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Adenomatous polyp of colon

MedGen UID:
163407
•Concept ID:
C0850572
•
Neoplastic Process
Synonym: Adenomatous colon polyp
SNOMED CT: Adenomatous polyp of colon (428054006)
 
Monarch Initiative: MONDO:0006498

Definition

A polypoid adenoma that arises from and protrudes into the lumen of the colon. Epithelial dysplasia is always present. According to the architectural pattern it is classified as tubular, tubulovillous, or villous. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Adenomatous polyp of colon

Professional guidelines

PubMed

Diagnosis and classification of ileal pouch disorders: consensus guidelines from the International Ileal Pouch Consortium.
Shen B, Kochhar GS, Kariv R, Liu X, Navaneethan U, Rubin DT, Cross RK, Sugita A, D'Hoore A, Schairer J, Farraye FA, Kiran RP, Fleshner P, Rosh J, Shah SA, Chang S, Scherl E, Pardi DS, Schwartz DA, Kotze PG, Bruining DH, Kane SV, Philpott J, Abraham B, Segal J, Sedano R, Kayal M, Bentley-Hibbert S, Tarabar D, El-Hachem S, Sehgal P, McCormick JT, Picoraro JA, Silverberg MS, Bernstein CN, Sandborn WJ, Vermeire S
Lancet Gastroenterol Hepatol 2021 Oct;6(10):826-849. Epub 2021 Aug 18 doi: 10.1016/S2468-1253(21)00101-1. PMID: 34416186
Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Pathophysiology, clinical presentation, and management of colon cancer.
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

Recent clinical studies

Etiology

Hierarchical contribution of individual lifestyle factors and their interactions on adenomatous and serrated polyp risk.
Kim J, Nath K, Schmidlin K, Schaufelberger H, Quattropani C, Vannini S, Mossi S, Thumshirn M, Manz M, Litichevskiy L, Fan J, Dmitrieva-Posocco O, Li M, Levy M, Schär P, Zwahlen M, Thaiss CA, Truninger K
J Gastroenterol 2023 Sep;58(9):856-867. Epub 2023 Jun 10 doi: 10.1007/s00535-023-02004-8. PMID: 37300599Free PMC Article
The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Gastritis, Gastric Polyps and Gastric Cancer.
Waldum H, Fossmark R
Int J Mol Sci 2021 Jun 18;22(12) doi: 10.3390/ijms22126548. PMID: 34207192Free PMC Article
Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline.
Ferlitsch M, Moss A, Hassan C, Bhandari P, Dumonceau JM, Paspatis G, Jover R, Langner C, Bronzwaer M, Nalankilli K, Fockens P, Hazzan R, Gralnek IM, Gschwantler M, Waldmann E, Jeschek P, Penz D, Heresbach D, Moons L, Lemmers A, Paraskeva K, Pohl J, Ponchon T, Regula J, Repici A, Rutter MD, Burgess NG, Bourke MJ
Endoscopy 2017 Mar;49(3):270-297. Epub 2017 Feb 17 doi: 10.1055/s-0043-102569. PMID: 28212588

Diagnosis

The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer.
Gupta S, Lieberman D, Anderson JC, Burke CA, Dominitz JA, Kaltenbach T, Robertson DJ, Shaukat A, Syngal S, Rex DK
Gastrointest Endosc 2020 Mar;91(3):463-485.e5. Epub 2020 Feb 7 doi: 10.1016/j.gie.2020.01.014. PMID: 32044106Free PMC Article
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline.
Ferlitsch M, Moss A, Hassan C, Bhandari P, Dumonceau JM, Paspatis G, Jover R, Langner C, Bronzwaer M, Nalankilli K, Fockens P, Hazzan R, Gralnek IM, Gschwantler M, Waldmann E, Jeschek P, Penz D, Heresbach D, Moons L, Lemmers A, Paraskeva K, Pohl J, Ponchon T, Regula J, Repici A, Rutter MD, Burgess NG, Bourke MJ
Endoscopy 2017 Mar;49(3):270-297. Epub 2017 Feb 17 doi: 10.1055/s-0043-102569. PMID: 28212588
Obesity and Colorectal Cancer.
Jochem C, Leitzmann M
Recent Results Cancer Res 2016;208:17-41. doi: 10.1007/978-3-319-42542-9_2. PMID: 27909900

