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Abnormal heart rate variability

MedGen UID:
1631567
•Concept ID:
C4703579
•
Finding
HPO: HP:0031860

Definition

Any abnormality in the variability of the time interval between successive heartbeats. [from HPO]

Professional guidelines

PubMed

Evaluation and treatment strategies in patients at high risk of sudden death post myocardial infarction.
Underwood RD, Sra J, Akhtar M
Clin Cardiol 1997 Sep;20(9):753-8. doi: 10.1002/clc.4960200908. PMID: 9294665Free PMC Article
Management strategies in patients at high risk of sudden cardiac death following myocardial infarction.
Sra J, Underwood RD, Akhtar M
Indian Heart J 1995 Mar-Apr;47(2):158-62. PMID: 7590846

Recent clinical studies

Etiology

Heart Rate Variability in Patients with Spontaneous Intracerebral Hemorrhage and its Relationship with Clinical Outcomes.
Qu Y, Yang Y, Sun X, Ma HY, Zhang P, Abuduxukuer R, Zhu HJ, Liu J, Zhang PD, Guo ZN
Neurocrit Care 2024 Feb;40(1):282-291. Epub 2023 Mar 29 doi: 10.1007/s12028-023-01704-6. PMID: 36991176
Abnormal heart rate variability and its application in predicting treatment efficacy in patients with chronic migraine: An exploratory study.
Chuang CH, Li JY, King JT, Chen WT, Chen SP, Wang YF, Liu HY, Hsiao FJ, Pan LH, Wang SJ, Lai KL
Cephalalgia 2023 Oct;43(10):3331024231206781. doi: 10.1177/03331024231206781. PMID: 37851663
Abnormal heart rate variability during non-REM sleep and postictal generalized EEG suppression in focal epilepsy.
Sakamoto M, Jin K, Kitazawa Y, Kakisaka Y, Nakasato N
Clin Neurophysiol 2022 Aug;140:40-44. Epub 2022 May 27 doi: 10.1016/j.clinph.2022.05.011. PMID: 35689915
Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise.
Martínez-Rosales E, Sola-Rodríguez S, Vargas-Hitos JA, Gavilán-Carrera B, Rosales-Castillo A, Hernández-Martínez A, Artero EG, Sabio JM, Soriano-Maldonado A
Int J Environ Res Public Health 2020 Dec 18;17(24) doi: 10.3390/ijerph17249501. PMID: 33352985Free PMC Article
Abnormal heart rate variability and atrial fibrillation after aortic surgery.
Compostella L, Russo N, D'Onofrio A, Setzu T, Compostella C, Bottio T, Gerosa G, Bellotto F
Rev Bras Cir Cardiovasc 2015 Jan-Mar;30(1):55-62. doi: 10.5935/1678-9741.20140100. PMID: 25859868Free PMC Article

Diagnosis

Abnormal heart rate variability during non-REM sleep and postictal generalized EEG suppression in focal epilepsy.
Sakamoto M, Jin K, Kitazawa Y, Kakisaka Y, Nakasato N
Clin Neurophysiol 2022 Aug;140:40-44. Epub 2022 May 27 doi: 10.1016/j.clinph.2022.05.011. PMID: 35689915
Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise.
Martínez-Rosales E, Sola-Rodríguez S, Vargas-Hitos JA, Gavilán-Carrera B, Rosales-Castillo A, Hernández-Martínez A, Artero EG, Sabio JM, Soriano-Maldonado A
Int J Environ Res Public Health 2020 Dec 18;17(24) doi: 10.3390/ijerph17249501. PMID: 33352985Free PMC Article
Medical Correlates of Chronic Multisymptom Illness in Gulf War Veterans.
Blanchard M, Molina-Vicenty HD, Stein PK, Li X, Karlinsky J, Alpern R, Reda DJ, Toomey R
Am J Med 2019 Apr;132(4):510-518. Epub 2018 Dec 18 doi: 10.1016/j.amjmed.2018.11.045. PMID: 30576630
Reproducibility of abnormal heart rate variability indices: the case of hypertensive sleep apnoea syndrome.
Salo TM, Voipio-Pulkki LM, Jalonen JO, Helenius H, Viikari JS, Kantola I
Clin Physiol 1999 May;19(3):258-68. doi: 10.1046/j.1365-2281.1999.00165.x. PMID: 10361617
Diabetic autonomic neuropathy.
Stevens MJ, Watkins PJ
Acta Diabetol Lat 1991 Jan-Mar;28(1):105-12. doi: 10.1007/BF02732120. PMID: 1862685

