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Abnormal heart rate variability

MedGen UID:
1631567
•Concept ID:
C4703579
•
Finding
HPO: HP:0031860

Definition

Any abnormality in the variability of the time interval between successive heartbeats. [from HPO]

Professional guidelines

PubMed

Evaluation and treatment strategies in patients at high risk of sudden death post myocardial infarction.
Underwood RD, Sra J, Akhtar M
Clin Cardiol 1997 Sep;20(9):753-8. doi: 10.1002/clc.4960200908. PMID: 9294665Free PMC Article
Management strategies in patients at high risk of sudden cardiac death following myocardial infarction.
Sra J, Underwood RD, Akhtar M
Indian Heart J 1995 Mar-Apr;47(2):158-62. PMID: 7590846

Recent clinical studies

Etiology

Abnormal heart rate variability during non-REM sleep and postictal generalized EEG suppression in focal epilepsy.
Sakamoto M, Jin K, Kitazawa Y, Kakisaka Y, Nakasato N
Clin Neurophysiol 2022 Aug;140:40-44. Epub 2022 May 27 doi: 10.1016/j.clinph.2022.05.011. PMID: 35689915
Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise.
Martínez-Rosales E, Sola-Rodríguez S, Vargas-Hitos JA, Gavilán-Carrera B, Rosales-Castillo A, Hernández-Martínez A, Artero EG, Sabio JM, Soriano-Maldonado A
Int J Environ Res Public Health 2020 Dec 18;17(24) doi: 10.3390/ijerph17249501. PMID: 33352985Free PMC Article
Abnormal heart rate variability at school age in survivors of neonatal hypoxic-ischemic encephalopathy managed with therapeutic hypothermia.
Suppiej A, Vedovelli L, Boschiero D, Bolzon M, Cainelli E
Eur J Paediatr Neurol 2020 Nov;29:66-70. Epub 2020 Aug 20 doi: 10.1016/j.ejpn.2020.08.004. PMID: 32863129
Abnormal heart rate variability and atrial fibrillation after aortic surgery.
Compostella L, Russo N, D'Onofrio A, Setzu T, Compostella C, Bottio T, Gerosa G, Bellotto F
Rev Bras Cir Cardiovasc 2015 Jan-Mar;30(1):55-62. doi: 10.5935/1678-9741.20140100. PMID: 25859868Free PMC Article
Abnormal heart rate variability reflecting autonomic dysfunction in brainstem infarction.
Korpelainen JT, Huikuri HV, Sotaniemi KA, Myllylä VV
Acta Neurol Scand 1996 Nov;94(5):337-42. doi: 10.1111/j.1600-0404.1996.tb07076.x. PMID: 8947286

Diagnosis

Abnormal heart rate variability during non-REM sleep and postictal generalized EEG suppression in focal epilepsy.
Sakamoto M, Jin K, Kitazawa Y, Kakisaka Y, Nakasato N
Clin Neurophysiol 2022 Aug;140:40-44. Epub 2022 May 27 doi: 10.1016/j.clinph.2022.05.011. PMID: 35689915
Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise.
Martínez-Rosales E, Sola-Rodríguez S, Vargas-Hitos JA, Gavilán-Carrera B, Rosales-Castillo A, Hernández-Martínez A, Artero EG, Sabio JM, Soriano-Maldonado A
Int J Environ Res Public Health 2020 Dec 18;17(24) doi: 10.3390/ijerph17249501. PMID: 33352985Free PMC Article
Abnormal heart rate variability and subtle atrial arrhythmia in patients with familial amyloidotic polyneuropathy.
Wiklund U, Hörnsten R, Karlsson M, Suhr OB, Jensen SM
Ann Noninvasive Electrocardiol 2008 Jul;13(3):249-56. doi: 10.1111/j.1542-474X.2008.00228.x. PMID: 18713325Free PMC Article
Reproducibility of abnormal heart rate variability indices: the case of hypertensive sleep apnoea syndrome.
Salo TM, Voipio-Pulkki LM, Jalonen JO, Helenius H, Viikari JS, Kantola I
Clin Physiol 1999 May;19(3):258-68. doi: 10.1046/j.1365-2281.1999.00165.x. PMID: 10361617
Effect of clonidine on heart rate variability in congestive heart failure.
Girgis I, Chakko S, de Marchena E, Jara C, Diaz P, Castellanos A, Myerburg RJ
Am J Cardiol 1998 Aug 1;82(3):335-7. doi: 10.1016/s0002-9149(98)00329-4. PMID: 9708663

