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Isolated systolic hypertension

MedGen UID:
1630966
•Concept ID:
C0745133
•
Disease or Syndrome
Synonyms: Hypertension, Isolated Systolic; Isolated Systolic Hypertension; Isolated Systolic Hypertensions; Systolic Hypertension, Isolated
 
HPO: HP:0500106

Definition

Elevated systolic blood pressure without an elevated blood pressure. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Isolated systolic hypertension

Professional guidelines

PubMed

Treatment strategies for isolated systolic hypertension in elderly patients.
Angeli F, Verdecchia P, Masnaghetti S, Vaudo G, Reboldi G
Expert Opin Pharmacother 2020 Oct;21(14):1713-1723. Epub 2020 Jun 25 doi: 10.1080/14656566.2020.1781092. PMID: 32584617
Management of hypertension in older people.
Abdelhafiz AH, Marshall R, Kavanagh J, El-Nahas M
Expert Rev Endocrinol Metab 2018 Jul;13(4):181-191. Epub 2018 Jul 23 doi: 10.1080/17446651.2018.1500893. PMID: 30063423
Drug treatment of isolated systolic hypertension.
van Zwieten PA
Nephrol Dial Transplant 2001 Jun;16(6):1095-7. doi: 10.1093/ndt/16.6.1095. PMID: 11390702

Recent clinical studies

Etiology

Isolated systolic hypertension in Asia.
Tsai TY, Cheng HM, Chuang SY, Chia YC, Soenarta AA, Minh HV, Siddique S, Turana Y, Tay JC, Kario K, Chen CH
J Clin Hypertens (Greenwich) 2021 Mar;23(3):467-474. Epub 2020 Nov 29 doi: 10.1111/jch.14111. PMID: 33249701Free PMC Article
Treatment strategies for isolated systolic hypertension in elderly patients.
Angeli F, Verdecchia P, Masnaghetti S, Vaudo G, Reboldi G
Expert Opin Pharmacother 2020 Oct;21(14):1713-1723. Epub 2020 Jun 25 doi: 10.1080/14656566.2020.1781092. PMID: 32584617
What is the most important component of blood pressure: systolic, diastolic or pulse pressure?
Strandberg TE, Pitkala K
Curr Opin Nephrol Hypertens 2003 May;12(3):293-7. doi: 10.1097/00041552-200305000-00011. PMID: 12698068
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
JAMA 1991 Jun 26;265(24):3255-64. PMID: 2046107
Geriatric hypertension.
Franklin SS
Med Clin North Am 1983 Mar;67(2):395-417. doi: 10.1016/s0025-7125(16)31211-1. PMID: 6338322

Diagnosis

Isolated systolic hypertension of the young and sodium intake.
D'Elia L, Strazzullo P
Minerva Med 2022 Oct;113(5):788-797. Epub 2021 Sep 29 doi: 10.23736/S0026-4806.21.07740-5. PMID: 34586768
Isolated systolic hypertension in Asia.
Tsai TY, Cheng HM, Chuang SY, Chia YC, Soenarta AA, Minh HV, Siddique S, Turana Y, Tay JC, Kario K, Chen CH
J Clin Hypertens (Greenwich) 2021 Mar;23(3):467-474. Epub 2020 Nov 29 doi: 10.1111/jch.14111. PMID: 33249701Free PMC Article
Hypertension and Organ Damage in Women.
Muiesan ML, Paini A, Aggiusti C, Bertacchini F, Rosei CA, Salvetti M
High Blood Press Cardiovasc Prev 2018 Sep;25(3):245-252. Epub 2018 Jun 26 doi: 10.1007/s40292-018-0265-0. PMID: 29943358
Diagnostic and therapeutic problems of isolated systolic hypertension.
Mancia G, Giannattasio C
J Hypertens 2015 Jan;33(1):33-43. doi: 10.1097/HJH.0000000000000424. PMID: 25426565
Hypertension in aging patients.
Logan AG
Expert Rev Cardiovasc Ther 2011 Jan;9(1):113-20. doi: 10.1586/erc.10.171. PMID: 21166533

