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Apical hypertrabeculation of the left ventricle

MedGen UID:
1624455
•Concept ID:
C4531285
•
Anatomical Abnormality
HPO: HP:0031195

Definition

An increased number and density of the trabeculae in the apex (tip) of the left ventricle. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVApical hypertrabeculation of the left ventricle

Recent clinical studies

Etiology

The use of 2-D speckle tracking echocardiography in assessing adolescent athletes with left ventricular hypertrabeculation meeting the criteria for left ventricular non-compaction cardiomyopathy.
Dorobantu DM, Radulescu CR, Riding N, McClean G, de la Garza MS, Abuli-Lluch M, Duarte N, Adamuz MC, Ryding D, Perry D, McNally S, Stuart AG, Sitges M, Oxborough DL, Wilson M, Williams CA, Pieles GE
Int J Cardiol 2023 Jan 15;371:500-507. Epub 2022 Oct 8 doi: 10.1016/j.ijcard.2022.09.076. PMID: 36216087
Left ventricular noncompaction in pediatric population: could cardiovascular magnetic resonance derived fractal analysis aid diagnosis?
Krupickova S, Hatipoglu S, DiSalvo G, Voges I, Redfearn D, Foldvari S, Eichhorn C, Chivers S, Puricelli F, Delle-Donne G, Barth C, Pennell DJ, Prasad SK, Daubeney PEF
J Cardiovasc Magn Reson 2021 Jul 8;23(1):90. doi: 10.1186/s12968-021-00778-5. PMID: 34233715Free PMC Article
Clinical outcomes in patients with left ventricle trabeculation or noncompaction.
Kim H, Kim IC, Chung JW
Int J Cardiovasc Imaging 2021 Feb;37(2):467-477. Epub 2020 Sep 8 doi: 10.1007/s10554-020-02013-1. PMID: 32901347
Hypertrabeculated Left Ventricular Myocardium in Relationship to Myocardial Function and Fibrosis: The Multi-Ethnic Study of Atherosclerosis.
Kawel-Boehm N, McClelland RL, Zemrak F, Captur G, Hundley WG, Liu CY, Moon JC, Petersen SE, Ambale-Venkatesh B, Lima JAC, Bluemke DA
Radiology 2017 Sep;284(3):667-675. Epub 2017 Apr 17 doi: 10.1148/radiol.2017161995. PMID: 28418811Free PMC Article
Diagnostic value of rigid body rotation in noncompaction cardiomyopathy.
van Dalen BM, Caliskan K, Soliman OI, Kauer F, van der Zwaan HB, Vletter WB, van Vark LC, Ten Cate FJ, Geleijnse ML
J Am Soc Echocardiogr 2011 May;24(5):548-55. Epub 2011 Feb 22 doi: 10.1016/j.echo.2011.01.002. PMID: 21345651

Diagnosis

The use of 2-D speckle tracking echocardiography in assessing adolescent athletes with left ventricular hypertrabeculation meeting the criteria for left ventricular non-compaction cardiomyopathy.
Dorobantu DM, Radulescu CR, Riding N, McClean G, de la Garza MS, Abuli-Lluch M, Duarte N, Adamuz MC, Ryding D, Perry D, McNally S, Stuart AG, Sitges M, Oxborough DL, Wilson M, Williams CA, Pieles GE
Int J Cardiol 2023 Jan 15;371:500-507. Epub 2022 Oct 8 doi: 10.1016/j.ijcard.2022.09.076. PMID: 36216087
Established and emerging roles for ultrasound enhancing agents (contrast echocardiography).
Cotter B, Raisinghani A, DeMaria AN
Clin Cardiol 2022 Nov;45(11):1114-1122. Epub 2022 Oct 2 doi: 10.1002/clc.23924. PMID: 36183366Free PMC Article
Left ventricular noncompaction in pediatric population: could cardiovascular magnetic resonance derived fractal analysis aid diagnosis?
Krupickova S, Hatipoglu S, DiSalvo G, Voges I, Redfearn D, Foldvari S, Eichhorn C, Chivers S, Puricelli F, Delle-Donne G, Barth C, Pennell DJ, Prasad SK, Daubeney PEF
J Cardiovasc Magn Reson 2021 Jul 8;23(1):90. doi: 10.1186/s12968-021-00778-5. PMID: 34233715Free PMC Article
Cardiac sarcoidosis mimicking left ventricular noncompaction: An approach to acquired apical hypertrabeculation.
Nagai T, Horinouchi H, Kitayama A, Ikari Y
Echocardiography 2019 Apr;36(4):791-793. Epub 2019 Mar 4 doi: 10.1111/echo.14288. PMID: 30834555
Diagnostic value of rigid body rotation in noncompaction cardiomyopathy.
van Dalen BM, Caliskan K, Soliman OI, Kauer F, van der Zwaan HB, Vletter WB, van Vark LC, Ten Cate FJ, Geleijnse ML
J Am Soc Echocardiogr 2011 May;24(5):548-55. Epub 2011 Feb 22 doi: 10.1016/j.echo.2011.01.002. PMID: 21345651

