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Extraosseous osteosarcoma

MedGen UID:
163186
•Concept ID:
C0855052
•
Neoplastic Process
Synonyms: Extraosseous Osteosarcoma; extraosseous osteosarcoma; Extraskeletal Osteogenic Sarcoma; extraskeletal osteogenic sarcoma; Extraskeletal osteosarcoma; Extraskeletal Osteosarcoma; extraskeletal osteosarcoma; osteosarcoma, extraskeletal, malignant; Soft Tissue Osteosarcoma; soft tissue osteosarcoma
SNOMED CT: Extraskeletal osteosarcoma (404077005)
 
Monarch Initiative: MONDO:0002621

Definition

An osteosarcoma arising from the soft tissue. [from NCI]

Professional guidelines

PubMed

Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma.
Wang XC, Zhang L, Lin JB, Huang XY, Liang JH, Zhong JP, Peng JD, Zhong JY
BMC Cancer 2024 Jan 2;24(1):11. doi: 10.1186/s12885-023-11731-3. PMID: 38166700Free PMC Article
Practical Management of Adult Ultra-Rare Primary Retroperitoneal Soft Tissue Sarcoma: A Focus on Perivascular Epithelioid Tumours and Extraosseous Ewing Sarcoma.
Apte SS, Mor E, Mitchell C, Gyorki DE
Curr Oncol 2023 Jun 21;30(7):5953-5972. doi: 10.3390/curroncol30070445. PMID: 37504306Free PMC Article
Extraosseous osteosarcoma: response to treatment and long-term outcome.
Ahmad SA, Patel SR, Ballo MT, Baker TP, Yasko AW, Wang X, Feig BW, Hunt KK, Lin PP, Weber KL, Chen LL, Zagars GK, Pollock RE, Benjamin RS, Pisters PW
J Clin Oncol 2002 Jan 15;20(2):521-7. doi: 10.1200/JCO.2002.20.2.521. PMID: 11786582

Recent clinical studies

Etiology

Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma.
Wang XC, Zhang L, Lin JB, Huang XY, Liang JH, Zhong JP, Peng JD, Zhong JY
BMC Cancer 2024 Jan 2;24(1):11. doi: 10.1186/s12885-023-11731-3. PMID: 38166700Free PMC Article
Survival Differences of Patients with Resected Extraskeletal Osteosarcoma Receiving Two Different (Neo)Adjuvant Chemotherapy Regimens: A Systematic Review and Meta-analysis.
Campos F, Téres R, Sebio A, Bettim BB, Martinez-Trufero J
Clin Oncol (R Coll Radiol) 2023 Dec;35(12):e720-e727. Epub 2023 Sep 22 doi: 10.1016/j.clon.2023.09.009. PMID: 37777356
Intraperitoneal extraosseous osteosarcoma: a case report and literatures review.
Wang T, Liao S, Ding X, Anil KC, Huang Q, Lin C, Mo J, Tang H, Liu Y
BMC Musculoskelet Disord 2020 Jul 11;21(1):452. doi: 10.1186/s12891-020-03429-5. PMID: 32653041Free PMC Article
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas?
Fan Z, Patel S, Lewis VO, Guadagnolo BA, Lin PP
Clin Orthop Relat Res 2015 Nov;473(11):3604-11. Epub 2015 Jul 22 doi: 10.1007/s11999-015-4463-y. PMID: 26197952Free PMC Article
Extraosseous osteosarcoma: response to treatment and long-term outcome.
Ahmad SA, Patel SR, Ballo MT, Baker TP, Yasko AW, Wang X, Feig BW, Hunt KK, Lin PP, Weber KL, Chen LL, Zagars GK, Pollock RE, Benjamin RS, Pisters PW
J Clin Oncol 2002 Jan 15;20(2):521-7. doi: 10.1200/JCO.2002.20.2.521. PMID: 11786582

Diagnosis

Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma.
Wang XC, Zhang L, Lin JB, Huang XY, Liang JH, Zhong JP, Peng JD, Zhong JY
BMC Cancer 2024 Jan 2;24(1):11. doi: 10.1186/s12885-023-11731-3. PMID: 38166700Free PMC Article
Practical Management of Adult Ultra-Rare Primary Retroperitoneal Soft Tissue Sarcoma: A Focus on Perivascular Epithelioid Tumours and Extraosseous Ewing Sarcoma.
Apte SS, Mor E, Mitchell C, Gyorki DE
Curr Oncol 2023 Jun 21;30(7):5953-5972. doi: 10.3390/curroncol30070445. PMID: 37504306Free PMC Article
Intraperitoneal extraosseous osteosarcoma: a case report and literatures review.
Wang T, Liao S, Ding X, Anil KC, Huang Q, Lin C, Mo J, Tang H, Liu Y
BMC Musculoskelet Disord 2020 Jul 11;21(1):452. doi: 10.1186/s12891-020-03429-5. PMID: 32653041Free PMC Article
Osteoblastic Extraosseous Osteosarcoma of the Neck.
Košec A, Vučić M, Bedeković V, Ivkić M
J Oral Maxillofac Surg 2017 Mar;75(3):650.e1-650.e5. Epub 2016 Nov 16 doi: 10.1016/j.joms.2016.11.008. PMID: 27914228
Extraosseous osteosarcoma: a case report and review of the literature.
Sangsin A, Pattamapaspong N, Settakorn J, Leerapun T, Pruksakorn D
J Med Assoc Thai 2013 Apr;96(4):491-5. PMID: 23691705

