U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Small superior frontal cortex

MedGen UID:
1622765
•Concept ID:
C4531133
•
Anatomical Abnormality
HPO: HP:0031421

Definition

Reduced size of the superior frontal portion of the cerebral cortex. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall superior frontal cortex

Professional guidelines

PubMed

Structural equation modeling of treatment-related changes in neural connectivity for youth with PTSD.
Garrett AS, Zhang W, Price LR, Cross J, Gomez-Giuliani N, van Hoof MJ, Carrion V, Cohen JA
J Affect Disord 2023 Aug 1;334:50-59. Epub 2023 Apr 30 doi: 10.1016/j.jad.2023.04.066. PMID: 37127117
Increases in orbitofrontal cortex thickness following antidepressant treatment are associated with changes in resting state autonomic function in adolescents with major depression - Preliminary findings from a pilot study.
Koenig J, Westlund Schreiner M, Klimes-Dougan B, Ubani B, Mueller BA, Lim KO, Kaess M, Cullen KR
Psychiatry Res Neuroimaging 2018 Nov 30;281:35-42. Epub 2018 Aug 24 doi: 10.1016/j.pscychresns.2018.08.013. PMID: 30216863Free PMC Article
Resection of primary motor cortex tumors: feasibility and surgical outcomes.
Magill ST, Han SJ, Li J, Berger MS
J Neurosurg 2018 Oct;129(4):961-972. Epub 2017 Dec 8 doi: 10.3171/2017.5.JNS163045. PMID: 29219753

Recent clinical studies

Etiology

Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study.
Si S, Bi A, Yu Z, See C, Kelly S, Ambrogi S, Arango C, Baeza I, Banaj N, Berk M, Castro-Fornieles J, Crespo-Facorro B, Crouse JJ, Díaz-Caneja CM, Fett AK, Fortea A, Frangou S, Goldstein BI, Hickie IB, Janssen J, Kennedy KG, Krabbendam L, Kyriakopoulos M, MacIntosh BJ, Morgado P, Nerland S, Pascual-Diaz S, Picó-Pérez M, Piras F, Rund BR, de la Serna E, Spalletta G, Sugranyes G, Suo C, Tordesillas-Gutiérrez D, Vecchio D, Radua J, McGuire P, Thomopoulos SI, Jahanshad N, Thompson PM, Barth C, Agartz I, James A, Kempton MJ
Mol Psychiatry 2024 Feb;29(2):496-504. Epub 2024 Jan 10 doi: 10.1038/s41380-023-02343-1. PMID: 38195979Free PMC Article
Altered brain structural and functional connectivity in cannabis users.
Soleimani N, Kazemi K, Helfroush MS, Aarabi A
Sci Rep 2023 Apr 10;13(1):5847. doi: 10.1038/s41598-023-32521-8. PMID: 37037859Free PMC Article
Gray matter alterations in adolescent major depressive disorder and adolescent bipolar disorder.
Long X, Li L, Wang X, Cao Y, Wu B, Roberts N, Gong Q, Kemp GJ, Jia Z
J Affect Disord 2023 Mar 15;325:550-563. Epub 2023 Jan 17 doi: 10.1016/j.jad.2023.01.049. PMID: 36669567
Single-case disconnectome lesion-symptom mapping: Identifying two subtypes of limb apraxia.
Metzgar R, Stoll H, Grafton ST, Buxbaum LJ, Garcea FE
Neuropsychologia 2022 Jun 6;170:108210. Epub 2022 Mar 11 doi: 10.1016/j.neuropsychologia.2022.108210. PMID: 35283160Free PMC Article
MRI anatomy of schizophrenia.
McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Fischer IA, Shenton ME
Biol Psychiatry 1999 May 1;45(9):1099-119. doi: 10.1016/s0006-3223(99)00018-9. PMID: 10331102Free PMC Article

