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Stage III Ovarian Choriocarcinoma

MedGen UID:
163166
•Concept ID:
C0854943
•
Neoplastic Process
Synonyms: Ovarian Germ Cell Choriocarcinoma Stage III; Ovarian Germ Cell Choriocarcinoma, Stage III; Stage III Ovarian Choriocarcinoma AJCC v6; Stage III Ovarian Choriocarcinoma AJCC v7; Stage III Ovarian Germ Cell Choriocarcinoma

Definition

Stage III includes: T3, N0, M0. T3: Tumor involves one or both both ovaries with microscopically confirmed peritoneal metastasis outside pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage III Ovarian Choriocarcinoma

Professional guidelines

PubMed

Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan.
Suita S, Shono K, Tajiri T, Takamatsu T, Mizote H, Nagasaki A, Inomata Y, Hara T, Okamura J, Miyazaki S, Kawakami K, Eguchi H, Tsuneyoshi M; Committee for Pediatric Solid Malignant Tumors in the Kyushu Area
J Pediatr Surg 2002 Dec;37(12):1703-6. doi: 10.1053/jpsu.2002.36700. PMID: 12483635
Treatment of malignant ovarian germ cell tumors with preservation of fertility: reproductive performance after persistent remission.
Kanazawa K, Suzuki T, Sakumoto K
Am J Clin Oncol 2000 Jun;23(3):244-8. doi: 10.1097/00000421-200006000-00007. PMID: 10857886

Recent clinical studies

Etiology

Characterizing Lymphovascular Invasion in Pediatric and Adolescent Malignant Ovarian Nongerminomatous Germ Cell Tumors: A Report from the Children's Oncology Group.
Rich BS, Dicken BJ, Billmire DF, Weil BR, Ross J, Fallahazad N, Krailo M, Shaikh F, Frazier AL, Hazard FK, Nuño MM
J Pediatr Surg 2023 Dec;58(12):2399-2404. Epub 2023 Aug 22 doi: 10.1016/j.jpedsurg.2023.08.008. PMID: 37699777Free PMC Article
Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution.
Lee CW, Song MJ, Park ST, Ki EY, Lee SJ, Lee KH, Ryu KS, Park JS, Hur SY
World J Surg Oncol 2011 Oct 11;9:123. doi: 10.1186/1477-7819-9-123. PMID: 21988930Free PMC Article
Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study.
Lee KH, Lee IH, Kim BG, Nam JH, Kim WK, Kang SB, Ryu SY, Cho CH, Choi HS, Kim KT; Korean Gynecologic Oncology Group
Int J Gynecol Cancer 2009 Jan;19(1):84-7. doi: 10.1111/IGC.0b013e31819914c5. PMID: 19258947
Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan.
Suita S, Shono K, Tajiri T, Takamatsu T, Mizote H, Nagasaki A, Inomata Y, Hara T, Okamura J, Miyazaki S, Kawakami K, Eguchi H, Tsuneyoshi M; Committee for Pediatric Solid Malignant Tumors in the Kyushu Area
J Pediatr Surg 2002 Dec;37(12):1703-6. doi: 10.1053/jpsu.2002.36700. PMID: 12483635
Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases.
Norris HJ, Zirkin HJ, Benson WL
Cancer 1976 May;37(5):2359-72. doi: 10.1002/1097-0142(197605)37:5<2359::aid-cncr2820370528>3.0.co;2-q. PMID: 1260722