Therapy

Survival Differences of Patients with Resected Extraskeletal Osteosarcoma Receiving Two Different (Neo)Adjuvant Chemotherapy Regimens: A Systematic Review and Meta-analysis.
Campos F, Téres R, Sebio A, Bettim BB, Martinez-Trufero J
Clin Oncol (R Coll Radiol) 2023 Dec;35(12):e720-e727. Epub 2023 Sep 22 doi: 10.1016/j.clon.2023.09.009. PMID: 37777356
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas?
Fan Z, Patel S, Lewis VO, Guadagnolo BA, Lin PP
Clin Orthop Relat Res 2015 Nov;473(11):3604-11. Epub 2015 Jul 22 doi: 10.1007/s11999-015-4463-y. PMID: 26197952Free PMC Article
Phase II trial of pegylated-liposomal doxorubicin (Doxil) in sarcoma.
Skubitz KM
Cancer Invest 2003 Apr;21(2):167-76. doi: 10.1081/cnv-120016412. PMID: 12743981
A chemosensitive pediatric extraosseous osteosarcoma: case report and review of the literature.
Wodowski K, Hill DA, Pappo AS, Shochat SJ, Kun LE, Spunt SL
J Pediatr Hematol Oncol 2003 Jan;25(1):73-7. doi: 10.1097/00043426-200301000-00015. PMID: 12544778
Extraosseous osteosarcoma: response to treatment and long-term outcome.
Ahmad SA, Patel SR, Ballo MT, Baker TP, Yasko AW, Wang X, Feig BW, Hunt KK, Lin PP, Weber KL, Chen LL, Zagars GK, Pollock RE, Benjamin RS, Pisters PW
J Clin Oncol 2002 Jan 15;20(2):521-7. doi: 10.1200/JCO.2002.20.2.521. PMID: 11786582

Prognosis

Intraperitoneal extraosseous osteosarcoma: a case report and literatures review.
Wang T, Liao S, Ding X, Anil KC, Huang Q, Lin C, Mo J, Tang H, Liu Y
BMC Musculoskelet Disord 2020 Jul 11;21(1):452. doi: 10.1186/s12891-020-03429-5. PMID: 32653041Free PMC Article
Osteoblastic Extraosseous Osteosarcoma of the Neck.
Košec A, Vučić M, Bedeković V, Ivkić M
J Oral Maxillofac Surg 2017 Mar;75(3):650.e1-650.e5. Epub 2016 Nov 16 doi: 10.1016/j.joms.2016.11.008. PMID: 27914228
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas?
Fan Z, Patel S, Lewis VO, Guadagnolo BA, Lin PP
Clin Orthop Relat Res 2015 Nov;473(11):3604-11. Epub 2015 Jul 22 doi: 10.1007/s11999-015-4463-y. PMID: 26197952Free PMC Article
Extraosseous osteosarcoma: a case report and review of the literature.
Sangsin A, Pattamapaspong N, Settakorn J, Leerapun T, Pruksakorn D
J Med Assoc Thai 2013 Apr;96(4):491-5. PMID: 23691705
Extraosseous osteosarcoma: response to treatment and long-term outcome.
Ahmad SA, Patel SR, Ballo MT, Baker TP, Yasko AW, Wang X, Feig BW, Hunt KK, Lin PP, Weber KL, Chen LL, Zagars GK, Pollock RE, Benjamin RS, Pisters PW
J Clin Oncol 2002 Jan 15;20(2):521-7. doi: 10.1200/JCO.2002.20.2.521. PMID: 11786582

Clinical prediction guides

Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas?
Fan Z, Patel S, Lewis VO, Guadagnolo BA, Lin PP
Clin Orthop Relat Res 2015 Nov;473(11):3604-11. Epub 2015 Jul 22 doi: 10.1007/s11999-015-4463-y. PMID: 26197952Free PMC Article
Phase II trial of pegylated-liposomal doxorubicin (Doxil) in sarcoma.
Skubitz KM
Cancer Invest 2003 Apr;21(2):167-76. doi: 10.1081/cnv-120016412. PMID: 12743981

Recent systematic reviews

Survival Differences of Patients with Resected Extraskeletal Osteosarcoma Receiving Two Different (Neo)Adjuvant Chemotherapy Regimens: A Systematic Review and Meta-analysis.
Campos F, Téres R, Sebio A, Bettim BB, Martinez-Trufero J
Clin Oncol (R Coll Radiol) 2023 Dec;35(12):e720-e727. Epub 2023 Sep 22 doi: 10.1016/j.clon.2023.09.009. PMID: 37777356

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