Diagnosis

Gray matter alterations in adolescent major depressive disorder and adolescent bipolar disorder.
Long X, Li L, Wang X, Cao Y, Wu B, Roberts N, Gong Q, Kemp GJ, Jia Z
J Affect Disord 2023 Mar 15;325:550-563. Epub 2023 Jan 17 doi: 10.1016/j.jad.2023.01.049. PMID: 36669567
Graph lesion-deficit mapping of fluid intelligence.
Cipolotti L, Ruffle JK, Mole J, Xu T, Hyare H, Shallice T, Chan E, Nachev P
Brain 2023 Jan 5;146(1):167-181. doi: 10.1093/brain/awac304. PMID: 36574957Free PMC Article
Correlation between cognitive deficits and dorsolateral prefrontal cortex functional connectivity in first-episode depression.
Zhang X, Zhang R, Lv L, Qi X, Shi J, Xie S
J Affect Disord 2022 Sep 1;312:152-158. Epub 2022 Jun 22 doi: 10.1016/j.jad.2022.06.024. PMID: 35752217
Apathy: a neurocircuitry model based on frontotemporal dementia.
Ducharme S, Price BH, Dickerson BC
J Neurol Neurosurg Psychiatry 2018 Apr;89(4):389-396. Epub 2017 Oct 24 doi: 10.1136/jnnp-2017-316277. PMID: 29066518Free PMC Article
Neuroimaging of reading intervention: a systematic review and activation likelihood estimate meta-analysis.
Barquero LA, Davis N, Cutting LE
PLoS One 2014;9(1):e83668. Epub 2014 Jan 10 doi: 10.1371/journal.pone.0083668. PMID: 24427278Free PMC Article

Therapy

Disrupted brain gray matter connectome in social anxiety disorder: a novel individualized structural covariance network analysis.
Zhang X, Lai H, Li Q, Yang X, Pan N, He M, Kemp GJ, Wang S, Gong Q
Cereb Cortex 2023 Aug 8;33(16):9627-9638. doi: 10.1093/cercor/bhad231. PMID: 37381581
Increased low-frequency brain responses to music after psilocybin therapy for depression.
Wall MB, Lam C, Ertl N, Kaelen M, Roseman L, Nutt DJ, Carhart-Harris RL
J Affect Disord 2023 Jul 15;333:321-330. Epub 2023 Apr 23 doi: 10.1016/j.jad.2023.04.081. PMID: 37094657
Neurotherapeutics for Attention Deficit/Hyperactivity Disorder (ADHD): A Review.
Rubia K, Westwood S, Aggensteiner PM, Brandeis D
Cells 2021 Aug 21;10(8) doi: 10.3390/cells10082156. PMID: 34440925Free PMC Article
Neuromodulation for chronic pain.
Knotkova H, Hamani C, Sivanesan E, Le Beuffe MFE, Moon JY, Cohen SP, Huntoon MA
Lancet 2021 May 29;397(10289):2111-2124. doi: 10.1016/S0140-6736(21)00794-7. PMID: 34062145
Gray-matter structure in long-term abstinent methamphetamine users.
Nie L, Zhao Z, Wen X, Luo W, Ju T, Ren A, Wu B, Li J
BMC Psychiatry 2020 Apr 10;20(1):158. doi: 10.1186/s12888-020-02567-3. PMID: 32272912Free PMC Article

Prognosis

Connectivity by the Frontal Aslant Tract (FAT) Explains Local Functional Specialization of the Superior and Inferior Frontal Gyri in Humans When Choosing Predictive over Reactive Strategies: A Tractography-Guided TMS Study.
Tagliaferri M, Giampiccolo D, Parmigiani S, Avesani P, Cattaneo L
J Neurosci 2023 Oct 11;43(41):6920-6929. Epub 2023 Sep 1 doi: 10.1523/JNEUROSCI.0406-23.2023. PMID: 37657931Free PMC Article
Spatial-temporal patterns of brain disconnectome in Alzheimer's disease.
Liang L, Zhou P, Ye C, Yang Q, Ma T
Hum Brain Mapp 2023 Aug 1;44(11):4272-4286. Epub 2023 May 25 doi: 10.1002/hbm.26344. PMID: 37227021Free PMC Article
Alcohol and cannabis co-use and longitudinal gray matter volumetric changes in early and late adolescence.
Luo X, Yang JJ, Buu A, Trucco EM, Li CR
Addict Biol 2022 Sep;27(5):e13208. doi: 10.1111/adb.13208. PMID: 36001427Free PMC Article
Speech-Driven Spectrotemporal Receptive Fields Beyond the Auditory Cortex.
Venezia JH, Richards VM, Hickok G
Hear Res 2021 Sep 1;408:108307. Epub 2021 Jul 10 doi: 10.1016/j.heares.2021.108307. PMID: 34311190Free PMC Article
Neuroimaging predictors of creativity in healthy adults.
Sunavsky A, Poppenk J
Neuroimage 2020 Feb 1;206:116292. Epub 2019 Oct 22 doi: 10.1016/j.neuroimage.2019.116292. PMID: 31654758

