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Recurrent Rhabdomyosarcoma

MedGen UID:
163188
•Concept ID:
C0855069
•
Neoplastic Process
Synonyms: Relapsed Rhabdomyosarcoma; Rhabdomyosarcoma Recurrent

Definition

The reemergence of rhabdomyosarcoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Role of high-dose chemotherapy with hematopoietic stem cell rescue in the treatment of metastatic or recurrent rhabdomyosarcoma.
Weigel BJ, Breitfeld PP, Hawkins D, Crist WM, Baker KS
J Pediatr Hematol Oncol 2001 Jun-Jul;23(5):272-6. doi: 10.1097/00043426-200106000-00007. PMID: 11464981
Primary cardiac tumors in infants and children: immediate and long-term operative results.
Takach TJ, Reul GJ, Ott DA, Cooley DA
Ann Thorac Surg 1996 Aug;62(2):559-64. PMID: 8694623

Recent clinical studies

Etiology

Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.
Shern JF, Chen L, Chmielecki J, Wei JS, Patidar R, Rosenberg M, Ambrogio L, Auclair D, Wang J, Song YK, Tolman C, Hurd L, Liao H, Zhang S, Bogen D, Brohl AS, Sindiri S, Catchpoole D, Badgett T, Getz G, Mora J, Anderson JR, Skapek SX, Barr FG, Meyerson M, Hawkins DS, Khan J
Cancer Discov 2014 Feb;4(2):216-31. Epub 2014 Jan 23 doi: 10.1158/2159-8290.CD-13-0639. PMID: 24436047Free PMC Article
A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: a report from the Children's Oncology Group.
Baruchel S, Pappo A, Krailo M, Baker KS, Wu B, Villaluna D, Lee-Scott M, Adamson PC, Blaney SM
Eur J Cancer 2012 Mar;48(4):579-85. Epub 2011 Nov 14 doi: 10.1016/j.ejca.2011.09.027. PMID: 22088484
Allogeneic hematopoietic stem cell transplantation against recurrent rhabdomyosarcoma.
Ohta H, Hashii Y, Yoshida H, Kusuki S, Tokimasa S, Yoneda A, Fukuzawa M, Inoue N, Hara J, Kusafuka T, Ozono K
J Pediatr Hematol Oncol 2011 Jan;33(1):e35-8. doi: 10.1097/MPH.0b013e3181e7ddc5. PMID: 20975586
Do patients with metastatic and recurrent rhabdomyosarcoma benefit from high-dose therapy with hematopoietic rescue? Report of the German/Austrian Pediatric Bone Marrow Transplantation Group.
Koscielniak E, Klingebiel TH, Peters C, Hermann J, Burdach ST, Bender-Götze C, Müller-Weihrich ST, Treuner J
Bone Marrow Transplant 1997 Feb;19(3):227-31. doi: 10.1038/sj.bmt.1700628. PMID: 9028550
Rhabdomyosarcoma of the ear in childhood. A report from the Intergroup Rhabdomyosarcoma Study-I.
Raney RB Jr, Lawrence W Jr, Maurer HM, Lindberg RD, Newton WA Jr, Ragab AH, Tefft M, Foulkes MA
Cancer 1983 Jun 15;51(12):2356-61. doi: 10.1002/1097-0142(19830615)51:12<2356::aid-cncr2820511232>3.0.co;2-l. PMID: 6342748

Diagnosis

Topotecan/carboplatin regimen for refractory/recurrent rhabdomyosarcoma in children: Report from the AIEOP Soft Tissue Sarcoma Committee.
Compostella A, Affinita MC, Casanova M, Milano GM, Scagnellato A, Dall'Igna P, Chiaravalli S, Pierobon M, Manzitti C, Zanetti I, Schiavetti A, Sorbara S, Mura RM, Ruggiero A, Ferrari A, Bisogno G
Tumori 2019 Apr;105(2):138-143. Epub 2018 Aug 22 doi: 10.1177/0300891618792479. PMID: 30131003
Recurrent alveolar rhabdomyosarcoma with prior surgery and radiotherapy: altered lymphatic drainage limits the reliability of sentinel lymph node biopsy.
Nishida Y, Tsukushi S, Yamada Y, Shimoyama Y, Shido Y, Wasa J, Ishiguro N
J Pediatr Hematol Oncol 2011 Jan;33(1):e26-8. doi: 10.1097/MPH.0b013e3181faf857. PMID: 21102351
Allogeneic hematopoietic stem cell transplantation against recurrent rhabdomyosarcoma.
Ohta H, Hashii Y, Yoshida H, Kusuki S, Tokimasa S, Yoneda A, Fukuzawa M, Inoue N, Hara J, Kusafuka T, Ozono K
J Pediatr Hematol Oncol 2011 Jan;33(1):e35-8. doi: 10.1097/MPH.0b013e3181e7ddc5. PMID: 20975586
Orbital metastasis in patients with rhabdomyosarcoma: case series and review of the literature.
Huh WW, Beverly Raney R
J Pediatr Hematol Oncol 2006 Oct;28(10):684-7. doi: 10.1097/01.mph.0000212959.66221.6a. PMID: 17023831
Soft tissue sarcomas.
Lawrence W Jr, Neifeld JP
Curr Probl Surg 1989 Nov;26(11):753-827. doi: 10.1016/0011-3840(89)90036-1. PMID: 2686945

