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CCND3 Protein Overexpression

MedGen UID:
1633149
Concept ID:
C4683759
Cell or Molecular Dysfunction
Synonyms: Cyclin D3 Protein Overexpression; Cyclin-D3 Protein Overexpression; G1/S-Specific Cyclin D3 Protein Overexpression; G1/S-Specific Cyclin-D3 Protein Overexpression

Definition

A molecular abnormality indicating the presence of an abnormally high level of the G1/S-specific cyclin-D3 protein. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCCND3 Protein Overexpression

Recent clinical studies

Etiology

Li L, Li M, Zheng J, Li Z, Chen X
Aging (Albany NY) 2023 Jun 1;15(11):4757-4773. doi: 10.18632/aging.204761. PMID: 37263638Free PMC Article
Gupta S, Argani P, Jungbluth AA, Chen YB, Tickoo SK, Fine SW, Gopalan A, Al-Ahmadie HA, Sirintrapun SJ, Sanchez A, Hakimi AA, Mcfarlane T, Salazar PA, Williamson SR, Skala SL, Mehra R, Hes O, Antonescu CR, Ladanyi M, Arcila ME, Reuter VE
Am J Surg Pathol 2019 Nov;43(11):1445-1461. doi: 10.1097/PAS.0000000000001307. PMID: 31600176Free PMC Article
Zhuang Y, Lu Y, Li D, Sun N, Ju X
Oncol Rep 2015 Mar;33(3):1319-25. Epub 2014 Dec 18 doi: 10.3892/or.2014.3677. PMID: 25524659
Zhuang Y, Li D, Fu J, Shi Q, Lu Y, Ju X
Oncol Rep 2014 Mar;31(3):1183-90. Epub 2013 Dec 31 doi: 10.3892/or.2013.2964. PMID: 24399134
Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S, Epstein J, Yaccoby S, Sawyer J, Burington B, Anaissie E, Hollmig K, Pineda-Roman M, Tricot G, van Rhee F, Walker R, Zangari M, Crowley J, Barlogie B, Shaughnessy JD Jr
Blood 2006 Sep 15;108(6):2020-8. Epub 2006 May 25 doi: 10.1182/blood-2005-11-013458. PMID: 16728703Free PMC Article

Diagnosis

Li L, Li M, Zheng J, Li Z, Chen X
Aging (Albany NY) 2023 Jun 1;15(11):4757-4773. doi: 10.18632/aging.204761. PMID: 37263638Free PMC Article
Gupta S, Argani P, Jungbluth AA, Chen YB, Tickoo SK, Fine SW, Gopalan A, Al-Ahmadie HA, Sirintrapun SJ, Sanchez A, Hakimi AA, Mcfarlane T, Salazar PA, Williamson SR, Skala SL, Mehra R, Hes O, Antonescu CR, Ladanyi M, Arcila ME, Reuter VE
Am J Surg Pathol 2019 Nov;43(11):1445-1461. doi: 10.1097/PAS.0000000000001307. PMID: 31600176Free PMC Article
Martín-Garcia D, Navarro A, Valdés-Mas R, Clot G, Gutiérrez-Abril J, Prieto M, Ribera-Cortada I, Woroniecka R, Rymkiewicz G, Bens S, de Leval L, Rosenwald A, Ferry JA, Hsi ED, Fu K, Delabie J, Weisenburger D, de Jong D, Climent F, O'Connor SJ, Swerdlow SH, Torrents D, Beltran S, Espinet B, González-Farré B, Veloza L, Costa D, Matutes E, Siebert R, Ott G, Quintanilla-Martinez L, Jaffe ES, López-Otín C, Salaverria I, Puente XS, Campo E, Beà S
Blood 2019 Feb 28;133(9):940-951. Epub 2018 Dec 11 doi: 10.1182/blood-2018-07-862151. PMID: 30538135Free PMC Article
Han LP, Fu T, Lin Y, Miao JL, Jiang QF
Tumour Biol 2016 Jan;37(1):291-8. Epub 2015 Jul 23 doi: 10.1007/s13277-015-3757-8. PMID: 26201895
Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S, Epstein J, Yaccoby S, Sawyer J, Burington B, Anaissie E, Hollmig K, Pineda-Roman M, Tricot G, van Rhee F, Walker R, Zangari M, Crowley J, Barlogie B, Shaughnessy JD Jr
Blood 2006 Sep 15;108(6):2020-8. Epub 2006 May 25 doi: 10.1182/blood-2005-11-013458. PMID: 16728703Free PMC Article

