U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Functioning pituitary gland adenoma

MedGen UID:
163135
•Concept ID:
C0854486
•
Neoplastic Process
Synonyms: Endocrine active pituitary adenoma; endocrine active pituitary adenoma; Functioning Adenoma of Pituitary; functioning adenoma of pituitary; Functioning Adenoma of Pituitary Gland; functioning adenoma of pituitary gland; Functioning Adenoma of the Pituitary; functioning adenoma of the pituitary; Functioning Adenoma of the Pituitary Gland; functioning adenoma of the pituitary gland; Functioning PitNET/Adenoma; Functioning Pituitary Adenoma; functioning pituitary adenoma; Functioning pituitary adenoma; Functioning Pituitary Gland Adenoma; functioning pituitary gland adenoma; functioning pituitary gland adenoma (benign); Functioning Pituitary Neuroendocrine Tumor; Functioning Pituitary Neuroendocrine Tumor/Adenoma; Secreting pituitary adenoma; secreting pituitary adenoma; Secretory Adenoma of Pituitary; secretory adenoma of pituitary; Secretory Adenoma of Pituitary Gland; secretory adenoma of pituitary gland; Secretory Adenoma of the Pituitary; secretory adenoma of the pituitary; Secretory Adenoma of the Pituitary Gland; secretory adenoma of the pituitary gland; Secretory Pituitary Adenoma; secretory pituitary adenoma; Secretory Pituitary Gland Adenoma; secretory pituitary gland adenoma
 
Monarch Initiative: MONDO:0003429
Orphanet: ORPHA314753

Definition

A hormone producing pituitary neuroendocrine tumor associated with a hormonal syndrome. [from NCI]

Professional guidelines

PubMed

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
A Pituitary Society update to acromegaly management guidelines.
Fleseriu M, Biller BMK, Freda PU, Gadelha MR, Giustina A, Katznelson L, Molitch ME, Samson SL, Strasburger CJ, van der Lely AJ, Melmed S
Pituitary 2021 Feb;24(1):1-13. Epub 2020 Oct 20 doi: 10.1007/s11102-020-01091-7. PMID: 33079318Free PMC Article

Recent clinical studies

Etiology

Clinically non-functioning pituitary adenomas.
Chanson P, Wolf P
Presse Med 2021 Dec;50(4):104086. Epub 2021 Oct 28 doi: 10.1016/j.lpm.2021.104086. PMID: 34718111
ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy.
Luger A, Broersen LHA, Biermasz NR, Biller BMK, Buchfelder M, Chanson P, Jorgensen JOL, Kelestimur F, Llahana S, Maiter D, Mintziori G, Petraglia F, Verkauskiene R, Webb SM, Dekkers OM
Eur J Endocrinol 2021 Aug 23;185(3):G1-G33. doi: 10.1530/EJE-21-0462. PMID: 34425558
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline.
Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO, Tabarin A; Endocrine Society
J Clin Endocrinol Metab 2015 Aug;100(8):2807-31. Epub 2015 Jul 29 doi: 10.1210/jc.2015-1818. PMID: 26222757Free PMC Article

Diagnosis

Pituitary Apoplexy: Risk Factors and Underlying Molecular Mechanisms.
Biagetti B, Simò R
Int J Mol Sci 2022 Aug 5;23(15) doi: 10.3390/ijms23158721. PMID: 35955859Free PMC Article
What to Do with Incidentally Discovered Pituitary Abnormalities?
Langlois F, Fleseriu M
Med Clin North Am 2021 Nov;105(6):1081-1098. Epub 2021 Sep 9 doi: 10.1016/j.mcna.2021.05.015. PMID: 34688416
ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy.
Luger A, Broersen LHA, Biermasz NR, Biller BMK, Buchfelder M, Chanson P, Jorgensen JOL, Kelestimur F, Llahana S, Maiter D, Mintziori G, Petraglia F, Verkauskiene R, Webb SM, Dekkers OM
Eur J Endocrinol 2021 Aug 23;185(3):G1-G33. doi: 10.1530/EJE-21-0462. PMID: 34425558
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Pituitary adenomas: an overview.
Lake MG, Krook LS, Cruz SV
Am Fam Physician 2013 Sep 1;88(5):319-27. PMID: 24010395

