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MET Gene Deletion

MedGen UID:
1634233
Concept ID:
C4687688
Cell or Molecular Dysfunction
Synonyms: c-MET Gene Deletion; Hepatocyte Growth Factor Receptor Gene Deletion; HGFR Gene Deletion; MET Proto-Oncogene, Receptor Tyrosine Kinase Gene Deletion

Definition

A molecular abnormality referring to the loss of at least one copy of the MET gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMET Gene Deletion

Professional guidelines

PubMed

Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Falsaperla R, Criscione R, Cimino C, Pisani F, Ruggieri M
Neuropediatrics 2023 Oct;54(5):297-307. Epub 2023 Mar 22 doi: 10.1055/a-2060-4576. PMID: 36948217
Stilgenbauer S
Hematology Am Soc Hematol Educ Program 2015;2015:368-77. doi: 10.1182/asheducation-2015.1.368. PMID: 26637745

Recent clinical studies

Etiology

Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Billingsley KJ, Ding J, Jerez PA, Illarionova A, Levine K, Grenn FP, Makarious MB, Moore A, Vitale D, Reed X, Hernandez D, Torkamani A, Ryten M, Hardy J; UK Brain Expression Consortium (UKBEC), Chia R, Scholz SW, Traynor BJ, Dalgard CL, Ehrlich DJ, Tanaka T, Ferrucci L, Beach TG, Serrano GE, Quinn JP, Bubb VJ, Collins RL, Zhao X, Walker M, Pierce-Hoffman E, Brand H, Talkowski ME, Casey B, Cookson MR, Markham A, Nalls MA, Mahmoud M, Sedlazeck FJ, Blauwendraat C, Gibbs JR, Singleton AB
Ann Neurol 2023 May;93(5):1012-1022. Epub 2023 Feb 3 doi: 10.1002/ana.26608. PMID: 36695634Free PMC Article
Weiner DJ, Ling E, Erdin S, Tai DJC, Yadav R, Grove J, Fu JM, Nadig A, Carey CE, Baya N, Bybjerg-Grauholm J; iPSYCH Consortium; ASD Working Group of the Psychiatric Genomics Consortium; ADHD Working Group of the Psychiatric Genomics Consortium, Berretta S, Macosko EZ, Sebat J, O'Connor LJ, Hougaard DM, Børglum AD, Talkowski ME, McCarroll SA, Robinson EB
Nat Genet 2022 Nov;54(11):1630-1639. Epub 2022 Oct 24 doi: 10.1038/s41588-022-01203-y. PMID: 36280734Free PMC Article
Collins RL, Glessner JT, Porcu E, Lepamets M, Brandon R, Lauricella C, Han L, Morley T, Niestroj LM, Ulirsch J, Everett S, Howrigan DP, Boone PM, Fu J, Karczewski KJ, Kellaris G, Lowther C, Lucente D, Mohajeri K, Nõukas M, Nuttle X, Samocha KE, Trinh M, Ullah F, Võsa U; Epi25 Consortium; Estonian Biobank Research Team, Hurles ME, Aradhya S, Davis EE, Finucane H, Gusella JF, Janze A, Katsanis N, Matyakhina L, Neale BM, Sanders D, Warren S, Hodge JC, Lal D, Ruderfer DM, Meck J, Mägi R, Esko T, Reymond A, Kutalik Z, Hakonarson H, Sunyaev S, Brand H, Talkowski ME
Cell 2022 Aug 4;185(16):3041-3055.e25. Epub 2022 Aug 1 doi: 10.1016/j.cell.2022.06.036. PMID: 35917817Free PMC Article
Witmer C, Mattingly A, DʼSouza P, Thurm A, Hadigan C
J Pediatr Gastroenterol Nutr 2019 Aug;69(2):e39-e42. doi: 10.1097/MPG.0000000000002342. PMID: 30921255Free PMC Article

Diagnosis

Leatham B, McNall K, Subramanian HKK, Jacky L, Alvarado J, Yurk D, Wang M, Green DC, Tsongalis GJ, Rajagopal A, Schwartz JJ
Mol Oncol 2023 Nov;17(11):2221-2234. Epub 2023 Oct 4 doi: 10.1002/1878-0261.13523. PMID: 37714814Free PMC Article
Collins RL, Glessner JT, Porcu E, Lepamets M, Brandon R, Lauricella C, Han L, Morley T, Niestroj LM, Ulirsch J, Everett S, Howrigan DP, Boone PM, Fu J, Karczewski KJ, Kellaris G, Lowther C, Lucente D, Mohajeri K, Nõukas M, Nuttle X, Samocha KE, Trinh M, Ullah F, Võsa U; Epi25 Consortium; Estonian Biobank Research Team, Hurles ME, Aradhya S, Davis EE, Finucane H, Gusella JF, Janze A, Katsanis N, Matyakhina L, Neale BM, Sanders D, Warren S, Hodge JC, Lal D, Ruderfer DM, Meck J, Mägi R, Esko T, Reymond A, Kutalik Z, Hakonarson H, Sunyaev S, Brand H, Talkowski ME
Cell 2022 Aug 4;185(16):3041-3055.e25. Epub 2022 Aug 1 doi: 10.1016/j.cell.2022.06.036. PMID: 35917817Free PMC Article
Cerqua M, Botti O, Arigoni M, Gioelli N, Serini G, Calogero R, Boccaccio C, Comoglio PM, Altintas DM
Life Sci Alliance 2022 Oct;5(10) Epub 2022 May 30 doi: 10.26508/lsa.202201409. PMID: 35636967Free PMC Article
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Cooley Coleman JA, Sarasua SM, Boccuto L, Moore HW, Skinner SA, DeLuca JM
Am J Med Genet A 2021 Dec;185(12):3884-3894. Epub 2021 Jun 29 doi: 10.1002/ajmg.a.62412. PMID: 34184825