Therapy

A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: a report from the Children's Oncology Group.
Baruchel S, Pappo A, Krailo M, Baker KS, Wu B, Villaluna D, Lee-Scott M, Adamson PC, Blaney SM
Eur J Cancer 2012 Mar;48(4):579-85. Epub 2011 Nov 14 doi: 10.1016/j.ejca.2011.09.027. PMID: 22088484
Efficacy of topotecan plus vincristine and doxorubicin in children with recurrent/refractory rhabdomyosarcoma.
Meazza C, Casanova M, Zaffignani E, Luksch R, Podda M, Favini F, Catania S, Biassoni V, Morosi C, Ferrari A
Med Oncol 2009;26(1):67-72. Epub 2008 Aug 5 doi: 10.1007/s12032-008-9085-8. PMID: 18679836
Recurrent rhabdomyosarcoma after 25 years: a possible association with estrogen and progestogen therapy.
Zacharin M, Waters K, Chow CW, Crock P, McKelvie P
J Pediatr Hematol Oncol 1997 Sep-Oct;19(5):477-81. doi: 10.1097/00043426-199709000-00015. PMID: 9329475
Do patients with metastatic and recurrent rhabdomyosarcoma benefit from high-dose therapy with hematopoietic rescue? Report of the German/Austrian Pediatric Bone Marrow Transplantation Group.
Koscielniak E, Klingebiel TH, Peters C, Hermann J, Burdach ST, Bender-Götze C, Müller-Weihrich ST, Treuner J
Bone Marrow Transplant 1997 Feb;19(3):227-31. doi: 10.1038/sj.bmt.1700628. PMID: 9028550
Rhabdomyosarcoma of the ear in childhood. A report from the Intergroup Rhabdomyosarcoma Study-I.
Raney RB Jr, Lawrence W Jr, Maurer HM, Lindberg RD, Newton WA Jr, Ragab AH, Tefft M, Foulkes MA
Cancer 1983 Jun 15;51(12):2356-61. doi: 10.1002/1097-0142(19830615)51:12<2356::aid-cncr2820511232>3.0.co;2-l. PMID: 6342748

Prognosis

CD56-chimeric antigen receptor T-cell therapy for refractory/recurrent rhabdomyosarcoma: A 3.5-year follow-up case report.
Jiang C, Zhao W, Qin M, Jin M, Chang L, Ma X
Medicine (Baltimore) 2019 Oct;98(43):e17572. doi: 10.1097/MD.0000000000017572. PMID: 31651858Free PMC Article
Recurrent rhabdomyosarcoma after 25 years: a possible association with estrogen and progestogen therapy.
Zacharin M, Waters K, Chow CW, Crock P, McKelvie P
J Pediatr Hematol Oncol 1997 Sep-Oct;19(5):477-81. doi: 10.1097/00043426-199709000-00015. PMID: 9329475
Do patients with metastatic and recurrent rhabdomyosarcoma benefit from high-dose therapy with hematopoietic rescue? Report of the German/Austrian Pediatric Bone Marrow Transplantation Group.
Koscielniak E, Klingebiel TH, Peters C, Hermann J, Burdach ST, Bender-Götze C, Müller-Weihrich ST, Treuner J
Bone Marrow Transplant 1997 Feb;19(3):227-31. doi: 10.1038/sj.bmt.1700628. PMID: 9028550
Soft tissue sarcomas.
Lawrence W Jr, Neifeld JP
Curr Probl Surg 1989 Nov;26(11):753-827. doi: 10.1016/0011-3840(89)90036-1. PMID: 2686945
Rhabdomyosarcoma of the ear in childhood. A report from the Intergroup Rhabdomyosarcoma Study-I.
Raney RB Jr, Lawrence W Jr, Maurer HM, Lindberg RD, Newton WA Jr, Ragab AH, Tefft M, Foulkes MA
Cancer 1983 Jun 15;51(12):2356-61. doi: 10.1002/1097-0142(19830615)51:12<2356::aid-cncr2820511232>3.0.co;2-l. PMID: 6342748

Clinical prediction guides

Do patients with metastatic and recurrent rhabdomyosarcoma benefit from high-dose therapy with hematopoietic rescue? Report of the German/Austrian Pediatric Bone Marrow Transplantation Group.
Koscielniak E, Klingebiel TH, Peters C, Hermann J, Burdach ST, Bender-Götze C, Müller-Weihrich ST, Treuner J
Bone Marrow Transplant 1997 Feb;19(3):227-31. doi: 10.1038/sj.bmt.1700628. PMID: 9028550
Karyotypic characterization of a new human embryonal rhabdomyosarcoma cell line.
Magnani I, Faustinella F, Nanni P, Nicoletti G, Larizza L
Cancer Genet Cytogenet 1991 Jul 1;54(1):83-9. doi: 10.1016/0165-4608(91)90034-r. PMID: 2065319

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