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Protein Carbamylation

MedGen UID:
1631601
Concept ID:
C1327377
Molecular Function
Synonyms: Carbamoylation, Protein; Carbamylation, Protein; Protein Carbamoylation; Protein Carbamoylations; Protein Carbamylations

Definition

Non-enzymatic addition of carbamoyl (-CONH2) on protein or amino acid functional groups from isocyanic acid or CARBAMOYL-PHOSPHATE. Carbamylation may induce a structural change that results in a functional loss and serves as a biomarker for protein aging and disease pathophysiology. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProtein Carbamylation

Professional guidelines

Recent clinical studies

Etiology

Tang M, Kalim S
Mol Aspects Med 2022 Aug;86:101083. Epub 2022 Feb 25 doi: 10.1016/j.mam.2022.101083. PMID: 35227517Free PMC Article
Desmons A, Okwieka A, Doué M, Gorisse L, Vuiblet V, Pietrement C, Gillery P, Jaisson S
Aging (Albany NY) 2019 Jun 6;11(11):3624-3638. doi: 10.18632/aging.102002. PMID: 31170093Free PMC Article
Santana JM, Brown CD
Front Biosci (Landmark Ed) 2018 Jun 1;23(12):2227-2234. doi: 10.2741/4701. PMID: 29772557
Jaisson S, Pietrement C, Gillery P
Adv Clin Chem 2018;84:1-38. doi: 10.1016/bs.acc.2017.12.001. PMID: 29478512
Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545Free PMC Article

Diagnosis

Bonifacio AF, Alunno A, La Paglia GMC, Valentini E, Leone MC, Bartoloni E, Gerli R
Reumatismo 2019 Apr 1;71(1):1-12. doi: 10.4081/reumatismo.2019.1102. PMID: 30932437
Makowski GS
Adv Clin Chem 2018;87:xiii-xiv. doi: 10.1016/S0065-2423(18)30065-9. PMID: 30342714
Long J, Vela Parada X, Kalim S
Adv Clin Chem 2018;87:37-67. Epub 2018 Aug 23 doi: 10.1016/bs.acc.2018.07.002. PMID: 30342712
Makowski GS
Adv Clin Chem 2018;84:ix. doi: 10.1016/S0065-2423(18)30015-5. PMID: 29478518
Jaisson S, Pietrement C, Gillery P
Clin Chem 2011 Nov;57(11):1499-505. Epub 2011 Jul 18 doi: 10.1373/clinchem.2011.163188. PMID: 21768218

Therapy

Lenglet A, Jaisson S, Gillery P, El Balkhi S, Liabeuf S, Massy ZA
Amino Acids 2023 Oct;55(10):1455-1460. Epub 2023 Aug 2 doi: 10.1007/s00726-023-03306-0. PMID: 37532908Free PMC Article
Di Iorio BR, Marzocco S, Bellasi A, De Simone E, Dal Piaz F, Rocchetti MT, Cosola C, Di Micco L, Gesualdo L
Nephrol Dial Transplant 2018 May 1;33(5):804-813. doi: 10.1093/ndt/gfx203. PMID: 28992314
Kalim S, Trottier CA, Wenger JB, Wibecan J, Ahmed R, Ankers E, Karumanchi SA, Thadhani R, Berg AH
Clin J Am Soc Nephrol 2016 Oct 7;11(10):1809-1816. Epub 2016 Jul 21 doi: 10.2215/CJN.02390316. PMID: 27445162Free PMC Article
Drechsler C, Kalim S, Wenger JB, Suntharalingam P, Hod T, Thadhani RI, Karumanchi SA, Wanner C, Berg AH
Kidney Int 2015 Jun;87(6):1201-8. Epub 2015 Feb 11 doi: 10.1038/ki.2014.429. PMID: 25671766Free PMC Article
Wang Z, Nicholls SJ, Rodriguez ER, Kummu O, Hörkkö S, Barnard J, Reynolds WF, Topol EJ, DiDonato JA, Hazen SL
Nat Med 2007 Oct;13(10):1176-84. Epub 2007 Sep 9 doi: 10.1038/nm1637. PMID: 17828273

Prognosis

Kalim S, Berg AH, Karumanchi SA, Thadhani R, Allegretti AS, Nigwekar S, Zhao S, Srivastava A, Raj D, Deo R, Frydrych A, Chen J, Sondheimer J, Shafi T, Weir M, Lash JP; CRIC Study Investigators
Nephrol Dial Transplant 2021 Dec 31;37(1):139-147. doi: 10.1093/ndt/gfaa347. PMID: 33661286Free PMC Article
Bonifacio AF, Alunno A, La Paglia GMC, Valentini E, Leone MC, Bartoloni E, Gerli R
Reumatismo 2019 Apr 1;71(1):1-12. doi: 10.4081/reumatismo.2019.1102. PMID: 30932437
de Brito Rocha S, Baldo DC, Andrade LEC
Adv Rheumatol 2019 Jan 17;59(1):2. doi: 10.1186/s42358-018-0042-8. PMID: 30657101
Mori D, Matsui I, Shimomura A, Hashimoto N, Matsumoto A, Shimada K, Yamaguchi S, Oka T, Kubota K, Yonemoto S, Sakaguchi Y, Takahashi A, Shintani Y, Takashima S, Takabatake Y, Hamano T, Isaka Y
Kidney Int 2018 Jul;94(1):72-90. Epub 2018 Apr 30 doi: 10.1016/j.kint.2018.01.033. PMID: 29716796
Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545Free PMC Article

Clinical prediction guides

Kalim S, Zhao S, Tang M, Rhee EP, Allegretti AS, Nigwekar S, Karumanchi SA, Lash JP, Berg AH
J Am Soc Nephrol 2023 May 1;34(5):876-885. Epub 2023 Jan 21 doi: 10.1681/ASN.0000000000000078. PMID: 36757153Free PMC Article
Kalim S, Berg AH, Karumanchi SA, Thadhani R, Allegretti AS, Nigwekar S, Zhao S, Srivastava A, Raj D, Deo R, Frydrych A, Chen J, Sondheimer J, Shafi T, Weir M, Lash JP; CRIC Study Investigators
Nephrol Dial Transplant 2021 Dec 31;37(1):139-147. doi: 10.1093/ndt/gfaa347. PMID: 33661286Free PMC Article
de Brito Rocha S, Baldo DC, Andrade LEC
Adv Rheumatol 2019 Jan 17;59(1):2. doi: 10.1186/s42358-018-0042-8. PMID: 30657101
Kalim S
Curr Opin Nephrol Hypertens 2018 Nov;27(6):454-462. doi: 10.1097/MNH.0000000000000454. PMID: 30148723Free PMC Article
Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545Free PMC Article

Recent systematic reviews

Simsek B, Yanar K, Çakatay U
Curr Diabetes Rev 2020;16(6):608-618. doi: 10.2174/1573399816666200107102918. PMID: 31914914
Li X, Wang Z, Yi H, Xie J, Zhu N
Clin Lab 2019 Dec 1;65(12) doi: 10.7754/Clin.Lab.2019.190419. PMID: 31850723

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