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Abnormal aortic valve cusp morphology

MedGen UID:
1623463
Concept ID:
C4531034
Anatomical Abnormality
HPO: HP:0031567

Definition

Any structural anomaly of the aortic valve leaflets. [from HPO]

Professional guidelines

PubMed

Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ
J Thorac Cardiovasc Surg 2021 Sep;162(3):e383-e414. Epub 2021 Jul 22 doi: 10.1016/j.jtcvs.2021.06.019. PMID: 34304896
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, Khoury GE, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ
J Thorac Cardiovasc Surg 2021 Sep;162(3):781-797. Epub 2021 Jul 22 doi: 10.1016/j.jtcvs.2021.05.008. PMID: 34304894
Dallard J, Labrosse MR, Sohmer B, Beller CJ, Boodhwani M
Int J Numer Method Biomed Eng 2018 Oct;34(10):e3117. Epub 2018 Jul 23 doi: 10.1002/cnm.3117. PMID: 29905015

Recent clinical studies

Etiology

Yanagawa B, Mazine A, El-Hamamsy I
Innovations (Phila) 2019 Jun;14(3):199-208. Epub 2019 May 14 doi: 10.1177/1556984519845905. PMID: 31084444
Kunihara T
J Med Ultrason (2001) 2019 Jan;46(1):51-62. Epub 2018 Sep 19 doi: 10.1007/s10396-018-0903-0. PMID: 30232651
Fedak PW, Barker AJ, Verma S
Curr Opin Cardiol 2016 Mar;31(2):132-8. doi: 10.1097/HCO.0000000000000258. PMID: 26808007Free PMC Article
Schäfers HJ, Raddatz A, Schmied W, Takahashi H, Miura Y, Kunihara T, Aicher D
J Thorac Cardiovasc Surg 2015 Feb;149(2 Suppl):S30-6. Epub 2014 Sep 18 doi: 10.1016/j.jtcvs.2014.09.048. PMID: 25439784
Settepani F, Cappai A, Raffa GM, Basciu A, Barbone A, Berwick D, Citterio E, Ornaghi D, Tarelli G, Malvindi PG
J Cardiovasc Med (Hagerstown) 2015 Apr;16(4):310-7. doi: 10.2459/JCM.0000000000000031. PMID: 24978873

Diagnosis

Tessler I, Goudot G, Albuisson J, Reshef N, Zwas DR, Carmi S, Shpitzen S, Levin G, Kelman G, Cheng C, Mazzella JM, Levin Y, Messas E, Gilon D, Durst R
Am J Cardiol 2022 Jan 15;163:85-90. Epub 2021 Nov 17 doi: 10.1016/j.amjcard.2021.09.051. PMID: 34799086
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ
J Thorac Cardiovasc Surg 2021 Sep;162(3):e383-e414. Epub 2021 Jul 22 doi: 10.1016/j.jtcvs.2021.06.019. PMID: 34304896
Kunihara T
J Med Ultrason (2001) 2019 Jan;46(1):51-62. Epub 2018 Sep 19 doi: 10.1007/s10396-018-0903-0. PMID: 30232651
Fedak PW, Barker AJ, Verma S
Curr Opin Cardiol 2016 Mar;31(2):132-8. doi: 10.1097/HCO.0000000000000258. PMID: 26808007Free PMC Article
Schäfers HJ, Raddatz A, Schmied W, Takahashi H, Miura Y, Kunihara T, Aicher D
J Thorac Cardiovasc Surg 2015 Feb;149(2 Suppl):S30-6. Epub 2014 Sep 18 doi: 10.1016/j.jtcvs.2014.09.048. PMID: 25439784