Diagnosis

Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside.
Santoro G, Laganà AS, Micali A, Barresi V, Giacobbe V, Palmara V
Arch Gynecol Obstet 2017 Jan;295(1):173-187. Epub 2016 Aug 22 doi: 10.1007/s00404-016-4182-y. PMID: 27549089
Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution.
Lee CW, Song MJ, Park ST, Ki EY, Lee SJ, Lee KH, Ryu KS, Park JS, Hur SY
World J Surg Oncol 2011 Oct 11;9:123. doi: 10.1186/1477-7819-9-123. PMID: 21988930Free PMC Article
Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study.
Lee KH, Lee IH, Kim BG, Nam JH, Kim WK, Kang SB, Ryu SY, Cho CH, Choi HS, Kim KT; Korean Gynecologic Oncology Group
Int J Gynecol Cancer 2009 Jan;19(1):84-7. doi: 10.1111/IGC.0b013e31819914c5. PMID: 19258947
Ovarian mixed germ cell tumor composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44-year-old woman: case report and literature review.
Akahira J, Ito K, Kosuge S, Konno R, Sato S, Yajima A, Sasano H
Pathol Int 1998 Jun;48(6):471-4. doi: 10.1111/j.1440-1827.1998.tb03935.x. PMID: 9702861
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

Therapy

Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution.
Lee CW, Song MJ, Park ST, Ki EY, Lee SJ, Lee KH, Ryu KS, Park JS, Hur SY
World J Surg Oncol 2011 Oct 11;9:123. doi: 10.1186/1477-7819-9-123. PMID: 21988930Free PMC Article
Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan.
Suita S, Shono K, Tajiri T, Takamatsu T, Mizote H, Nagasaki A, Inomata Y, Hara T, Okamura J, Miyazaki S, Kawakami K, Eguchi H, Tsuneyoshi M; Committee for Pediatric Solid Malignant Tumors in the Kyushu Area
J Pediatr Surg 2002 Dec;37(12):1703-6. doi: 10.1053/jpsu.2002.36700. PMID: 12483635
Treatment of malignant ovarian germ cell tumors with preservation of fertility: reproductive performance after persistent remission.
Kanazawa K, Suzuki T, Sakumoto K
Am J Clin Oncol 2000 Jun;23(3):244-8. doi: 10.1097/00000421-200006000-00007. PMID: 10857886
Primary pure choriocarcinoma of the ovary.
Grover V, Grover RK, Usha R, Logani KB
Gynecol Obstet Invest 1990;30(1):61-3. doi: 10.1159/000293216. PMID: 1699856
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

Prognosis

Characterizing Lymphovascular Invasion in Pediatric and Adolescent Malignant Ovarian Nongerminomatous Germ Cell Tumors: A Report from the Children's Oncology Group.
Rich BS, Dicken BJ, Billmire DF, Weil BR, Ross J, Fallahazad N, Krailo M, Shaikh F, Frazier AL, Hazard FK, Nuño MM
J Pediatr Surg 2023 Dec;58(12):2399-2404. Epub 2023 Aug 22 doi: 10.1016/j.jpedsurg.2023.08.008. PMID: 37699777Free PMC Article
Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside.
Santoro G, Laganà AS, Micali A, Barresi V, Giacobbe V, Palmara V
Arch Gynecol Obstet 2017 Jan;295(1):173-187. Epub 2016 Aug 22 doi: 10.1007/s00404-016-4182-y. PMID: 27549089
Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study.
Lee KH, Lee IH, Kim BG, Nam JH, Kim WK, Kang SB, Ryu SY, Cho CH, Choi HS, Kim KT; Korean Gynecologic Oncology Group
Int J Gynecol Cancer 2009 Jan;19(1):84-7. doi: 10.1111/IGC.0b013e31819914c5. PMID: 19258947
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993
Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases.
Norris HJ, Zirkin HJ, Benson WL
Cancer 1976 May;37(5):2359-72. doi: 10.1002/1097-0142(197605)37:5<2359::aid-cncr2820370528>3.0.co;2-q. PMID: 1260722

Clinical prediction guides

Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study.
Lee KH, Lee IH, Kim BG, Nam JH, Kim WK, Kang SB, Ryu SY, Cho CH, Choi HS, Kim KT; Korean Gynecologic Oncology Group
Int J Gynecol Cancer 2009 Jan;19(1):84-7. doi: 10.1111/IGC.0b013e31819914c5. PMID: 19258947
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

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