Therapy

Wang F, Demir S, Gehringer F, Osswald CD, Seyfried F, Enzenmüller S, Eckhoff SM, Maier T, Holzmann K, Debatin KM, Wirth T, Meyer LH, Ushmorov A
Blood 2018 Jun 28;131(26):2929-2942. Epub 2018 Apr 5 doi: 10.1182/blood-2017-10-813576. PMID: 29622548
Zhang X, Liu D, Li M, Cao C, Wan D, Xi B, Li W, Tan J, Wang J, Wu Z, Ma D, Gao Q
J Hematol Oncol 2017 Jan 23;10(1):29. doi: 10.1186/s13045-017-0400-8. PMID: 28114995Free PMC Article
Atsaves V, Lekakis L, Drakos E, Leventaki V, Ghaderi M, Baltatzis GE, Chioureas D, Jones D, Feretzaki M, Liakou C, Panayiotidis P, Gorgoulis V, Patsouris E, Medeiros LJ, Claret FX, Rassidakis GZ
Br J Haematol 2014 Nov;167(4):514-23. Epub 2014 Aug 22 doi: 10.1111/bjh.13079. PMID: 25145835
Follo MY, Mongiorgi S, Clissa C, Paolini S, Martinelli G, Martelli AM, Fioravanti G, Manzoli L, Finelli C, Cocco L
Leukemia 2012 Dec;26(12):2474-82. Epub 2012 May 18 doi: 10.1038/leu.2012.133. PMID: 22596089
Mao X, Liang SB, Hurren R, Gronda M, Chow S, Xu GW, Wang X, Beheshti Zavareh R, Jamal N, Messner H, Hedley DW, Datti A, Wrana JL, Zhu Y, Shi CX, Lee K, Tiedemann R, Trudel S, Stewart AK, Schimmer AD
Blood 2008 Aug 1;112(3):760-9. Epub 2008 May 23 doi: 10.1182/blood-2008-02-142687. PMID: 18502826

Prognosis

Wu W, Deng J, Chen C, Ma X, Yu L, Chen L
Hematology 2023 Dec;28(1):2240133. doi: 10.1080/16078454.2023.2240133. PMID: 37585722
Gupta S, Argani P, Jungbluth AA, Chen YB, Tickoo SK, Fine SW, Gopalan A, Al-Ahmadie HA, Sirintrapun SJ, Sanchez A, Hakimi AA, Mcfarlane T, Salazar PA, Williamson SR, Skala SL, Mehra R, Hes O, Antonescu CR, Ladanyi M, Arcila ME, Reuter VE
Am J Surg Pathol 2019 Nov;43(11):1445-1461. doi: 10.1097/PAS.0000000000001307. PMID: 31600176Free PMC Article
Kang H, Heo S, Shin JJ, Ji E, Tak H, Ahn S, Lee KJ, Lee EK, Kim W
J Pathol 2019 Nov;249(3):395-408. Epub 2019 Aug 27 doi: 10.1002/path.5325. PMID: 31301177
Martín-Garcia D, Navarro A, Valdés-Mas R, Clot G, Gutiérrez-Abril J, Prieto M, Ribera-Cortada I, Woroniecka R, Rymkiewicz G, Bens S, de Leval L, Rosenwald A, Ferry JA, Hsi ED, Fu K, Delabie J, Weisenburger D, de Jong D, Climent F, O'Connor SJ, Swerdlow SH, Torrents D, Beltran S, Espinet B, González-Farré B, Veloza L, Costa D, Matutes E, Siebert R, Ott G, Quintanilla-Martinez L, Jaffe ES, López-Otín C, Salaverria I, Puente XS, Campo E, Beà S
Blood 2019 Feb 28;133(9):940-951. Epub 2018 Dec 11 doi: 10.1182/blood-2018-07-862151. PMID: 30538135Free PMC Article
Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S, Epstein J, Yaccoby S, Sawyer J, Burington B, Anaissie E, Hollmig K, Pineda-Roman M, Tricot G, van Rhee F, Walker R, Zangari M, Crowley J, Barlogie B, Shaughnessy JD Jr
Blood 2006 Sep 15;108(6):2020-8. Epub 2006 May 25 doi: 10.1182/blood-2005-11-013458. PMID: 16728703Free PMC Article

Clinical prediction guides

Li L, Li M, Zheng J, Li Z, Chen X
Aging (Albany NY) 2023 Jun 1;15(11):4757-4773. doi: 10.18632/aging.204761. PMID: 37263638Free PMC Article
Boldrin E, Gaffo E, Niedermayer A, Boer JM, Zimmermann M, Weichenhan D, Claus R, Münch V, Sun Q, Enzenmüller S, Seyfried F, Demir S, Zinngrebe J, Cario G, Schrappe M, Den Boer ML, Plass C, Debatin KM, Te Kronnie G, Bortoluzzi S, Meyer LH
Blood 2021 Nov 18;138(20):1953-1965. doi: 10.1182/blood.2020007591. PMID: 34098582
Wang W, Zhao LJ, Tan YX, Ren H, Qi ZT
Carcinogenesis 2012 May;33(5):1113-20. Epub 2012 Feb 23 doi: 10.1093/carcin/bgs113. PMID: 22362728Free PMC Article
Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S, Epstein J, Yaccoby S, Sawyer J, Burington B, Anaissie E, Hollmig K, Pineda-Roman M, Tricot G, van Rhee F, Walker R, Zangari M, Crowley J, Barlogie B, Shaughnessy JD Jr
Blood 2006 Sep 15;108(6):2020-8. Epub 2006 May 25 doi: 10.1182/blood-2005-11-013458. PMID: 16728703Free PMC Article
Kasugai Y, Tagawa H, Kameoka Y, Morishima Y, Nakamura S, Seto M
Clin Cancer Res 2005 Dec 1;11(23):8265-72. doi: 10.1158/1078-0432.CCR-05-1028. PMID: 16322284

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