Therapy

Tamer S, Mastrobuoni S, Vancraeynest D, Lemaire G, Navarra E, Khoury GE, de Kerchove L
J Thorac Cardiovasc Surg 2023 Mar;165(3):995-1006.e3. Epub 2021 Apr 16 doi: 10.1016/j.jtcvs.2021.04.011. PMID: 34049711
David TE
Semin Thorac Cardiovasc Surg 2019 Winter;31(4):661-663. Epub 2019 Apr 10 doi: 10.1053/j.semtcvs.2019.03.009. PMID: 30980931
Schäfers HJ, Raddatz A, Schmied W, Takahashi H, Miura Y, Kunihara T, Aicher D
J Thorac Cardiovasc Surg 2015 Feb;149(2 Suppl):S30-6. Epub 2014 Sep 18 doi: 10.1016/j.jtcvs.2014.09.048. PMID: 25439784
Settepani F, Cappai A, Raffa GM, Basciu A, Barbone A, Berwick D, Citterio E, Ornaghi D, Tarelli G, Malvindi PG
J Cardiovasc Med (Hagerstown) 2015 Apr;16(4):310-7. doi: 10.2459/JCM.0000000000000031. PMID: 24978873
Neragi-Miandoab S
J Cardiovasc Surg (Torino) 2014 Jun;55(3):435-44. Epub 2012 Nov 8 PMID: 23138607

Prognosis

Tessler I, Goudot G, Albuisson J, Reshef N, Zwas DR, Carmi S, Shpitzen S, Levin G, Kelman G, Cheng C, Mazzella JM, Levin Y, Messas E, Gilon D, Durst R
Am J Cardiol 2022 Jan 15;163:85-90. Epub 2021 Nov 17 doi: 10.1016/j.amjcard.2021.09.051. PMID: 34799086
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ
J Thorac Cardiovasc Surg 2021 Sep;162(3):e383-e414. Epub 2021 Jul 22 doi: 10.1016/j.jtcvs.2021.06.019. PMID: 34304896
Yanagawa B, Mazine A, El-Hamamsy I
Innovations (Phila) 2019 Jun;14(3):199-208. Epub 2019 May 14 doi: 10.1177/1556984519845905. PMID: 31084444
Maredia AK, Greenway SC, Verma S, Fedak PWM
Curr Opin Cardiol 2018 Mar;33(2):134-139. doi: 10.1097/HCO.0000000000000481. PMID: 29095713
Schäfers HJ, Raddatz A, Schmied W, Takahashi H, Miura Y, Kunihara T, Aicher D
J Thorac Cardiovasc Surg 2015 Feb;149(2 Suppl):S30-6. Epub 2014 Sep 18 doi: 10.1016/j.jtcvs.2014.09.048. PMID: 25439784

Clinical prediction guides

Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ
J Thorac Cardiovasc Surg 2021 Sep;162(3):e383-e414. Epub 2021 Jul 22 doi: 10.1016/j.jtcvs.2021.06.019. PMID: 34304896
Ram E, Orlov B, Shinfeld A, Kogan A, Sternik L, Raanani E
Innovations (Phila) 2019 Jun;14(3):209-217. doi: 10.1177/1556984519845657. PMID: 31203738
Yanagawa B, Mazine A, El-Hamamsy I
Innovations (Phila) 2019 Jun;14(3):199-208. Epub 2019 May 14 doi: 10.1177/1556984519845905. PMID: 31084444
Maredia AK, Greenway SC, Verma S, Fedak PWM
Curr Opin Cardiol 2018 Mar;33(2):134-139. doi: 10.1097/HCO.0000000000000481. PMID: 29095713
Schäfers HJ, Raddatz A, Schmied W, Takahashi H, Miura Y, Kunihara T, Aicher D
J Thorac Cardiovasc Surg 2015 Feb;149(2 Suppl):S30-6. Epub 2014 Sep 18 doi: 10.1016/j.jtcvs.2014.09.048. PMID: 25439784

Recent systematic reviews

Edlin J, Youssefi P, Bilkhu R, Figueroa CA, Morgan R, Nowell J, Jahangiri M
Eur J Cardiothorac Surg 2019 Apr 1;55(4):610-617. doi: 10.1093/ejcts/ezy312. PMID: 30239633
Miśkowiec D, Lipiec P, Szymczyk E, Wejner-Mik P, Michalski B, Kupczyńska K, Wierzbowska-Drabik K, Kasprzak JD
Echocardiography 2018 May;35(5):667-677. Epub 2018 Feb 4 doi: 10.1111/echo.13818. PMID: 29399873

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