article

Recent clinical studies

Etiology

Prognostic factors for primary cutaneous anaplastic large-cell lymphoma: a multicentre retrospective study from Japan.
Miyagaki T, Inoue N, Kamijo H, Boki H, Takahashi-Shishido N, Suga H, Shimauchi T, Kiyohara E, Hirai Y, Yonekura K, Takeuchi K, Sugaya M
Br J Dermatol 2023 Oct 25;189(5):612-620. doi: 10.1093/bjd/ljad266. PMID: 37539944
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
ALCL by any other name: the many facets of anaplastic large cell lymphoma.
Irshaid L, Xu ML
Pathology 2020 Jan;52(1):100-110. Epub 2019 Nov 6 doi: 10.1016/j.pathol.2019.09.007. PMID: 31706671
Fluorescence in-situ hybridisation for TP63 rearrangements in T cell lymphomas: single-site experience of 470 patients and implications for clinical testing.
Peterson JF, Pearce KE, Meyer RG, Greipp PT, Knudson RA, Baughn LB, Ketterling RP, Feldman AL
Histopathology 2020 Feb;76(3):481-485. Epub 2020 Jan 17 doi: 10.1111/his.14005. PMID: 31557339Free PMC Article
Chromosomal rearrangements and copy number abnormalities of TP63 correlate with p63 protein expression in lung adenocarcinoma.
Aubry MC, Roden A, Murphy SJ, Vasmatzis G, Johnson SH, Harris FR, Halling G, Knudson RA, Ketterling RP, Feldman AL
Mod Pathol 2015 Mar;28(3):359-66. Epub 2014 Sep 5 doi: 10.1038/modpathol.2014.118. PMID: 25189640

Diagnosis

Prognostic factors for primary cutaneous anaplastic large-cell lymphoma: a multicentre retrospective study from Japan.
Miyagaki T, Inoue N, Kamijo H, Boki H, Takahashi-Shishido N, Suga H, Shimauchi T, Kiyohara E, Hirai Y, Yonekura K, Takeuchi K, Sugaya M
Br J Dermatol 2023 Oct 25;189(5):612-620. doi: 10.1093/bjd/ljad266. PMID: 37539944
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
ALCL by any other name: the many facets of anaplastic large cell lymphoma.
Irshaid L, Xu ML
Pathology 2020 Jan;52(1):100-110. Epub 2019 Nov 6 doi: 10.1016/j.pathol.2019.09.007. PMID: 31706671
Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping.
Wang X, Boddicker RL, Dasari S, Sidhu JS, Kadin ME, Macon WR, Ansell SM, Ketterling RP, Rech KL, Feldman AL
Hum Pathol 2017 Jun;64:19-27. Epub 2017 Jan 30 doi: 10.1016/j.humpath.2017.01.003. PMID: 28153507Free PMC Article
Chromosomal rearrangements and copy number abnormalities of TP63 correlate with p63 protein expression in lung adenocarcinoma.
Aubry MC, Roden A, Murphy SJ, Vasmatzis G, Johnson SH, Harris FR, Halling G, Knudson RA, Ketterling RP, Feldman AL
Mod Pathol 2015 Mar;28(3):359-66. Epub 2014 Sep 5 doi: 10.1038/modpathol.2014.118. PMID: 25189640

Therapy

"Double-hit" of DUSP22 and TP63 rearrangements in anaplastic large cell lymphoma, ALK-negative.
Karube K, Feldman AL
Blood 2020 Feb 27;135(9):700. doi: 10.1182/blood.2019004164. PMID: 32106310
Genetics of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL).
Oishi N, Miranda RN, Feldman AL
Aesthet Surg J 2019 Jan 31;39(Suppl_1):S14-S20. doi: 10.1093/asj/sjy311. PMID: 30715169

Prognosis

Prognostic factors for primary cutaneous anaplastic large-cell lymphoma: a multicentre retrospective study from Japan.
Miyagaki T, Inoue N, Kamijo H, Boki H, Takahashi-Shishido N, Suga H, Shimauchi T, Kiyohara E, Hirai Y, Yonekura K, Takeuchi K, Sugaya M
Br J Dermatol 2023 Oct 25;189(5):612-620. doi: 10.1093/bjd/ljad266. PMID: 37539944
Immunohistochemical Approach to Genetic Subtyping of Anaplastic Large Cell Lymphoma.
Feldman AL, Oishi N, Ketterling RP, Ansell SM, Shi M, Dasari S
Am J Surg Pathol 2022 Nov 1;46(11):1490-1499. Epub 2022 Aug 8 doi: 10.1097/PAS.0000000000001941. PMID: 35941721Free PMC Article
ALK-Negative Anaplastic Large Cell Lymphoma (ALCL): Prognostic Implications of Molecular Subtyping and JAK-STAT Pathway.
Parkhi M, Bal A, Das A, Kashyap D, Bhardwaj S, Prakash G, Malhotra P
Appl Immunohistochem Mol Morphol 2021 Oct 1;29(9):648-656. doi: 10.1097/PAI.0000000000000936. PMID: 33901030
ALCL by any other name: the many facets of anaplastic large cell lymphoma.
Irshaid L, Xu ML
Pathology 2020 Jan;52(1):100-110. Epub 2019 Nov 6 doi: 10.1016/j.pathol.2019.09.007. PMID: 31706671
Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping.
Wang X, Boddicker RL, Dasari S, Sidhu JS, Kadin ME, Macon WR, Ansell SM, Ketterling RP, Rech KL, Feldman AL
Hum Pathol 2017 Jun;64:19-27. Epub 2017 Jan 30 doi: 10.1016/j.humpath.2017.01.003. PMID: 28153507Free PMC Article

Clinical prediction guides

Immunohistochemical Approach to Genetic Subtyping of Anaplastic Large Cell Lymphoma.
Feldman AL, Oishi N, Ketterling RP, Ansell SM, Shi M, Dasari S
Am J Surg Pathol 2022 Nov 1;46(11):1490-1499. Epub 2022 Aug 8 doi: 10.1097/PAS.0000000000001941. PMID: 35941721Free PMC Article
Primary cutaneous anaplastic large-cell lymphoma with DUSP22-IRF4 rearrangement following insect bites.
Zhang Y, Chen M, Yu Y, Liu X, Liu W, Jiang L, Zhang W
J Cutan Pathol 2022 Feb;49(2):187-190. Epub 2021 Oct 20 doi: 10.1111/cup.14147. PMID: 34622970Free PMC Article
Genetic Subtypes of Systemic Anaplastic Large Cell Lymphoma Show Distinct Differences in PD-L1 Expression and Regulatory and Cytotoxic T Cells in the Tumor Microenvironment.
Ferreira CR, Manohar V, Zhao S, Bangs CD, Cherry A, Azevedo RS, Lage LAPC, Pereira J, Zerbini MCN, Gratzinger D, Natkunam Y
Appl Immunohistochem Mol Morphol 2020 Jan;28(1):10-16. doi: 10.1097/PAI.0000000000000798. PMID: 31809310
Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping.
Wang X, Boddicker RL, Dasari S, Sidhu JS, Kadin ME, Macon WR, Ansell SM, Ketterling RP, Rech KL, Feldman AL
Hum Pathol 2017 Jun;64:19-27. Epub 2017 Jan 30 doi: 10.1016/j.humpath.2017.01.003. PMID: 28153507Free PMC Article
Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma.
Roden AC, García JJ, Wehrs RN, Colby TV, Khoor A, Leslie KO, Chen L
Mod Pathol 2014 Nov;27(11):1479-88. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.72. PMID: 24743219

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