Therapy

Dietary Inflammatory Potential and the Risk of Serrated and Adenomatous Colorectal Polyps.
Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Inflammatory and Metabolic Biomarker Assessment in a Randomized Presurgical Trial of Curcumin and Anthocyanin Supplements in Patients with Colorectal Adenomas.
Macis D, Briata IM, D'Ecclesiis O, Johansson H, Aristarco V, Buttiron Webber T, Oppezzi M, Gandini S, Bonanni B, DeCensi A
Nutrients 2023 Sep 7;15(18) doi: 10.3390/nu15183894. PMID: 37764678Free PMC Article
Artificial intelligence-assisted optical diagnosis for the resect-and-discard strategy in clinical practice: the Artificial intelligence BLI Characterization (ABC) study.
Rondonotti E, Hassan C, Tamanini G, Antonelli G, Andrisani G, Leonetti G, Paggi S, Amato A, Scardino G, Di Paolo D, Mandelli G, Lenoci N, Terreni N, Andrealli A, Maselli R, Spadaccini M, Galtieri PA, Correale L, Repici A, Di Matteo FM, Ambrosiani L, Filippi E, Sharma P, Radaelli F
Endoscopy 2023 Jan;55(1):14-22. Epub 2022 May 13 doi: 10.1055/a-1852-0330. PMID: 35562098
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Chemoprevention of colorectal neoplasia.
Wakeman C, Keenan J, Eteuati J, Hollington P, Eglinton T, Frizelle F
ANZ J Surg 2017 Dec;87(12):E228-E232. Epub 2015 Dec 21 doi: 10.1111/ans.13392. PMID: 26686322

Prognosis

The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer.
Gupta S, Lieberman D, Anderson JC, Burke CA, Dominitz JA, Kaltenbach T, Robertson DJ, Shaukat A, Syngal S, Rex DK
Gastrointest Endosc 2020 Mar;91(3):463-485.e5. Epub 2020 Feb 7 doi: 10.1016/j.gie.2020.01.014. PMID: 32044106Free PMC Article
Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Heart Failure Stimulates Tumor Growth by Circulating Factors.
Meijers WC, Maglione M, Bakker SJL, Oberhuber R, Kieneker LM, de Jong S, Haubner BJ, Nagengast WB, Lyon AR, van der Vegt B, van Veldhuisen DJ, Westenbrink BD, van der Meer P, Silljé HHW, de Boer RA
Circulation 2018 Aug 14;138(7):678-691. doi: 10.1161/CIRCULATIONAHA.117.030816. PMID: 29459363
Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths.
Zauber AG, Winawer SJ, O'Brien MJ, Lansdorp-Vogelaar I, van Ballegooijen M, Hankey BF, Shi W, Bond JH, Schapiro M, Panish JF, Stewart ET, Waye JD
N Engl J Med 2012 Feb 23;366(8):687-96. doi: 10.1056/NEJMoa1100370. PMID: 22356322Free PMC Article

Clinical prediction guides

Dietary Inflammatory Potential and the Risk of Serrated and Adenomatous Colorectal Polyps.
Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Integrated Analysis of the Endoscopic, Pathological and Molecular Characteristics of Colorectal Tumorigenesis.
Suzuki H, Yamamoto E, Yamano HO, Nakase H, Sugai T
Digestion 2019;99(1):33-38. Epub 2018 Dec 14 doi: 10.1159/000494410. PMID: 30554192
Heart Failure Stimulates Tumor Growth by Circulating Factors.
Meijers WC, Maglione M, Bakker SJL, Oberhuber R, Kieneker LM, de Jong S, Haubner BJ, Nagengast WB, Lyon AR, van der Vegt B, van Veldhuisen DJ, Westenbrink BD, van der Meer P, Silljé HHW, de Boer RA
Circulation 2018 Aug 14;138(7):678-691. doi: 10.1161/CIRCULATIONAHA.117.030816. PMID: 29459363
Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths.
Zauber AG, Winawer SJ, O'Brien MJ, Lansdorp-Vogelaar I, van Ballegooijen M, Hankey BF, Shi W, Bond JH, Schapiro M, Panish JF, Stewart ET, Waye JD
N Engl J Med 2012 Feb 23;366(8):687-96. doi: 10.1056/NEJMoa1100370. PMID: 22356322Free PMC Article

Recent systematic reviews

Irritable Bowel Syndrome Is Not Associated with an Increased Risk of Polyps and Colorectal Cancer: A Systematic Review and Meta-Analysis.
Vichos T, Rezaie A, Vichos P, Cash B, Pimentel M
Dig Dis Sci 2023 Jun;68(6):2585-2596. Epub 2023 Mar 4 doi: 10.1007/s10620-023-07885-6. PMID: 36871131Free PMC Article
Diagnosis and Management of Functional Pouch Disorders: A Systematic Review.
Roussel BN, Shah SA
Dis Colon Rectum 2022 Dec 1;65(S1):S113-S118. Epub 2022 Aug 25 doi: 10.1097/DCR.0000000000002586. PMID: 36399771
Diagnosis and Management of Cuffitis: A Systematic Review.
Hembree AE, Scherl E
Dis Colon Rectum 2022 Dec 1;65(S1):S85-S91. Epub 2022 Aug 25 doi: 10.1097/DCR.0000000000002593. PMID: 36399769
Association between breast cancer and the risk of colorectal cancer.
Lai JH, Park G, Gerson LB
Gastrointest Endosc 2017 Sep;86(3):429-441.e1. Epub 2017 Apr 20 doi: 10.1016/j.gie.2017.04.008. PMID: 28433614
Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
Stanich PP, Pilarski R, Rock J, Frankel WL, El-Dika S, Meyer MM
World J Gastroenterol 2014 Feb 21;20(7):1833-8. doi: 10.3748/wjg.v20.i7.1833. PMID: 24587660Free PMC Article

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