Therapy

Abnormal heart rate variability and its application in predicting treatment efficacy in patients with chronic migraine: An exploratory study.
Chuang CH, Li JY, King JT, Chen WT, Chen SP, Wang YF, Liu HY, Hsiao FJ, Pan LH, Wang SJ, Lai KL
Cephalalgia 2023 Oct;43(10):3331024231206781. doi: 10.1177/03331024231206781. PMID: 37851663
Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise.
Martínez-Rosales E, Sola-Rodríguez S, Vargas-Hitos JA, Gavilán-Carrera B, Rosales-Castillo A, Hernández-Martínez A, Artero EG, Sabio JM, Soriano-Maldonado A
Int J Environ Res Public Health 2020 Dec 18;17(24) doi: 10.3390/ijerph17249501. PMID: 33352985Free PMC Article
Medical Correlates of Chronic Multisymptom Illness in Gulf War Veterans.
Blanchard M, Molina-Vicenty HD, Stein PK, Li X, Karlinsky J, Alpern R, Reda DJ, Toomey R
Am J Med 2019 Apr;132(4):510-518. Epub 2018 Dec 18 doi: 10.1016/j.amjmed.2018.11.045. PMID: 30576630
Alterations in heart rate variability in patients with peripheral arterial disease requiring surgical revascularization have limited association with postoperative major adverse cardiovascular and cerebrovascular events.
Utriainen KT, Airaksinen JK, Polo OJ, Scheinin H, Laitio RM, Leino KA, Vahlberg TJ, Kuusela TA, Laitio TT
PLoS One 2018;13(9):e0203519. Epub 2018 Sep 13 doi: 10.1371/journal.pone.0203519. PMID: 30212552Free PMC Article
Acute pain increases heart rate: differential mechanisms during rest and mental stress.
Terkelsen AJ, Mølgaard H, Hansen J, Andersen OK, Jensen TS
Auton Neurosci 2005 Aug 31;121(1-2):101-9. doi: 10.1016/j.autneu.2005.07.001. PMID: 16081322

Prognosis

Heart Rate Variability in Patients with Spontaneous Intracerebral Hemorrhage and its Relationship with Clinical Outcomes.
Qu Y, Yang Y, Sun X, Ma HY, Zhang P, Abuduxukuer R, Zhu HJ, Liu J, Zhang PD, Guo ZN
Neurocrit Care 2024 Feb;40(1):282-291. Epub 2023 Mar 29 doi: 10.1007/s12028-023-01704-6. PMID: 36991176
Abnormal heart rate variability and its application in predicting treatment efficacy in patients with chronic migraine: An exploratory study.
Chuang CH, Li JY, King JT, Chen WT, Chen SP, Wang YF, Liu HY, Hsiao FJ, Pan LH, Wang SJ, Lai KL
Cephalalgia 2023 Oct;43(10):3331024231206781. doi: 10.1177/03331024231206781. PMID: 37851663
Heart rate variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations.
Matusik PS, Matusik PT, Stein PK
Lupus 2018 Jul;27(8):1225-1239. Epub 2018 Apr 26 doi: 10.1177/0961203318771502. PMID: 29697012
How brain influences neuro-cardiovascular dysfunction.
Neki NS, Singh RB, Rastogi SS
J Assoc Physicians India 2004 Mar;52:223-30. PMID: 15636314
Diabetic autonomic neuropathy.
Stevens MJ, Watkins PJ
Acta Diabetol Lat 1991 Jan-Mar;28(1):105-12. doi: 10.1007/BF02732120. PMID: 1862685

Clinical prediction guides

Heart Rate Variability in Patients with Spontaneous Intracerebral Hemorrhage and its Relationship with Clinical Outcomes.
Qu Y, Yang Y, Sun X, Ma HY, Zhang P, Abuduxukuer R, Zhu HJ, Liu J, Zhang PD, Guo ZN
Neurocrit Care 2024 Feb;40(1):282-291. Epub 2023 Mar 29 doi: 10.1007/s12028-023-01704-6. PMID: 36991176
Abnormal heart rate variability and its application in predicting treatment efficacy in patients with chronic migraine: An exploratory study.
Chuang CH, Li JY, King JT, Chen WT, Chen SP, Wang YF, Liu HY, Hsiao FJ, Pan LH, Wang SJ, Lai KL
Cephalalgia 2023 Oct;43(10):3331024231206781. doi: 10.1177/03331024231206781. PMID: 37851663
Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise.
Martínez-Rosales E, Sola-Rodríguez S, Vargas-Hitos JA, Gavilán-Carrera B, Rosales-Castillo A, Hernández-Martínez A, Artero EG, Sabio JM, Soriano-Maldonado A
Int J Environ Res Public Health 2020 Dec 18;17(24) doi: 10.3390/ijerph17249501. PMID: 33352985Free PMC Article
Medical Correlates of Chronic Multisymptom Illness in Gulf War Veterans.
Blanchard M, Molina-Vicenty HD, Stein PK, Li X, Karlinsky J, Alpern R, Reda DJ, Toomey R
Am J Med 2019 Apr;132(4):510-518. Epub 2018 Dec 18 doi: 10.1016/j.amjmed.2018.11.045. PMID: 30576630
Abnormal heart rate variability and atrial fibrillation after aortic surgery.
Compostella L, Russo N, D'Onofrio A, Setzu T, Compostella C, Bottio T, Gerosa G, Bellotto F
Rev Bras Cir Cardiovasc 2015 Jan-Mar;30(1):55-62. doi: 10.5935/1678-9741.20140100. PMID: 25859868Free PMC Article

Recent systematic reviews

Heart rate variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations.
Matusik PS, Matusik PT, Stein PK
Lupus 2018 Jul;27(8):1225-1239. Epub 2018 Apr 26 doi: 10.1177/0961203318771502. PMID: 29697012

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