U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Digital ulcer

MedGen UID:
1630953
•Concept ID:
C3267035
•
Disease or Syndrome
Synonyms: digital ulcer; digital ulcers
 
HPO: HP:0031917

Definition

An open sore on the surface of the skin of a finger or toe. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigital ulcer

Professional guidelines

PubMed

Pharmacological management of digital ulcers in systemic sclerosis - what is new?
Herrick AL, Philobos M
Expert Opin Pharmacother 2023 May-Aug;24(10):1159-1170. Epub 2023 Jun 9 doi: 10.1080/14656566.2023.2213434. PMID: 37291891
Consensus best practice pathway of the UK Scleroderma Study Group: digital vasculopathy in systemic sclerosis.
Hughes M, Ong VH, Anderson ME, Hall F, Moinzadeh P, Griffiths B, Baildam E, Denton CP, Herrick AL
Rheumatology (Oxford) 2015 Nov;54(11):2015-24. Epub 2015 Jun 26 doi: 10.1093/rheumatology/kev201. PMID: 26116156
Scleroderma and evidence based non-pharmaceutical treatment modalities for digital ulcers: a systematic review.
Moran ME
J Wound Care 2014 Oct;23(10):510-6. doi: 10.12968/jowc.2014.23.10.510. PMID: 25296352

Recent clinical studies

Etiology

Reproductive health in female patients with systemic sclerosis: a cross-sectional study.
Dai L, Xu D, Li X, Huang S, Duan X, Zheng A, Yang J, Zhao J, Zeng L, Mu R
Rheumatology (Oxford) 2024 Jul 1;63(7):1911-1916. doi: 10.1093/rheumatology/kead497. PMID: 37738273
MRI Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis: a prospective cohort study.
Hughes M, Di Donato S, Gjeloshi K, Abignano G, Danzo F, Lettieri G, De Lorenzis E, Bertham D, O'Connor P, Kubassova O, Dehmeshki J, Del Galdo F
Lancet Rheumatol 2023 Oct;5(10):e611-e621. Epub 2023 Sep 25 doi: 10.1016/S2665-9913(23)00189-3. PMID: 38251485
Systemic pharmacological treatment of digital ulcers in systemic sclerosis: a systematic literature review.
Ross L, Maltez N, Hughes M, Schoones JW, Baron M, Chung L, Giuggioli D, Moinzadeh P, Suliman YA, Campochiaro C, Allanore Y, Denton CP, Distler O, Frech T, Furst DE, Khanna D, Krieg T, Kuwana M, Matucci-Cerinic M, Pope J, Alunno A
Rheumatology (Oxford) 2023 Dec 1;62(12):3785-3800. doi: 10.1093/rheumatology/kead289. PMID: 37335850Free PMC Article
Filling in the Gaps of Scleroderma Ulcer Care: A Review.
Wagner KD, Woolridge K, Group A
Adv Skin Wound Care 2019 Dec;32(12):553-557. doi: 10.1097/01.ASW.0000582636.98643.3b. PMID: 31663924
Capillary density: An important parameter in nailfold capillaroscopy.
Emrani Z, Karbalaie A, Fatemi A, Etehadtavakol M, Erlandsson BE
Microvasc Res 2017 Jan;109:7-18. Epub 2016 Sep 7 doi: 10.1016/j.mvr.2016.09.001. PMID: 27614146

Diagnosis

MRI Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis: a prospective cohort study.
Hughes M, Di Donato S, Gjeloshi K, Abignano G, Danzo F, Lettieri G, De Lorenzis E, Bertham D, O'Connor P, Kubassova O, Dehmeshki J, Del Galdo F
Lancet Rheumatol 2023 Oct;5(10):e611-e621. Epub 2023 Sep 25 doi: 10.1016/S2665-9913(23)00189-3. PMID: 38251485
Pharmacological management of digital ulcers in systemic sclerosis - what is new?
Herrick AL, Philobos M
Expert Opin Pharmacother 2023 May-Aug;24(10):1159-1170. Epub 2023 Jun 9 doi: 10.1080/14656566.2023.2213434. PMID: 37291891
Osteomyelitis Complicating Digital Ulcer Disease.
Cox M, Hughes M
J Clin Rheumatol 2021 Sep 1;27(6):e230-e231. doi: 10.1097/RHU.0000000000001325. PMID: 31977650
Filling in the Gaps of Scleroderma Ulcer Care: A Review.
Wagner KD, Woolridge K, Group A
Adv Skin Wound Care 2019 Dec;32(12):553-557. doi: 10.1097/01.ASW.0000582636.98643.3b. PMID: 31663924
Capillary density: An important parameter in nailfold capillaroscopy.
Emrani Z, Karbalaie A, Fatemi A, Etehadtavakol M, Erlandsson BE
Microvasc Res 2017 Jan;109:7-18. Epub 2016 Sep 7 doi: 10.1016/j.mvr.2016.09.001. PMID: 27614146

