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Invasive Lung Mucinous Adenocarcinoma

MedGen UID:
1626367
•Concept ID:
C4522160
•
Neoplastic Process
Synonym: Mucinous Invasive Lung Adenocarcinoma

Definition

An invasive adenocarcinoma that arises from the lung. It is characterized by the presence of tall columnar cells and mucin production. This category refers to cases formerly classified as mucinous bronchioloalveolar carcinoma, excluding cases that meet the criteria for adenocarcinoma in situ or mucinous minimally invasive adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Lung Mucinous Adenocarcinoma

Professional guidelines

PubMed

Inclusion of multiple high-risk histopathological criteria improves the prediction of adjuvant chemotherapy efficacy in lung adenocarcinoma.
Sereno M, He Z, Smith CR, Baena J, Das M, Hastings RK, Rake G, Fennell DA, Nakas A, Moore DA, Le Quesne J
Histopathology 2021 May;78(6):838-848. Epub 2021 Feb 7 doi: 10.1111/his.14301. PMID: 33155719Free PMC Article
Invasive mucinous adenocarcinoma of the lung: Serial CT findings, clinical features, and treatment and survival outcomes.
Beck KS, Sung YE, Lee KY, Han DH
Thorac Cancer 2020 Dec;11(12):3463-3472. Epub 2020 Oct 5 doi: 10.1111/1759-7714.13674. PMID: 33021074Free PMC Article
About thymic carcinomas: challenges in diagnosis and management.
Mlika M, Boudaya S, Braham E, Chermiti F, Sayi A, Marghli A, El Mezni F
Asian Cardiovasc Thorac Ann 2016 May;24(4):350-4. Epub 2016 Mar 21 doi: 10.1177/0218492316640129. PMID: 27002097

Recent clinical studies

Etiology

Stepwise progression of invasive mucinous adenocarcinoma based on radiological and biological characteristics.
Goto E, Takamochi K, Kishikawa S, Hayashi T, Ueda T, Hattori A, Fukui M, Matsunaga T, Suzuki K; Tokyo Metropolitan Innovative Oncology Research Group (TMIG)
Lung Cancer 2023 Oct;184:107348. Epub 2023 Aug 20 doi: 10.1016/j.lungcan.2023.107348. PMID: 37619407
Pneumonic-type invasive mucinous adenocarcinoma and infectious pneumonia: clinical and CT imaging analysis from multiple centers.
Zhang S, Yu X, Huang Y, Nie P, Deng Y, Mao N, Li S, Zhu B, Wang L, Wang B, Wang X
BMC Pulm Med 2022 Dec 3;22(1):460. doi: 10.1186/s12890-022-02268-5. PMID: 36461012Free PMC Article
Radiological and clinical features of screening-detected pulmonary invasive mucinous adenocarcinoma.
Kim DH, Bae SY, Na KJ, Park S, Park IK, Kang CH, Kim YT
Interact Cardiovasc Thorac Surg 2022 Jan 18;34(2):229-235. doi: 10.1093/icvts/ivab257. PMID: 34570199Free PMC Article
Comparison of Surgical Outcomes Between Invasive Mucinous and Non-Mucinous Lung Adenocarcinoma.
Matsui T, Sakakura N, Koyama S, Nakanishi K, Sasaki E, Kato S, Hosoda W, Murakami Y, Kuroda H, Yatabe Y
Ann Thorac Surg 2021 Oct;112(4):1118-1126. Epub 2020 Nov 24 doi: 10.1016/j.athoracsur.2020.09.042. PMID: 33242433
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000

Diagnosis

Radiological and clinical features of screening-detected pulmonary invasive mucinous adenocarcinoma.
Kim DH, Bae SY, Na KJ, Park S, Park IK, Kang CH, Kim YT
Interact Cardiovasc Thorac Surg 2022 Jan 18;34(2):229-235. doi: 10.1093/icvts/ivab257. PMID: 34570199Free PMC Article
Unusual lung involvements of invasive mucinous adenocarcinoma with chylothorax.
Aoki A, Hara Y, Okudela K, Ishikawa Y, Doshita K, Hashimoto H, Nakashima K, Horita N, Kobayashi N, Kaneko T
Thorac Cancer 2020 Nov;11(11):3407-3408. Epub 2020 Sep 18 doi: 10.1111/1759-7714.13665. PMID: 32945109Free PMC Article
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer.
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Therapy

