U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Extranodal Diffuse Large B-cell Lymphoma

MedGen UID:
1624258
•Concept ID:
C4528746
•
Neoplastic Process

Definition

Extranodal diffuse large B-cell lymphoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Extranodal Diffuse Large B-cell Lymphoma

Professional guidelines

PubMed

Development and validation of the post-CAR prognostic index for large B-cell lymphoma patients after CAR-T progression in third or later line treatment.
Iacoboni G, Navarro V, Sesques P, Rejeski K, Bastos-Oreiro M, Serpenti F, Martin Lopez AA, Iraola-Truchuelo J, Delgado J, Perez A, Guerreiro M, Caballero AC, Martinez-Cibrian N, Luzardo Henriquez H, Sanchez Pina JM, Sancho JM, Ghesquieres H, Mussetti A, Lopez Corral L, Hernani R, Reguera JL, Sureda A, Bosch F, Martin Garcia-Sancho A, Kwon M, Subklewe M, Kuhnl A, Bachy E, Barba P, Villacampa G, Abrisqueta P
J Hematol Oncol 2024 Oct 29;17(1):102. doi: 10.1186/s13045-024-01608-8. PMID: 39468591Free PMC Article
Multicenter development of a PET-based risk assessment tool for product-specific outcome prediction in large B-cell lymphoma patients undergoing CAR T-cell therapy.
Voltin CA, Paccagnella A, Winkelmann M, Heger JM, Casadei B, Beckmann L, Herrmann K, Dekorsy FJ, Kutsch N, Borchmann P, Fanti S, Kunz WG, Subklewe M, Kobe C, Zinzani PL, Stelljes M, Roth KS, Drzezga A, Noppeney R, Rahbar K, Reinhardt HC, von Tresckow B, Seifert R, Albring JC, Blumenberg V, Farolfi A, Flossdorf S, Gödel P, Hanoun C
Eur J Nucl Med Mol Imaging 2024 Apr;51(5):1361-1370. Epub 2023 Dec 20 doi: 10.1007/s00259-023-06554-0. PMID: 38114616Free PMC Article
Risk assessment with low-pass whole-genome sequencing of cell-free DNA before CD19 CAR T-cell therapy for large B-cell lymphoma.
Cherng HJ, Sun R, Sugg B, Irwin R, Yang H, Le CC, Deng Q, Fayad L, Fowler NH, Parmar S, Steiner R, Hagemeister F, Nair R, Lee HJ, Rodriguez M, Samaniego F, Iyer SP, Flowers CR, Wang L, Nastoupil LJ, Neelapu SS, Ahmed S, Strati P, Green MR, Westin J
Blood 2022 Aug 4;140(5):504-515. doi: 10.1182/blood.2022015601. PMID: 35512184Free PMC Article

