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Urine xenobiotic

MedGen UID:
1631449
•Concept ID:
C4703569
•
Finding
HPO: HP:0031840

Definition

The presence of a xenobiotic in urine. [from HPO]

Professional guidelines

PubMed

Occupational risk assessment of exposure to metals in chrome plating workers.
Muller CD, Garcia SC, Brucker N, Goethel G, Sauer E, Lacerda LM, Oliveira E, Trombini TL, Machado AB, Pressotto A, Rech VC, Klauck CR, Basso da Silva L, Gioda A, Feksa LR
Drug Chem Toxicol 2022 Mar;45(2):560-567. Epub 2020 Feb 27 doi: 10.1080/01480545.2020.1731527. PMID: 32106715
Advances in drug metabolism and pharmacogenetics research in Australia.
Mackenzie PI, Somogyi AA, Miners JO
Pharmacol Res 2017 Feb;116:7-19. Epub 2016 Dec 9 doi: 10.1016/j.phrs.2016.12.008. PMID: 27956261
Metabonomic applications in toxicity screening and disease diagnosis.
Shockcor JP, Holmes E
Curr Top Med Chem 2002 Jan;2(1):35-51. doi: 10.2174/1568026023394498. PMID: 11899064

Recent clinical studies

Etiology

Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: Comparison of three statistical models.
Zhang Y, Dong T, Hu W, Wang X, Xu B, Lin Z, Hofer T, Stefanoff P, Chen Y, Wang X, Xia Y
Environ Int 2019 Feb;123:325-336. Epub 2018 Dec 14 doi: 10.1016/j.envint.2018.11.076. PMID: 30557812
Xenobiotic Conjugation with Dicarboxylic Acids.
Mitchell SC, Steventon GB
Curr Drug Metab 2018;19(13):1130-1137. doi: 10.2174/1389200219666180803142233. PMID: 30073923
Toxico-/biokinetics of nanomaterials.
Landsiedel R, Fabian E, Ma-Hock L, van Ravenzwaay B, Wohlleben W, Wiench K, Oesch F
Arch Toxicol 2012 Jul;86(7):1021-60. Epub 2012 May 11 doi: 10.1007/s00204-012-0858-7. PMID: 22576463
NMR-based metabolomics.
Reo NV
Drug Chem Toxicol 2002 Nov;25(4):375-82. doi: 10.1081/dct-120014789. PMID: 12378948
Detoxification pathways in the liver.
Grant DM
J Inherit Metab Dis 1991;14(4):421-30. doi: 10.1007/BF01797915. PMID: 1749210

Diagnosis

Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in Female ME/CFS Patients.
Glass KA, Germain A, Huang YV, Hanson MR
Int J Mol Sci 2023 Feb 12;24(4) doi: 10.3390/ijms24043685. PMID: 36835097Free PMC Article
Alternative matrices in forensic toxicology: a critical review.
de Campos EG, da Costa BRB, Dos Santos FS, Monedeiro F, Alves MNR, Santos Junior WJR, De Martinis BS
Forensic Toxicol 2022 Jan;40(1):1-18. Epub 2021 Aug 19 doi: 10.1007/s11419-021-00596-5. PMID: 36454488Free PMC Article
Paper spray ionization mass spectrometry: recent advances and clinical applications.
Chiang S, Zhang W, Ouyang Z
Expert Rev Proteomics 2018 Oct;15(10):781-789. Epub 2018 Sep 26 doi: 10.1080/14789450.2018.1525295. PMID: 30223684Free PMC Article
Glutathione S - transferases class Pi and Mi and their significance in oncology.
Marchewka Z, Piwowar A, Ruzik S, Długosz A
Postepy Hig Med Dosw (Online) 2017 Jun 19;71(0):541-550. doi: 10.5604/01.3001.0010.3835. PMID: 28665283
Toxic nephropathy: environmental chemicals.
Van Vleet TR, Schnellmann RG
Semin Nephrol 2003 Sep;23(5):500-8. doi: 10.1016/s0270-9295(03)00094-9. PMID: 13680539

Therapy

Environmental exposure of the general population to cadmium as a risk factor of the damage to the nervous system: A critical review of current data.
Ruczaj A, Brzóska MM
J Appl Toxicol 2023 Jan;43(1):66-88. Epub 2022 Apr 1 doi: 10.1002/jat.4322. PMID: 35304765Free PMC Article
Percutaneous Absorption of Sunscreen Filters: Review of Issues and Challenges.
Surber C, Plautz J, Sohn M, Maibach HI
Curr Probl Dermatol 2021;55:188-202. Epub 2021 Oct 25 doi: 10.1159/000517595. PMID: 34698027
Complexation of Bioelements and Toxic Metals by Polyphenolic Compounds - Implications for Health.
Borowska S, Brzoska MM, Tomczyk M
Curr Drug Targets 2018;19(14):1612-1638. doi: 10.2174/1389450119666180403101555. PMID: 29611487
Toxico-/biokinetics of nanomaterials.
Landsiedel R, Fabian E, Ma-Hock L, van Ravenzwaay B, Wohlleben W, Wiench K, Oesch F
Arch Toxicol 2012 Jul;86(7):1021-60. Epub 2012 May 11 doi: 10.1007/s00204-012-0858-7. PMID: 22576463
Toxic nephropathy: environmental chemicals.
Van Vleet TR, Schnellmann RG
Semin Nephrol 2003 Sep;23(5):500-8. doi: 10.1016/s0270-9295(03)00094-9. PMID: 13680539

