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Unresectable Malignant Liver Neoplasm

MedGen UID:
163147
•Concept ID:
C0854793
•
Neoplastic Process
Synonyms: Non-Resectable Hepatic Malignant Neoplasm; Non-Resectable Malignant Liver Neoplasm; Non-Resectable Malignant Neoplasm of Liver

Definition

A malignant liver neoplasm that is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Management of Hepatocellular Carcinoma: A Review.
Brown ZJ, Tsilimigras DI, Ruff SM, Mohseni A, Kamel IR, Cloyd JM, Pawlik TM
JAMA Surg 2023 Apr 1;158(4):410-420. doi: 10.1001/jamasurg.2022.7989. PMID: 36790767
Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, D'Angelica MI, Abbott DE, Anaya DA, Anders R, Are C, Bachini M, Borad M, Brown D, Burgoyne A, Chahal P, Chang DT, Cloyd J, Covey AM, Glazer ES, Goyal L, Hawkins WG, Iyer R, Jacob R, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Sahai V, Schefter T, Singh G, Stein S, Vauthey JN, Venook AP, Yopp A, McMillian NR, Hochstetler C, Darlow SD
J Natl Compr Canc Netw 2021 May 1;19(5):541-565. doi: 10.6004/jnccn.2021.0022. PMID: 34030131
Yttrium-90 Radioembolization for the Treatment of Solitary, Unresectable HCC: The LEGACY Study.
Salem R, Johnson GE, Kim E, Riaz A, Bishay V, Boucher E, Fowers K, Lewandowski R, Padia SA
Hepatology 2021 Nov;74(5):2342-2352. Epub 2021 Jun 11 doi: 10.1002/hep.31819. PMID: 33739462Free PMC Article

Recent clinical studies

Etiology

Management of Hepatocellular Carcinoma: A Review.
Brown ZJ, Tsilimigras DI, Ruff SM, Mohseni A, Kamel IR, Cloyd JM, Pawlik TM
JAMA Surg 2023 Apr 1;158(4):410-420. doi: 10.1001/jamasurg.2022.7989. PMID: 36790767
Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification.
Chidambaranathan-Reghupaty S, Fisher PB, Sarkar D
Adv Cancer Res 2021;149:1-61. Epub 2020 Nov 28 doi: 10.1016/bs.acr.2020.10.001. PMID: 33579421Free PMC Article
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Transplantation for cholangiocarcinoma.
Masuoka HC, Rosen CB
Clin Liver Dis 2011 Nov;15(4):699-715. doi: 10.1016/j.cld.2011.08.004. PMID: 22032524
Hepatocellular carcinoma.
Llovet JM, Burroughs A, Bruix J
Lancet 2003 Dec 6;362(9399):1907-17. doi: 10.1016/S0140-6736(03)14964-1. PMID: 14667750

Diagnosis

Management of Hepatocellular Carcinoma: A Review.
Brown ZJ, Tsilimigras DI, Ruff SM, Mohseni A, Kamel IR, Cloyd JM, Pawlik TM
JAMA Surg 2023 Apr 1;158(4):410-420. doi: 10.1001/jamasurg.2022.7989. PMID: 36790767
Conversion therapy and maintenance therapy for primary hepatocellular carcinoma.
Zhou H, Song T
Biosci Trends 2021 Jul 6;15(3):155-160. Epub 2021 May 27 doi: 10.5582/bst.2021.01091. PMID: 34039818
Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, D'Angelica MI, Abbott DE, Anaya DA, Anders R, Are C, Bachini M, Borad M, Brown D, Burgoyne A, Chahal P, Chang DT, Cloyd J, Covey AM, Glazer ES, Goyal L, Hawkins WG, Iyer R, Jacob R, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Sahai V, Schefter T, Singh G, Stein S, Vauthey JN, Venook AP, Yopp A, McMillian NR, Hochstetler C, Darlow SD
J Natl Compr Canc Netw 2021 May 1;19(5):541-565. doi: 10.6004/jnccn.2021.0022. PMID: 34030131
Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification.
Chidambaranathan-Reghupaty S, Fisher PB, Sarkar D
Adv Cancer Res 2021;149:1-61. Epub 2020 Nov 28 doi: 10.1016/bs.acr.2020.10.001. PMID: 33579421Free PMC Article
Goals and targets for personalized therapy for HCC.
Couri T, Pillai A
Hepatol Int 2019 Mar;13(2):125-137. Epub 2019 Jan 1 doi: 10.1007/s12072-018-9919-1. PMID: 30600478

