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Nuclear Cataract Grade 4

MedGen UID:
1623861
•Concept ID:
C4525726
•
Disease or Syndrome

Definition

A stage of nuclear sclerotic cataract marked by severe yellowing and sclerosis of the lens nucleus. (Modified LOCS II) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNuclear Cataract Grade 4

Professional guidelines

PubMed

Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS-001 clinical trial.
Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Management of Severely Subluxated Cataracts Using Femtosecond Laser-Assisted Cataract Surgery.
Chee SP, Wong MH, Jap A
Am J Ophthalmol 2017 Jan;173:7-15. Epub 2016 Sep 23 doi: 10.1016/j.ajo.2016.09.021. PMID: 27670621

Recent clinical studies

Etiology

Prevalence of Refractive Error in Vientiane Province, Lao People's Democratic Republic.
Patel C, Tan Y, Nygaard S, Guo B, Carrillo C, Burgess J, Souksamone K, Nouansavanh KO, Casson R
Ophthalmic Epidemiol 2023 Feb;30(1):57-65. Epub 2022 Feb 3 doi: 10.1080/09286586.2022.2028294. PMID: 35112939
Comparative study between conventional and 4 mm manual small-incision cataract surgery.
Chauhan RA, Agrawal SO, Sawarkar RR, Agrawal S
Indian J Ophthalmol 2022 Nov;70(11):3879-3882. doi: 10.4103/ijo.IJO_1607_22. PMID: 36308119Free PMC Article
Comparability of subjective and objective measurements of nuclear density in cataract patients.
Makhotkina NY, Berendschot TTJM, van den Biggelaar FJHM, Weik ARH, Nuijts RMMA
Acta Ophthalmol 2018 Jun;96(4):356-363. Epub 2018 Mar 25 doi: 10.1111/aos.13694. PMID: 29575599
Cataract and quality of life in patients with glaucoma.
Skalicky SE, Martin KR, Fenwick E, Crowston JG, Goldberg I, McCluskey P
Clin Exp Ophthalmol 2015 May-Jun;43(4):335-41. Epub 2014 Oct 30 doi: 10.1111/ceo.12454. PMID: 25294739
Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems.
Lim SA, Hwang J, Hwang KY, Chung SH
J Cataract Refract Surg 2014 May;40(5):716-21. doi: 10.1016/j.jcrs.2013.10.032. PMID: 24767907

Diagnosis

New technology using crystalline lens autofluorescence for presbyopia and cataract grading.
Eom Y, Suh YW, Kim SW, Lee YJ, Jeon HS, Lee SY, Lee IH, Song JS, Kim HM
Graefes Arch Clin Exp Ophthalmol 2023 Jul;261(7):1923-1932. Epub 2023 Feb 24 doi: 10.1007/s00417-023-05999-1. PMID: 36826601
Comparing retinal sensitivities on blue-on-yellow and green-on-yellow perimetry in glaucoma suspects.
Pokal U, Swathi N, Rajalakshmi AR, Lokeshmaran A
Indian J Ophthalmol 2022 Oct;70(10):3550-3555. doi: 10.4103/ijo.IJO_944_22. PMID: 36190045Free PMC Article
Comparability of subjective and objective measurements of nuclear density in cataract patients.
Makhotkina NY, Berendschot TTJM, van den Biggelaar FJHM, Weik ARH, Nuijts RMMA
Acta Ophthalmol 2018 Jun;96(4):356-363. Epub 2018 Mar 25 doi: 10.1111/aos.13694. PMID: 29575599
Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems.
Lim SA, Hwang J, Hwang KY, Chung SH
J Cataract Refract Surg 2014 May;40(5):716-21. doi: 10.1016/j.jcrs.2013.10.032. PMID: 24767907
Myopia and the long-term incidence of cataract and cataract surgery: the Blue Mountains Eye Study.
Kanthan GL, Mitchell P, Rochtchina E, Cumming RG, Wang JJ
Clin Exp Ophthalmol 2014 May-Jun;42(4):347-53. Epub 2013 Oct 11 doi: 10.1111/ceo.12206. PMID: 24024555

