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Refractory Histiocytic and Dendritic Cell Neoplasm

MedGen UID:
1623727
•Concept ID:
C4525072
•
Neoplastic Process

Definition

A histiocytic and dendritic cell neoplasm that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Histiocytic and Dendritic Cell Neoplasm

Recent clinical studies

Diagnosis

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex.
Kennedy K, Thomas R, Durrant J, Jiang T, Motsinger-Reif A, Breen M
Chromosome Res 2019 Sep;27(3):179-202. Epub 2019 Apr 23 doi: 10.1007/s10577-019-09606-0. PMID: 31011867
Uncommon histiocytic disorders: Rosai-Dorfman, juvenile xanthogranuloma, and Erdheim-Chester disease.
Haroche J, Abla O
Hematology Am Soc Hematol Educ Program 2015;2015:571-8. doi: 10.1182/asheducation-2015.1.571. PMID: 26637774

Therapy

Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms.
Diamond EL, Durham BH, Haroche J, Yao Z, Ma J, Parikh SA, Wang Z, Choi J, Kim E, Cohen-Aubart F, Lee SC, Gao Y, Micol JB, Campbell P, Walsh MP, Sylvester B, Dolgalev I, Aminova O, Heguy A, Zappile P, Nakitandwe J, Ganzel C, Dalton JD, Ellison DW, Estrada-Veras J, Lacouture M, Gahl WA, Stephens PJ, Miller VA, Ross JS, Ali SM, Briggs SR, Fasan O, Block J, Héritier S, Donadieu J, Solit DB, Hyman DM, Baselga J, Janku F, Taylor BS, Park CY, Amoura Z, Dogan A, Emile JF, Rosen N, Gruber TA, Abdel-Wahab O
Cancer Discov 2016 Feb;6(2):154-65. Epub 2015 Nov 13 doi: 10.1158/2159-8290.CD-15-0913. PMID: 26566875Free PMC Article

Prognosis

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex.
Kennedy K, Thomas R, Durrant J, Jiang T, Motsinger-Reif A, Breen M
Chromosome Res 2019 Sep;27(3):179-202. Epub 2019 Apr 23 doi: 10.1007/s10577-019-09606-0. PMID: 31011867
Uncommon histiocytic disorders: Rosai-Dorfman, juvenile xanthogranuloma, and Erdheim-Chester disease.
Haroche J, Abla O
Hematology Am Soc Hematol Educ Program 2015;2015:571-8. doi: 10.1182/asheducation-2015.1.571. PMID: 26637774

Clinical prediction guides

Uncommon histiocytic disorders: Rosai-Dorfman, juvenile xanthogranuloma, and Erdheim-Chester disease.
Haroche J, Abla O
Hematology Am Soc Hematol Educ Program 2015;2015:571-8. doi: 10.1182/asheducation-2015.1.571. PMID: 26637774

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