U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ROS1 Gene Inversion

MedGen UID:
1632140
•Concept ID:
C4688373
•
Cell or Molecular Dysfunction
Synonyms: c-ros-1 Gene Inversion; MCF3 Gene Inversion; ROS Gene Inversion; ROS Proto-Oncogene 1, Receptor Tyrosine Kinase Gene Inversion; ROS1 Inversion; ROS1 Inversion Mutation

Definition

A genetic rearrangement that refers to any inversion involving the ROS1 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVROS1 Gene Inversion

Recent clinical studies

Therapy

Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer.
Amatu A, Somaschini A, Cerea G, Bosotti R, Valtorta E, Buonandi P, Marrapese G, Veronese S, Luo D, Hornby Z, Multani P, Murphy D, Shoemaker R, Lauricella C, Giannetta L, Maiolani M, Vanzulli A, Ardini E, Galvani A, Isacchi A, Sartore-Bianchi A, Siena S
Br J Cancer 2015 Dec 22;113(12):1730-4. Epub 2015 Dec 3 doi: 10.1038/bjc.2015.401. PMID: 26633560Free PMC Article

Clinical prediction guides

Targeted genomic rearrangements using CRISPR/Cas technology.
Choi PS, Meyerson M
Nat Commun 2014 Apr 24;5:3728. doi: 10.1038/ncomms4728. PMID: 24759083Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...