CT Radiomics Combined With Clinicopathological Features to Predict Invasive Mucinous Adenocarcinoma in Patients With Lung Adenocarcinoma.
Zhang J, Hao L, Li M, Xu Q, Shi G
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338231174306. doi: 10.1177/15330338231174306. PMID: 37278046Free PMC Article
NRG1 fusion-driven tumors: biology, detection, and the therapeutic role of afatinib and other ErbB-targeting agents.
Laskin J, Liu SV, Tolba K, Heining C, Schlenk RF, Cheema P, Cadranel J, Jones MR, Drilon A, Cseh A, Gyorffy S, Solca F, Duruisseaux M
Ann Oncol 2020 Dec;31(12):1693-1703. Epub 2020 Sep 9 doi: 10.1016/j.annonc.2020.08.2335. PMID: 32916265Free PMC Article
Clinical course of stage IV invasive mucinous adenocarcinoma of the lung.
Cha YJ, Kim HR, Lee HJ, Cho BC, Shim HS
Lung Cancer 2016 Dec;102:82-88. Epub 2016 Nov 6 doi: 10.1016/j.lungcan.2016.11.004. PMID: 27987593
Druggable oncogene fusions in invasive mucinous lung adenocarcinoma.
Nakaoku T, Tsuta K, Ichikawa H, Shiraishi K, Sakamoto H, Enari M, Furuta K, Shimada Y, Ogiwara H, Watanabe S, Nokihara H, Yasuda K, Hiramoto M, Nammo T, Ishigame T, Schetter AJ, Okayama H, Harris CC, Kim YH, Mishima M, Yokota J, Yoshida T, Kohno T
Clin Cancer Res 2014 Jun 15;20(12):3087-93. Epub 2014 Apr 11 doi: 10.1158/1078-0432.CCR-14-0107. PMID: 24727320Free PMC Article
New pathologic classification of lung cancer: relevance for clinical practice and clinical trials.
Travis WD, Brambilla E, Riely GJ
J Clin Oncol 2013 Mar 10;31(8):992-1001. Epub 2013 Feb 11 doi: 10.1200/JCO.2012.46.9270. PMID: 23401443

Prognosis

Radiological and clinical features of screening-detected pulmonary invasive mucinous adenocarcinoma.
Kim DH, Bae SY, Na KJ, Park S, Park IK, Kang CH, Kim YT
Interact Cardiovasc Thorac Surg 2022 Jan 18;34(2):229-235. doi: 10.1093/icvts/ivab257. PMID: 34570199Free PMC Article
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer.
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000

Clinical prediction guides

Computed Tomography and (18)F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Imaging Biomarkers of Lung Invasive Non-mucinous Adenocarcinoma: Prediction of Grade 3 Tumour Based on World Health Organization Grading System.
Kawaguchi M, Kato H, Hanamatsu Y, Suto T, Noda Y, Kaneko Y, Iwata H, Hyodo F, Miyazaki T, Matsuo M
Clin Oncol (R Coll Radiol) 2023 Oct;35(10):e601-e610. Epub 2023 Aug 8 doi: 10.1016/j.clon.2023.08.002. PMID: 37587000
Pneumonic-type invasive mucinous adenocarcinoma and infectious pneumonia: clinical and CT imaging analysis from multiple centers.
Zhang S, Yu X, Huang Y, Nie P, Deng Y, Mao N, Li S, Zhu B, Wang L, Wang B, Wang X
BMC Pulm Med 2022 Dec 3;22(1):460. doi: 10.1186/s12890-022-02268-5. PMID: 36461012Free PMC Article
Comparison of Surgical Outcomes Between Invasive Mucinous and Non-Mucinous Lung Adenocarcinoma.
Matsui T, Sakakura N, Koyama S, Nakanishi K, Sasaki E, Kato S, Hosoda W, Murakami Y, Kuroda H, Yatabe Y
Ann Thorac Surg 2021 Oct;112(4):1118-1126. Epub 2020 Nov 24 doi: 10.1016/j.athoracsur.2020.09.042. PMID: 33242433
The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer.
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Recent systematic reviews

Association between the novel classification of lung adenocarcinoma subtypes and EGFR/KRAS mutation status: A systematic literature review and pooled-data analysis.
Jiang L, Mino-Kenudson M, Roden AC, Rosell R, Molina MÁ, Flores RM, Pilz LR, Brunelli A, Venuta F, He J; AME Lung Cancer Collaborative Group
Eur J Surg Oncol 2019 May;45(5):870-876. Epub 2019 Feb 16 doi: 10.1016/j.ejso.2019.02.006. PMID: 30833014
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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