Therapy

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
The Progress of Immunotherapy in Refractory Pituitary Adenomas and Pituitary Carcinomas.
Dai C, Liang S, Sun B, Kang J
Front Endocrinol (Lausanne) 2020;11:608422. Epub 2020 Dec 11 doi: 10.3389/fendo.2020.608422. PMID: 33362722Free PMC Article
Use of radiotherapy after pituitary surgery for non-functioning pituitary adenomas.
Chanson P, Dormoy A, Dekkers OM
Eur J Endocrinol 2019 Jul;181(1):D1-D13. doi: 10.1530/EJE-19-0058. PMID: 31048560
Giant pituitary adenoma: histological types, clinical features and therapeutic approaches.
Iglesias P, Rodríguez Berrocal V, Díez JJ
Endocrine 2018 Sep;61(3):407-421. Epub 2018 Jun 16 doi: 10.1007/s12020-018-1645-x. PMID: 29909598
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067

Prognosis

Clinically non-functioning pituitary adenomas.
Chanson P, Wolf P
Presse Med 2021 Dec;50(4):104086. Epub 2021 Oct 28 doi: 10.1016/j.lpm.2021.104086. PMID: 34718111
What to Do with Incidentally Discovered Pituitary Abnormalities?
Langlois F, Fleseriu M
Med Clin North Am 2021 Nov;105(6):1081-1098. Epub 2021 Sep 9 doi: 10.1016/j.mcna.2021.05.015. PMID: 34688416
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
The 2017 World Health Organization classification of tumors of the pituitary gland: a summary.
Lopes MBS
Acta Neuropathol 2017 Oct;134(4):521-535. Epub 2017 Aug 18 doi: 10.1007/s00401-017-1769-8. PMID: 28821944

Clinical prediction guides

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Clinically non-functioning pituitary adenomas.
Chanson P, Wolf P
Presse Med 2021 Dec;50(4):104086. Epub 2021 Oct 28 doi: 10.1016/j.lpm.2021.104086. PMID: 34718111
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Pituitary adenomas: an overview.
Lake MG, Krook LS, Cruz SV
Am Fam Physician 2013 Sep 1;88(5):319-27. PMID: 24010395

Recent systematic reviews

Treatment of non-functioning pituitary adenoma with cabergoline: a systematic review and meta-analysis.
Botelho MS, Franzini ÍA, Nunes-Nogueira VDS, Boguszewski CL
Pituitary 2022 Dec;25(6):810-818. Epub 2022 Jul 28 doi: 10.1007/s11102-022-01257-5. PMID: 35902444
Surgery as a Viable Alternative First-Line Treatment for Prolactinoma Patients. A Systematic Review and Meta-Analysis.
Zamanipoor Najafabadi AH, Zandbergen IM, de Vries F, Broersen LHA, van den Akker-van Marle ME, Pereira AM, Peul WC, Dekkers OM, van Furth WR, Biermasz NR
J Clin Endocrinol Metab 2020 Mar 1;105(3):e32-41. doi: 10.1210/clinem/dgz144. PMID: 31665485Free PMC Article
Primary tumors of the posterior pituitary: A systematic review.
Guerrero-Pérez F, Marengo AP, Vidal N, Iglesias P, Villabona C
Rev Endocr Metab Disord 2019 Jun;20(2):219-238. doi: 10.1007/s11154-019-09484-1. PMID: 30864049
Plurihormonal ACTH-GH Pituitary Adenoma: Case Report and Systematic Literature Review.
Roca E, Mattogno PP, Porcelli T, Poliani L, Belotti F, Schreiber A, Maffezzoni F, Fontanella MM, Doglietto F
World Neurosurg 2018 Jun;114:e158-e164. Epub 2018 Mar 6 doi: 10.1016/j.wneu.2018.02.120. PMID: 29501516
Headache and pituitary disease: a systematic review.
Kreitschmann-Andermahr I, Siegel S, Weber Carneiro R, Maubach JM, Harbeck B, Brabant G
Clin Endocrinol (Oxf) 2013 Dec;79(6):760-9. Epub 2013 Sep 20 doi: 10.1111/cen.12314. PMID: 23941570

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...