Therapy

Isolated systolic hypertension of the young and sodium intake.
D'Elia L, Strazzullo P
Minerva Med 2022 Oct;113(5):788-797. Epub 2021 Sep 29 doi: 10.23736/S0026-4806.21.07740-5. PMID: 34586768
Treatment strategies for isolated systolic hypertension in elderly patients.
Angeli F, Verdecchia P, Masnaghetti S, Vaudo G, Reboldi G
Expert Opin Pharmacother 2020 Oct;21(14):1713-1723. Epub 2020 Jun 25 doi: 10.1080/14656566.2020.1781092. PMID: 32584617
Isolated Systolic Hypertension: An Update After SPRINT.
Bavishi C, Goel S, Messerli FH
Am J Med 2016 Dec;129(12):1251-1258. Epub 2016 Sep 14 doi: 10.1016/j.amjmed.2016.08.032. PMID: 27639873
Diagnostic and therapeutic problems of isolated systolic hypertension.
Mancia G, Giannattasio C
J Hypertens 2015 Jan;33(1):33-43. doi: 10.1097/HJH.0000000000000424. PMID: 25426565
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
JAMA 1991 Jun 26;265(24):3255-64. PMID: 2046107

Prognosis

Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review.
Chirinos JA, Segers P, Hughes T, Townsend R
J Am Coll Cardiol 2019 Sep 3;74(9):1237-1263. doi: 10.1016/j.jacc.2019.07.012. PMID: 31466622Free PMC Article
Excess Body Weight, Insulin Resistance and Isolated Systolic Hypertension: Potential Pathophysiological Links.
D'Elia L, Strazzullo P
High Blood Press Cardiovasc Prev 2018 Mar;25(1):17-23. Epub 2017 Nov 2 doi: 10.1007/s40292-017-0240-1. PMID: 29098651
What is the most important component of blood pressure: systolic, diastolic or pulse pressure?
Strandberg TE, Pitkala K
Curr Opin Nephrol Hypertens 2003 May;12(3):293-7. doi: 10.1097/00041552-200305000-00011. PMID: 12698068
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
JAMA 1991 Jun 26;265(24):3255-64. PMID: 2046107
Geriatric hypertension.
Franklin SS
Med Clin North Am 1983 Mar;67(2):395-417. doi: 10.1016/s0025-7125(16)31211-1. PMID: 6338322

Clinical prediction guides

Vascular function: a key player in hypertension.
Tomiyama H
Hypertens Res 2023 Sep;46(9):2145-2158. Epub 2023 Jun 27 doi: 10.1038/s41440-023-01354-3. PMID: 37369849
Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review.
Chirinos JA, Segers P, Hughes T, Townsend R
J Am Coll Cardiol 2019 Sep 3;74(9):1237-1263. doi: 10.1016/j.jacc.2019.07.012. PMID: 31466622Free PMC Article
Hypertension and Organ Damage in Women.
Muiesan ML, Paini A, Aggiusti C, Bertacchini F, Rosei CA, Salvetti M
High Blood Press Cardiovasc Prev 2018 Sep;25(3):245-252. Epub 2018 Jun 26 doi: 10.1007/s40292-018-0265-0. PMID: 29943358
Isolated Systolic Hypertension in Young Individuals: Pathophysiological Mechanisms, Prognostic Significance, and Clinical Implications.
Saladini F, Palatini P
High Blood Press Cardiovasc Prev 2017 Jun;24(2):133-139. Epub 2017 Apr 3 doi: 10.1007/s40292-017-0199-y. PMID: 28374153
What is the most important component of blood pressure: systolic, diastolic or pulse pressure?
Strandberg TE, Pitkala K
Curr Opin Nephrol Hypertens 2003 May;12(3):293-7. doi: 10.1097/00041552-200305000-00011. PMID: 12698068

Recent systematic reviews

Effect of antihypertensive treatment in isolated systolic hypertension (ISH) - systematic review and meta-analysis of randomised controlled trials.
Brunström M, Carlberg B, Kjeldsen SE
Blood Press 2023 Dec;32(1):2226757. doi: 10.1080/08037051.2023.2226757. PMID: 37395100
Treatment strategies for isolated systolic hypertension in elderly patients.
Angeli F, Verdecchia P, Masnaghetti S, Vaudo G, Reboldi G
Expert Opin Pharmacother 2020 Oct;21(14):1713-1723. Epub 2020 Jun 25 doi: 10.1080/14656566.2020.1781092. PMID: 32584617
Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis.
Cao Y, Liu LT, Wu M
Chin J Integr Med 2017 Apr;23(4):298-305. Epub 2016 May 25 doi: 10.1007/s11655-016-2257-z. PMID: 27225294
Pharmacotherapy for hypertension in the elderly.
Musini VM, Tejani AM, Bassett K, Wright JM
Cochrane Database Syst Rev 2009 Oct 7;(4):CD000028. doi: 10.1002/14651858.CD000028.pub2. PMID: 19821263
Pharmacotherapy for hypertension in the elderly.
Mulrow C, Lau J, Cornell J, Brand M
Cochrane Database Syst Rev 2000;(2):CD000028. doi: 10.1002/14651858.CD000028. PMID: 10796688

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