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RISS Stage II Plasma Cell Myeloma

MedGen UID:
1632954
•Concept ID:
C4683784
•
Neoplastic Process
Synonym: Revised International Staging System Stage II Plasma Cell Myeloma

Definition

Not stage I or III. (from AJCC 8th Ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRISS Stage II Plasma Cell Myeloma

Professional guidelines

PubMed

Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345
Role of Conventional Karyotyping in Multiple Myeloma in the Era of Modern Treatment and FISH Analysis.
Soekojo CY, Wang GM, Chen Y, Casan J, Wolyncewicz G, Lin A, Poon LM, de Mel S, Koh LP, Tan LK, Ooi MG, Nagarajan C, Liu Y, Lai YY, Huang XJ, Spencer A, Gopalakrishnan SK, Lu J, Chng WJ
Clin Lymphoma Myeloma Leuk 2019 Aug;19(8):e470-e477. Epub 2019 Apr 28 doi: 10.1016/j.clml.2019.04.011. PMID: 31171473
Clinical utility of the Revised International Staging System in unselected patients with newly diagnosed and relapsed multiple myeloma.
Tandon N, Rajkumar SV, LaPlant B, Pettinger A, Lacy MQ, Dispenzieri A, Buadi FK, Gertz MA, Hayman SR, Leung N, Go RS, Dingli D, Kapoor P, Lin Y, Hwa YL, Fonder AL, Hobbs MA, Zeldenrust SR, Lust JA, Gonsalves WI, Russell SJ, Kumar SK
Blood Cancer J 2017 Feb 17;7(2):e528. doi: 10.1038/bcj.2017.13. PMID: 28211889Free PMC Article

Recent clinical studies

Etiology

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma (MM).
Zhong L, Hao P, Zhang Q, Jiang T, Li H, Xiao J, Li C, Luo L, Xie C, Hu J, Wang L, Liu Y, Shi Y, Zhang W, Gong B
Elife 2022 Oct 31;11 doi: 10.7554/eLife.75340. PMID: 36315425Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345
A simple additive staging system for newly diagnosed multiple myeloma.
Abdallah NH, Binder M, Rajkumar SV, Greipp PT, Kapoor P, Dispenzieri A, Gertz MA, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder AL, Hobbs MA, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui MA, Kyle RA, Bergsagel PL, Fonseca R, Ketterling RP, Kumar SK
Blood Cancer J 2022 Jan 31;12(1):21. doi: 10.1038/s41408-022-00611-x. PMID: 35102148Free PMC Article
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Diagnosis

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma (MM).
Zhong L, Hao P, Zhang Q, Jiang T, Li H, Xiao J, Li C, Luo L, Xie C, Hu J, Wang L, Liu Y, Shi Y, Zhang W, Gong B
Elife 2022 Oct 31;11 doi: 10.7554/eLife.75340. PMID: 36315425Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345
A simple additive staging system for newly diagnosed multiple myeloma.
Abdallah NH, Binder M, Rajkumar SV, Greipp PT, Kapoor P, Dispenzieri A, Gertz MA, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder AL, Hobbs MA, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui MA, Kyle RA, Bergsagel PL, Fonseca R, Ketterling RP, Kumar SK
Blood Cancer J 2022 Jan 31;12(1):21. doi: 10.1038/s41408-022-00611-x. PMID: 35102148Free PMC Article
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Therapy