Recent clinical studies

Etiology

Real life clinical outcomes of relapsed/refractory diffuse large B cell lymphoma in the rituximab era: The STRIDER study.
Dogliotti I, Peri V, Clerico M, Vassallo F, Musto D, Mercadante S, Ragaini S, Botto B, Levis M, Novo M, Ghislieri M, Molinaro L, Mortara U, Consoli C, Lonardo A, Bondielli G, Ferrero S, Freilone R, Ricardi U, Bruno B, Cavallo F
Cancer Med 2024 Jul;13(14):e7448. doi: 10.1002/cam4.7448. PMID: 39030982Free PMC Article
IELSG30 phase 2 trial: intravenous and intrathecal CNS prophylaxis in primary testicular diffuse large B-cell lymphoma.
Conconi A, Chiappella A, Ferreri AJM, Stathis A, Botto B, Sassone M, Gaidano G, Balzarotti M, Merli F, Tucci A, Vanazzi A, Tani M, Bruna R, Orsucci L, Cabras MG, Celli M, Annibali O, Liberati AM, Zanni M, Ghiggi C, Pisani F, Pinotti G, Dore F, Esposito F, Pirosa MC, Cesaretti M, Bonomini L, Vitolo U, Zucca E
Blood Adv 2024 Mar 26;8(6):1541-1549. doi: 10.1182/bloodadvances.2023011251. PMID: 38181782Free PMC Article
Prognostic differences of refractory/relapsed nodal and extranodal diffuse large B-cell lymphoma in the chimeric antigen receptor T cell therapy era.
Song Z, Xu L, Tang G, Gao L, Wang L, Ni X, Chen L, Chen J, Wang T, Feng D, Yu X, Yang J, Wang Y
Clin Chim Acta 2022 Jul 1;532:72-78. Epub 2022 Jun 2 doi: 10.1016/j.cca.2022.05.018. PMID: 35660013
Diffuse Large B-Cell Lymphoma.
Sehn LH, Salles G
N Engl J Med 2021 Mar 4;384(9):842-858. doi: 10.1056/NEJMra2027612. PMID: 33657296Free PMC Article
Predictive factors of early progression after CAR T-cell therapy in relapsed/refractory diffuse large B-cell lymphoma.
Vercellino L, Di Blasi R, Kanoun S, Tessoulin B, Rossi C, D'Aveni-Piney M, Obéric L, Bodet-Milin C, Bories P, Olivier P, Lafon I, Berriolo-Riedinger A, Galli E, Bernard S, Rubio MT, Bossard C, Meignin V, Merlet P, Feugier P, Le Gouill S, Ysebaert L, Casasnovas O, Meignan M, Chevret S, Thieblemont C
Blood Adv 2020 Nov 24;4(22):5607-5615. doi: 10.1182/bloodadvances.2020003001. PMID: 33180899Free PMC Article

Diagnosis

Double hit lymphoma: contemporary understanding and practices.
Somasundaram E, Abramson JS
Leuk Lymphoma 2025 Jan;66(1):26-33. Epub 2024 Oct 8 doi: 10.1080/10428194.2024.2412295. PMID: 39378204
Real life clinical outcomes of relapsed/refractory diffuse large B cell lymphoma in the rituximab era: The STRIDER study.
Dogliotti I, Peri V, Clerico M, Vassallo F, Musto D, Mercadante S, Ragaini S, Botto B, Levis M, Novo M, Ghislieri M, Molinaro L, Mortara U, Consoli C, Lonardo A, Bondielli G, Ferrero S, Freilone R, Ricardi U, Bruno B, Cavallo F
Cancer Med 2024 Jul;13(14):e7448. doi: 10.1002/cam4.7448. PMID: 39030982Free PMC Article
Diffuse large B-cell lymphoma involving osseous sites: utility of response assessment by PET/CT and good longterm outcomes.
Ghione P, Ahsanuddin S, Luttwak E, Varela SB, Nakajima R, Michaud L, Gupta K, Navitski A, Straus D, Palomba ML, Moskowitz A, Noy A, Hamlin P, Matasar M, Kumar A, Falchi L, Yahalom J, Horwitz S, Zelenetz A, Younes A, Salles G, Schöder H, Joffe E
Haematologica 2024 Jan 1;109(1):200-208. doi: 10.3324/haematol.2022.282643. PMID: 37646672Free PMC Article
Diffuse Large B-Cell Lymphoma with Cutaneous Manifestations in a Young Patient Using Clozapine for Schizophrenia: A Case Report.
Moraes de Brito MC, Guedes MMV, Nascimento JDS, Pimentel Jatobá V, Alves Junior MP, Lira AC, Gouveia PADC
Am J Case Rep 2023 Nov 21;24:e941746. doi: 10.12659/AJCR.941746. PMID: 37986560Free PMC Article
Predictive factors of early progression after CAR T-cell therapy in relapsed/refractory diffuse large B-cell lymphoma.
Vercellino L, Di Blasi R, Kanoun S, Tessoulin B, Rossi C, D'Aveni-Piney M, Obéric L, Bodet-Milin C, Bories P, Olivier P, Lafon I, Berriolo-Riedinger A, Galli E, Bernard S, Rubio MT, Bossard C, Meignin V, Merlet P, Feugier P, Le Gouill S, Ysebaert L, Casasnovas O, Meignan M, Chevret S, Thieblemont C
Blood Adv 2020 Nov 24;4(22):5607-5615. doi: 10.1182/bloodadvances.2020003001. PMID: 33180899Free PMC Article