Prognosis

Drug toxicity in the proximal tubule: new models, methods and mechanisms.
Hall AM, Trepiccione F, Unwin RJ
Pediatr Nephrol 2022 May;37(5):973-982. Epub 2021 May 28 doi: 10.1007/s00467-021-05121-9. PMID: 34050397Free PMC Article
3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans.
Vermillion Maier ML, Siddens LK, Uesugi SL, Choi J, Leonard SW, Pennington JM, Tilton SC, Smith JN, Ho E, Chow HHS, Nguyen BD, Kolluri SK, Williams DE
Drug Metab Dispos 2021 Aug;49(8):694-705. Epub 2021 May 25 doi: 10.1124/dmd.120.000346. PMID: 34035125Free PMC Article
Is It Realistic to Propose Determination of a Lifetime Internal Exposome?
Sabbioni G, Berset JD, Day BW
Chem Res Toxicol 2020 Aug 17;33(8):2010-2021. Epub 2020 Jul 16 doi: 10.1021/acs.chemrestox.0c00092. PMID: 32672951
Advances in drug metabolism and pharmacogenetics research in Australia.
Mackenzie PI, Somogyi AA, Miners JO
Pharmacol Res 2017 Feb;116:7-19. Epub 2016 Dec 9 doi: 10.1016/j.phrs.2016.12.008. PMID: 27956261
Interplay of Breast Cancer Resistance Protein (BCRP) and Metabolizing Enzymes.
Tian Y, Bian Y, Jiang Y, Qian S, Yu A, Zeng S
Curr Drug Metab 2015;16(10):877-93. doi: 10.2174/138920021610151210184205. PMID: 26652256

Clinical prediction guides

Is It Realistic to Propose Determination of a Lifetime Internal Exposome?
Sabbioni G, Berset JD, Day BW
Chem Res Toxicol 2020 Aug 17;33(8):2010-2021. Epub 2020 Jul 16 doi: 10.1021/acs.chemrestox.0c00092. PMID: 32672951
Xenobiotic Conjugation with Dicarboxylic Acids.
Mitchell SC, Steventon GB
Curr Drug Metab 2018;19(13):1130-1137. doi: 10.2174/1389200219666180803142233. PMID: 30073923
Advances in drug metabolism and pharmacogenetics research in Australia.
Mackenzie PI, Somogyi AA, Miners JO
Pharmacol Res 2017 Feb;116:7-19. Epub 2016 Dec 9 doi: 10.1016/j.phrs.2016.12.008. PMID: 27956261
Toxicology of decamethylcyclopentasiloxane (D5).
Dekant W, Klaunig JE
Regul Toxicol Pharmacol 2016 Feb;74 Suppl:S67-76. Epub 2015 Jun 22 doi: 10.1016/j.yrtph.2015.06.011. PMID: 26111607
Toxico-/biokinetics of nanomaterials.
Landsiedel R, Fabian E, Ma-Hock L, van Ravenzwaay B, Wohlleben W, Wiench K, Oesch F
Arch Toxicol 2012 Jul;86(7):1021-60. Epub 2012 May 11 doi: 10.1007/s00204-012-0858-7. PMID: 22576463

Recent systematic reviews

Toxic implications of silver nanoparticles on the central nervous system: A systematic literature review.
Suthar JK, Vaidya A, Ravindran S
J Appl Toxicol 2023 Jan;43(1):4-21. Epub 2022 Mar 23 doi: 10.1002/jat.4317. PMID: 35285037
Urinary 8-isoprostane as a biomarker for oxidative stress. A systematic review and meta-analysis.
Graille M, Wild P, Sauvain JJ, Hemmendinger M, Guseva Canu I, Hopf NB
Toxicol Lett 2020 Aug 1;328:19-27. Epub 2020 Apr 19 doi: 10.1016/j.toxlet.2020.04.006. PMID: 32320775
The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis.
Bonde JP, Flachs EM, Rimborg S, Glazer CH, Giwercman A, Ramlau-Hansen CH, Hougaard KS, Høyer BB, Hærvig KK, Petersen SB, Rylander L, Specht IO, Toft G, Bräuner EV
Hum Reprod Update 2016 Dec;23(1):104-125. Epub 2016 Sep 21 doi: 10.1093/humupd/dmw036. PMID: 27655588Free PMC Article

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