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Myocardial immune cell infiltration

MedGen UID:
1627222
•Concept ID:
C4531202
•
Finding
HPO: HP:0031321

Definition

An increase in the number of immune cells in myocardial tissue (which can be assumed to have migrated into the myocardium). [from HPO]

Professional guidelines

PubMed

Diagnosis and Treatment of Acute Myocarditis: A Review.
Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
DNA Vaccine Treatment in Dogs Experimentally Infected with Trypanosoma cruzi.
Arce-Fonseca M, Carbajal-Hernández AC, Lozano-Camacho M, Carrillo-Sánchez SDC, Roldán FJ, Aranda-Fraustro A, Rosales-Encina JL, Rodríguez-Morales O
J Immunol Res 2020;2020:9794575. Epub 2020 May 5 doi: 10.1155/2020/9794575. PMID: 32455143Free PMC Article
Viral myocarditis: diagnosis, aetiology and management.
Kühl U, Schultheiss HP
Drugs 2009 Jul 9;69(10):1287-302. doi: 10.2165/00003495-200969100-00001. PMID: 19583449

Recent clinical studies

Etiology

Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
Ma P, Liu J, Qin J, Lai L, Heo GS, Luehmann H, Sultan D, Bredemeyer A, Bajapa G, Feng G, Jimenez J, He R, Parks A, Amrute J, Villanueva A, Liu Y, Lin CY, Mack M, Amancherla K, Moslehi J, Lavine KJ
Circulation 2024 Jan 2;149(1):48-66. Epub 2023 Sep 25 doi: 10.1161/CIRCULATIONAHA.122.062551. PMID: 37746718
Recent Advances in Pathology: the 2023 Annual Review Issue of The Journal of Pathology.
Jones JL, Poulsom R, Coates PJ
J Pathol 2023 Aug;260(5):495-497. Epub 2023 Aug 14 doi: 10.1002/path.6192. PMID: 37580852
The Microenvironment of the Pathogenesis of Cardiac Hypertrophy.
Bazgir F, Nau J, Nakhaei-Rad S, Amin E, Wolf MJ, Saucerman JJ, Lorenz K, Ahmadian MR
Cells 2023 Jul 4;12(13) doi: 10.3390/cells12131780. PMID: 37443814Free PMC Article
Advances in immune checkpoint inhibitors induced-cardiotoxicity.
Li X, Peng W, Wu J, Yeung SJ, Yang R
Front Immunol 2023;14:1130438. Epub 2023 Feb 23 doi: 10.3389/fimmu.2023.1130438. PMID: 36911712Free PMC Article
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.
Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article

Diagnosis

Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury.
Gao L, Zhao Y, Wu H, Lin X, Guo F, Li J, Long Y, Zhou B, She J, Zhang C, Sheng J, Jin L, Wu Y, Huang H
Circulation 2023 Dec 12;148(24):1958-1973. Epub 2023 Nov 8 doi: 10.1161/CIRCULATIONAHA.123.065827. PMID: 37937441Free PMC Article
Diagnosis and Treatment of Acute Myocarditis: A Review.
Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
A case of fatal multi-organ inflammation following COVID-19 vaccination.
Nushida H, Ito A, Kurata H, Umemoto H, Tokunaga I, Iseki H, Nishimura A
Leg Med (Tokyo) 2023 Jul;63:102244. Epub 2023 Mar 20 doi: 10.1016/j.legalmed.2023.102244. PMID: 36990036Free PMC Article
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.
Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA Jr, Anders RA, Sosman JA, Moslehi JJ
N Engl J Med 2016 Nov 3;375(18):1749-1755. doi: 10.1056/NEJMoa1609214. PMID: 27806233Free PMC Article

Therapy

Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
Ma P, Liu J, Qin J, Lai L, Heo GS, Luehmann H, Sultan D, Bredemeyer A, Bajapa G, Feng G, Jimenez J, He R, Parks A, Amrute J, Villanueva A, Liu Y, Lin CY, Mack M, Amancherla K, Moslehi J, Lavine KJ
Circulation 2024 Jan 2;149(1):48-66. Epub 2023 Sep 25 doi: 10.1161/CIRCULATIONAHA.122.062551. PMID: 37746718
Diagnosis and Treatment of Acute Myocarditis: A Review.
Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
A case of fatal multi-organ inflammation following COVID-19 vaccination.
Nushida H, Ito A, Kurata H, Umemoto H, Tokunaga I, Iseki H, Nishimura A
Leg Med (Tokyo) 2023 Jul;63:102244. Epub 2023 Mar 20 doi: 10.1016/j.legalmed.2023.102244. PMID: 36990036Free PMC Article
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.
Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA Jr, Anders RA, Sosman JA, Moslehi JJ
N Engl J Med 2016 Nov 3;375(18):1749-1755. doi: 10.1056/NEJMoa1609214. PMID: 27806233Free PMC Article