Therapy

Systemic pharmacological treatment of digital ulcers in systemic sclerosis: a systematic literature review.
Ross L, Maltez N, Hughes M, Schoones JW, Baron M, Chung L, Giuggioli D, Moinzadeh P, Suliman YA, Campochiaro C, Allanore Y, Denton CP, Distler O, Frech T, Furst DE, Khanna D, Krieg T, Kuwana M, Matucci-Cerinic M, Pope J, Alunno A
Rheumatology (Oxford) 2023 Dec 1;62(12):3785-3800. doi: 10.1093/rheumatology/kead289. PMID: 37335850Free PMC Article
Filling in the Gaps of Scleroderma Ulcer Care: A Review.
Wagner KD, Woolridge K, Group A
Adv Skin Wound Care 2019 Dec;32(12):553-557. doi: 10.1097/01.ASW.0000582636.98643.3b. PMID: 31663924
Exploring the patient experience of digital ulcers in systemic sclerosis.
Hughes M, Pauling JD
Semin Arthritis Rheum 2019 Apr;48(5):888-894. Epub 2018 Aug 11 doi: 10.1016/j.semarthrit.2018.08.001. PMID: 30205981
Calcium channel blockers for primary Raynaud's phenomenon.
Ennis H, Hughes M, Anderson ME, Wilkinson J, Herrick AL
Cochrane Database Syst Rev 2016 Feb 25;2(2):CD002069. doi: 10.1002/14651858.CD002069.pub5. PMID: 26914257Free PMC Article
Efficacy of Raynaud's phenomenon and digital ulcer pharmacological treatment in systemic sclerosis patients: a systematic literature review.
García de la Peña Lefebvre P, Nishishinya MB, Pereda CA, Loza E, Sifuentes Giraldo WA, Román Ivorra JA, Carreira P, Rúa-Figueroa I, Pego-Reigosa JM, Muñoz-Fernández S
Rheumatol Int 2015 Sep;35(9):1447-59. Epub 2015 Apr 1 doi: 10.1007/s00296-015-3241-1. PMID: 25824427

Prognosis

MRI Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis: a prospective cohort study.
Hughes M, Di Donato S, Gjeloshi K, Abignano G, Danzo F, Lettieri G, De Lorenzis E, Bertham D, O'Connor P, Kubassova O, Dehmeshki J, Del Galdo F
Lancet Rheumatol 2023 Oct;5(10):e611-e621. Epub 2023 Sep 25 doi: 10.1016/S2665-9913(23)00189-3. PMID: 38251485
Machine learning for screening and predicting the risk of anti-MDA5 antibody in juvenile dermatomyositis children.
Xue Y, Zhang J, Li C, Liu X, Kuang W, Deng J, Wang J, Tan X, Li S, Li C
Front Immunol 2022;13:940802. Epub 2023 Jan 10 doi: 10.3389/fimmu.2022.940802. PMID: 36703989Free PMC Article
Filling in the Gaps of Scleroderma Ulcer Care: A Review.
Wagner KD, Woolridge K, Group A
Adv Skin Wound Care 2019 Dec;32(12):553-557. doi: 10.1097/01.ASW.0000582636.98643.3b. PMID: 31663924
Exploring the patient experience of digital ulcers in systemic sclerosis.
Hughes M, Pauling JD
Semin Arthritis Rheum 2019 Apr;48(5):888-894. Epub 2018 Aug 11 doi: 10.1016/j.semarthrit.2018.08.001. PMID: 30205981
A PRISMA-driven systematic review for predictive risk factors of digital ulcers in systemic sclerosis patients.
Silva I, Almeida J, Vasconcelos C
Autoimmun Rev 2015 Feb;14(2):140-52. Epub 2014 Oct 14 doi: 10.1016/j.autrev.2014.10.009. PMID: 25449678