Therapy

Cisplatin in Liver Cancer Therapy.
Hamaya S, Oura K, Morishita A, Masaki T
Int J Mol Sci 2023 Jun 29;24(13) doi: 10.3390/ijms241310858. PMID: 37446035Free PMC Article
Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma.
Zhu AX, Abbas AR, de Galarreta MR, Guan Y, Lu S, Koeppen H, Zhang W, Hsu CH, He AR, Ryoo BY, Yau T, Kaseb AO, Burgoyne AM, Dayyani F, Spahn J, Verret W, Finn RS, Toh HC, Lujambio A, Wang Y
Nat Med 2022 Aug;28(8):1599-1611. Epub 2022 Jun 23 doi: 10.1038/s41591-022-01868-2. PMID: 35739268
Regional Therapy for Colorectal Cancer Liver Metastases: Which Modality and When?
Raphael MJ, Karanicolas PJ
J Clin Oncol 2022 Aug 20;40(24):2806-2817. Epub 2022 Jun 1 doi: 10.1200/JCO.21.02505. PMID: 35649228
IMbrave 050: a Phase III trial of atezolizumab plus bevacizumab in high-risk hepatocellular carcinoma after curative resection or ablation.
Hack SP, Spahn J, Chen M, Cheng AL, Kaseb A, Kudo M, Lee HC, Yopp A, Chow P, Qin S
Future Oncol 2020 May;16(15):975-989. Epub 2020 Apr 30 doi: 10.2217/fon-2020-0162. PMID: 32352320
Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus.
Adam R, de Gramont A, Figueras J, Kokudo N, Kunstlinger F, Loyer E, Poston G, Rougier P, Rubbia-Brandt L, Sobrero A, Teh C, Tejpar S, Van Cutsem E, Vauthey JN, Påhlman L; of the EGOSLIM (Expert Group on OncoSurgery management of LIver Metastases) group
Cancer Treat Rev 2015 Nov;41(9):729-41. Epub 2015 Jun 30 doi: 10.1016/j.ctrv.2015.06.006. PMID: 26417845

Prognosis

Gut microbiome is associated with the clinical response to anti-PD-1 based immunotherapy in hepatobiliary cancers.
Mao J, Wang D, Long J, Yang X, Lin J, Song Y, Xie F, Xun Z, Wang Y, Wang Y, Li Y, Sun H, Xue J, Song Y, Zuo B, Zhang J, Bian J, Zhang T, Yang X, Zhang L, Sang X, Zhao H
J Immunother Cancer 2021 Dec;9(12) doi: 10.1136/jitc-2021-003334. PMID: 34873013Free PMC Article
Conversion therapy and maintenance therapy for primary hepatocellular carcinoma.
Zhou H, Song T
Biosci Trends 2021 Jul 6;15(3):155-160. Epub 2021 May 27 doi: 10.5582/bst.2021.01091. PMID: 34039818
Liver transplantation for unresectable neuroendocrine tumor liver metastases.
Rossi RE, Burroughs AK, Caplin ME
Ann Surg Oncol 2014 Jul;21(7):2398-405. Epub 2014 Feb 22 doi: 10.1245/s10434-014-3523-y. PMID: 24562931
Transplantation for cholangiocarcinoma.
Masuoka HC, Rosen CB
Clin Liver Dis 2011 Nov;15(4):699-715. doi: 10.1016/j.cld.2011.08.004. PMID: 22032524
Hepatocellular carcinoma.
Llovet JM, Burroughs A, Bruix J
Lancet 2003 Dec 6;362(9399):1907-17. doi: 10.1016/S0140-6736(03)14964-1. PMID: 14667750

