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Chromosome 13 Abnormality

MedGen UID:
1633507
•Concept ID:
C4683646
•
Cell or Molecular Dysfunction

Definition

An irregularity in the structure of chromosome 13. [from NCI]

Professional guidelines

PubMed

Monosomy 13 in metaphase spreads is a predictor of poor long-term outcome after bortezomib plus dexamethasone treatment for relapsed/refractory multiple myeloma.
Kiyota M, Kobayashi T, Fuchida S, Yamamoto-Sugitani M, Ohshiro M, Shimura Y, Mizutani S, Nagoshi H, Sasaki N, Nakayama R, Chinen Y, Sakamoto N, Uchiyama H, Matsumoto Y, Horiike S, Shimazaki C, Kuroda J, Taniwaki M
Int J Hematol 2012 May;95(5):516-26. Epub 2012 Mar 17 doi: 10.1007/s12185-012-1035-8. PMID: 22426624

Recent clinical studies

Etiology

Monosomy 13 in metaphase spreads is a predictor of poor long-term outcome after bortezomib plus dexamethasone treatment for relapsed/refractory multiple myeloma.
Kiyota M, Kobayashi T, Fuchida S, Yamamoto-Sugitani M, Ohshiro M, Shimura Y, Mizutani S, Nagoshi H, Sasaki N, Nakayama R, Chinen Y, Sakamoto N, Uchiyama H, Matsumoto Y, Horiike S, Shimazaki C, Kuroda J, Taniwaki M
Int J Hematol 2012 May;95(5):516-26. Epub 2012 Mar 17 doi: 10.1007/s12185-012-1035-8. PMID: 22426624
Myelomatous pleural effusion: a case series in a single institution and literature review.
Cho YU, Chi HS, Park CJ, Jang S, Seo EJ, Suh C
Korean J Lab Med 2011 Oct;31(4):225-30. Epub 2011 Oct 3 doi: 10.3343/kjlm.2011.31.4.225. PMID: 22016674Free PMC Article
Improved outcome of allogeneic transplantation in high-risk multiple myeloma patients after nonmyeloablative conditioning.
Badros A, Barlogie B, Siegel E, Cottler-Fox M, Zangari M, Fassas A, Morris C, Anaissie E, Van Rhee F, Tricot G
J Clin Oncol 2002 Mar 1;20(5):1295-303. doi: 10.1200/JCO.2002.20.5.1295. PMID: 11870172
Sinonasal small cell neoplasm developing after radiation therapy for retinoblastoma: an immunohistologic, ultrastructural, and cytogenetic study.
Saw D, Chan JK, Jagirdar J, Greco MA, Lee M
Hum Pathol 1992 Aug;23(8):896-9. doi: 10.1016/0046-8177(92)90401-n. PMID: 1322860

Diagnosis

Monosomy 13 in metaphase spreads is a predictor of poor long-term outcome after bortezomib plus dexamethasone treatment for relapsed/refractory multiple myeloma.
Kiyota M, Kobayashi T, Fuchida S, Yamamoto-Sugitani M, Ohshiro M, Shimura Y, Mizutani S, Nagoshi H, Sasaki N, Nakayama R, Chinen Y, Sakamoto N, Uchiyama H, Matsumoto Y, Horiike S, Shimazaki C, Kuroda J, Taniwaki M
Int J Hematol 2012 May;95(5):516-26. Epub 2012 Mar 17 doi: 10.1007/s12185-012-1035-8. PMID: 22426624
Myelomatous pleural effusion: a case series in a single institution and literature review.
Cho YU, Chi HS, Park CJ, Jang S, Seo EJ, Suh C
Korean J Lab Med 2011 Oct;31(4):225-30. Epub 2011 Oct 3 doi: 10.3343/kjlm.2011.31.4.225. PMID: 22016674Free PMC Article
Improved outcome of allogeneic transplantation in high-risk multiple myeloma patients after nonmyeloablative conditioning.
Badros A, Barlogie B, Siegel E, Cottler-Fox M, Zangari M, Fassas A, Morris C, Anaissie E, Van Rhee F, Tricot G
J Clin Oncol 2002 Mar 1;20(5):1295-303. doi: 10.1200/JCO.2002.20.5.1295. PMID: 11870172

Therapy

Monosomy 13 in metaphase spreads is a predictor of poor long-term outcome after bortezomib plus dexamethasone treatment for relapsed/refractory multiple myeloma.
Kiyota M, Kobayashi T, Fuchida S, Yamamoto-Sugitani M, Ohshiro M, Shimura Y, Mizutani S, Nagoshi H, Sasaki N, Nakayama R, Chinen Y, Sakamoto N, Uchiyama H, Matsumoto Y, Horiike S, Shimazaki C, Kuroda J, Taniwaki M
Int J Hematol 2012 May;95(5):516-26. Epub 2012 Mar 17 doi: 10.1007/s12185-012-1035-8. PMID: 22426624

Prognosis

Monosomy 13 in metaphase spreads is a predictor of poor long-term outcome after bortezomib plus dexamethasone treatment for relapsed/refractory multiple myeloma.
Kiyota M, Kobayashi T, Fuchida S, Yamamoto-Sugitani M, Ohshiro M, Shimura Y, Mizutani S, Nagoshi H, Sasaki N, Nakayama R, Chinen Y, Sakamoto N, Uchiyama H, Matsumoto Y, Horiike S, Shimazaki C, Kuroda J, Taniwaki M
Int J Hematol 2012 May;95(5):516-26. Epub 2012 Mar 17 doi: 10.1007/s12185-012-1035-8. PMID: 22426624
Myelomatous pleural effusion: a case series in a single institution and literature review.
Cho YU, Chi HS, Park CJ, Jang S, Seo EJ, Suh C
Korean J Lab Med 2011 Oct;31(4):225-30. Epub 2011 Oct 3 doi: 10.3343/kjlm.2011.31.4.225. PMID: 22016674Free PMC Article
t(11;14) and t(4;14) translocations correlated with mature lymphoplasmacytoid and immature morphology, respectively, in multiple myeloma.
Garand R, Avet-Loiseau H, Accard F, Moreau P, Harousseau JL, Bataille R
Leukemia 2003 Oct;17(10):2032-5. doi: 10.1038/sj.leu.2403091. PMID: 14513054
Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13.
Avet-Louseau H, Daviet A, Sauner S, Bataille R; Intergroupe Francophone du Myélome
Br J Haematol 2000 Dec;111(4):1116-7. doi: 10.1046/j.1365-2141.2000.02488.x. PMID: 11227093

Clinical prediction guides

Monosomy 13 in metaphase spreads is a predictor of poor long-term outcome after bortezomib plus dexamethasone treatment for relapsed/refractory multiple myeloma.
Kiyota M, Kobayashi T, Fuchida S, Yamamoto-Sugitani M, Ohshiro M, Shimura Y, Mizutani S, Nagoshi H, Sasaki N, Nakayama R, Chinen Y, Sakamoto N, Uchiyama H, Matsumoto Y, Horiike S, Shimazaki C, Kuroda J, Taniwaki M
Int J Hematol 2012 May;95(5):516-26. Epub 2012 Mar 17 doi: 10.1007/s12185-012-1035-8. PMID: 22426624
Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13.
Avet-Louseau H, Daviet A, Sauner S, Bataille R; Intergroupe Francophone du Myélome
Br J Haematol 2000 Dec;111(4):1116-7. doi: 10.1046/j.1365-2141.2000.02488.x. PMID: 11227093

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