Therapy

Cardiac sarcoidosis mimicking left ventricular noncompaction: An approach to acquired apical hypertrabeculation.
Nagai T, Horinouchi H, Kitayama A, Ikari Y
Echocardiography 2019 Apr;36(4):791-793. Epub 2019 Mar 4 doi: 10.1111/echo.14288. PMID: 30834555
Disappearance of left ventricular hypertrabeculation/noncompaction after biventricular pacing in a patient with polyneuropathy.
Stöllberger C, Keller H, Finsterer J
J Card Fail 2007 Apr;13(3):211-4. doi: 10.1016/j.cardfail.2006.11.007. PMID: 17448419

Prognosis

Left ventricular noncompaction in pediatric population: could cardiovascular magnetic resonance derived fractal analysis aid diagnosis?
Krupickova S, Hatipoglu S, DiSalvo G, Voges I, Redfearn D, Foldvari S, Eichhorn C, Chivers S, Puricelli F, Delle-Donne G, Barth C, Pennell DJ, Prasad SK, Daubeney PEF
J Cardiovasc Magn Reson 2021 Jul 8;23(1):90. doi: 10.1186/s12968-021-00778-5. PMID: 34233715Free PMC Article
Clinical outcomes in patients with left ventricle trabeculation or noncompaction.
Kim H, Kim IC, Chung JW
Int J Cardiovasc Imaging 2021 Feb;37(2):467-477. Epub 2020 Sep 8 doi: 10.1007/s10554-020-02013-1. PMID: 32901347
Diagnostic value of rigid body rotation in noncompaction cardiomyopathy.
van Dalen BM, Caliskan K, Soliman OI, Kauer F, van der Zwaan HB, Vletter WB, van Vark LC, Ten Cate FJ, Geleijnse ML
J Am Soc Echocardiogr 2011 May;24(5):548-55. Epub 2011 Feb 22 doi: 10.1016/j.echo.2011.01.002. PMID: 21345651
Disappearance of left ventricular hypertrabeculation/noncompaction after biventricular pacing in a patient with polyneuropathy.
Stöllberger C, Keller H, Finsterer J
J Card Fail 2007 Apr;13(3):211-4. doi: 10.1016/j.cardfail.2006.11.007. PMID: 17448419

Clinical prediction guides

The use of 2-D speckle tracking echocardiography in assessing adolescent athletes with left ventricular hypertrabeculation meeting the criteria for left ventricular non-compaction cardiomyopathy.
Dorobantu DM, Radulescu CR, Riding N, McClean G, de la Garza MS, Abuli-Lluch M, Duarte N, Adamuz MC, Ryding D, Perry D, McNally S, Stuart AG, Sitges M, Oxborough DL, Wilson M, Williams CA, Pieles GE
Int J Cardiol 2023 Jan 15;371:500-507. Epub 2022 Oct 8 doi: 10.1016/j.ijcard.2022.09.076. PMID: 36216087
Left ventricular noncompaction in pediatric population: could cardiovascular magnetic resonance derived fractal analysis aid diagnosis?
Krupickova S, Hatipoglu S, DiSalvo G, Voges I, Redfearn D, Foldvari S, Eichhorn C, Chivers S, Puricelli F, Delle-Donne G, Barth C, Pennell DJ, Prasad SK, Daubeney PEF
J Cardiovasc Magn Reson 2021 Jul 8;23(1):90. doi: 10.1186/s12968-021-00778-5. PMID: 34233715Free PMC Article
Left Ventricular Apical Thrombus Mimicking Hypertrabeculation.
Misumi I, Sato K, Nagano M, Obata M, Urata J, Usuku H, Kaikita K, Tsujita K
Intern Med 2021 Jul 15;60(14):2245-2250. Epub 2021 Feb 22 doi: 10.2169/internalmedicine.6482-20. PMID: 33612677Free PMC Article
Clinical outcomes in patients with left ventricle trabeculation or noncompaction.
Kim H, Kim IC, Chung JW
Int J Cardiovasc Imaging 2021 Feb;37(2):467-477. Epub 2020 Sep 8 doi: 10.1007/s10554-020-02013-1. PMID: 32901347
Cardiac sarcoidosis mimicking left ventricular noncompaction: An approach to acquired apical hypertrabeculation.
Nagai T, Horinouchi H, Kitayama A, Ikari Y
Echocardiography 2019 Apr;36(4):791-793. Epub 2019 Mar 4 doi: 10.1111/echo.14288. PMID: 30834555

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