Therapy

Real life clinical outcomes of relapsed/refractory diffuse large B cell lymphoma in the rituximab era: The STRIDER study.
Dogliotti I, Peri V, Clerico M, Vassallo F, Musto D, Mercadante S, Ragaini S, Botto B, Levis M, Novo M, Ghislieri M, Molinaro L, Mortara U, Consoli C, Lonardo A, Bondielli G, Ferrero S, Freilone R, Ricardi U, Bruno B, Cavallo F
Cancer Med 2024 Jul;13(14):e7448. doi: 10.1002/cam4.7448. PMID: 39030982Free PMC Article
IELSG30 phase 2 trial: intravenous and intrathecal CNS prophylaxis in primary testicular diffuse large B-cell lymphoma.
Conconi A, Chiappella A, Ferreri AJM, Stathis A, Botto B, Sassone M, Gaidano G, Balzarotti M, Merli F, Tucci A, Vanazzi A, Tani M, Bruna R, Orsucci L, Cabras MG, Celli M, Annibali O, Liberati AM, Zanni M, Ghiggi C, Pisani F, Pinotti G, Dore F, Esposito F, Pirosa MC, Cesaretti M, Bonomini L, Vitolo U, Zucca E
Blood Adv 2024 Mar 26;8(6):1541-1549. doi: 10.1182/bloodadvances.2023011251. PMID: 38181782Free PMC Article
Prognostic differences of refractory/relapsed nodal and extranodal diffuse large B-cell lymphoma in the chimeric antigen receptor T cell therapy era.
Song Z, Xu L, Tang G, Gao L, Wang L, Ni X, Chen L, Chen J, Wang T, Feng D, Yu X, Yang J, Wang Y
Clin Chim Acta 2022 Jul 1;532:72-78. Epub 2022 Jun 2 doi: 10.1016/j.cca.2022.05.018. PMID: 35660013
Diffuse Large B-Cell Lymphoma.
Sehn LH, Salles G
N Engl J Med 2021 Mar 4;384(9):842-858. doi: 10.1056/NEJMra2027612. PMID: 33657296Free PMC Article
Interim FDG-PET Imaging in Lymphoma.
Gallamini A, Zwarthoed C
Semin Nucl Med 2018 Jan;48(1):17-27. Epub 2017 Oct 14 doi: 10.1053/j.semnuclmed.2017.09.002. PMID: 29195613

Prognosis

Bridging Radiation Rapidly and Effectively Cytoreduces High-Risk Relapsed/Refractory Aggressive B Cell Lymphomas Prior to Chimeric Antigen Receptor T Cell Therapy.
Hubbeling H, Silverman EA, Michaud L, Tomas AA, Shouval R, Flynn J, Devlin S, Wijetunga NA, Tringale KR, Batlevi C, Dahi P, Giralt S, Lin R, Park J, Scordo M, Sauter C, Shah G, Hajj C, Salles G, Schoder H, Palomba ML, Perales MA, Yahalom J, Imber BS
Transplant Cell Ther 2023 Apr;29(4):259.e1-259.e10. Epub 2022 Dec 30 doi: 10.1016/j.jtct.2022.12.021. PMID: 36587744Free PMC Article
Prognostic differences of refractory/relapsed nodal and extranodal diffuse large B-cell lymphoma in the chimeric antigen receptor T cell therapy era.
Song Z, Xu L, Tang G, Gao L, Wang L, Ni X, Chen L, Chen J, Wang T, Feng D, Yu X, Yang J, Wang Y
Clin Chim Acta 2022 Jul 1;532:72-78. Epub 2022 Jun 2 doi: 10.1016/j.cca.2022.05.018. PMID: 35660013
Diffuse Large B-Cell Lymphoma.
Sehn LH, Salles G
N Engl J Med 2021 Mar 4;384(9):842-858. doi: 10.1056/NEJMra2027612. PMID: 33657296Free PMC Article
Predictive factors of early progression after CAR T-cell therapy in relapsed/refractory diffuse large B-cell lymphoma.
Vercellino L, Di Blasi R, Kanoun S, Tessoulin B, Rossi C, D'Aveni-Piney M, Obéric L, Bodet-Milin C, Bories P, Olivier P, Lafon I, Berriolo-Riedinger A, Galli E, Bernard S, Rubio MT, Bossard C, Meignin V, Merlet P, Feugier P, Le Gouill S, Ysebaert L, Casasnovas O, Meignan M, Chevret S, Thieblemont C
Blood Adv 2020 Nov 24;4(22):5607-5615. doi: 10.1182/bloodadvances.2020003001. PMID: 33180899Free PMC Article
Interim FDG-PET Imaging in Lymphoma.
Gallamini A, Zwarthoed C
Semin Nucl Med 2018 Jan;48(1):17-27. Epub 2017 Oct 14 doi: 10.1053/j.semnuclmed.2017.09.002. PMID: 29195613