Clinical prediction guides

MRI Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis: a prospective cohort study.
Hughes M, Di Donato S, Gjeloshi K, Abignano G, Danzo F, Lettieri G, De Lorenzis E, Bertham D, O'Connor P, Kubassova O, Dehmeshki J, Del Galdo F
Lancet Rheumatol 2023 Oct;5(10):e611-e621. Epub 2023 Sep 25 doi: 10.1016/S2665-9913(23)00189-3. PMID: 38251485
Systemic pharmacological treatment of digital ulcers in systemic sclerosis: a systematic literature review.
Ross L, Maltez N, Hughes M, Schoones JW, Baron M, Chung L, Giuggioli D, Moinzadeh P, Suliman YA, Campochiaro C, Allanore Y, Denton CP, Distler O, Frech T, Furst DE, Khanna D, Krieg T, Kuwana M, Matucci-Cerinic M, Pope J, Alunno A
Rheumatology (Oxford) 2023 Dec 1;62(12):3785-3800. doi: 10.1093/rheumatology/kead289. PMID: 37335850Free PMC Article
Are Digital Arthroplasty and Arthrodesis Useful and Safe Surgical Techniques for the Management of Patients with Diabetic Foot?
Tardáguila-García A, Sanz-Corbalán I, López-Moral M, García-Madrid M, García-Morales E, Lázaro-Martínez JL
Adv Skin Wound Care 2022 Jul 1;35(7):1-6. doi: 10.1097/01.ASW.0000831088.63458.d3. PMID: 35723960
Preliminary Validation of the Digital Ulcer Clinical Assessment Score in Systemic Sclerosis.
Bruni C, Ngcozana T, Braschi F, Pucci T, Piemonte G, Benelli L, Poli M, Suliman YA, Guiducci S, Bellando-Randone S, Balduzzi S, Grotts J, Denton CP, Rasero L, Montecucco C, Furst DE, Matucci-Cerinic M
J Rheumatol 2019 Jun;46(6):603-608. Epub 2018 Nov 15 doi: 10.3899/jrheum.171486. PMID: 30442833
Capillary density: An important parameter in nailfold capillaroscopy.
Emrani Z, Karbalaie A, Fatemi A, Etehadtavakol M, Erlandsson BE
Microvasc Res 2017 Jan;109:7-18. Epub 2016 Sep 7 doi: 10.1016/j.mvr.2016.09.001. PMID: 27614146

Recent systematic reviews

Systemic pharmacological treatment of digital ulcers in systemic sclerosis: a systematic literature review.
Ross L, Maltez N, Hughes M, Schoones JW, Baron M, Chung L, Giuggioli D, Moinzadeh P, Suliman YA, Campochiaro C, Allanore Y, Denton CP, Distler O, Frech T, Furst DE, Khanna D, Krieg T, Kuwana M, Matucci-Cerinic M, Pope J, Alunno A
Rheumatology (Oxford) 2023 Dec 1;62(12):3785-3800. doi: 10.1093/rheumatology/kead289. PMID: 37335850Free PMC Article
Prevalence and predictors of small intestinal bacterial overgrowth in systemic sclerosis: a systematic review and meta-analysis.
Feng X, Li XQ, Jiang Z
Clin Rheumatol 2021 Aug;40(8):3039-3051. Epub 2021 Jan 11 doi: 10.1007/s10067-020-05549-8. PMID: 33426631
Digital ulcer debridement in systemic sclerosis: a systematic literature review.
Hughes M, Alcacer-Pitarch B, Gheorghiu AM, Praino E, Sandler RD, Tavor Y, Bruni C, Matucci-Cerinic M
Clin Rheumatol 2020 Mar;39(3):805-811. Epub 2020 Jan 18 doi: 10.1007/s10067-019-04924-4. PMID: 31955323
Efficacy of Raynaud's phenomenon and digital ulcer pharmacological treatment in systemic sclerosis patients: a systematic literature review.
García de la Peña Lefebvre P, Nishishinya MB, Pereda CA, Loza E, Sifuentes Giraldo WA, Román Ivorra JA, Carreira P, Rúa-Figueroa I, Pego-Reigosa JM, Muñoz-Fernández S
Rheumatol Int 2015 Sep;35(9):1447-59. Epub 2015 Apr 1 doi: 10.1007/s00296-015-3241-1. PMID: 25824427
Scleroderma and evidence based non-pharmaceutical treatment modalities for digital ulcers: a systematic review.
Moran ME
J Wound Care 2014 Oct;23(10):510-6. doi: 10.12968/jowc.2014.23.10.510. PMID: 25296352

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...