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Cutaneous Melanoma by AJCC v8 Stage

MedGen UID:
1627083
•Concept ID:
C4527160
•
Neoplastic Process
Synonym: Melanoma of the Skin by AJCC v8 Stage

Definition

A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system. This staging system does not apply to melanoma of the conjunctiva, melanoma of the uvea, mucosal melanoma arising in the head and neck, and mucosal melanoma of the urethra, vagina, rectum, and anus. (from AJCC 8th Ed.) [from NCI]

Professional guidelines

PubMed

Surgical cost implications of the AJCC v8 staging system for melanoma and the melanoma in focus consensus statement.
Thomson DR, King ICC, Cooper L, Odili J, Powell BWEM
J Plast Reconstr Aesthet Surg 2019 Oct;72(10):1700-1738. Epub 2019 Jul 16 doi: 10.1016/j.bjps.2019.06.035. PMID: 31362864

Recent clinical studies

Etiology

Isolated melanoma cells in sentinel lymph node in stage IIIA melanoma correlate with a favorable prognosis similar to stage IB.
Amaral T, Nanz L, Stadler R, Berking C, Ulmer A, Forschner A, Meiwes A, Wolfsperger F, Meraz-Torres F, Chatziioannou E, Martus P, Flatz L, Garbe C, Leiter U
Eur J Cancer 2024 Apr;201:113912. Epub 2024 Feb 10 doi: 10.1016/j.ejca.2024.113912. PMID: 38368742
Identification of high-risk patients with a seven-biomarker prognostic signature for adjuvant treatment trial recruitment in American Joint Committee on Cancer v8 stage I-IIA cutaneous melanoma.
Meyer S, Buser L, Haferkamp S, Berneburg M, Maisch T, Klinkhammer-Schalke M, Pauer A, Vogt T, Garbe C
Eur J Cancer 2023 Mar;182:77-86. Epub 2023 Jan 7 doi: 10.1016/j.ejca.2023.01.002. PMID: 36753835
Clinical validation of a prognostic 11-gene expression profiling score in prospectively collected FFPE tissue of patients with AJCC v8 stage II cutaneous melanoma.
Amaral TMS, Hoffmann MC, Sinnberg T, Niessner H, Sülberg H, Eigentler TK, Garbe C
Eur J Cancer 2020 Jan;125:38-45. Epub 2019 Dec 12 doi: 10.1016/j.ejca.2019.10.027. PMID: 31838403

Diagnosis

Pregnancy-associated melanoma: characteristics and outcomes from 2002 to 2020.
Davidson TM, Hieken TJ, Glasgow AE, Habermann EB, Yan Y
Melanoma Res 2024 Apr 1;34(2):175-181. Epub 2024 Jan 23 doi: 10.1097/CMR.0000000000000953. PMID: 38265469Free PMC Article
Clinical validation of a prognostic 11-gene expression profiling score in prospectively collected FFPE tissue of patients with AJCC v8 stage II cutaneous melanoma.
Amaral TMS, Hoffmann MC, Sinnberg T, Niessner H, Sülberg H, Eigentler TK, Garbe C
Eur J Cancer 2020 Jan;125:38-45. Epub 2019 Dec 12 doi: 10.1016/j.ejca.2019.10.027. PMID: 31838403

Prognosis

Isolated melanoma cells in sentinel lymph node in stage IIIA melanoma correlate with a favorable prognosis similar to stage IB.
Amaral T, Nanz L, Stadler R, Berking C, Ulmer A, Forschner A, Meiwes A, Wolfsperger F, Meraz-Torres F, Chatziioannou E, Martus P, Flatz L, Garbe C, Leiter U
Eur J Cancer 2024 Apr;201:113912. Epub 2024 Feb 10 doi: 10.1016/j.ejca.2024.113912. PMID: 38368742
Identification of high-risk patients with a seven-biomarker prognostic signature for adjuvant treatment trial recruitment in American Joint Committee on Cancer v8 stage I-IIA cutaneous melanoma.
Meyer S, Buser L, Haferkamp S, Berneburg M, Maisch T, Klinkhammer-Schalke M, Pauer A, Vogt T, Garbe C
Eur J Cancer 2023 Mar;182:77-86. Epub 2023 Jan 7 doi: 10.1016/j.ejca.2023.01.002. PMID: 36753835
Clinical validation of a prognostic 11-gene expression profiling score in prospectively collected FFPE tissue of patients with AJCC v8 stage II cutaneous melanoma.
Amaral TMS, Hoffmann MC, Sinnberg T, Niessner H, Sülberg H, Eigentler TK, Garbe C
Eur J Cancer 2020 Jan;125:38-45. Epub 2019 Dec 12 doi: 10.1016/j.ejca.2019.10.027. PMID: 31838403

Clinical prediction guides

Pregnancy-associated melanoma: characteristics and outcomes from 2002 to 2020.
Davidson TM, Hieken TJ, Glasgow AE, Habermann EB, Yan Y
Melanoma Res 2024 Apr 1;34(2):175-181. Epub 2024 Jan 23 doi: 10.1097/CMR.0000000000000953. PMID: 38265469Free PMC Article
Identification of high-risk patients with a seven-biomarker prognostic signature for adjuvant treatment trial recruitment in American Joint Committee on Cancer v8 stage I-IIA cutaneous melanoma.
Meyer S, Buser L, Haferkamp S, Berneburg M, Maisch T, Klinkhammer-Schalke M, Pauer A, Vogt T, Garbe C
Eur J Cancer 2023 Mar;182:77-86. Epub 2023 Jan 7 doi: 10.1016/j.ejca.2023.01.002. PMID: 36753835
Clinical validation of a prognostic 11-gene expression profiling score in prospectively collected FFPE tissue of patients with AJCC v8 stage II cutaneous melanoma.
Amaral TMS, Hoffmann MC, Sinnberg T, Niessner H, Sülberg H, Eigentler TK, Garbe C
Eur J Cancer 2020 Jan;125:38-45. Epub 2019 Dec 12 doi: 10.1016/j.ejca.2019.10.027. PMID: 31838403

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