Therapy

Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Niu C, Chen Z, Kim KT, Sun J, Xue M, Chen G, Li S, Shen Y, Zhu Z, Wang X, Liang J, Jiang C, Cong W, Jin L, Li X
Autophagy 2019 May;15(5):843-870. Epub 2019 Jan 27 doi: 10.1080/15548627.2019.1569913. PMID: 30653446Free PMC Article
Salgia R
Mol Cancer Ther 2017 Apr;16(4):555-565. doi: 10.1158/1535-7163.MCT-16-0472. PMID: 28373408
Finisguerra V, Di Conza G, Di Matteo M, Serneels J, Costa S, Thompson AA, Wauters E, Walmsley S, Prenen H, Granot Z, Casazza A, Mazzone M
Nature 2015 Jun 18;522(7556):349-53. Epub 2015 May 18 doi: 10.1038/nature14407. PMID: 25985180Free PMC Article

Prognosis

Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Guo Y, Tian C, Cheng Z, Chen R, Li Y, Su F, Shi Y, Tan H
Neuroendocrinology 2023;113(9):943-956. Epub 2023 May 12 doi: 10.1159/000530968. PMID: 37232011Free PMC Article
Wu F, Yin YY, Fan WH, Zhai Y, Yu MC, Wang D, Pan CQ, Zhao Z, Li GZ, Zhang W
EBioMedicine 2023 Jan;87:104410. Epub 2022 Dec 14 doi: 10.1016/j.ebiom.2022.104410. PMID: 36525723Free PMC Article
Collins RL, Glessner JT, Porcu E, Lepamets M, Brandon R, Lauricella C, Han L, Morley T, Niestroj LM, Ulirsch J, Everett S, Howrigan DP, Boone PM, Fu J, Karczewski KJ, Kellaris G, Lowther C, Lucente D, Mohajeri K, Nõukas M, Nuttle X, Samocha KE, Trinh M, Ullah F, Võsa U; Epi25 Consortium; Estonian Biobank Research Team, Hurles ME, Aradhya S, Davis EE, Finucane H, Gusella JF, Janze A, Katsanis N, Matyakhina L, Neale BM, Sanders D, Warren S, Hodge JC, Lal D, Ruderfer DM, Meck J, Mägi R, Esko T, Reymond A, Kutalik Z, Hakonarson H, Sunyaev S, Brand H, Talkowski ME
Cell 2022 Aug 4;185(16):3041-3055.e25. Epub 2022 Aug 1 doi: 10.1016/j.cell.2022.06.036. PMID: 35917817Free PMC Article
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916

Clinical prediction guides

Wu F, Yin YY, Fan WH, Zhai Y, Yu MC, Wang D, Pan CQ, Zhao Z, Li GZ, Zhang W
EBioMedicine 2023 Jan;87:104410. Epub 2022 Dec 14 doi: 10.1016/j.ebiom.2022.104410. PMID: 36525723Free PMC Article
Collins RL, Glessner JT, Porcu E, Lepamets M, Brandon R, Lauricella C, Han L, Morley T, Niestroj LM, Ulirsch J, Everett S, Howrigan DP, Boone PM, Fu J, Karczewski KJ, Kellaris G, Lowther C, Lucente D, Mohajeri K, Nõukas M, Nuttle X, Samocha KE, Trinh M, Ullah F, Võsa U; Epi25 Consortium; Estonian Biobank Research Team, Hurles ME, Aradhya S, Davis EE, Finucane H, Gusella JF, Janze A, Katsanis N, Matyakhina L, Neale BM, Sanders D, Warren S, Hodge JC, Lal D, Ruderfer DM, Meck J, Mägi R, Esko T, Reymond A, Kutalik Z, Hakonarson H, Sunyaev S, Brand H, Talkowski ME
Cell 2022 Aug 4;185(16):3041-3055.e25. Epub 2022 Aug 1 doi: 10.1016/j.cell.2022.06.036. PMID: 35917817Free PMC Article
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Niu C, Chen Z, Kim KT, Sun J, Xue M, Chen G, Li S, Shen Y, Zhu Z, Wang X, Liang J, Jiang C, Cong W, Jin L, Li X
Autophagy 2019 May;15(5):843-870. Epub 2019 Jan 27 doi: 10.1080/15548627.2019.1569913. PMID: 30653446Free PMC Article
Salgia R
Mol Cancer Ther 2017 Apr;16(4):555-565. doi: 10.1158/1535-7163.MCT-16-0472. PMID: 28373408

Recent systematic reviews

Falsaperla R, Criscione R, Cimino C, Pisani F, Ruggieri M
Neuropediatrics 2023 Oct;54(5):297-307. Epub 2023 Mar 22 doi: 10.1055/a-2060-4576. PMID: 36948217
Cooley Coleman JA, Sarasua SM, Boccuto L, Moore HW, Skinner SA, DeLuca JM
Am J Med Genet A 2021 Dec;185(12):3884-3894. Epub 2021 Jun 29 doi: 10.1002/ajmg.a.62412. PMID: 34184825
Babačić H, Mehta A, Merkel O, Schoser B
PLoS One 2019;14(2):e0212198. Epub 2019 Feb 22 doi: 10.1371/journal.pone.0212198. PMID: 30794581Free PMC Article
Bentley AR, Emrani P, Cassano PA
Thorax 2008 Nov;63(11):956-61. Epub 2008 Jun 19 doi: 10.1136/thx.2007.086199. PMID: 18566111Free PMC Article
Anguelova M, Benkelfat C, Turecki G
Mol Psychiatry 2003 Jul;8(7):646-53. doi: 10.1038/sj.mp.4001336. PMID: 12874600

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