Therapy

Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise.
Martínez-Rosales E, Sola-Rodríguez S, Vargas-Hitos JA, Gavilán-Carrera B, Rosales-Castillo A, Hernández-Martínez A, Artero EG, Sabio JM, Soriano-Maldonado A
Int J Environ Res Public Health 2020 Dec 18;17(24) doi: 10.3390/ijerph17249501. PMID: 33352985Free PMC Article
Medical Correlates of Chronic Multisymptom Illness in Gulf War Veterans.
Blanchard M, Molina-Vicenty HD, Stein PK, Li X, Karlinsky J, Alpern R, Reda DJ, Toomey R
Am J Med 2019 Apr;132(4):510-518. Epub 2018 Dec 18 doi: 10.1016/j.amjmed.2018.11.045. PMID: 30576630
Alterations in heart rate variability in patients with peripheral arterial disease requiring surgical revascularization have limited association with postoperative major adverse cardiovascular and cerebrovascular events.
Utriainen KT, Airaksinen JK, Polo OJ, Scheinin H, Laitio RM, Leino KA, Vahlberg TJ, Kuusela TA, Laitio TT
PLoS One 2018;13(9):e0203519. Epub 2018 Sep 13 doi: 10.1371/journal.pone.0203519. PMID: 30212552Free PMC Article
Trans-fatty acid consumption and heart rate variability in 2 separate cohorts of older and younger adults.
Soares-Miranda L, Stein PK, Imamura F, Sattelmair J, Lemaitre RN, Siscovick DS, Mota J, Mozaffarian D
Circ Arrhythm Electrophysiol 2012 Aug 1;5(4):728-38. Epub 2012 Jul 6 doi: 10.1161/CIRCEP.111.966259. PMID: 22772898Free PMC Article
Effect of clonidine on heart rate variability in congestive heart failure.
Girgis I, Chakko S, de Marchena E, Jara C, Diaz P, Castellanos A, Myerburg RJ
Am J Cardiol 1998 Aug 1;82(3):335-7. doi: 10.1016/s0002-9149(98)00329-4. PMID: 9708663

Prognosis

Heart rate variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations.
Matusik PS, Matusik PT, Stein PK
Lupus 2018 Jul;27(8):1225-1239. Epub 2018 Apr 26 doi: 10.1177/0961203318771502. PMID: 29697012
The association between abnormal heart rate variability and new onset of chronic kidney disease in patients with type 2 diabetes: a ten-year follow-up study.
Yun JS, Ahn YB, Song KH, Yoo KD, Kim HW, Park YM, Ko SH
Diabetes Res Clin Pract 2015 Apr;108(1):31-7. Epub 2015 Jan 23 doi: 10.1016/j.diabres.2015.01.031. PMID: 25656759
Effect of clonidine on heart rate variability in congestive heart failure.
Girgis I, Chakko S, de Marchena E, Jara C, Diaz P, Castellanos A, Myerburg RJ
Am J Cardiol 1998 Aug 1;82(3):335-7. doi: 10.1016/s0002-9149(98)00329-4. PMID: 9708663
Abnormal heart rate variability reflecting autonomic dysfunction in brainstem infarction.
Korpelainen JT, Huikuri HV, Sotaniemi KA, Myllylä VV
Acta Neurol Scand 1996 Nov;94(5):337-42. doi: 10.1111/j.1600-0404.1996.tb07076.x. PMID: 8947286
Abnormal heart rate variability as a manifestation of autonomic dysfunction in hemispheric brain infarction.
Korpelainen JT, Sotaniemi KA, Huikuri HV, Myllyä VV
Stroke 1996 Nov;27(11):2059-63. doi: 10.1161/01.str.27.11.2059. PMID: 8898816

Clinical prediction guides

Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise.
Martínez-Rosales E, Sola-Rodríguez S, Vargas-Hitos JA, Gavilán-Carrera B, Rosales-Castillo A, Hernández-Martínez A, Artero EG, Sabio JM, Soriano-Maldonado A
Int J Environ Res Public Health 2020 Dec 18;17(24) doi: 10.3390/ijerph17249501. PMID: 33352985Free PMC Article
Abnormal heart rate variability and atrial fibrillation after aortic surgery.
Compostella L, Russo N, D'Onofrio A, Setzu T, Compostella C, Bottio T, Gerosa G, Bellotto F
Rev Bras Cir Cardiovasc 2015 Jan-Mar;30(1):55-62. doi: 10.5935/1678-9741.20140100. PMID: 25859868Free PMC Article
The association between abnormal heart rate variability and new onset of chronic kidney disease in patients with type 2 diabetes: a ten-year follow-up study.
Yun JS, Ahn YB, Song KH, Yoo KD, Kim HW, Park YM, Ko SH
Diabetes Res Clin Pract 2015 Apr;108(1):31-7. Epub 2015 Jan 23 doi: 10.1016/j.diabres.2015.01.031. PMID: 25656759
Trans-fatty acid consumption and heart rate variability in 2 separate cohorts of older and younger adults.
Soares-Miranda L, Stein PK, Imamura F, Sattelmair J, Lemaitre RN, Siscovick DS, Mota J, Mozaffarian D
Circ Arrhythm Electrophysiol 2012 Aug 1;5(4):728-38. Epub 2012 Jul 6 doi: 10.1161/CIRCEP.111.966259. PMID: 22772898Free PMC Article
Effect of clonidine on heart rate variability in congestive heart failure.
Girgis I, Chakko S, de Marchena E, Jara C, Diaz P, Castellanos A, Myerburg RJ
Am J Cardiol 1998 Aug 1;82(3):335-7. doi: 10.1016/s0002-9149(98)00329-4. PMID: 9708663

Recent systematic reviews

Heart rate variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations.
Matusik PS, Matusik PT, Stein PK
Lupus 2018 Jul;27(8):1225-1239. Epub 2018 Apr 26 doi: 10.1177/0961203318771502. PMID: 29697012

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