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Atherosclerotic lesion

MedGen UID:
1632481
Concept ID:
C4703473
Disease or Syndrome
HPO: HP:0031678

Definition

A lesion associated with atherosclerosis, a multifactorial and multipart progressive disease manifested by the focal development within the arterial wall of lesions, that ranges from teh development of a fatty streak, plaque progression, and plaque disruption. Atherosclerotic lesions demonstrate consistent morphological characteristics, which indicate that each type may stabilize temporarily or permanently and that progression to the next type may require an additional stimulus. [from HPO]

Professional guidelines

PubMed

Giménez VMM, Camargo AB, Kassuha D, Manucha W
Curr Pharm Des 2018;24(39):4681-4684. doi: 10.2174/1381612825666190110154609. PMID: 30636583
Winter C, Soehnlein O
Curr Opin Lipidol 2018 Oct;29(5):368-374. doi: 10.1097/MOL.0000000000000545. PMID: 30063471
Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL
Cell 2015 Dec 17;163(7):1585-95. doi: 10.1016/j.cell.2015.11.055. PMID: 26687352Free PMC Article

Recent clinical studies

Etiology

Paeslack N, Mimmler M, Becker S, Gao Z, Khuu MP, Mann A, Malinarich F, Regen T, Reinhardt C
Amino Acids 2022 Oct;54(10):1339-1356. Epub 2022 Apr 22 doi: 10.1007/s00726-022-03161-5. PMID: 35451695Free PMC Article
Poznyak A, Grechko AV, Poggio P, Myasoedova VA, Alfieri V, Orekhov AN
Int J Mol Sci 2020 Mar 6;21(5) doi: 10.3390/ijms21051835. PMID: 32155866Free PMC Article
Gimbrone MA Jr, García-Cardeña G
Circ Res 2016 Feb 19;118(4):620-36. doi: 10.1161/CIRCRESAHA.115.306301. PMID: 26892962Free PMC Article
Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL
Cell 2015 Dec 17;163(7):1585-95. doi: 10.1016/j.cell.2015.11.055. PMID: 26687352Free PMC Article
Badimon L, Vilahur G
J Intern Med 2014 Dec;276(6):618-32. Epub 2014 Sep 25 doi: 10.1111/joim.12296. PMID: 25156650

Diagnosis

Razeghian-Jahromi I, Karimi Akhormeh A, Razmkhah M, Zibaeenezhad MJ
Int J Immunopathol Pharmacol 2022 Jan-Dec;36:3946320221092188. doi: 10.1177/03946320221092188. PMID: 35410514Free PMC Article
Summerhill V, Orekhov A
Adv Exp Med Biol 2019;1147:279-297. doi: 10.1007/978-3-030-16908-4_13. PMID: 31147883
Giménez VMM, Camargo AB, Kassuha D, Manucha W
Curr Pharm Des 2018;24(39):4681-4684. doi: 10.2174/1381612825666190110154609. PMID: 30636583
Feinberg MW, Moore KJ
Circ Res 2016 Feb 19;118(4):703-20. doi: 10.1161/CIRCRESAHA.115.306300. PMID: 26892968Free PMC Article
Reape TJ, Groot PH
Atherosclerosis 1999 Dec;147(2):213-25. doi: 10.1016/s0021-9150(99)00346-9. PMID: 10559506

Therapy

Haghikia A, Zimmermann F, Schumann P, Jasina A, Roessler J, Schmidt D, Heinze P, Kaisler J, Nageswaran V, Aigner A, Ceglarek U, Cineus R, Hegazy AN, van der Vorst EPC, Döring Y, Strauch CM, Nemet I, Tremaroli V, Dwibedi C, Kränkel N, Leistner DM, Heimesaat MM, Bereswill S, Rauch G, Seeland U, Soehnlein O, Müller DN, Gold R, Bäckhed F, Hazen SL, Haghikia A, Landmesser U
Eur Heart J 2022 Feb 10;43(6):518-533. doi: 10.1093/eurheartj/ehab644. PMID: 34597388Free PMC Article
Zhu Y, Li Q, Jiang H
APMIS 2020 May;128(5):353-366. Epub 2020 Mar 30 doi: 10.1111/apm.13038. PMID: 32108960Free PMC Article
Dewey FE, Gusarova V, Dunbar RL, O'Dushlaine C, Schurmann C, Gottesman O, McCarthy S, Van Hout CV, Bruse S, Dansky HM, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Habegger L, Lopez A, Penn J, Zhao A, Shao W, Stahl N, Murphy AJ, Hamon S, Bouzelmat A, Zhang R, Shumel B, Pordy R, Gipe D, Herman GA, Sheu WHH, Lee IT, Liang KW, Guo X, Rotter JI, Chen YI, Kraus WE, Shah SH, Damrauer S, Small A, Rader DJ, Wulff AB, Nordestgaard BG, Tybjærg-Hansen A, van den Hoek AM, Princen HMG, Ledbetter DH, Carey DJ, Overton JD, Reid JG, Sasiela WJ, Banerjee P, Shuldiner AR, Borecki IB, Teslovich TM, Yancopoulos GD, Mellis SJ, Gromada J, Baras A
N Engl J Med 2017 Jul 20;377(3):211-221. Epub 2017 May 24 doi: 10.1056/NEJMoa1612790. PMID: 28538136Free PMC Article
Feinberg MW, Moore KJ
Circ Res 2016 Feb 19;118(4):703-20. doi: 10.1161/CIRCRESAHA.115.306300. PMID: 26892968Free PMC Article
Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL
Cell 2015 Dec 17;163(7):1585-95. doi: 10.1016/j.cell.2015.11.055. PMID: 26687352Free PMC Article