Prognosis

Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
Ma P, Liu J, Qin J, Lai L, Heo GS, Luehmann H, Sultan D, Bredemeyer A, Bajapa G, Feng G, Jimenez J, He R, Parks A, Amrute J, Villanueva A, Liu Y, Lin CY, Mack M, Amancherla K, Moslehi J, Lavine KJ
Circulation 2024 Jan 2;149(1):48-66. Epub 2023 Sep 25 doi: 10.1161/CIRCULATIONAHA.122.062551. PMID: 37746718
Diagnosis and Treatment of Acute Myocarditis: A Review.
Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy.
Michel L, Helfrich I, Hendgen-Cotta UB, Mincu RI, Korste S, Mrotzek SM, Spomer A, Odersky A, Rischpler C, Herrmann K, Umutlu L, Coman C, Ahrends R, Sickmann A, Löffek S, Livingstone E, Ugurel S, Zimmer L, Gunzer M, Schadendorf D, Totzeck M, Rassaf T
Eur Heart J 2022 Jan 31;43(4):316-329. doi: 10.1093/eurheartj/ehab430. PMID: 34389849
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.
Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA Jr, Anders RA, Sosman JA, Moslehi JJ
N Engl J Med 2016 Nov 3;375(18):1749-1755. doi: 10.1056/NEJMoa1609214. PMID: 27806233Free PMC Article

Clinical prediction guides

Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
Ma P, Liu J, Qin J, Lai L, Heo GS, Luehmann H, Sultan D, Bredemeyer A, Bajapa G, Feng G, Jimenez J, He R, Parks A, Amrute J, Villanueva A, Liu Y, Lin CY, Mack M, Amancherla K, Moslehi J, Lavine KJ
Circulation 2024 Jan 2;149(1):48-66. Epub 2023 Sep 25 doi: 10.1161/CIRCULATIONAHA.122.062551. PMID: 37746718
Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury.
Gao L, Zhao Y, Wu H, Lin X, Guo F, Li J, Long Y, Zhou B, She J, Zhang C, Sheng J, Jin L, Wu Y, Huang H
Circulation 2023 Dec 12;148(24):1958-1973. Epub 2023 Nov 8 doi: 10.1161/CIRCULATIONAHA.123.065827. PMID: 37937441Free PMC Article
Diagnosis and Treatment of Acute Myocarditis: A Review.
Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Wei SC, Meijers WC, Axelrod ML, Anang NAS, Screever EM, Wescott EC, Johnson DB, Whitley E, Lehmann L, Courand PY, Mancuso JJ, Himmel LE, Lebrun-Vignes B, Wleklinski MJ, Knollmann BC, Srinivasan J, Li Y, Atolagbe OT, Rao X, Zhao Y, Wang J, Ehrlich LIR, Sharma P, Salem JE, Balko JM, Moslehi JJ, Allison JP
Cancer Discov 2021 Mar;11(3):614-625. Epub 2020 Nov 30 doi: 10.1158/2159-8290.CD-20-0856. PMID: 33257470Free PMC Article
Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration.
Fan Q, Tao R, Zhang H, Xie H, Lu L, Wang T, Su M, Hu J, Zhang Q, Chen Q, Iwakura Y, Shen W, Zhang R, Yan X
Circulation 2019 Jan 29;139(5):663-678. doi: 10.1161/CIRCULATIONAHA.118.036044. PMID: 30586706

Recent systematic reviews

Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition.
Panahi M, Papanikolaou A, Torabi A, Zhang JG, Khan H, Vazir A, Hasham MG, Cleland JGF, Rosenthal NA, Harding SE, Sattler S
Cardiovasc Res 2018 Sep 1;114(11):1445-1461. doi: 10.1093/cvr/cvy145. PMID: 30010800Free PMC Article

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