Clinical prediction guides

Real life clinical outcomes of relapsed/refractory diffuse large B cell lymphoma in the rituximab era: The STRIDER study.
Dogliotti I, Peri V, Clerico M, Vassallo F, Musto D, Mercadante S, Ragaini S, Botto B, Levis M, Novo M, Ghislieri M, Molinaro L, Mortara U, Consoli C, Lonardo A, Bondielli G, Ferrero S, Freilone R, Ricardi U, Bruno B, Cavallo F
Cancer Med 2024 Jul;13(14):e7448. doi: 10.1002/cam4.7448. PMID: 39030982Free PMC Article
Multicenter development of a PET-based risk assessment tool for product-specific outcome prediction in large B-cell lymphoma patients undergoing CAR T-cell therapy.
Voltin CA, Paccagnella A, Winkelmann M, Heger JM, Casadei B, Beckmann L, Herrmann K, Dekorsy FJ, Kutsch N, Borchmann P, Fanti S, Kunz WG, Subklewe M, Kobe C, Zinzani PL, Stelljes M, Roth KS, Drzezga A, Noppeney R, Rahbar K, Reinhardt HC, von Tresckow B, Seifert R, Albring JC, Blumenberg V, Farolfi A, Flossdorf S, Gödel P, Hanoun C
Eur J Nucl Med Mol Imaging 2024 Apr;51(5):1361-1370. Epub 2023 Dec 20 doi: 10.1007/s00259-023-06554-0. PMID: 38114616Free PMC Article
Bridging Radiation Rapidly and Effectively Cytoreduces High-Risk Relapsed/Refractory Aggressive B Cell Lymphomas Prior to Chimeric Antigen Receptor T Cell Therapy.
Hubbeling H, Silverman EA, Michaud L, Tomas AA, Shouval R, Flynn J, Devlin S, Wijetunga NA, Tringale KR, Batlevi C, Dahi P, Giralt S, Lin R, Park J, Scordo M, Sauter C, Shah G, Hajj C, Salles G, Schoder H, Palomba ML, Perales MA, Yahalom J, Imber BS
Transplant Cell Ther 2023 Apr;29(4):259.e1-259.e10. Epub 2022 Dec 30 doi: 10.1016/j.jtct.2022.12.021. PMID: 36587744Free PMC Article
Predictive factors of early progression after CAR T-cell therapy in relapsed/refractory diffuse large B-cell lymphoma.
Vercellino L, Di Blasi R, Kanoun S, Tessoulin B, Rossi C, D'Aveni-Piney M, Obéric L, Bodet-Milin C, Bories P, Olivier P, Lafon I, Berriolo-Riedinger A, Galli E, Bernard S, Rubio MT, Bossard C, Meignin V, Merlet P, Feugier P, Le Gouill S, Ysebaert L, Casasnovas O, Meignan M, Chevret S, Thieblemont C
Blood Adv 2020 Nov 24;4(22):5607-5615. doi: 10.1182/bloodadvances.2020003001. PMID: 33180899Free PMC Article
Interim FDG-PET Imaging in Lymphoma.
Gallamini A, Zwarthoed C
Semin Nucl Med 2018 Jan;48(1):17-27. Epub 2017 Oct 14 doi: 10.1053/j.semnuclmed.2017.09.002. PMID: 29195613

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...