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Multilobulated spleen

MedGen UID:
Concept ID:
Congenital Abnormality
Synonym: Multi-lobulated spleen
HPO: HP:0020186


The fetal spleen is lobulated, and these lobules normally disappear before the birth. Lobulation of the spleen may persist into adult life and be typically seen along the medial part of the spleen. A persisting lobule results in a variation in shape of the spleen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultilobulated spleen

Conditions with this feature

Matthew-Wood syndrome
MedGen UID:
Concept ID:
Disease or Syndrome
Syndromic microphthalmia-9 (MCOPS9), also referred to as pulmonary hypoplasia-diaphragmatic hernia-anophthalmia-cardiac defect, is characterized by bilateral clinical anophthalmia, pulmonary hypoplasia/aplasia, cardiac malformations, and diaphragmatic defects. The phenotype is variable, ranging from isolated clinical anophthalmia or microphthalmia to complex presentations involving the cardiac, pulmonary, diaphragmatic, and renal systems. At its most severe, infants are born without pulmonary structures and die soon after birth (Marcadier et al., 2015).

Recent clinical studies


Yang SO, Lee DS, Lee KS, Kim MJ, Choi HS, Jun YH, Park YK
J Korean Med Sci 1988 Mar;3(1):31-4. doi: 10.3346/jkms.1988.3.1.31. PMID: 3267351Free PMC Article

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