Therapy

Cataract progression after Nd:YAG laser iridotomy in primary angle-closure suspect eyes.
Chang DS, Jiang Y, Kim JA, Huang S, Munoz B, Aung T, He M, Foster PJ, Friedman D
Br J Ophthalmol 2023 Sep;107(9):1264-1268. Epub 2022 May 2 doi: 10.1136/bjophthalmol-2021-320929. PMID: 35501120
Comparative study between conventional and 4 mm manual small-incision cataract surgery.
Chauhan RA, Agrawal SO, Sawarkar RR, Agrawal S
Indian J Ophthalmol 2022 Nov;70(11):3879-3882. doi: 10.4103/ijo.IJO_1607_22. PMID: 36308119Free PMC Article
Ultrasound energy consumption and macular changes with manual and femtolaser-assisted high-fluidics cataract surgery: a prospective randomized comparison.
Menapace R, Schartmüller D, Röggla V, Reiter GS, Leydolt C, Schwarzenbacher L
Acta Ophthalmol 2022 Mar;100(2):e414-e422. Epub 2021 Sep 20 doi: 10.1111/aos.14983. PMID: 34543523Free PMC Article
Evaluating the associations between obesity and age-related cataract: a Mendelian randomization study.
Tan AG, Kifley A, Flood VM, Holliday EG, Scott RJ, Cumming RG, Mitchell P, Wang JJ
Am J Clin Nutr 2019 Oct 1;110(4):969-976. doi: 10.1093/ajcn/nqz167. PMID: 31401654
Statin use and incident nuclear cataract.
Klein BE, Klein R, Lee KE, Grady LM
JAMA 2006 Jun 21;295(23):2752-8. doi: 10.1001/jama.295.23.2752. PMID: 16788130

Prognosis

The Influence of Cataract on Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO).
Lincke JB, Dysli C, Jaggi D, Fink R, Wolf S, Zinkernagel MS
Transl Vis Sci Technol 2021 Apr 1;10(4):33. doi: 10.1167/tvst.10.4.33. PMID: 34004011Free PMC Article
Comparability of subjective and objective measurements of nuclear density in cataract patients.
Makhotkina NY, Berendschot TTJM, van den Biggelaar FJHM, Weik ARH, Nuijts RMMA
Acta Ophthalmol 2018 Jun;96(4):356-363. Epub 2018 Mar 25 doi: 10.1111/aos.13694. PMID: 29575599
Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems.
Lim SA, Hwang J, Hwang KY, Chung SH
J Cataract Refract Surg 2014 May;40(5):716-21. doi: 10.1016/j.jcrs.2013.10.032. PMID: 24767907
Myopia and the long-term incidence of cataract and cataract surgery: the Blue Mountains Eye Study.
Kanthan GL, Mitchell P, Rochtchina E, Cumming RG, Wang JJ
Clin Exp Ophthalmol 2014 May-Jun;42(4):347-53. Epub 2013 Oct 11 doi: 10.1111/ceo.12206. PMID: 24024555
Lens retrodots and vacuoles and their associations with the prevalence and incidence of age-related cataract.
Tan AG, Mitchell P, Rochtchina E, Hong T, Cumming RG, Wang JJ
Eye (Lond) 2012 Apr;26(4):568-75. Epub 2011 Dec 23 doi: 10.1038/eye.2011.349. PMID: 22193877Free PMC Article

Clinical prediction guides

Comparative study between conventional and 4 mm manual small-incision cataract surgery.
Chauhan RA, Agrawal SO, Sawarkar RR, Agrawal S
Indian J Ophthalmol 2022 Nov;70(11):3879-3882. doi: 10.4103/ijo.IJO_1607_22. PMID: 36308119Free PMC Article
The Influence of Cataract on Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO).
Lincke JB, Dysli C, Jaggi D, Fink R, Wolf S, Zinkernagel MS
Transl Vis Sci Technol 2021 Apr 1;10(4):33. doi: 10.1167/tvst.10.4.33. PMID: 34004011Free PMC Article
Comparability of subjective and objective measurements of nuclear density in cataract patients.
Makhotkina NY, Berendschot TTJM, van den Biggelaar FJHM, Weik ARH, Nuijts RMMA
Acta Ophthalmol 2018 Jun;96(4):356-363. Epub 2018 Mar 25 doi: 10.1111/aos.13694. PMID: 29575599
Cataract and quality of life in patients with glaucoma.
Skalicky SE, Martin KR, Fenwick E, Crowston JG, Goldberg I, McCluskey P
Clin Exp Ophthalmol 2015 May-Jun;43(4):335-41. Epub 2014 Oct 30 doi: 10.1111/ceo.12454. PMID: 25294739
Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems.
Lim SA, Hwang J, Hwang KY, Chung SH
J Cataract Refract Surg 2014 May;40(5):716-21. doi: 10.1016/j.jcrs.2013.10.032. PMID: 24767907

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