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Optic pathway glioma

MedGen UID:
162950
Concept ID:
C0796418
Neoplastic Process
Synonyms: glioma of optic tract; glioma of the optic tract; Glioma of the Visual Pathway; glioma of the visual pathway; Glioma of Visual Pathway; glioma of visual pathway; optic pathway glioma; optic tract glioma; Visual Pathway Glioma; visual pathway glioma
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0016167
Orphanet: ORPHA2086

Definition

Optic pathway glioma (OPG) is a benign tumor that develop along the optic nerve (chiasm, tracts, and radiations) characterized by impairment or loss of vision and may be accompanied by diencephalic symptoms such as reduced growth and alteration in sleeping patterns. OPG are often linked to neurofibromatosis type 1 (NF1, see this term). [from ORDO]

Professional guidelines

PubMed

Kerashvili N, Gutmann DH
Expert Rev Neurother 2024 Apr;24(4):409-420. Epub 2024 Feb 27 doi: 10.1080/14737175.2024.2324117. PMID: 38406862
Kotch C, Avery R, Getz KD, Bouffet E, de Blank P, Listernick R, Gutmann DH, Bornhorst M, Campen C, Liu GT, Aplenc R, Li Y, Fisher MJ
Neuro Oncol 2022 Aug 1;24(8):1377-1386. doi: 10.1093/neuonc/noac013. PMID: 35018469Free PMC Article
Ferner RE, Gutmann DH
Handb Clin Neurol 2013;115:939-55. doi: 10.1016/B978-0-444-52902-2.00053-9. PMID: 23931823

Recent clinical studies

Etiology

Amato A, Imbimbo BP, Falsini B
Eur Rev Med Pharmacol Sci 2023 Jun;27(12):5636-5653. doi: 10.26355/eurrev_202306_32804. PMID: 37401302
Romo CG, Piotrowski AF, Campian JL, Diarte J, Rodriguez FJ, Bale TA, Dahiya S, Gutmann DH, Lucas CG, Prichett L, Mellinghoff I, Blakeley JO
Neuro Oncol 2023 Aug 3;25(8):1474-1486. doi: 10.1093/neuonc/noad033. PMID: 36840626Free PMC Article
Bowman R, Walters B, Smith V, Prise KL, Handley SE, Green K, Mankad K, O'Hare P, Dahl C, Jorgensen M, Opocher E, Hargrave D, Thompson DA
Eye (Lond) 2023 Apr;37(6):1178-1183. Epub 2022 May 13 doi: 10.1038/s41433-022-02096-1. PMID: 35562551Free PMC Article
Gil Margolis M, Yackobovitz-Gavan M, Toledano H, Tenenbaum A, Cohen R, Phillip M, Shalitin S
Pediatr Res 2023 Jan;93(1):233-241. Epub 2022 May 10 doi: 10.1038/s41390-022-02098-5. PMID: 35538247
Anderson JL, Gutmann DH
Handb Clin Neurol 2015;132:75-86. doi: 10.1016/B978-0-444-62702-5.00004-4. PMID: 26564071

Diagnosis

Amato A, Imbimbo BP, Falsini B
Eur Rev Med Pharmacol Sci 2023 Jun;27(12):5636-5653. doi: 10.26355/eurrev_202306_32804. PMID: 37401302
Romo CG, Piotrowski AF, Campian JL, Diarte J, Rodriguez FJ, Bale TA, Dahiya S, Gutmann DH, Lucas CG, Prichett L, Mellinghoff I, Blakeley JO
Neuro Oncol 2023 Aug 3;25(8):1474-1486. doi: 10.1093/neuonc/noad033. PMID: 36840626Free PMC Article
Aihara Y, Chiba K, Eguchi S, Amano K, Kawamata T
Neurol Med Chir (Tokyo) 2018 Jan 15;58(1):1-9. Epub 2017 Nov 9 doi: 10.2176/nmc.ra.2017-0081. PMID: 29118304Free PMC Article
Rasool N, Odel JG, Kazim M
Curr Opin Ophthalmol 2017 May;28(3):289-295. doi: 10.1097/ICU.0000000000000370. PMID: 28257299
Ferner RE, Gutmann DH
Handb Clin Neurol 2013;115:939-55. doi: 10.1016/B978-0-444-52902-2.00053-9. PMID: 23931823

Therapy

Amato A, Imbimbo BP, Falsini B
Eur Rev Med Pharmacol Sci 2023 Jun;27(12):5636-5653. doi: 10.26355/eurrev_202306_32804. PMID: 37401302
Fangusaro J, Onar-Thomas A, Poussaint TY, Wu S, Ligon AH, Lindeman N, Campagne O, Banerjee A, Gururangan S, Kilburn LB, Goldman S, Qaddoumi I, Baxter P, Vezina G, Bregman C, Patay Z, Jones JY, Stewart CF, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Neuro Oncol 2021 Oct 1;23(10):1777-1788. doi: 10.1093/neuonc/noab047. PMID: 33631016Free PMC Article
Azizi AA, Walker DA, Liu JF, Sehested A, Jaspan T, Pemp B, Simmons I, Ferner R, Grill J, Hargrave D, Driever PH, Evans DG, Opocher E; SIOPE NF1 OPG Nottingham, UK, Workshop 2014
Neuro Oncol 2021 Jan 30;23(1):100-111. doi: 10.1093/neuonc/noaa153. PMID: 32628746Free PMC Article
Karaconji T, Whist E, Jamieson RV, Flaherty MP, Grigg JRB
Asia Pac J Ophthalmol (Phila) 2019 Jan-Feb;8(1):62-72. Epub 2018 Nov 2 doi: 10.22608/APO.2018182. PMID: 30387339
Desai SS, Paulino AC, Mai WY, Teh BS
Int J Radiat Oncol Biol Phys 2006 Jul 15;65(4):1222-7. Epub 2006 Apr 19 doi: 10.1016/j.ijrobp.2006.01.038. PMID: 16626890