Isatuximab Plus Carfilzomib and Dexamethasone Versus Carfilzomib and Dexamethasone in Patients with Relapsed Multiple Myeloma: IKEMA Subgroup Analysis by Prior Transplantation.
Martin TG, Capra M, Mohty M, Suzuki K, Quach H, Cavo M, Moreau P, Dimopoulos M, Yong K, Tekle C, Foster MC, Barnes Y, Risse ML, Mikhael J
Transplant Cell Ther 2023 Feb;29(2):134.e1-134.e7. Epub 2022 Nov 11 doi: 10.1016/j.jtct.2022.11.005. PMID: 36372355
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345
Propensity-score matched analysis of the efficacy of maintenance/continuous therapy in newly diagnosed patients with multiple myeloma: a multicenter retrospective collaborative study of the Japanese Society of Myeloma.
Ozaki S, Handa H, Koiso H, Saitoh T, Sunami K, Ishida T, Suzuki K, Narita T, Iida S, Nakamura Y, Suzuki K, Nishimura N, Murakami H, Shimizu K
J Cancer Res Clin Oncol 2022 Jan;148(1):191-203. Epub 2021 Jun 2 doi: 10.1007/s00432-021-03668-6. PMID: 34080068
Prognostic and predictive performance of R-ISS with SKY92 in older patients with multiple myeloma: the HOVON-87/NMSG-18 trial.
Kuiper R, Zweegman S, van Duin M, van Vliet MH, van Beers EH, Dumee B, Vermeulen M, Koenders J, van der Holt B, Visser-Wisselaar H, Hansson M, van der Velden AWG, Beverloo HB, Stevens-Kroef M, Levin MD, Broijl A, Waage A, Sonneveld P
Blood Adv 2020 Dec 22;4(24):6298-6309. doi: 10.1182/bloodadvances.2020002838. PMID: 33351127Free PMC Article
Enhancing the R-ISS classification of newly diagnosed multiple myeloma by quantifying circulating clonal plasma cells.
Gonsalves WI, Jevremovic D, Nandakumar B, Dispenzieri A, Buadi FK, Dingli D, Lacy MQ, Hayman SR, Kapoor P, Leung N, Fonder A, Hobbs M, Hwa YL, Muchtar E, Warsame R, Kourelis TV, Russell S, Lust JA, Lin Y, Go RS, Siddiqui MA, Kyle RA, Gertz MA, Rajkumar SV, Kumar SK
Am J Hematol 2020 Mar;95(3):310-315. Epub 2020 Jan 8 doi: 10.1002/ajh.25709. PMID: 31867775Free PMC Article

Prognosis

Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345
A simple additive staging system for newly diagnosed multiple myeloma.
Abdallah NH, Binder M, Rajkumar SV, Greipp PT, Kapoor P, Dispenzieri A, Gertz MA, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder AL, Hobbs MA, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui MA, Kyle RA, Bergsagel PL, Fonseca R, Ketterling RP, Kumar SK
Blood Cancer J 2022 Jan 31;12(1):21. doi: 10.1038/s41408-022-00611-x. PMID: 35102148Free PMC Article
Clinical characteristics and prognosis of immunoglobulin D myeloma in the novel agent era.
Chen L, Fan F, Deng J, Xu J, Xu A, Sun C, Hu Y
Ann Hematol 2019 Apr;98(4):963-970. Epub 2019 Jan 4 doi: 10.1007/s00277-018-3582-4. PMID: 30610280
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Clinical prediction guides

Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Evaluation of prognostic staging systems of multiple myeloma in the era of novel agents.
Shang Y, Jin Y, Liu H, Ding L, Tong X, Tu H, Zang L, Lin C, Hu J, Zhou F
Hematol Oncol 2022 Apr;40(2):212-222. Epub 2021 Dec 12 doi: 10.1002/hon.2955. PMID: 34860428
Prognostic and predictive performance of R-ISS with SKY92 in older patients with multiple myeloma: the HOVON-87/NMSG-18 trial.
Kuiper R, Zweegman S, van Duin M, van Vliet MH, van Beers EH, Dumee B, Vermeulen M, Koenders J, van der Holt B, Visser-Wisselaar H, Hansson M, van der Velden AWG, Beverloo HB, Stevens-Kroef M, Levin MD, Broijl A, Waage A, Sonneveld P
Blood Adv 2020 Dec 22;4(24):6298-6309. doi: 10.1182/bloodadvances.2020002838. PMID: 33351127Free PMC Article
Clinical characteristics and prognosis of immunoglobulin D myeloma in the novel agent era.
Chen L, Fan F, Deng J, Xu J, Xu A, Sun C, Hu Y
Ann Hematol 2019 Apr;98(4):963-970. Epub 2019 Jan 4 doi: 10.1007/s00277-018-3582-4. PMID: 30610280
Automatic digital quantification of bone marrow myeloma volume in appendicular skeletons - clinical implications and prognostic significance.
Nishida Y, Kimura S, Mizobe H, Yamamichi J, Kojima K, Kawaguchi A, Fujisawa M, Matsue K
Sci Rep 2017 Oct 10;7(1):12885. doi: 10.1038/s41598-017-13255-w. PMID: 29018236Free PMC Article

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