Prognosis

Julius U, Schatz U, Tselmin S, Morawietz H
Horm Metab Res 2022 Aug;54(8):514-521. Epub 2022 Jul 14 doi: 10.1055/a-1860-2610. PMID: 35835148
Haghikia A, Zimmermann F, Schumann P, Jasina A, Roessler J, Schmidt D, Heinze P, Kaisler J, Nageswaran V, Aigner A, Ceglarek U, Cineus R, Hegazy AN, van der Vorst EPC, Döring Y, Strauch CM, Nemet I, Tremaroli V, Dwibedi C, Kränkel N, Leistner DM, Heimesaat MM, Bereswill S, Rauch G, Seeland U, Soehnlein O, Müller DN, Gold R, Bäckhed F, Hazen SL, Haghikia A, Landmesser U
Eur Heart J 2022 Feb 10;43(6):518-533. doi: 10.1093/eurheartj/ehab644. PMID: 34597388Free PMC Article
Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabási AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M
Circulation 2019 Jan 2;139(1):78-96. doi: 10.1161/CIRCULATIONAHA.118.034588. PMID: 30586693Free PMC Article
Feinberg MW, Moore KJ
Circ Res 2016 Feb 19;118(4):703-20. doi: 10.1161/CIRCRESAHA.115.306300. PMID: 26892968Free PMC Article
Gimbrone MA Jr, García-Cardeña G
Circ Res 2016 Feb 19;118(4):620-36. doi: 10.1161/CIRCRESAHA.115.306301. PMID: 26892962Free PMC Article

Clinical prediction guides

Alencar GF, Owsiany KM, Karnewar S, Sukhavasi K, Mocci G, Nguyen AT, Williams CM, Shamsuzzaman S, Mokry M, Henderson CA, Haskins R, Baylis RA, Finn AV, McNamara CA, Zunder ER, Venkata V, Pasterkamp G, Björkegren J, Bekiranov S, Owens GK
Circulation 2020 Nov 24;142(21):2045-2059. Epub 2020 Jul 17 doi: 10.1161/CIRCULATIONAHA.120.046672. PMID: 32674599Free PMC Article
Jinnouchi H, Sato Y, Sakamoto A, Cornelissen A, Mori M, Kawakami R, Gadhoke NV, Kolodgie FD, Virmani R, Finn AV
Atherosclerosis 2020 Aug;306:85-95. Epub 2020 Jun 14 doi: 10.1016/j.atherosclerosis.2020.05.017. PMID: 32654790
Zhu J, Liu B, Wang Z, Wang D, Ni H, Zhang L, Wang Y
Theranostics 2019;9(23):6901-6919. Epub 2019 Sep 21 doi: 10.7150/thno.37357. PMID: 31660076Free PMC Article
Zhuang T, Liu J, Chen X, Zhang L, Pi J, Sun H, Li L, Bauer R, Wang H, Yu Z, Zhang Q, Tomlinson B, Chan P, Zheng X, Morrisey E, Liu Z, Reilly M, Zhang Y
Circ Res 2019 Aug 30;125(6):590-605. Epub 2019 Jul 18 doi: 10.1161/CIRCRESAHA.118.314402. PMID: 31318658
Feinberg MW, Moore KJ
Circ Res 2016 Feb 19;118(4):703-20. doi: 10.1161/CIRCRESAHA.115.306300. PMID: 26892968Free PMC Article

Recent systematic reviews

Li S, Liu P, Feng X, Wang Y, Du M, Wang J
PLoS One 2022;17(5):e0267968. Epub 2022 May 2 doi: 10.1371/journal.pone.0267968. PMID: 35500001Free PMC Article
Phie J, Krishna SM, Moxon JV, Omer SM, Kinobe R, Golledge J
PLoS One 2017;12(7):e0181832. Epub 2017 Jul 25 doi: 10.1371/journal.pone.0181832. PMID: 28742839Free PMC Article
Pasterkamp G, van der Laan SW, Haitjema S, Foroughi Asl H, Siemelink MA, Bezemer T, van Setten J, Dichgans M, Malik R, Worrall BB, Schunkert H, Samani NJ, de Kleijn DP, Markus HS, Hoefer IE, Michoel T, de Jager SC, Björkegren JL, den Ruijter HM, Asselbergs FW
Arterioscler Thromb Vasc Biol 2016 Jun;36(6):1240-6. Epub 2016 Apr 14 doi: 10.1161/ATVBAHA.115.306958. PMID: 27079880
Ji YN, Wang Q, Zhan P
Mol Biol Rep 2012 May;39(5):6043-8. Epub 2011 Dec 28 doi: 10.1007/s11033-011-1418-6. PMID: 22203486

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