Clinical prediction guides

Management of Hepatocellular Carcinoma: A Review.
Brown ZJ, Tsilimigras DI, Ruff SM, Mohseni A, Kamel IR, Cloyd JM, Pawlik TM
JAMA Surg 2023 Apr 1;158(4):410-420. doi: 10.1001/jamasurg.2022.7989. PMID: 36790767
Exposure-Response Analyses of Tremelimumab Monotherapy or in Combination with Durvalumab in Patients with Unresectable Hepatocellular Carcinoma.
Song X, Kelley RK, Khan AA, Standifer N, Zhou D, Lim K, Krishna R, Liu L, Wang K, McCoon P, Negro A, He P, Gibbs M, Kurland JF, Abou-Alfa GK
Clin Cancer Res 2023 Feb 16;29(4):754-763. doi: 10.1158/1078-0432.CCR-22-1983. PMID: 36477555Free PMC Article
Radiation segmentectomy for curative intent of unresectable very early to early stage hepatocellular carcinoma (RASER): a single-centre, single-arm study.
Kim E, Sher A, Abboud G, Schwartz M, Facciuto M, Tabrizian P, Knešaurek K, Fischman A, Patel R, Nowakowski S, Llovet J, Taouli B, Lookstein R
Lancet Gastroenterol Hepatol 2022 Sep;7(9):843-850. Epub 2022 May 23 doi: 10.1016/S2468-1253(22)00091-7. PMID: 35617978
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Role of Hepatic Artery Infusion Chemotherapy in Treatment of Initially Unresectable Colorectal Liver Metastases: A Review.
Datta J, Narayan RR, Kemeny NE, D'Angelica MI
JAMA Surg 2019 Aug 1;154(8):768-776. doi: 10.1001/jamasurg.2019.1694. PMID: 31188415

Recent systematic reviews

Management of neuroendocrine tumor liver metastases.
Harrelson A, Wang R, Stewart A, Ingram C, Gillis A, Rose JB, El-Rayes B, Azmi A, Chen H
Am J Surg 2023 Nov;226(5):623-630. Epub 2023 Aug 16 doi: 10.1016/j.amjsurg.2023.08.011. PMID: 37657968
Treatment of Metastatic Colorectal Cancer: ASCO Guideline.
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
A contemporary systematic review on liver transplantation for unresectable liver metastases of colorectal cancer.
Lebeck Lee CM, Ziogas IA, Agarwal R, Alexopoulos SP, Ciombor KK, Matsuoka LK, Brown DB, Eng C
Cancer 2022 Jun 15;128(12):2243-2257. Epub 2022 Mar 14 doi: 10.1002/cncr.34170. PMID: 35285949Free PMC Article
External Beam Radiation Therapy for Primary Liver Cancers: An ASTRO Clinical Practice Guideline.
Apisarnthanarax S, Barry A, Cao M, Czito B, DeMatteo R, Drinane M, Hallemeier CL, Koay EJ, Lasley F, Meyer J, Owen D, Pursley J, Schaub SK, Smith G, Venepalli NK, Zibari G, Cardenes H
Pract Radiat Oncol 2022 Jan-Feb;12(1):28-51. Epub 2021 Oct 21 doi: 10.1016/j.prro.2021.09.004. PMID: 34688956
Yttrium-90 radioembolization for unresectable metastatic neuroendocrine liver tumor: A systematic review.
Jia Z, Wang W
Eur J Radiol 2018 Mar;100:23-29. Epub 2018 Jan 9 doi: 10.1016/j.ejrad.2018.01.012. PMID: 29496075

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