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Digital ulcer

MedGen UID:
1630953
•Concept ID:
C3267035
•
Disease or Syndrome
Synonyms: digital ulcer; digital ulcers
 
HPO: HP:0031917

Definition

An open sore on the surface of the skin of a finger or toe. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigital ulcer

Professional guidelines

PubMed

Pharmacological management of digital ulcers in systemic sclerosis - what is new?
Herrick AL, Philobos M
Expert Opin Pharmacother 2023 May-Aug;24(10):1159-1170. Epub 2023 Jun 9 doi: 10.1080/14656566.2023.2213434. PMID: 37291891
Consensus best practice pathway of the UK Scleroderma Study Group: digital vasculopathy in systemic sclerosis.
Hughes M, Ong VH, Anderson ME, Hall F, Moinzadeh P, Griffiths B, Baildam E, Denton CP, Herrick AL
Rheumatology (Oxford) 2015 Nov;54(11):2015-24. Epub 2015 Jun 26 doi: 10.1093/rheumatology/kev201. PMID: 26116156
Scleroderma and evidence based non-pharmaceutical treatment modalities for digital ulcers: a systematic review.
Moran ME
J Wound Care 2014 Oct;23(10):510-6. doi: 10.12968/jowc.2014.23.10.510. PMID: 25296352

Recent clinical studies

Etiology

A 4-week comparison of capillaroscopy changes, healing effect, and cost-effectiveness of botulinum toxin-A vs prostaglandin analog infusion in refractory digital ulcers in systemic sclerosis.
Shenavandeh S, Sepaskhah M, Dehghani S, Nazarinia M
Clin Rheumatol 2022 Jan;41(1):95-104. Epub 2021 Sep 1 doi: 10.1007/s10067-021-05900-7. PMID: 34471968Free PMC Article
Prevalence and predictors of small intestinal bacterial overgrowth in systemic sclerosis: a systematic review and meta-analysis.
Feng X, Li XQ, Jiang Z
Clin Rheumatol 2021 Aug;40(8):3039-3051. Epub 2021 Jan 11 doi: 10.1007/s10067-020-05549-8. PMID: 33426631
Filling in the Gaps of Scleroderma Ulcer Care: A Review.
Wagner KD, Woolridge K, Group A
Adv Skin Wound Care 2019 Dec;32(12):553-557. doi: 10.1097/01.ASW.0000582636.98643.3b. PMID: 31663924
Capillary density: An important parameter in nailfold capillaroscopy.
Emrani Z, Karbalaie A, Fatemi A, Etehadtavakol M, Erlandsson BE
Microvasc Res 2017 Jan;109:7-18. Epub 2016 Sep 7 doi: 10.1016/j.mvr.2016.09.001. PMID: 27614146
Scleroderma and evidence based non-pharmaceutical treatment modalities for digital ulcers: a systematic review.
Moran ME
J Wound Care 2014 Oct;23(10):510-6. doi: 10.12968/jowc.2014.23.10.510. PMID: 25296352

Diagnosis

Pharmacological management of digital ulcers in systemic sclerosis - what is new?
Herrick AL, Philobos M
Expert Opin Pharmacother 2023 May-Aug;24(10):1159-1170. Epub 2023 Jun 9 doi: 10.1080/14656566.2023.2213434. PMID: 37291891
Osteomyelitis Complicating Digital Ulcer Disease.
Cox M, Hughes M
J Clin Rheumatol 2021 Sep 1;27(6):e230-e231. doi: 10.1097/RHU.0000000000001325. PMID: 31977650
Filling in the Gaps of Scleroderma Ulcer Care: A Review.
Wagner KD, Woolridge K, Group A
Adv Skin Wound Care 2019 Dec;32(12):553-557. doi: 10.1097/01.ASW.0000582636.98643.3b. PMID: 31663924
Capillary density: An important parameter in nailfold capillaroscopy.
Emrani Z, Karbalaie A, Fatemi A, Etehadtavakol M, Erlandsson BE
Microvasc Res 2017 Jan;109:7-18. Epub 2016 Sep 7 doi: 10.1016/j.mvr.2016.09.001. PMID: 27614146
Efficacy of Raynaud's phenomenon and digital ulcer pharmacological treatment in systemic sclerosis patients: a systematic literature review.
García de la Peña Lefebvre P, Nishishinya MB, Pereda CA, Loza E, Sifuentes Giraldo WA, Román Ivorra JA, Carreira P, Rúa-Figueroa I, Pego-Reigosa JM, Muñoz-Fernández S
Rheumatol Int 2015 Sep;35(9):1447-59. Epub 2015 Apr 1 doi: 10.1007/s00296-015-3241-1. PMID: 25824427