Clinical prediction guides

Altered brain structural and functional connectivity in cannabis users.
Soleimani N, Kazemi K, Helfroush MS, Aarabi A
Sci Rep 2023 Apr 10;13(1):5847. doi: 10.1038/s41598-023-32521-8. PMID: 37037859Free PMC Article
Gray matter alterations in adolescent major depressive disorder and adolescent bipolar disorder.
Long X, Li L, Wang X, Cao Y, Wu B, Roberts N, Gong Q, Kemp GJ, Jia Z
J Affect Disord 2023 Mar 15;325:550-563. Epub 2023 Jan 17 doi: 10.1016/j.jad.2023.01.049. PMID: 36669567
Alcohol and cannabis co-use and longitudinal gray matter volumetric changes in early and late adolescence.
Luo X, Yang JJ, Buu A, Trucco EM, Li CR
Addict Biol 2022 Sep;27(5):e13208. doi: 10.1111/adb.13208. PMID: 36001427Free PMC Article
Correlation between cognitive deficits and dorsolateral prefrontal cortex functional connectivity in first-episode depression.
Zhang X, Zhang R, Lv L, Qi X, Shi J, Xie S
J Affect Disord 2022 Sep 1;312:152-158. Epub 2022 Jun 22 doi: 10.1016/j.jad.2022.06.024. PMID: 35752217
Apathy: a neurocircuitry model based on frontotemporal dementia.
Ducharme S, Price BH, Dickerson BC
J Neurol Neurosurg Psychiatry 2018 Apr;89(4):389-396. Epub 2017 Oct 24 doi: 10.1136/jnnp-2017-316277. PMID: 29066518Free PMC Article

Recent systematic reviews

Meta-analysis of cortical thickness reduction in adult schizophrenia.
Sun S, Xiao S, Guo Z, Gong J, Tang G, Huang L, Wang Y
J Psychiatry Neurosci 2023 Nov-Dec;48(6):E461-E470. Epub 2023 Dec 20 doi: 10.1503/jpn.230081. PMID: 38123240Free PMC Article
Neural mapping of guilt: a quantitative meta-analysis of functional imaging studies.
Gifuni AJ, Kendal A, Jollant F
Brain Imaging Behav 2017 Aug;11(4):1164-1178. doi: 10.1007/s11682-016-9606-6. PMID: 27704409
Repetitive transcranial magnetic stimulation (rTMS) for panic disorder in adults.
Li H, Wang J, Li C, Xiao Z
Cochrane Database Syst Rev 2014 Sep 17;2014(9):CD009083. doi: 10.1002/14651858.CD009083.pub2. PMID: 25230088Free PMC Article
Neuroimaging of reading intervention: a systematic review and activation likelihood estimate meta-analysis.
Barquero LA, Davis N, Cutting LE
PLoS One 2014;9(1):e83668. Epub 2014 Jan 10 doi: 10.1371/journal.pone.0083668. PMID: 24427278Free PMC Article
Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review.
Schacht JP, Anton RF, Myrick H
Addict Biol 2013 Jan;18(1):121-33. Epub 2012 May 10 doi: 10.1111/j.1369-1600.2012.00464.x. PMID: 22574861Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...