Prognosis

Dal Bello S, Martinuzzi D, Tereshko Y, Veritti D, Sarao V, Gigli GL, Lanzetta P, Valente M
Cells 2023 Sep 29;12(19) doi: 10.3390/cells12192380. PMID: 37830595Free PMC Article
Romo CG, Piotrowski AF, Campian JL, Diarte J, Rodriguez FJ, Bale TA, Dahiya S, Gutmann DH, Lucas CG, Prichett L, Mellinghoff I, Blakeley JO
Neuro Oncol 2023 Aug 3;25(8):1474-1486. doi: 10.1093/neuonc/noad033. PMID: 36840626Free PMC Article
Fangusaro J, Onar-Thomas A, Poussaint TY, Wu S, Ligon AH, Lindeman N, Campagne O, Banerjee A, Gururangan S, Kilburn LB, Goldman S, Qaddoumi I, Baxter P, Vezina G, Bregman C, Patay Z, Jones JY, Stewart CF, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Neuro Oncol 2021 Oct 1;23(10):1777-1788. doi: 10.1093/neuonc/noab047. PMID: 33631016Free PMC Article
Aihara Y, Chiba K, Eguchi S, Amano K, Kawamata T
Neurol Med Chir (Tokyo) 2018 Jan 15;58(1):1-9. Epub 2017 Nov 9 doi: 10.2176/nmc.ra.2017-0081. PMID: 29118304Free PMC Article
Rasool N, Odel JG, Kazim M
Curr Opin Ophthalmol 2017 May;28(3):289-295. doi: 10.1097/ICU.0000000000000370. PMID: 28257299

Clinical prediction guides

Bowman R, Walters B, Smith V, Prise KL, Handley SE, Green K, Mankad K, O'Hare P, Dahl C, Jorgensen M, Opocher E, Hargrave D, Thompson DA
Eye (Lond) 2023 Apr;37(6):1178-1183. Epub 2022 May 13 doi: 10.1038/s41433-022-02096-1. PMID: 35562551Free PMC Article
José P, Couceiro R, Passos J, Jorge Teixeira F
J Pediatr Ophthalmol Strabismus 2022 Mar-Apr;59(2):128-135. Epub 2021 Sep 30 doi: 10.3928/01913913-20210720-02. PMID: 34592874
Siwá A, Autrata R, Vejmělková K, Pavelka Z, Zitterbart K
Cesk Slov Oftalmol 2019 Winter;75(4):200-208. doi: 10.31348/2019/4/4. PMID: 32397722
Eoli M, Saletti V, Finocchiaro G
Curr Opin Oncol 2019 Nov;31(6):554-561. doi: 10.1097/CCO.0000000000000576. PMID: 31436563
Robert-Boire V, Rosca L, Samson Y, Ospina LH, Perreault S
Pediatr Neurol 2017 Oct;75:55-60. Epub 2017 Jul 6 doi: 10.1016/j.pediatrneurol.2017.06.019. PMID: 28847625

Recent systematic reviews

Giotta Lucifero A, Elbabaa SK, Baldoncini M, Bruno N, Savasta S, Marseglia GL, Luzzi S
Pediatr Neurosurg 2022;57(3):161-174. Epub 2022 May 4 doi: 10.1159/000524873. PMID: 35588700
Bennebroek CAM, Wijninga LE, Limpens J, Schouten-van Meeteren AYN, Saeed P
PLoS One 2021;16(10):e0258548. Epub 2021 Oct 21 doi: 10.1371/journal.pone.0258548. PMID: 34673789Free PMC Article
Bernier A, Larbrisseau A, Perreault S
Pediatr Neurol 2016 Jul;60:24-29.e1. Epub 2016 Mar 19 doi: 10.1016/j.pediatrneurol.2016.03.003. PMID: 27212418
Moreno L, Bautista F, Ashley S, Duncan C, Zacharoulis S
Eur J Cancer 2010 Aug;46(12):2253-9. Epub 2010 Apr 17 doi: 10.1016/j.ejca.2010.03.028. PMID: 20400294
Opocher E, Kremer LC, Da Dalt L, van de Wetering MD, Viscardi E, Caron HN, Perilongo G
Eur J Cancer 2006 Aug;42(12):1807-16. Epub 2006 Jun 30 doi: 10.1016/j.ejca.2006.02.022. PMID: 16809032

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