Therapy

Efficacy of local oxygen-ozone therapy for the treatment of digital ulcer refractory to medical therapy in systemic sclerosis: A randomized controlled study.
Kaymaz S, Karasu U, Alkan H, Ulutaş F, Albayrak Yaşar C, Dündar Ök Z, Çobankara V, Yiğit M, Yıldız N, Ardıç F
Mod Rheumatol 2022 Oct 15;32(6):1102-1107. doi: 10.1093/mr/roab117. PMID: 34865095
A 4-week comparison of capillaroscopy changes, healing effect, and cost-effectiveness of botulinum toxin-A vs prostaglandin analog infusion in refractory digital ulcers in systemic sclerosis.
Shenavandeh S, Sepaskhah M, Dehghani S, Nazarinia M
Clin Rheumatol 2022 Jan;41(1):95-104. Epub 2021 Sep 1 doi: 10.1007/s10067-021-05900-7. PMID: 34471968Free PMC Article
Filling in the Gaps of Scleroderma Ulcer Care: A Review.
Wagner KD, Woolridge K, Group A
Adv Skin Wound Care 2019 Dec;32(12):553-557. doi: 10.1097/01.ASW.0000582636.98643.3b. PMID: 31663924
Exploring the patient experience of digital ulcers in systemic sclerosis.
Hughes M, Pauling JD
Semin Arthritis Rheum 2019 Apr;48(5):888-894. Epub 2018 Aug 11 doi: 10.1016/j.semarthrit.2018.08.001. PMID: 30205981
Efficacy of Raynaud's phenomenon and digital ulcer pharmacological treatment in systemic sclerosis patients: a systematic literature review.
García de la Peña Lefebvre P, Nishishinya MB, Pereda CA, Loza E, Sifuentes Giraldo WA, Román Ivorra JA, Carreira P, Rúa-Figueroa I, Pego-Reigosa JM, Muñoz-Fernández S
Rheumatol Int 2015 Sep;35(9):1447-59. Epub 2015 Apr 1 doi: 10.1007/s00296-015-3241-1. PMID: 25824427

Prognosis

Prevalence and predictors of small intestinal bacterial overgrowth in systemic sclerosis: a systematic review and meta-analysis.
Feng X, Li XQ, Jiang Z
Clin Rheumatol 2021 Aug;40(8):3039-3051. Epub 2021 Jan 11 doi: 10.1007/s10067-020-05549-8. PMID: 33426631
Filling in the Gaps of Scleroderma Ulcer Care: A Review.
Wagner KD, Woolridge K, Group A
Adv Skin Wound Care 2019 Dec;32(12):553-557. doi: 10.1097/01.ASW.0000582636.98643.3b. PMID: 31663924
Association between baseline clinical and imaging findings and the development of digital ulcers in patients with systemic sclerosis.
Friedrich S, Lüders S, Glimm AM, Werner SG, Schmittat G, Burmester GR, Backhaus M, Riemekasten G, Ohrndorf S
Arthritis Res Ther 2019 Apr 15;21(1):96. doi: 10.1186/s13075-019-1875-1. PMID: 30987674Free PMC Article
Exploring the patient experience of digital ulcers in systemic sclerosis.
Hughes M, Pauling JD
Semin Arthritis Rheum 2019 Apr;48(5):888-894. Epub 2018 Aug 11 doi: 10.1016/j.semarthrit.2018.08.001. PMID: 30205981
A PRISMA-driven systematic review for predictive risk factors of digital ulcers in systemic sclerosis patients.
Silva I, Almeida J, Vasconcelos C
Autoimmun Rev 2015 Feb;14(2):140-52. Epub 2014 Oct 14 doi: 10.1016/j.autrev.2014.10.009. PMID: 25449678

