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Rearrangement of 6p25.3

MedGen UID:
1626255
•Concept ID:
C4528214
•
Cell or Molecular Dysfunction
Synonym: Rearrangement of 6p25

Definition

A cytogenetic abnormality indicating rearrangement of the 6p25.3 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRearrangement of 6p25.3

Recent clinical studies

Etiology

Anaplastic large cell lymphomas with the 6p25.3 rearrangement are a heterogeneous group of tumours with a diverse molecular background.
Díaz de la Pinta FJ, Rodríguez Moreno M, Salgado RN, Carvajal García N, Santonja C, Pérez Buira S, Piris MA, Requena L, Manso R, Rodríguez-Pinilla SM
Hum Pathol 2023 Jul;137:71-78. Epub 2023 Apr 29 doi: 10.1016/j.humpath.2023.04.015. PMID: 37127078
Primary cutaneous anaplastic large-cell lymphoma with 6p25.3 rearrangement exhibits a biphasic histopathologic pattern: Two case reports and literature review.
Xue YN, Wang Z, Sun JF, Chen H
J Cutan Pathol 2021 Dec;48(12):1463-1470. Epub 2021 Jul 21 doi: 10.1111/cup.14089. PMID: 34164830
Array comparative genomic hybridization profiling analysis reveals deoxyribonucleic acid copy number variations associated with premature ovarian failure.
Aboura A, Dupas C, Tachdjian G, Portnoï MF, Bourcigaux N, Dewailly D, Frydman R, Fauser B, Ronci-Chaix N, Donadille B, Bouchard P, Christin-Maitre S
J Clin Endocrinol Metab 2009 Nov;94(11):4540-6. Epub 2009 Oct 16 doi: 10.1210/jc.2009-0186. PMID: 19837940

Diagnosis

Vesicular Lymphomatoid Papulosis With DUSP22-IRF4 Rearrangement on Chromosome 6p25.3: A Case Report.
Pan PY, Liao JB, Hsieh SM, Tseng HW
Am J Dermatopathol 2023 Jun 1;45(6):391-396. Epub 2023 Mar 20 doi: 10.1097/DAD.0000000000002403. PMID: 36939126
Lymphomatoid papulosis subtype C: A case report and literature review.
Wang L, Chen F, Zhao S, Wang X, Fang J, Zhu X
Dermatol Ther 2021 Jan;34(1):e14452. Epub 2020 Nov 3 doi: 10.1111/dth.14452. PMID: 33099866
Primary Cutaneous Anaplastic Large-Cell Lymphoma With 6p25.3 Rearrangement in a Cardiac Transplant Recipient: A Case Report and Review of the Literature.
Olson LC, Cheng E, Mathew S, Torres-Quinones M, Magro C
Am J Dermatopathol 2016 Jun;38(6):461-5. doi: 10.1097/DAD.0000000000000505. PMID: 26863058
Complex chromosome rearrangement of 6p25.3->p23 and 12q24.32->qter in a child with moyamoya.
Rosenberg RE, Egan M, Rodgers S, Harter D, Burnside RD, Milla S, Pappas J
Pediatrics 2013 Jun;131(6):e1996-2001. Epub 2013 May 27 doi: 10.1542/peds.2012-0749. PMID: 23713105
Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis.
Karai LJ, Kadin ME, Hsi ED, Sluzevich JC, Ketterling RP, Knudson RA, Feldman AL
Am J Surg Pathol 2013 Aug;37(8):1173-81. doi: 10.1097/PAS.0b013e318282d01e. PMID: 23648461

Prognosis

Primary Cutaneous Anaplastic Large Cell Lymphoma With 6p25.3 Rearrangement and Epidermotropism.
Dutra E, Maia T, Cabeçadas J
Am J Dermatopathol 2022 Mar 1;44(3):196-197. doi: 10.1097/DAD.0000000000002084. PMID: 34966054
Primary cutaneous anaplastic large-cell lymphoma with 6p25.3 rearrangement exhibits a biphasic histopathologic pattern: Two case reports and literature review.
Xue YN, Wang Z, Sun JF, Chen H
J Cutan Pathol 2021 Dec;48(12):1463-1470. Epub 2021 Jul 21 doi: 10.1111/cup.14089. PMID: 34164830
Lymphomatoid papulosis.
Wagner G, Rose C, Klapper W, Sachse MM
J Dtsch Dermatol Ges 2020 Mar;18(3):199-205. Epub 2020 Feb 26 doi: 10.1111/ddg.14041. PMID: 32100965
Primary Cutaneous Anaplastic Large-Cell Lymphoma With 6p25.3 Rearrangement in a Cardiac Transplant Recipient: A Case Report and Review of the Literature.
Olson LC, Cheng E, Mathew S, Torres-Quinones M, Magro C
Am J Dermatopathol 2016 Jun;38(6):461-5. doi: 10.1097/DAD.0000000000000505. PMID: 26863058
Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis.
Karai LJ, Kadin ME, Hsi ED, Sluzevich JC, Ketterling RP, Knudson RA, Feldman AL
Am J Surg Pathol 2013 Aug;37(8):1173-81. doi: 10.1097/PAS.0b013e318282d01e. PMID: 23648461

Clinical prediction guides

Primary cutaneous anaplastic large-cell lymphoma with 6p25.3 rearrangement exhibits a biphasic histopathologic pattern: Two case reports and literature review.
Xue YN, Wang Z, Sun JF, Chen H
J Cutan Pathol 2021 Dec;48(12):1463-1470. Epub 2021 Jul 21 doi: 10.1111/cup.14089. PMID: 34164830
Cutaneous Lymphoproliferative Disorders: What's New in the Revised 4th Edition of the World Health Organization (WHO) Classification of Lymphoid Neoplasms.
Sundram U
Adv Anat Pathol 2019 Mar;26(2):93-113. doi: 10.1097/PAP.0000000000000208. PMID: 30199396
Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping.
Wang X, Boddicker RL, Dasari S, Sidhu JS, Kadin ME, Macon WR, Ansell SM, Ketterling RP, Rech KL, Feldman AL
Hum Pathol 2017 Jun;64:19-27. Epub 2017 Jan 30 doi: 10.1016/j.humpath.2017.01.003. PMID: 28153507Free PMC Article
Primary Cutaneous Anaplastic Large-Cell Lymphoma With 6p25.3 Rearrangement in a Cardiac Transplant Recipient: A Case Report and Review of the Literature.
Olson LC, Cheng E, Mathew S, Torres-Quinones M, Magro C
Am J Dermatopathol 2016 Jun;38(6):461-5. doi: 10.1097/DAD.0000000000000505. PMID: 26863058
Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis.
Karai LJ, Kadin ME, Hsi ED, Sluzevich JC, Ketterling RP, Knudson RA, Feldman AL
Am J Surg Pathol 2013 Aug;37(8):1173-81. doi: 10.1097/PAS.0b013e318282d01e. PMID: 23648461

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