Clinical prediction guides

Are Digital Arthroplasty and Arthrodesis Useful and Safe Surgical Techniques for the Management of Patients with Diabetic Foot?
Tardáguila-García A, Sanz-Corbalán I, López-Moral M, García-Madrid M, García-Morales E, Lázaro-Martínez JL
Adv Skin Wound Care 2022 Jul 1;35(7):1-6. doi: 10.1097/01.ASW.0000831088.63458.d3. PMID: 35723960
Prevalence and predictors of small intestinal bacterial overgrowth in systemic sclerosis: a systematic review and meta-analysis.
Feng X, Li XQ, Jiang Z
Clin Rheumatol 2021 Aug;40(8):3039-3051. Epub 2021 Jan 11 doi: 10.1007/s10067-020-05549-8. PMID: 33426631
Association between baseline clinical and imaging findings and the development of digital ulcers in patients with systemic sclerosis.
Friedrich S, Lüders S, Glimm AM, Werner SG, Schmittat G, Burmester GR, Backhaus M, Riemekasten G, Ohrndorf S
Arthritis Res Ther 2019 Apr 15;21(1):96. doi: 10.1186/s13075-019-1875-1. PMID: 30987674Free PMC Article
Preliminary Validation of the Digital Ulcer Clinical Assessment Score in Systemic Sclerosis.
Bruni C, Ngcozana T, Braschi F, Pucci T, Piemonte G, Benelli L, Poli M, Suliman YA, Guiducci S, Bellando-Randone S, Balduzzi S, Grotts J, Denton CP, Rasero L, Montecucco C, Furst DE, Matucci-Cerinic M
J Rheumatol 2019 Jun;46(6):603-608. Epub 2018 Nov 15 doi: 10.3899/jrheum.171486. PMID: 30442833
Capillary density: An important parameter in nailfold capillaroscopy.
Emrani Z, Karbalaie A, Fatemi A, Etehadtavakol M, Erlandsson BE
Microvasc Res 2017 Jan;109:7-18. Epub 2016 Sep 7 doi: 10.1016/j.mvr.2016.09.001. PMID: 27614146

Recent systematic reviews

Prevalence and predictors of small intestinal bacterial overgrowth in systemic sclerosis: a systematic review and meta-analysis.
Feng X, Li XQ, Jiang Z
Clin Rheumatol 2021 Aug;40(8):3039-3051. Epub 2021 Jan 11 doi: 10.1007/s10067-020-05549-8. PMID: 33426631
Digital ulcer debridement in systemic sclerosis: a systematic literature review.
Hughes M, Alcacer-Pitarch B, Gheorghiu AM, Praino E, Sandler RD, Tavor Y, Bruni C, Matucci-Cerinic M
Clin Rheumatol 2020 Mar;39(3):805-811. Epub 2020 Jan 18 doi: 10.1007/s10067-019-04924-4. PMID: 31955323
Efficacy of Raynaud's phenomenon and digital ulcer pharmacological treatment in systemic sclerosis patients: a systematic literature review.
García de la Peña Lefebvre P, Nishishinya MB, Pereda CA, Loza E, Sifuentes Giraldo WA, Román Ivorra JA, Carreira P, Rúa-Figueroa I, Pego-Reigosa JM, Muñoz-Fernández S
Rheumatol Int 2015 Sep;35(9):1447-59. Epub 2015 Apr 1 doi: 10.1007/s00296-015-3241-1. PMID: 25824427
A PRISMA-driven systematic review for predictive risk factors of digital ulcers in systemic sclerosis patients.
Silva I, Almeida J, Vasconcelos C
Autoimmun Rev 2015 Feb;14(2):140-52. Epub 2014 Oct 14 doi: 10.1016/j.autrev.2014.10.009. PMID: 25449678
Scleroderma and evidence based non-pharmaceutical treatment modalities for digital ulcers: a systematic review.
Moran ME
J Wound Care 2014 Oct;23(10):510-6. doi: 10.12968/jowc.2014.23.10.510. PMID: 25296352

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